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Q9D8K8

- S2539_MOUSE

UniProt

Q9D8K8 - S2539_MOUSE

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Protein
Solute carrier family 25 member 39
Gene
Slc25a39, D11Ertd333e
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Required for normal heme biosynthesis By similarity.

GO - Biological processi

  1. heme biosynthetic process Source: UniProtKB-KW
  2. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Heme biosynthesis, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 39
Gene namesi
Name:Slc25a39
Synonyms:D11Ertd333e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1196386. Slc25a39.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3521Helical; Name=1; Reviewed prediction
Add
BLAST
Transmembranei122 – 14221Helical; Name=2; Reviewed prediction
Add
BLAST
Transmembranei165 – 18521Helical; Name=3; Reviewed prediction
Add
BLAST
Transmembranei215 – 23521Helical; Name=4; Reviewed prediction
Add
BLAST
Transmembranei256 – 27621Helical; Name=5; Reviewed prediction
Add
BLAST
Transmembranei318 – 33821Helical; Name=6; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Solute carrier family 25 member 39
PRO_0000090597Add
BLAST

Proteomic databases

PaxDbiQ9D8K8.
PRIDEiQ9D8K8.

Expressioni

Tissue specificityi

Abundant expression in bone marrow, spleen, testis and kidney.1 Publication

Developmental stagei

Highly express in primitive erythroblast that fill yorlk sac blood islands at early somite pair stages, and in fetal liver at E12.5.1 Publication

Gene expression databases

ArrayExpressiQ9D8K8.
BgeeiQ9D8K8.
CleanExiMM_SLC25A39.
GenevestigatoriQ9D8K8.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018821.

Structurei

3D structure databases

ProteinModelPortaliQ9D8K8.
SMRiQ9D8K8. Positions 14-352.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati9 – 151143Solcar 1
Add
BLAST
Repeati159 – 24385Solcar 2
Add
BLAST
Repeati253 – 34795Solcar 3
Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG276989.
GeneTreeiENSGT00390000000106.
HOGENOMiHOG000214473.
HOVERGENiHBG011439.
InParanoidiQ9D8K8.
KOiK15119.
OMAiRRQIEMD.
PhylomeDBiQ9D8K8.
TreeFamiTF314720.

Family and domain databases

Gene3Di1.50.40.10. 2 hits.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 4 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 2 hits.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D8K8-1 [UniParc]FASTAAdd to Basket

« Hide

MDDQDPGGIS PLQQMVASGA GAVVTSLFMT PLDVVKVRLQ SQRPSATSEL    50
TTPSRFWSLS YTKSSSALQS PGKCLLYCNG VLEPLYLCPN GTRCATWFQD 100
PTRFTGTLDA FVKIVRHEGT RTLWSGLPAT LVMTVPATAI YFTAYDQLKA 150
FLCGQSLTSD LYAPMVAGAL ARMGTVTVVS PLELVRTKLQ AQHVSYRELA 200
SSVQAAVTQG GWRSLWLGWG PTALRDVPFS ALYWFNYELV KSWLSGLRPK 250
DQTSVGISFV AGGISGMVAA TLTLPFDVVK TQRQMSLGAV EAVRVKPPRV 300
DSTWLLLRRI RAESGTRGLF AGFLPRIIKA APSCAIMIST YEFGKSFFQR 350
LNQEQPLGR 359
Length:359
Mass (Da):39,221
Last modified:June 1, 2001 - v1
Checksum:iED986C79395DBFCA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK007934 mRNA. Translation: BAB25360.1.
AK078417 mRNA. Translation: BAC37264.1.
AK161289 mRNA. Translation: BAE36297.1.
CCDSiCCDS25498.1.
RefSeqiNP_080818.1. NM_026542.3.
XP_006534097.1. XM_006534034.1.
XP_006534098.1. XM_006534035.1.
UniGeneiMm.44226.

Genome annotation databases

EnsembliENSMUST00000018821; ENSMUSP00000018821; ENSMUSG00000018677.
GeneIDi68066.
KEGGimmu:68066.
UCSCiuc007lrt.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK007934 mRNA. Translation: BAB25360.1 .
AK078417 mRNA. Translation: BAC37264.1 .
AK161289 mRNA. Translation: BAE36297.1 .
CCDSi CCDS25498.1.
RefSeqi NP_080818.1. NM_026542.3.
XP_006534097.1. XM_006534034.1.
XP_006534098.1. XM_006534035.1.
UniGenei Mm.44226.

3D structure databases

ProteinModelPortali Q9D8K8.
SMRi Q9D8K8. Positions 14-352.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000018821.

Proteomic databases

PaxDbi Q9D8K8.
PRIDEi Q9D8K8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000018821 ; ENSMUSP00000018821 ; ENSMUSG00000018677 .
GeneIDi 68066.
KEGGi mmu:68066.
UCSCi uc007lrt.3. mouse.

Organism-specific databases

CTDi 51629.
MGIi MGI:1196386. Slc25a39.

Phylogenomic databases

eggNOGi NOG276989.
GeneTreei ENSGT00390000000106.
HOGENOMi HOG000214473.
HOVERGENi HBG011439.
InParanoidi Q9D8K8.
KOi K15119.
OMAi RRQIEMD.
PhylomeDBi Q9D8K8.
TreeFami TF314720.

Miscellaneous databases

NextBioi 326344.
PROi Q9D8K8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9D8K8.
Bgeei Q9D8K8.
CleanExi MM_SLC25A39.
Genevestigatori Q9D8K8.

Family and domain databases

Gene3Di 1.50.40.10. 2 hits.
InterProi IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view ]
Pfami PF00153. Mito_carr. 4 hits.
[Graphical view ]
SUPFAMi SSF103506. SSF103506. 2 hits.
PROSITEi PS50920. SOLCAR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pancreas, Testis and Wolffian duct.
  2. Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiS2539_MOUSE
AccessioniPrimary (citable) accession number: Q9D8K8
Secondary accession number(s): Q3TTM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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