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Protein

Regenerating islet-derived protein 4

Gene

Reg4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Regenerating islet-derived protein 4
Short name:
REG-4
Gene namesi
Name:Reg4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1914959. Reg4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000001743823 – 157Regenerating islet-derived protein 4Add BLAST135

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 40PROSITE-ProRule annotation
Glycosylationi49N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi57 ↔ 153PROSITE-ProRule annotation
Glycosylationi62N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi128 ↔ 145PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9D8G5.
PaxDbiQ9D8G5.
PeptideAtlasiQ9D8G5.
PRIDEiQ9D8G5.

PTM databases

iPTMnetiQ9D8G5.
PhosphoSitePlusiQ9D8G5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027876.
CleanExiMM_REG4.
GenevisibleiQ9D8G5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029469.

Structurei

3D structure databases

ProteinModelPortaliQ9D8G5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 154C-type lectinPROSITE-ProRule annotationAdd BLAST119

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni97 – 102Carbohydrate-bindingBy similarity6
Regioni134 – 136Carbohydrate-bindingBy similarity3

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00700000104249.
HOGENOMiHOG000010281.
HOVERGENiHBG004151.
InParanoidiQ9D8G5.
OMAiCNKRQHF.
OrthoDBiEOG091G0PSR.
PhylomeDBiQ9D8G5.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D8G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKGVRLLL LLSWVAGPEV LSDILRPSCA PGWFYYRSHC YGYFRKLRNW
60 70 80 90 100
SHAELECQSY GNGSHLASVL NQKEASVISK YITGYQRNLP VWIGLHDPQK
110 120 130 140 150
KQLWQWTDGS TNLYRRWNPR TKSEARHCAE MNPKDKFLTW NKNGCANRQH

FLCKYKT
Length:157
Mass (Da):18,398
Last modified:June 1, 2001 - v1
Checksum:iF3981722BBD83968
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3S → Y in BAB25669 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008049 mRNA. Translation: BAB25429.1.
AK008438 mRNA. Translation: BAB25669.1.
AK162316 mRNA. Translation: BAE36851.1.
BC019465 mRNA. Translation: AAH19465.1.
CCDSiCCDS17661.1.
RefSeqiNP_080604.2. NM_026328.2.
UniGeneiMm.46306.

Genome annotation databases

EnsembliENSMUST00000029469; ENSMUSP00000029469; ENSMUSG00000027876.
GeneIDi67709.
KEGGimmu:67709.
UCSCiuc008qpq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008049 mRNA. Translation: BAB25429.1.
AK008438 mRNA. Translation: BAB25669.1.
AK162316 mRNA. Translation: BAE36851.1.
BC019465 mRNA. Translation: AAH19465.1.
CCDSiCCDS17661.1.
RefSeqiNP_080604.2. NM_026328.2.
UniGeneiMm.46306.

3D structure databases

ProteinModelPortaliQ9D8G5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029469.

PTM databases

iPTMnetiQ9D8G5.
PhosphoSitePlusiQ9D8G5.

Proteomic databases

MaxQBiQ9D8G5.
PaxDbiQ9D8G5.
PeptideAtlasiQ9D8G5.
PRIDEiQ9D8G5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029469; ENSMUSP00000029469; ENSMUSG00000027876.
GeneIDi67709.
KEGGimmu:67709.
UCSCiuc008qpq.1. mouse.

Organism-specific databases

CTDi83998.
MGIiMGI:1914959. Reg4.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00700000104249.
HOGENOMiHOG000010281.
HOVERGENiHBG004151.
InParanoidiQ9D8G5.
OMAiCNKRQHF.
OrthoDBiEOG091G0PSR.
PhylomeDBiQ9D8G5.

Miscellaneous databases

PROiQ9D8G5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027876.
CleanExiMM_REG4.
GenevisibleiQ9D8G5. MM.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiREG4_MOUSE
AccessioniPrimary (citable) accession number: Q9D8G5
Secondary accession number(s): Q3TS25, Q9D858
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.