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Protein

Heme transporter HRG1

Gene

Slc48a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Heme transporter HRG1
Alternative name(s):
Heme-responsive gene 1 protein homolog
Short name:
HRG-1
Solute carrier family 48 member 1
Gene namesi
Name:Slc48a1
Synonyms:Hrg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1914989. Slc48a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221HelicalSequence analysisAdd
BLAST
Transmembranei40 – 6021HelicalSequence analysisAdd
BLAST
Transmembranei74 – 9421HelicalSequence analysisAdd
BLAST
Transmembranei110 – 13021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 146146Heme transporter HRG1PRO_0000348576Add
BLAST

Proteomic databases

PaxDbiQ9D8M3.
PeptideAtlasiQ9D8M3.
PRIDEiQ9D8M3.

PTM databases

iPTMnetiQ9D8M3.
PhosphoSiteiQ9D8M3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000081534.
ExpressionAtlasiQ9D8M3. baseline and differential.
GenevisibleiQ9D8M3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000112644.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi142 – 1432Di-leucine motif

Sequence similaritiesi

Belongs to the HRG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J2XM. Eukaryota.
ENOG4111YMM. LUCA.
GeneTreeiENSGT00390000002307.
HOGENOMiHOG000069906.
HOVERGENiHBG059709.
InParanoidiQ9D8M3.
KOiK15380.
OMAiVATFCTF.
OrthoDBiEOG091G0NVJ.
TreeFamiTF332621.

Family and domain databases

InterProiIPR026218. HRG.
[Graphical view]
PfamiPF16954. HRG. 2 hits.
[Graphical view]
PRINTSiPR02095. TRNSPORTRHRG.

Sequencei

Sequence statusi: Complete.

Q9D8M3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPSRLQLGL RAAYSGFSSV AGFSIFFVWT VVYRQPGTAA MGGLAGVLAL
60 70 80 90 100
WVLVTHVMYM QDYWRTWLRG LRGFFFVGAL FSAVSVSAFC TFLALAITQH
110 120 130 140
QSLKDPNSYY LSCVWSFISF KWAFLLSLYA HRYRADFADI SILSDF
Length:146
Mass (Da):16,489
Last modified:June 1, 2001 - v1
Checksum:iD71B3DBB4AC38A3B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti98 – 981T → N in BAB22311 (PubMed:16141072).Curated
Sequence conflicti109 – 1091Y → C in BAE23759 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002729 mRNA. Translation: BAB22311.1.
AK007888 mRNA. Translation: BAB25331.1.
AK088485 mRNA. Translation: BAC40384.1.
AK089421 mRNA. Translation: BAC40874.1.
AK138729 mRNA. Translation: BAE23759.1.
AK150552 mRNA. Translation: BAE29654.1.
AK155824 mRNA. Translation: BAE33448.1.
AK159879 mRNA. Translation: BAE35451.1.
AK159892 mRNA. Translation: BAE35459.1.
AK159898 mRNA. Translation: BAE35464.1.
AK170393 mRNA. Translation: BAE41765.1.
BC022913 mRNA. Translation: AAH22913.1.
CCDSiCCDS49715.1.
RefSeqiNP_080629.1. NM_026353.4.
UniGeneiMm.28955.

Genome annotation databases

EnsembliENSMUST00000117892; ENSMUSP00000112644; ENSMUSG00000081534.
GeneIDi67739.
KEGGimmu:67739.
UCSCiuc007xlb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002729 mRNA. Translation: BAB22311.1.
AK007888 mRNA. Translation: BAB25331.1.
AK088485 mRNA. Translation: BAC40384.1.
AK089421 mRNA. Translation: BAC40874.1.
AK138729 mRNA. Translation: BAE23759.1.
AK150552 mRNA. Translation: BAE29654.1.
AK155824 mRNA. Translation: BAE33448.1.
AK159879 mRNA. Translation: BAE35451.1.
AK159892 mRNA. Translation: BAE35459.1.
AK159898 mRNA. Translation: BAE35464.1.
AK170393 mRNA. Translation: BAE41765.1.
BC022913 mRNA. Translation: AAH22913.1.
CCDSiCCDS49715.1.
RefSeqiNP_080629.1. NM_026353.4.
UniGeneiMm.28955.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000112644.

PTM databases

iPTMnetiQ9D8M3.
PhosphoSiteiQ9D8M3.

Proteomic databases

PaxDbiQ9D8M3.
PeptideAtlasiQ9D8M3.
PRIDEiQ9D8M3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000117892; ENSMUSP00000112644; ENSMUSG00000081534.
GeneIDi67739.
KEGGimmu:67739.
UCSCiuc007xlb.2. mouse.

Organism-specific databases

CTDi55652.
MGIiMGI:1914989. Slc48a1.

Phylogenomic databases

eggNOGiENOG410J2XM. Eukaryota.
ENOG4111YMM. LUCA.
GeneTreeiENSGT00390000002307.
HOGENOMiHOG000069906.
HOVERGENiHBG059709.
InParanoidiQ9D8M3.
KOiK15380.
OMAiVATFCTF.
OrthoDBiEOG091G0NVJ.
TreeFamiTF332621.

Miscellaneous databases

ChiTaRSiSlc48a1. mouse.
PROiQ9D8M3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000081534.
ExpressionAtlasiQ9D8M3. baseline and differential.
GenevisibleiQ9D8M3. MM.

Family and domain databases

InterProiIPR026218. HRG.
[Graphical view]
PfamiPF16954. HRG. 2 hits.
[Graphical view]
PRINTSiPR02095. TRNSPORTRHRG.
ProtoNetiSearch...

Entry informationi

Entry nameiHRG1_MOUSE
AccessioniPrimary (citable) accession number: Q9D8M3
Secondary accession number(s): Q3UU69, Q9DCK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.