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Protein

Solute carrier family 25 member 39

Gene

Slc25a39

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for normal heme biosynthesis.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHeme biosynthesis, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 39
Gene namesi
Name:Slc25a39
Synonyms:D11Ertd333e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1196386 Slc25a39

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 35Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei122 – 142Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei165 – 185Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei215 – 235Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei256 – 276Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei318 – 338Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000905971 – 359Solute carrier family 25 member 39Add BLAST359

Proteomic databases

MaxQBiQ9D8K8
PaxDbiQ9D8K8
PRIDEiQ9D8K8

PTM databases

iPTMnetiQ9D8K8
PhosphoSitePlusiQ9D8K8

Expressioni

Tissue specificityi

Abundant expression in bone marrow, spleen, testis and kidney.1 Publication

Developmental stagei

Highly express in primitive erythroblast that fill yorlk sac blood islands at early somite pair stages, and in fetal liver at E12.5.1 Publication

Gene expression databases

BgeeiENSMUSG00000018677
CleanExiMM_SLC25A39
ExpressionAtlasiQ9D8K8 baseline and differential
GenevisibleiQ9D8K8 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018821

Structurei

3D structure databases

ProteinModelPortaliQ9D8K8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati9 – 151Solcar 1Add BLAST143
Repeati159 – 243Solcar 2Add BLAST85
Repeati253 – 347Solcar 3Add BLAST95

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0761 Eukaryota
ENOG410XQVP LUCA
GeneTreeiENSGT00790000123051
HOGENOMiHOG000214473
HOVERGENiHBG011439
InParanoidiQ9D8K8
KOiK15119
OMAiDHIYVCQ
OrthoDBiEOG091G07QQ
PhylomeDBiQ9D8K8
TreeFamiTF314720

Family and domain databases

Gene3Di1.50.40.10, 2 hits
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 2 hits
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q9D8K8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDQDPGGIS PLQQMVASGA GAVVTSLFMT PLDVVKVRLQ SQRPSATSEL
60 70 80 90 100
TTPSRFWSLS YTKSSSALQS PGKCLLYCNG VLEPLYLCPN GTRCATWFQD
110 120 130 140 150
PTRFTGTLDA FVKIVRHEGT RTLWSGLPAT LVMTVPATAI YFTAYDQLKA
160 170 180 190 200
FLCGQSLTSD LYAPMVAGAL ARMGTVTVVS PLELVRTKLQ AQHVSYRELA
210 220 230 240 250
SSVQAAVTQG GWRSLWLGWG PTALRDVPFS ALYWFNYELV KSWLSGLRPK
260 270 280 290 300
DQTSVGISFV AGGISGMVAA TLTLPFDVVK TQRQMSLGAV EAVRVKPPRV
310 320 330 340 350
DSTWLLLRRI RAESGTRGLF AGFLPRIIKA APSCAIMIST YEFGKSFFQR

LNQEQPLGR
Length:359
Mass (Da):39,221
Last modified:June 1, 2001 - v1
Checksum:iED986C79395DBFCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007934 mRNA Translation: BAB25360.1
AK078417 mRNA Translation: BAC37264.1
AK161289 mRNA Translation: BAE36297.1
CCDSiCCDS25498.1
RefSeqiNP_080818.1, NM_026542.3
XP_006534097.1, XM_006534034.1
XP_006534098.1, XM_006534035.1
UniGeneiMm.44226

Genome annotation databases

EnsembliENSMUST00000018821; ENSMUSP00000018821; ENSMUSG00000018677
GeneIDi68066
KEGGimmu:68066
UCSCiuc007lrt.3 mouse

Similar proteinsi

Entry informationi

Entry nameiS2539_MOUSE
AccessioniPrimary (citable) accession number: Q9D8K8
Secondary accession number(s): Q3TTM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health