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Q9D8I2 (P2Y13_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
P2Y purinoceptor 13
Short name=P2Y13
Alternative name(s):
G-protein coupled receptor 86
Gene names
Name:P2yr13
Synonyms:Gpr86
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length337 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 337337P2Y purinoceptor 13
PRO_0000070042

Regions

Topological domain1 – 3131Extracellular Potential
Transmembrane32 – 5221Helical; Name=1; Potential
Topological domain53 – 608Cytoplasmic Potential
Transmembrane61 – 8121Helical; Name=2; Potential
Topological domain82 – 10120Extracellular Potential
Transmembrane102 – 12221Helical; Name=3; Potential
Topological domain123 – 14422Cytoplasmic Potential
Transmembrane145 – 16521Helical; Name=4; Potential
Topological domain166 – 19328Extracellular Potential
Transmembrane194 – 21421Helical; Name=5; Potential
Topological domain215 – 23723Cytoplasmic Potential
Transmembrane238 – 25821Helical; Name=6; Potential
Topological domain259 – 28123Extracellular Potential
Transmembrane282 – 30221Helical; Name=7; Potential
Topological domain303 – 33735Cytoplasmic Potential

Amino acid modifications

Glycosylation61N-linked (GlcNAc...) Potential
Glycosylation141N-linked (GlcNAc...) Potential
Glycosylation2661N-linked (GlcNAc...) Potential
Disulfide bond99 ↔ 176 By similarity

Experimental info

Sequence conflict1971F → L in BAB25409. Ref.1
Sequence conflict2371K → R in BAC30043. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9D8I2 [UniParc].

Last modified October 10, 2003. Version 2.
Checksum: 2C1A7B969D5CBD48

FASTA33738,727
        10         20         30         40         50         60 
MLGTINTTGM QGFNKSERCP RDTRMTQLLF PVLYTVVFLA GILLNTVALW VFVHIPSNST 

        70         80         90        100        110        120 
FIVYLKNTLV ADLIMALMLP FKILSDSHLA PWQLRGFVCT LSSVVFYETM YVGIMMLGLI 

       130        140        150        160        170        180 
AFDRFLKIIM PFRKTFVKKT AFAKTVSISV WSLMFFISLP NMILNKEATP SSVKKCASLK 

       190        200        210        220        230        240 
SPLGLWWHQV VSHTCQFIFW AVFILMLLFY AVITKKVYNS YRKFRSKDSR HKRLEVKVFI 

       250        260        270        280        290        300 
VMAVFFVCFA PLHFVRIPYT YSQTTNKTDC RLENQLFIAK EATLFLATTN ICMDPLIYII 

       310        320        330 
LCKKFTQKVP CVRWGKARTA GSSEDHHSSQ TDNITLA

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Hippocampus, Hypothalamus and Small intestine.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK008013 mRNA. Translation: BAB25409.1.
AK083264 mRNA. Translation: BAC38835.1.
AK038560 mRNA. Translation: BAC30043.1.
BC119043 mRNA. Translation: AAI19044.1.
IPIIPI00111538.
RefSeqNP_083084.2. NM_028808.3.
UniGeneMm.90067.

3D structure databases

ProteinModelPortalQ9D8I2.
SMRQ9D8I2. Positions 28-305.
ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9D8I2.

Proteomic databases

PRIDEQ9D8I2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000040622; ENSMUSP00000044730; ENSMUSG00000036362.
GeneID74191.
KEGGmmu:74191.
UCSCuc008piq.3. mouse.

Organism-specific databases

CTD53829.
MGIMGI:1921441. P2ry13.

Phylogenomic databases

eggNOGNOG148143.
GeneTreeENSGT00640000091213.
HOGENOMHOG000273884.
HOVERGENHBG108228.
InParanoidQ0VF10.
KOK08388.
OMALIAFDRF.
OrthoDBEOG49S679.

Gene expression databases

BgeeQ9D8I2.
CleanExMM_P2RY13.
GenevestigatorQ9D8I2.
GermOnlineENSMUSG00000036362. Mus musculus.

Family and domain databases

InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008109. P2Y13_purnocptor.
IPR002286. purinergic_P2Y_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01735. P2Y13PRNCPTR.
PR01157. P2YPURNOCPTR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio340054.
SOURCESearch...

Entry information

Entry nameP2Y13_MOUSE
AccessionPrimary (citable) accession number: Q9D8I2
Secondary accession number(s): Q0VF10, Q8C412, Q8CAL2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: May 29, 2013
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents