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Q9D8K8 (S2539_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 25 member 39
Gene names
Name:Slc25a39
Synonyms:D11Ertd333e
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Required for normal heme biosynthesis By similarity.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Abundant expression in bone marrow, spleen, testis and kidney. Ref.2

Developmental stage

Highly express in primitive erythroblast that fill yorlk sac blood islands at early somite pair stages, and in fetal liver at E12.5. Ref.2

Sequence similarities

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]

Contains 3 Solcar repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359Solute carrier family 25 member 39
PRO_0000090597

Regions

Transmembrane15 – 3521Helical; Name=1; Potential
Transmembrane122 – 14221Helical; Name=2; Potential
Transmembrane165 – 18521Helical; Name=3; Potential
Transmembrane215 – 23521Helical; Name=4; Potential
Transmembrane256 – 27621Helical; Name=5; Potential
Transmembrane318 – 33821Helical; Name=6; Potential
Repeat9 – 151143Solcar 1
Repeat159 – 24385Solcar 2
Repeat253 – 34795Solcar 3

Sequences

Sequence LengthMass (Da)Tools
Q9D8K8 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: ED986C79395DBFCA

FASTA35939,221
        10         20         30         40         50         60 
MDDQDPGGIS PLQQMVASGA GAVVTSLFMT PLDVVKVRLQ SQRPSATSEL TTPSRFWSLS 

        70         80         90        100        110        120 
YTKSSSALQS PGKCLLYCNG VLEPLYLCPN GTRCATWFQD PTRFTGTLDA FVKIVRHEGT 

       130        140        150        160        170        180 
RTLWSGLPAT LVMTVPATAI YFTAYDQLKA FLCGQSLTSD LYAPMVAGAL ARMGTVTVVS 

       190        200        210        220        230        240 
PLELVRTKLQ AQHVSYRELA SSVQAAVTQG GWRSLWLGWG PTALRDVPFS ALYWFNYELV 

       250        260        270        280        290        300 
KSWLSGLRPK DQTSVGISFV AGGISGMVAA TLTLPFDVVK TQRQMSLGAV EAVRVKPPRV 

       310        320        330        340        350 
DSTWLLLRRI RAESGTRGLF AGFLPRIIKA APSCAIMIST YEFGKSFFQR LNQEQPLGR 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Pancreas, Testis and Wolffian duct.
[2]"Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis."
Nilsson R., Schultz I.J., Pierce E.L., Soltis K.A., Naranuntarat A., Ward D.M., Baughman J.M., Paradkar P.N., Kingsley P.D., Culotta V.C., Kaplan J., Palis J., Paw B.H., Mootha V.K.
Cell Metab. 10:119-130(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK007934 mRNA. Translation: BAB25360.1.
AK078417 mRNA. Translation: BAC37264.1.
AK161289 mRNA. Translation: BAE36297.1.
RefSeqNP_080818.1. NM_026542.3.
XP_006534097.1. XM_006534034.1.
XP_006534098.1. XM_006534035.1.
UniGeneMm.44226.

3D structure databases

ProteinModelPortalQ9D8K8.
SMRQ9D8K8. Positions 14-352.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000018821.

Proteomic databases

PaxDbQ9D8K8.
PRIDEQ9D8K8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000018821; ENSMUSP00000018821; ENSMUSG00000018677.
GeneID68066.
KEGGmmu:68066.
UCSCuc007lrt.3. mouse.

Organism-specific databases

CTD51629.
MGIMGI:1196386. Slc25a39.

Phylogenomic databases

eggNOGNOG276989.
GeneTreeENSGT00390000000106.
HOGENOMHOG000214473.
HOVERGENHBG011439.
InParanoidQ9D8K8.
KOK15119.
OMAPGKCLLY.
PhylomeDBQ9D8K8.
TreeFamTF314720.

Gene expression databases

ArrayExpressQ9D8K8.
BgeeQ9D8K8.
CleanExMM_SLC25A39.
GenevestigatorQ9D8K8.

Family and domain databases

Gene3D1.50.40.10. 2 hits.
InterProIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamPF00153. Mito_carr. 4 hits.
[Graphical view]
SUPFAMSSF103506. SSF103506. 2 hits.
PROSITEPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio326344.
PROQ9D8K8.
SOURCESearch...

Entry information

Entry nameS2539_MOUSE
AccessionPrimary (citable) accession number: Q9D8K8
Secondary accession number(s): Q3TTM8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot