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Q9D8I2

- P2Y13_MOUSE

UniProt

Q9D8I2 - P2Y13_MOUSE

Protein

P2Y purinoceptor 13

Gene

P2yr13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (10 Oct 2003)
      Previous versions | rss
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    Functioni

    Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system By similarity.By similarity

    GO - Molecular functioni

    1. G-protein coupled purinergic nucleotide receptor activity Source: Ensembl

    GO - Biological processi

    1. negative regulation of adenylate cyclase activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    P2Y purinoceptor 13
    Short name:
    P2Y13
    Alternative name(s):
    G-protein coupled receptor 86
    Gene namesi
    Name:P2yr13
    Synonyms:Gpr86
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1921441. P2ry13.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 337337P2Y purinoceptor 13PRO_0000070042Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi99 ↔ 176PROSITE-ProRule annotation
    Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ9D8I2.

    PTM databases

    PhosphoSiteiQ9D8I2.

    Expressioni

    Gene expression databases

    BgeeiQ9D8I2.
    CleanExiMM_P2RY13.
    GenevestigatoriQ9D8I2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D8I2.
    SMRiQ9D8I2. Positions 18-312.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3131ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini53 – 608CytoplasmicSequence Analysis
    Topological domaini82 – 10120ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini123 – 14422CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini166 – 19328ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini215 – 23723CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 28123ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini303 – 33735CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei32 – 5221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei61 – 8121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei102 – 12221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei145 – 16521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei194 – 21421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei282 – 30221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148143.
    GeneTreeiENSGT00640000091213.
    HOGENOMiHOG000273884.
    HOVERGENiHBG108228.
    InParanoidiQ0VF10.
    KOiK08388.
    OMAiFYVVIAK.
    OrthoDBiEOG7JQBNQ.
    PhylomeDBiQ9D8I2.
    TreeFamiTF330969.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR008109. P2Y13_rcpt.
    [Graphical view]
    PANTHERiPTHR24233:SF7. PTHR24233:SF7. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01735. P2Y13PRNCPTR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9D8I2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGTINTTGM QGFNKSERCP RDTRMTQLLF PVLYTVVFLA GILLNTVALW    50
    VFVHIPSNST FIVYLKNTLV ADLIMALMLP FKILSDSHLA PWQLRGFVCT 100
    LSSVVFYETM YVGIMMLGLI AFDRFLKIIM PFRKTFVKKT AFAKTVSISV 150
    WSLMFFISLP NMILNKEATP SSVKKCASLK SPLGLWWHQV VSHTCQFIFW 200
    AVFILMLLFY AVITKKVYNS YRKFRSKDSR HKRLEVKVFI VMAVFFVCFA 250
    PLHFVRIPYT YSQTTNKTDC RLENQLFIAK EATLFLATTN ICMDPLIYII 300
    LCKKFTQKVP CVRWGKARTA GSSEDHHSSQ TDNITLA 337
    Length:337
    Mass (Da):38,727
    Last modified:October 10, 2003 - v2
    Checksum:i2C1A7B969D5CBD48
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti197 – 1971F → L in BAB25409. (PubMed:16141072)Curated
    Sequence conflicti237 – 2371K → R in BAC30043. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK008013 mRNA. Translation: BAB25409.1.
    AK083264 mRNA. Translation: BAC38835.1.
    AK038560 mRNA. Translation: BAC30043.1.
    BC119043 mRNA. Translation: AAI19044.1.
    CCDSiCCDS17372.1.
    RefSeqiNP_083084.2. NM_028808.3.
    UniGeneiMm.90067.

    Genome annotation databases

    EnsembliENSMUST00000040622; ENSMUSP00000044730; ENSMUSG00000036362.
    GeneIDi74191.
    KEGGimmu:74191.
    UCSCiuc008piq.3. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK008013 mRNA. Translation: BAB25409.1 .
    AK083264 mRNA. Translation: BAC38835.1 .
    AK038560 mRNA. Translation: BAC30043.1 .
    BC119043 mRNA. Translation: AAI19044.1 .
    CCDSi CCDS17372.1.
    RefSeqi NP_083084.2. NM_028808.3.
    UniGenei Mm.90067.

    3D structure databases

    ProteinModelPortali Q9D8I2.
    SMRi Q9D8I2. Positions 18-312.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 329.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9D8I2.

    Proteomic databases

    PRIDEi Q9D8I2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000040622 ; ENSMUSP00000044730 ; ENSMUSG00000036362 .
    GeneIDi 74191.
    KEGGi mmu:74191.
    UCSCi uc008piq.3. mouse.

    Organism-specific databases

    CTDi 53829.
    MGIi MGI:1921441. P2ry13.

    Phylogenomic databases

    eggNOGi NOG148143.
    GeneTreei ENSGT00640000091213.
    HOGENOMi HOG000273884.
    HOVERGENi HBG108228.
    InParanoidi Q0VF10.
    KOi K08388.
    OMAi FYVVIAK.
    OrthoDBi EOG7JQBNQ.
    PhylomeDBi Q9D8I2.
    TreeFami TF330969.

    Miscellaneous databases

    NextBioi 340054.
    PROi Q9D8I2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9D8I2.
    CleanExi MM_P2RY13.
    Genevestigatori Q9D8I2.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR008109. P2Y13_rcpt.
    [Graphical view ]
    PANTHERi PTHR24233:SF7. PTHR24233:SF7. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01735. P2Y13PRNCPTR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Hippocampus, Hypothalamus and Small intestine.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiP2Y13_MOUSE
    AccessioniPrimary (citable) accession number: Q9D8I2
    Secondary accession number(s): Q0VF10, Q8C412, Q8CAL2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 10, 2003
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3