Q9D8K8 (S2539_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Solute carrier family 25 member 39

Gene names

Name:	Slc25a39
Synonyms:	D11Ertd333e

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Required for normal heme biosynthesis By similarity.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Tissue specificity	Abundant expression in bone marrow, spleen, testis and kidney. Ref.2
Developmental stage	Highly express in primitive erythroblast that fill yorlk sac blood islands at early somite pair stages, and in fetal liver at E12.5. Ref.2
Sequence similarities	Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification] Contains 3 Solcar repeats.

Ontologies

Keywords
Biological process	Heme biosynthesis Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Repeat Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	heme biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from direct assay PubMed 14651853PubMed 18614015. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	Solute carrier family 25 member 39		PRO_0000090597
Regions
	Transmembrane	15 – 35	21	Helical; Name=1; Potential
	Transmembrane	122 – 142	21	Helical; Name=2; Potential
	Transmembrane	165 – 185	21	Helical; Name=3; Potential
	Transmembrane	215 – 235	21	Helical; Name=4; Potential
	Transmembrane	256 – 276	21	Helical; Name=5; Potential
	Transmembrane	318 – 338	21	Helical; Name=6; Potential
	Repeat	9 – 151	143	Solcar 1
	Repeat	159 – 243	85	Solcar 2
	Repeat	253 – 347	95	Solcar 3

Sequences

	Sequence		Length	Mass (Da)
	Q9D8K8 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: ED986C79395DBFCA	FASTA	359	39,221
	10 20 30 40 50 60 MDDQDPGGIS PLQQMVASGA GAVVTSLFMT PLDVVKVRLQ SQRPSATSEL TTPSRFWSLS 70 80 90 100 110 120 YTKSSSALQS PGKCLLYCNG VLEPLYLCPN GTRCATWFQD PTRFTGTLDA FVKIVRHEGT 130 140 150 160 170 180 RTLWSGLPAT LVMTVPATAI YFTAYDQLKA FLCGQSLTSD LYAPMVAGAL ARMGTVTVVS 190 200 210 220 230 240 PLELVRTKLQ AQHVSYRELA SSVQAAVTQG GWRSLWLGWG PTALRDVPFS ALYWFNYELV 250 260 270 280 290 300 KSWLSGLRPK DQTSVGISFV AGGISGMVAA TLTLPFDVVK TQRQMSLGAV EAVRVKPPRV 310 320 330 340 350 DSTWLLLRRI RAESGTRGLF AGFLPRIIKA APSCAIMIST YEFGKSFFQR LNQEQPLGR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Pancreas, Testis and Wolffian duct.
[2]	"Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis." Nilsson R., Schultz I.J., Pierce E.L., Soltis K.A., Naranuntarat A., Ward D.M., Baughman J.M., Paradkar P.N., Kingsley P.D., Culotta V.C., Kaplan J., Palis J., Paw B.H., Mootha V.K. Cell Metab. 10:119-130(2009) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK007934 mRNA. Translation: BAB25360.1. AK078417 mRNA. Translation: BAC37264.1. AK161289 mRNA. Translation: BAE36297.1.
IPI	IPI00111628.
RefSeq	NP_080818.1. NM_026542.3.
UniGene	Mm.44226.
3D structure databases
ProteinModelPortal	Q9D8K8.
SMR	Q9D8K8. Positions 14-352.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000018821.
Proteomic databases
PaxDb	Q9D8K8.
PRIDE	Q9D8K8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000018821; ENSMUSP00000018821; ENSMUSG00000018677.
GeneID	68066.
KEGG	mmu:68066.
Organism-specific databases
CTD	51629.
MGI	MGI:1196386. Slc25a39.
Phylogenomic databases
eggNOG	NOG276989.
GeneTree	ENSGT00390000000106.
HOGENOM	HOG000214473.
HOVERGEN	HBG011439.
InParanoid	Q9D8K8.
KO	K15119.
OMA	WSLSYTK.
OrthoDB	EOG498V12.
Gene expression databases
ArrayExpress	Q9D8K8.
Bgee	Q9D8K8.
CleanEx	MM_SLC25A39.
Genevestigator	Q9D8K8.
GermOnline	ENSMUSG00000018677. Mus musculus.
Family and domain databases
Gene3D	1.50.40.10. 2 hits.
InterPro	IPR018108. Mitochondrial_sb/sol_carrier. IPR023395. Mt_carrier_dom. [Graphical view]
Pfam	PF00153. Mito_carr. 4 hits. [Graphical view]
SUPFAM	SSF103506. Mitoch_carrier. 1 hit.
PROSITE	PS50920. SOLCAR. 3 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	326344.
SOURCE	Search...

Entry information

Entry name

S2539_MOUSE

Accession

Primary (citable) accession number: Q9D8K8
Secondary accession number(s): Q3TTM8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program