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Protein

P2Y purinoceptor 13

Gene

P2yr13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system (By similarity).By similarity

GO - Molecular functioni

  1. G-protein coupled purinergic nucleotide receptor activity Source: GO_Central

GO - Biological processi

  1. cellular response to organic cyclic compound Source: MGI
  2. G-protein coupled purinergic nucleotide receptor signaling pathway Source: GOC
  3. G-protein coupled receptor signaling pathway Source: GO_Central
  4. negative regulation of adenylate cyclase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_326987. P2Y receptors.
REACT_331048. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 13
Short name:
P2Y13
Alternative name(s):
G-protein coupled receptor 86
Gene namesi
Name:P2yr13
Synonyms:Gpr86
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1921441. P2ry13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131ExtracellularSequence AnalysisAdd
BLAST
Transmembranei32 – 5221Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini53 – 608CytoplasmicSequence Analysis
Transmembranei61 – 8121Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini82 – 10120ExtracellularSequence AnalysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini123 – 14422CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei145 – 16521Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini166 – 19328ExtracellularSequence AnalysisAdd
BLAST
Transmembranei194 – 21421Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini215 – 23723CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini259 – 28123ExtracellularSequence AnalysisAdd
BLAST
Transmembranei282 – 30221Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini303 – 33735CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: MGI
  2. integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337P2Y purinoceptor 13PRO_0000070042Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi99 ↔ 176PROSITE-ProRule annotation
Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9D8I2.

PTM databases

PhosphoSiteiQ9D8I2.

Expressioni

Gene expression databases

BgeeiQ9D8I2.
CleanExiMM_P2RY13.
GenevestigatoriQ9D8I2.

Structurei

3D structure databases

SMRiQ9D8I2. Positions 19-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148143.
GeneTreeiENSGT00640000091213.
HOGENOMiHOG000273884.
HOVERGENiHBG108228.
InParanoidiQ9D8I2.
KOiK08388.
OMAiFYVVIAK.
OrthoDBiEOG7JQBNQ.
PhylomeDBiQ9D8I2.
TreeFamiTF330969.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008109. P2Y13_rcpt.
[Graphical view]
PANTHERiPTHR24233:SF7. PTHR24233:SF7. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01735. P2Y13PRNCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D8I2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGTINTTGM QGFNKSERCP RDTRMTQLLF PVLYTVVFLA GILLNTVALW
60 70 80 90 100
VFVHIPSNST FIVYLKNTLV ADLIMALMLP FKILSDSHLA PWQLRGFVCT
110 120 130 140 150
LSSVVFYETM YVGIMMLGLI AFDRFLKIIM PFRKTFVKKT AFAKTVSISV
160 170 180 190 200
WSLMFFISLP NMILNKEATP SSVKKCASLK SPLGLWWHQV VSHTCQFIFW
210 220 230 240 250
AVFILMLLFY AVITKKVYNS YRKFRSKDSR HKRLEVKVFI VMAVFFVCFA
260 270 280 290 300
PLHFVRIPYT YSQTTNKTDC RLENQLFIAK EATLFLATTN ICMDPLIYII
310 320 330
LCKKFTQKVP CVRWGKARTA GSSEDHHSSQ TDNITLA
Length:337
Mass (Da):38,727
Last modified:October 9, 2003 - v2
Checksum:i2C1A7B969D5CBD48
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti197 – 1971F → L in BAB25409 (PubMed:16141072).Curated
Sequence conflicti237 – 2371K → R in BAC30043 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008013 mRNA. Translation: BAB25409.1.
AK083264 mRNA. Translation: BAC38835.1.
AK038560 mRNA. Translation: BAC30043.1.
BC119043 mRNA. Translation: AAI19044.1.
CCDSiCCDS17372.1.
RefSeqiNP_083084.2. NM_028808.3.
UniGeneiMm.90067.

Genome annotation databases

EnsembliENSMUST00000040622; ENSMUSP00000044730; ENSMUSG00000036362.
GeneIDi74191.
KEGGimmu:74191.
UCSCiuc008piq.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008013 mRNA. Translation: BAB25409.1.
AK083264 mRNA. Translation: BAC38835.1.
AK038560 mRNA. Translation: BAC30043.1.
BC119043 mRNA. Translation: AAI19044.1.
CCDSiCCDS17372.1.
RefSeqiNP_083084.2. NM_028808.3.
UniGeneiMm.90067.

3D structure databases

SMRiQ9D8I2. Positions 19-305.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

GuidetoPHARMACOLOGYi329.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9D8I2.

Proteomic databases

PRIDEiQ9D8I2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040622; ENSMUSP00000044730; ENSMUSG00000036362.
GeneIDi74191.
KEGGimmu:74191.
UCSCiuc008piq.3. mouse.

Organism-specific databases

CTDi53829.
MGIiMGI:1921441. P2ry13.

Phylogenomic databases

eggNOGiNOG148143.
GeneTreeiENSGT00640000091213.
HOGENOMiHOG000273884.
HOVERGENiHBG108228.
InParanoidiQ9D8I2.
KOiK08388.
OMAiFYVVIAK.
OrthoDBiEOG7JQBNQ.
PhylomeDBiQ9D8I2.
TreeFamiTF330969.

Enzyme and pathway databases

ReactomeiREACT_326987. P2Y receptors.
REACT_331048. G alpha (i) signalling events.

Miscellaneous databases

NextBioi340054.
PROiQ9D8I2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D8I2.
CleanExiMM_P2RY13.
GenevestigatoriQ9D8I2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008109. P2Y13_rcpt.
[Graphical view]
PANTHERiPTHR24233:SF7. PTHR24233:SF7. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01735. P2Y13PRNCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Hippocampus, Hypothalamus and Small intestine.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiP2Y13_MOUSE
AccessioniPrimary (citable) accession number: Q9D8I2
Secondary accession number(s): Q0VF10, Q8C412, Q8CAL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 9, 2003
Last sequence update: October 9, 2003
Last modified: March 31, 2015
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.