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Protein

Solute carrier family 52, riboflavin transporter, member 2

Gene

Slc52a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Riboflavin transporter. Riboflavin transport is Na+-independent but moderately pH-sensitive. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin. Weakly inhibited by flavin adenine dinucleotide (FAD). In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 52, riboflavin transporter, member 2
Alternative name(s):
Porcine endogenous retrovirus A receptor 2 homolog
Short name:
PERV-A receptor 2 homolog
Protein GPR172B
Riboflavin transporter 1
Short name:
mRFT1
Gene namesi
Name:Slc52a2
Synonyms:Gpr172b, Rft1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1289288. Slc52a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei14 – 3421HelicalSequence analysisAdd
BLAST
Transmembranei47 – 6721HelicalSequence analysisAdd
BLAST
Transmembranei86 – 10621HelicalSequence analysisAdd
BLAST
Transmembranei112 – 13221HelicalSequence analysisAdd
BLAST
Transmembranei147 – 16721HelicalSequence analysisAdd
BLAST
Transmembranei201 – 22121HelicalSequence analysisAdd
BLAST
Transmembranei282 – 30221HelicalSequence analysisAdd
BLAST
Transmembranei317 – 33721HelicalSequence analysisAdd
BLAST
Transmembranei344 – 36421HelicalSequence analysisAdd
BLAST
Transmembranei369 – 38921HelicalSequence analysisAdd
BLAST
Transmembranei409 – 42921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450Solute carrier family 52, riboflavin transporter, member 2PRO_0000042633Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9D8F3.
PeptideAtlasiQ9D8F3.
PRIDEiQ9D8F3.

PTM databases

iPTMnetiQ9D8F3.
PhosphoSiteiQ9D8F3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022560.
CleanExiMM_GPR172B.
GenevisibleiQ9D8F3. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9D8F3. 1 interaction.
STRINGi10090.ENSMUSP00000023220.

Structurei

3D structure databases

ProteinModelPortaliQ9D8F3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi244 – 2518Poly-Glu

Sequence similaritiesi

Belongs to the riboflavin transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4255. Eukaryota.
ENOG410YE1U. LUCA.
GeneTreeiENSGT00390000003774.
HOVERGENiHBG051170.
InParanoidiQ9D8F3.
OMAiAPLWHHV.
OrthoDBiEOG091G0BZA.
PhylomeDBiQ9D8F3.
TreeFamiTF314820.

Family and domain databases

InterProiIPR009357. Riboflavin_transptr.
[Graphical view]
PANTHERiPTHR12929. PTHR12929. 1 hit.
PfamiPF06237. DUF1011. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D8F3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPPLGRLV LTHLLVALFG MGSWAAVNGI WVELPVVVKE LPEGWSLPSY
60 70 80 90 100
LSVLVALGNL GLLLVTLWRR LARGKGEQVP IRVVQGLGIV GTGLLASLWN
110 120 130 140 150
HVAPVAGKPY SVAFLTLAFV LALACCASNV TFLPFLSHLP PPFLRSFFLG
160 170 180 190 200
QGLSALLPCV LALGQGVGRL ECLHVPANRT TGPPIEVSPI NFPERFSATT
210 220 230 240 250
FFWVLTALLG TSAAAFQGLL LLLPSPTSEP TTGTGLRVET PGTEEEEEEE
260 270 280 290 300
EASPLQEPPG QVAGIVSSPD PKAHQLFSSR SACLLGLLAI TNALTNGVLP
310 320 330 340 350
AVQSFSCLPY GRLAYHLAVV LGSCANPLAC FLAMAVLCRS LAGLCGLSLL
360 370 380 390 400
GMLLGSYLMT LAALSPCPPL VGTSAGVVLV VLSWVLCAGT FSYIKVAISS
410 420 430 440 450
MLHSGGRPAL LAAGVAIQVG SLLGAVAMFP PTSIYRVFRS GKDCVDQCGL
Length:450
Mass (Da):46,864
Last modified:June 1, 2001 - v1
Checksum:i7A2CCCCCDD337791
GO
Isoform 2 (identifier: Q9D8F3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     340-351: SLAGLCGLSLLG → CSRTPKPPWGRA
     352-450: Missing.

Show »
Length:351
Mass (Da):37,020
Checksum:i0E13624076364E8E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei340 – 35112SLAGL…LSLLG → CSRTPKPPWGRA in isoform 2. 1 PublicationVSP_015940Add
BLAST
Alternative sequencei352 – 45099Missing in isoform 2. 1 PublicationVSP_015941Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008081 mRNA. Translation: BAB25447.1.
AK029579 mRNA. Translation: BAC26522.1.
AK032015 mRNA. Translation: BAC27648.1.
AK080449 mRNA. Translation: BAC37920.1.
AK142597 mRNA. Translation: BAE25123.1.
AK152335 mRNA. Translation: BAE31133.1.
AK161447 mRNA. Translation: BAE36401.1.
BC016264 mRNA. Translation: AAH16264.1.
CCDSiCCDS27575.1. [Q9D8F3-1]
RefSeqiNP_083919.1. NM_029643.3. [Q9D8F3-1]
XP_006521214.1. XM_006521151.2. [Q9D8F3-1]
UniGeneiMm.28597.

Genome annotation databases

EnsembliENSMUST00000023220; ENSMUSP00000023220; ENSMUSG00000022560. [Q9D8F3-1]
GeneIDi52710.
KEGGimmu:52710.
UCSCiuc007wkt.1. mouse. [Q9D8F3-2]
uc007wku.1. mouse. [Q9D8F3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008081 mRNA. Translation: BAB25447.1.
AK029579 mRNA. Translation: BAC26522.1.
AK032015 mRNA. Translation: BAC27648.1.
AK080449 mRNA. Translation: BAC37920.1.
AK142597 mRNA. Translation: BAE25123.1.
AK152335 mRNA. Translation: BAE31133.1.
AK161447 mRNA. Translation: BAE36401.1.
BC016264 mRNA. Translation: AAH16264.1.
CCDSiCCDS27575.1. [Q9D8F3-1]
RefSeqiNP_083919.1. NM_029643.3. [Q9D8F3-1]
XP_006521214.1. XM_006521151.2. [Q9D8F3-1]
UniGeneiMm.28597.

3D structure databases

ProteinModelPortaliQ9D8F3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D8F3. 1 interaction.
STRINGi10090.ENSMUSP00000023220.

PTM databases

iPTMnetiQ9D8F3.
PhosphoSiteiQ9D8F3.

Proteomic databases

PaxDbiQ9D8F3.
PeptideAtlasiQ9D8F3.
PRIDEiQ9D8F3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023220; ENSMUSP00000023220; ENSMUSG00000022560. [Q9D8F3-1]
GeneIDi52710.
KEGGimmu:52710.
UCSCiuc007wkt.1. mouse. [Q9D8F3-2]
uc007wku.1. mouse. [Q9D8F3-1]

Organism-specific databases

CTDi79581.
MGIiMGI:1289288. Slc52a2.

Phylogenomic databases

eggNOGiKOG4255. Eukaryota.
ENOG410YE1U. LUCA.
GeneTreeiENSGT00390000003774.
HOVERGENiHBG051170.
InParanoidiQ9D8F3.
OMAiAPLWHHV.
OrthoDBiEOG091G0BZA.
PhylomeDBiQ9D8F3.
TreeFamiTF314820.

Miscellaneous databases

PROiQ9D8F3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022560.
CleanExiMM_GPR172B.
GenevisibleiQ9D8F3. MM.

Family and domain databases

InterProiIPR009357. Riboflavin_transptr.
[Graphical view]
PANTHERiPTHR12929. PTHR12929. 1 hit.
PfamiPF06237. DUF1011. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS52A2_MOUSE
AccessioniPrimary (citable) accession number: Q9D8F3
Secondary accession number(s): Q8CCV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.