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Protein

Solute carrier family 25 member 39

Gene

Slc25a39

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Required for normal heme biosynthesis.By similarity

GO - Biological processi

  1. heme biosynthetic process Source: UniProtKB-KW
  2. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Heme biosynthesis, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 39
Gene namesi
Name:Slc25a39
Synonyms:D11Ertd333e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1196386. Slc25a39.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3521Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei122 – 14221Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei165 – 18521Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei215 – 23521Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei256 – 27621Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei318 – 33821Helical; Name=6Sequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Solute carrier family 25 member 39PRO_0000090597Add
BLAST

Proteomic databases

MaxQBiQ9D8K8.
PaxDbiQ9D8K8.
PRIDEiQ9D8K8.

Expressioni

Tissue specificityi

Abundant expression in bone marrow, spleen, testis and kidney.1 Publication

Developmental stagei

Highly express in primitive erythroblast that fill yorlk sac blood islands at early somite pair stages, and in fetal liver at E12.5.1 Publication

Gene expression databases

BgeeiQ9D8K8.
CleanExiMM_SLC25A39.
ExpressionAtlasiQ9D8K8. baseline and differential.
GenevestigatoriQ9D8K8.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018821.

Structurei

3D structure databases

ProteinModelPortaliQ9D8K8.
SMRiQ9D8K8. Positions 14-352.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati9 – 151143Solcar 1Add
BLAST
Repeati159 – 24385Solcar 2Add
BLAST
Repeati253 – 34795Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG276989.
GeneTreeiENSGT00780000121925.
HOGENOMiHOG000214473.
HOVERGENiHBG011439.
InParanoidiQ9D8K8.
KOiK15119.
OMAiKWKCLLY.
PhylomeDBiQ9D8K8.
TreeFamiTF314720.

Family and domain databases

Gene3Di1.50.40.10. 2 hits.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 4 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 2 hits.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D8K8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDQDPGGIS PLQQMVASGA GAVVTSLFMT PLDVVKVRLQ SQRPSATSEL
60 70 80 90 100
TTPSRFWSLS YTKSSSALQS PGKCLLYCNG VLEPLYLCPN GTRCATWFQD
110 120 130 140 150
PTRFTGTLDA FVKIVRHEGT RTLWSGLPAT LVMTVPATAI YFTAYDQLKA
160 170 180 190 200
FLCGQSLTSD LYAPMVAGAL ARMGTVTVVS PLELVRTKLQ AQHVSYRELA
210 220 230 240 250
SSVQAAVTQG GWRSLWLGWG PTALRDVPFS ALYWFNYELV KSWLSGLRPK
260 270 280 290 300
DQTSVGISFV AGGISGMVAA TLTLPFDVVK TQRQMSLGAV EAVRVKPPRV
310 320 330 340 350
DSTWLLLRRI RAESGTRGLF AGFLPRIIKA APSCAIMIST YEFGKSFFQR

LNQEQPLGR
Length:359
Mass (Da):39,221
Last modified:June 1, 2001 - v1
Checksum:iED986C79395DBFCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007934 mRNA. Translation: BAB25360.1.
AK078417 mRNA. Translation: BAC37264.1.
AK161289 mRNA. Translation: BAE36297.1.
CCDSiCCDS25498.1.
RefSeqiNP_080818.1. NM_026542.3.
XP_006534097.1. XM_006534034.1.
XP_006534098.1. XM_006534035.1.
UniGeneiMm.44226.

Genome annotation databases

EnsembliENSMUST00000018821; ENSMUSP00000018821; ENSMUSG00000018677.
GeneIDi68066.
KEGGimmu:68066.
UCSCiuc007lrt.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007934 mRNA. Translation: BAB25360.1.
AK078417 mRNA. Translation: BAC37264.1.
AK161289 mRNA. Translation: BAE36297.1.
CCDSiCCDS25498.1.
RefSeqiNP_080818.1. NM_026542.3.
XP_006534097.1. XM_006534034.1.
XP_006534098.1. XM_006534035.1.
UniGeneiMm.44226.

3D structure databases

ProteinModelPortaliQ9D8K8.
SMRiQ9D8K8. Positions 14-352.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018821.

Proteomic databases

MaxQBiQ9D8K8.
PaxDbiQ9D8K8.
PRIDEiQ9D8K8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018821; ENSMUSP00000018821; ENSMUSG00000018677.
GeneIDi68066.
KEGGimmu:68066.
UCSCiuc007lrt.3. mouse.

Organism-specific databases

CTDi51629.
MGIiMGI:1196386. Slc25a39.

Phylogenomic databases

eggNOGiNOG276989.
GeneTreeiENSGT00780000121925.
HOGENOMiHOG000214473.
HOVERGENiHBG011439.
InParanoidiQ9D8K8.
KOiK15119.
OMAiKWKCLLY.
PhylomeDBiQ9D8K8.
TreeFamiTF314720.

Miscellaneous databases

NextBioi326344.
PROiQ9D8K8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D8K8.
CleanExiMM_SLC25A39.
ExpressionAtlasiQ9D8K8. baseline and differential.
GenevestigatoriQ9D8K8.

Family and domain databases

Gene3Di1.50.40.10. 2 hits.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 4 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 2 hits.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pancreas, Testis and Wolffian duct.
  2. Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiS2539_MOUSE
AccessioniPrimary (citable) accession number: Q9D8K8
Secondary accession number(s): Q3TTM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 1, 2001
Last modified: February 4, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.