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Q9D8I2

- P2Y13_MOUSE

UniProt

Q9D8I2 - P2Y13_MOUSE

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Protein

P2Y purinoceptor 13

Gene

P2yr13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system (By similarity).By similarity

GO - Molecular functioni

  1. G-protein coupled purinergic nucleotide receptor activity Source: Ensembl

GO - Biological processi

  1. negative regulation of adenylate cyclase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_239564. P2Y receptors.
REACT_250376. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 13
Short name:
P2Y13
Alternative name(s):
G-protein coupled receptor 86
Gene namesi
Name:P2yr13
Synonyms:Gpr86
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1921441. P2ry13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131ExtracellularSequence AnalysisAdd
BLAST
Transmembranei32 – 5221Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini53 – 608CytoplasmicSequence Analysis
Transmembranei61 – 8121Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini82 – 10120ExtracellularSequence AnalysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini123 – 14422CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei145 – 16521Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini166 – 19328ExtracellularSequence AnalysisAdd
BLAST
Transmembranei194 – 21421Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini215 – 23723CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini259 – 28123ExtracellularSequence AnalysisAdd
BLAST
Transmembranei282 – 30221Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini303 – 33735CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337P2Y purinoceptor 13PRO_0000070042Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi99 ↔ 176PROSITE-ProRule annotation
Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9D8I2.

PTM databases

PhosphoSiteiQ9D8I2.

Expressioni

Gene expression databases

BgeeiQ9D8I2.
CleanExiMM_P2RY13.
GenevestigatoriQ9D8I2.

Structurei

3D structure databases

ProteinModelPortaliQ9D8I2.
SMRiQ9D8I2. Positions 19-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148143.
GeneTreeiENSGT00640000091213.
HOGENOMiHOG000273884.
HOVERGENiHBG108228.
InParanoidiQ9D8I2.
KOiK08388.
OMAiFYVVIAK.
OrthoDBiEOG7JQBNQ.
PhylomeDBiQ9D8I2.
TreeFamiTF330969.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008109. P2Y13_rcpt.
[Graphical view]
PANTHERiPTHR24233:SF7. PTHR24233:SF7. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01735. P2Y13PRNCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D8I2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLGTINTTGM QGFNKSERCP RDTRMTQLLF PVLYTVVFLA GILLNTVALW
60 70 80 90 100
VFVHIPSNST FIVYLKNTLV ADLIMALMLP FKILSDSHLA PWQLRGFVCT
110 120 130 140 150
LSSVVFYETM YVGIMMLGLI AFDRFLKIIM PFRKTFVKKT AFAKTVSISV
160 170 180 190 200
WSLMFFISLP NMILNKEATP SSVKKCASLK SPLGLWWHQV VSHTCQFIFW
210 220 230 240 250
AVFILMLLFY AVITKKVYNS YRKFRSKDSR HKRLEVKVFI VMAVFFVCFA
260 270 280 290 300
PLHFVRIPYT YSQTTNKTDC RLENQLFIAK EATLFLATTN ICMDPLIYII
310 320 330
LCKKFTQKVP CVRWGKARTA GSSEDHHSSQ TDNITLA
Length:337
Mass (Da):38,727
Last modified:October 10, 2003 - v2
Checksum:i2C1A7B969D5CBD48
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti197 – 1971F → L in BAB25409. (PubMed:16141072)Curated
Sequence conflicti237 – 2371K → R in BAC30043. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008013 mRNA. Translation: BAB25409.1.
AK083264 mRNA. Translation: BAC38835.1.
AK038560 mRNA. Translation: BAC30043.1.
BC119043 mRNA. Translation: AAI19044.1.
CCDSiCCDS17372.1.
RefSeqiNP_083084.2. NM_028808.3.
UniGeneiMm.90067.

Genome annotation databases

EnsembliENSMUST00000040622; ENSMUSP00000044730; ENSMUSG00000036362.
GeneIDi74191.
KEGGimmu:74191.
UCSCiuc008piq.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008013 mRNA. Translation: BAB25409.1 .
AK083264 mRNA. Translation: BAC38835.1 .
AK038560 mRNA. Translation: BAC30043.1 .
BC119043 mRNA. Translation: AAI19044.1 .
CCDSi CCDS17372.1.
RefSeqi NP_083084.2. NM_028808.3.
UniGenei Mm.90067.

3D structure databases

ProteinModelPortali Q9D8I2.
SMRi Q9D8I2. Positions 19-305.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 329.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9D8I2.

Proteomic databases

PRIDEi Q9D8I2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000040622 ; ENSMUSP00000044730 ; ENSMUSG00000036362 .
GeneIDi 74191.
KEGGi mmu:74191.
UCSCi uc008piq.3. mouse.

Organism-specific databases

CTDi 53829.
MGIi MGI:1921441. P2ry13.

Phylogenomic databases

eggNOGi NOG148143.
GeneTreei ENSGT00640000091213.
HOGENOMi HOG000273884.
HOVERGENi HBG108228.
InParanoidi Q9D8I2.
KOi K08388.
OMAi FYVVIAK.
OrthoDBi EOG7JQBNQ.
PhylomeDBi Q9D8I2.
TreeFami TF330969.

Enzyme and pathway databases

Reactomei REACT_239564. P2Y receptors.
REACT_250376. G alpha (i) signalling events.

Miscellaneous databases

NextBioi 340054.
PROi Q9D8I2.
SOURCEi Search...

Gene expression databases

Bgeei Q9D8I2.
CleanExi MM_P2RY13.
Genevestigatori Q9D8I2.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008109. P2Y13_rcpt.
[Graphical view ]
PANTHERi PTHR24233:SF7. PTHR24233:SF7. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01735. P2Y13PRNCPTR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Hippocampus, Hypothalamus and Small intestine.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiP2Y13_MOUSE
AccessioniPrimary (citable) accession number: Q9D8I2
Secondary accession number(s): Q0VF10, Q8C412, Q8CAL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: November 26, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3