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Protein

Derlin-3

Gene

Derl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Derlin-3
Alternative name(s):
Degradation in endoplasmic reticulum protein 3
Der1-like protein 3
Protein IZP6
Gene namesi
Name:Derl3
Synonyms:Der3, Izp6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1917627. Derl3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222CytoplasmicSequence analysisAdd
BLAST
Transmembranei23 – 4321Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini44 – 5714LumenalSequence analysisAdd
BLAST
Transmembranei58 – 7821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini79 – 9820CytoplasmicSequence analysisAdd
BLAST
Transmembranei99 – 11921Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini120 – 16849LumenalSequence analysisAdd
BLAST
Transmembranei169 – 18921Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini190 – 22839CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228228Derlin-3PRO_0000219049Add
BLAST

Proteomic databases

PaxDbiQ9D8K3.
PRIDEiQ9D8K3.

Expressioni

Tissue specificityi

Highly expressed in spleen, lung, liver, spleen and testis. Expressed at intermediate level in kidney. Weakly or not expressed in brain, heart and skeletal muscle.1 Publication

Developmental stagei

Expressed in neural cells during enbryogenesis. From E11.5 until E14.5, it is mainly expressed in the forebrain. From E15.5 until birth, expression in the forebrain becomes weaker but is still observed in the olfactory bulb and the skin around the eyes, nose, limbs and tail, showing that its pattern of expression changes from the central nervous system to the peripheral tissues during development.1 Publication

Gene expression databases

BgeeiENSMUSG00000009092.
CleanExiMM_DERL3.
ExpressionAtlasiQ9D8K3. baseline and differential.
GenevisibleiQ9D8K3. MM.

Interactioni

Subunit structurei

Forms homo- and heterooligomers with DERL2 and, to a lesser extent, with DERL1. Interacts with VCP, EDEM1, SELK and VIMP/SELS.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000009236.

Structurei

3D structure databases

ProteinModelPortaliQ9D8K3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the derlin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0858. Eukaryota.
COG5291. LUCA.
GeneTreeiENSGT00530000063156.
HOGENOMiHOG000200948.
HOVERGENiHBG051338.
InParanoidiQ9D8K3.
KOiK13989.
OMAiNDIYPPL.
OrthoDBiEOG091G0IPJ.
PhylomeDBiQ9D8K3.
TreeFamiTF314715.

Family and domain databases

InterProiIPR007599. DER1.
[Graphical view]
PANTHERiPTHR11009. PTHR11009. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D8K3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGQRLAAGF LQVPAVTRAY TAACVLTTAA VQLELLSPFQ LYFNPHLVFR
60 70 80 90 100
KFQVWRLITT FLFFGPLGFG FFFNMLFVFR YCRMLEEGSF RGRKADFVFM
110 120 130 140 150
FLFGGVLMTL LGFLGSLFFL GQALMAMLVY VWSRRSPHVR VNFFGLLNFQ
160 170 180 190 200
APFLPWALMG FSLLLGNSVV TDLLGILVGH IYYFLEDVFP NQPGGKRLLL
210 220
TPSVLKLLLD DPQEDPDYLP LPEEQPEL
Length:228
Mass (Da):25,978
Last modified:June 1, 2001 - v1
Checksum:iC60D830C83D42D0D
GO
Isoform 2 (identifier: Q9D8K3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     110-150: Missing.

Note: No experimental confirmation available.
Show »
Length:187
Mass (Da):21,249
Checksum:i9CC43D33DEB958E0
GO

Sequence cautioni

The sequence AAH04729 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151A → T in AAH04729 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei110 – 15041Missing in isoform 2. 1 PublicationVSP_011090Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047555 mRNA. Translation: BAB32788.1.
AK007348 mRNA. Translation: BAB24977.1.
AK007948 mRNA. Translation: BAB25367.1.
AK172429 mRNA. Translation: BAE43003.1.
BC004729 mRNA. Translation: AAH04729.1. Different initiation.
CCDSiCCDS23935.1. [Q9D8K3-1]
RefSeqiNP_077760.1. NM_024440.2. [Q9D8K3-1]
UniGeneiMm.275878.

Genome annotation databases

EnsembliENSMUST00000009236; ENSMUSP00000009236; ENSMUSG00000009092. [Q9D8K3-1]
GeneIDi70377.
KEGGimmu:70377.
UCSCiuc007ftj.1. mouse. [Q9D8K3-1]
uc007ftk.1. mouse. [Q9D8K3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047555 mRNA. Translation: BAB32788.1.
AK007348 mRNA. Translation: BAB24977.1.
AK007948 mRNA. Translation: BAB25367.1.
AK172429 mRNA. Translation: BAE43003.1.
BC004729 mRNA. Translation: AAH04729.1. Different initiation.
CCDSiCCDS23935.1. [Q9D8K3-1]
RefSeqiNP_077760.1. NM_024440.2. [Q9D8K3-1]
UniGeneiMm.275878.

3D structure databases

ProteinModelPortaliQ9D8K3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000009236.

Proteomic databases

PaxDbiQ9D8K3.
PRIDEiQ9D8K3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000009236; ENSMUSP00000009236; ENSMUSG00000009092. [Q9D8K3-1]
GeneIDi70377.
KEGGimmu:70377.
UCSCiuc007ftj.1. mouse. [Q9D8K3-1]
uc007ftk.1. mouse. [Q9D8K3-2]

Organism-specific databases

CTDi91319.
MGIiMGI:1917627. Derl3.

Phylogenomic databases

eggNOGiKOG0858. Eukaryota.
COG5291. LUCA.
GeneTreeiENSGT00530000063156.
HOGENOMiHOG000200948.
HOVERGENiHBG051338.
InParanoidiQ9D8K3.
KOiK13989.
OMAiNDIYPPL.
OrthoDBiEOG091G0IPJ.
PhylomeDBiQ9D8K3.
TreeFamiTF314715.

Miscellaneous databases

ChiTaRSiDerl3. mouse.
PROiQ9D8K3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000009092.
CleanExiMM_DERL3.
ExpressionAtlasiQ9D8K3. baseline and differential.
GenevisibleiQ9D8K3. MM.

Family and domain databases

InterProiIPR007599. DER1.
[Graphical view]
PANTHERiPTHR11009. PTHR11009. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDERL3_MOUSE
AccessioniPrimary (citable) accession number: Q9D8K3
Secondary accession number(s): Q3T9L7, Q99KC6, Q9D954
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.