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Q9D8K8

- S2539_MOUSE

UniProt

Q9D8K8 - S2539_MOUSE

Protein

Solute carrier family 25 member 39

Gene

Slc25a39

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Required for normal heme biosynthesis.By similarity

    GO - Biological processi

    1. heme biosynthetic process Source: UniProtKB-KW
    2. transport Source: UniProtKB-KW

    Keywords - Biological processi

    Heme biosynthesis, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 25 member 39
    Gene namesi
    Name:Slc25a39
    Synonyms:D11Ertd333e
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1196386. Slc25a39.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359Solute carrier family 25 member 39PRO_0000090597Add
    BLAST

    Proteomic databases

    PaxDbiQ9D8K8.
    PRIDEiQ9D8K8.

    Expressioni

    Tissue specificityi

    Abundant expression in bone marrow, spleen, testis and kidney.1 Publication

    Developmental stagei

    Highly express in primitive erythroblast that fill yorlk sac blood islands at early somite pair stages, and in fetal liver at E12.5.1 Publication

    Gene expression databases

    ArrayExpressiQ9D8K8.
    BgeeiQ9D8K8.
    CleanExiMM_SLC25A39.
    GenevestigatoriQ9D8K8.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000018821.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D8K8.
    SMRiQ9D8K8. Positions 14-352.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei15 – 3521Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei122 – 14221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei165 – 18521Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei215 – 23521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei256 – 27621Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei318 – 33821Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati9 – 151143Solcar 1Add
    BLAST
    Repeati159 – 24385Solcar 2Add
    BLAST
    Repeati253 – 34795Solcar 3Add
    BLAST

    Sequence similaritiesi

    Contains 3 Solcar repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG276989.
    GeneTreeiENSGT00390000000106.
    HOGENOMiHOG000214473.
    HOVERGENiHBG011439.
    InParanoidiQ9D8K8.
    KOiK15119.
    OMAiRRQIEMD.
    PhylomeDBiQ9D8K8.
    TreeFamiTF314720.

    Family and domain databases

    Gene3Di1.50.40.10. 2 hits.
    InterProiIPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 4 hits.
    [Graphical view]
    SUPFAMiSSF103506. SSF103506. 2 hits.
    PROSITEiPS50920. SOLCAR. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9D8K8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDDQDPGGIS PLQQMVASGA GAVVTSLFMT PLDVVKVRLQ SQRPSATSEL    50
    TTPSRFWSLS YTKSSSALQS PGKCLLYCNG VLEPLYLCPN GTRCATWFQD 100
    PTRFTGTLDA FVKIVRHEGT RTLWSGLPAT LVMTVPATAI YFTAYDQLKA 150
    FLCGQSLTSD LYAPMVAGAL ARMGTVTVVS PLELVRTKLQ AQHVSYRELA 200
    SSVQAAVTQG GWRSLWLGWG PTALRDVPFS ALYWFNYELV KSWLSGLRPK 250
    DQTSVGISFV AGGISGMVAA TLTLPFDVVK TQRQMSLGAV EAVRVKPPRV 300
    DSTWLLLRRI RAESGTRGLF AGFLPRIIKA APSCAIMIST YEFGKSFFQR 350
    LNQEQPLGR 359
    Length:359
    Mass (Da):39,221
    Last modified:June 1, 2001 - v1
    Checksum:iED986C79395DBFCA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK007934 mRNA. Translation: BAB25360.1.
    AK078417 mRNA. Translation: BAC37264.1.
    AK161289 mRNA. Translation: BAE36297.1.
    CCDSiCCDS25498.1.
    RefSeqiNP_080818.1. NM_026542.3.
    XP_006534097.1. XM_006534034.1.
    XP_006534098.1. XM_006534035.1.
    UniGeneiMm.44226.

    Genome annotation databases

    EnsembliENSMUST00000018821; ENSMUSP00000018821; ENSMUSG00000018677.
    GeneIDi68066.
    KEGGimmu:68066.
    UCSCiuc007lrt.3. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK007934 mRNA. Translation: BAB25360.1 .
    AK078417 mRNA. Translation: BAC37264.1 .
    AK161289 mRNA. Translation: BAE36297.1 .
    CCDSi CCDS25498.1.
    RefSeqi NP_080818.1. NM_026542.3.
    XP_006534097.1. XM_006534034.1.
    XP_006534098.1. XM_006534035.1.
    UniGenei Mm.44226.

    3D structure databases

    ProteinModelPortali Q9D8K8.
    SMRi Q9D8K8. Positions 14-352.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000018821.

    Proteomic databases

    PaxDbi Q9D8K8.
    PRIDEi Q9D8K8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000018821 ; ENSMUSP00000018821 ; ENSMUSG00000018677 .
    GeneIDi 68066.
    KEGGi mmu:68066.
    UCSCi uc007lrt.3. mouse.

    Organism-specific databases

    CTDi 51629.
    MGIi MGI:1196386. Slc25a39.

    Phylogenomic databases

    eggNOGi NOG276989.
    GeneTreei ENSGT00390000000106.
    HOGENOMi HOG000214473.
    HOVERGENi HBG011439.
    InParanoidi Q9D8K8.
    KOi K15119.
    OMAi RRQIEMD.
    PhylomeDBi Q9D8K8.
    TreeFami TF314720.

    Miscellaneous databases

    NextBioi 326344.
    PROi Q9D8K8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9D8K8.
    Bgeei Q9D8K8.
    CleanExi MM_SLC25A39.
    Genevestigatori Q9D8K8.

    Family and domain databases

    Gene3Di 1.50.40.10. 2 hits.
    InterProi IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 4 hits.
    [Graphical view ]
    SUPFAMi SSF103506. SSF103506. 2 hits.
    PROSITEi PS50920. SOLCAR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Pancreas, Testis and Wolffian duct.
    2. Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiS2539_MOUSE
    AccessioniPrimary (citable) accession number: Q9D8K8
    Secondary accession number(s): Q3TTM8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3