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Protein

Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4

Gene

Alkbh4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. May be involved in transcription regulation (By similarity).By similarity

Cofactori

Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi167Iron; catalyticBy similarity1
Metal bindingi169Iron; catalyticBy similarity1
Metal bindingi252Iron; catalyticBy similarity1
Binding sitei2632-oxoglutarateSequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Dioxygenase, Oxidoreductase
Biological processTranscription, Transcription regulation
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 (EC:1.14.11.-)
Alternative name(s):
Alkylated DNA repair protein alkB homolog 4
Gene namesi
Name:Alkbh4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1919291 Alkbh4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Embryonic lethality.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002392822 – 300Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4Add BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9D8F1
PRIDEiQ9D8F1

PTM databases

PhosphoSitePlusiQ9D8F1

Expressioni

Gene expression databases

BgeeiENSMUSG00000039754
CleanExiMM_ALKBH4
ExpressionAtlasiQ9D8F1 baseline and differential
GenevisibleiQ9D8F1 MM

Interactioni

Subunit structurei

Interacts with ZFHX3, MLLT3, MLLT1, HSF4, EP300, TES, EIF3C, MTMR6 and PSMA6.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098134

Structurei

3D structure databases

ProteinModelPortaliQ9D8F1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alkB family.Curated

Phylogenomic databases

eggNOGiKOG3959 Eukaryota
ENOG4111IQR LUCA
GeneTreeiENSGT00390000006344
HOGENOMiHOG000015835
HOVERGENiHBG062006
InParanoidiQ9D8F1
KOiK10766
OMAiHLDDSWL
OrthoDBiEOG091G0REU
PhylomeDBiQ9D8F1
TreeFamiTF314885

Family and domain databases

Gene3Di2.60.120.590, 1 hit
InterProiView protein in InterPro
IPR037151 AlkB-like_sf
IPR032857 ALKBH4
PANTHERiPTHR12463 PTHR12463, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D8F1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAEVSLL QECGCKGIRT CLICERQRHR DPPWQICLQK KCCFLYCPDT
60 70 80 90 100
GWAAGAEGSD LEGWAFPFPG VTLIQDFVTP EEEAEMVRLM DCDPWKLSQS
110 120 130 140 150
GRKKQDYGPK VNFRKQKLKM AGFQGLPGFS QKVVQRMGLY PGLEDFQPVE
160 170 180 190 200
QCNLDYSPER GSAIDPHLDD AWLWGERLVS LNLLSATVVS MSPEAPGSLL
210 220 230 240 250
LCSAPSVRPD AFEDSLVAPS RSVPCQEVEV AITVPRRSLL VLTGAARHQW
260 270 280 290 300
THAIHRRHIK ARRVCATFRE LSSEFLPGGK QQELGQELLQ AALSFQGRPV
Length:300
Mass (Da):33,394
Last modified:June 1, 2001 - v1
Checksum:iC19FBBB89095B6ED
GO
Isoform 2 (identifier: Q9D8F1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Note: No experimental confirmation available.
Show »
Length:215
Mass (Da):23,976
Checksum:i1345834B207D258E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0191291 – 85Missing in isoform 2. 1 PublicationAdd BLAST85

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008083 mRNA Translation: BAB25449.1
GL456122 Genomic DNA No translation available.
BC022729 mRNA Translation: AAH22729.1
CCDSiCCDS19753.1 [Q9D8F1-2]
CCDS84973.1 [Q9D8F1-1]
RefSeqiNP_001334421.1, NM_001347492.1 [Q9D8F1-1]
NP_082346.1, NM_028070.1 [Q9D8F1-2]
XP_006504566.1, XM_006504503.3
XP_006504567.1, XM_006504504.2
XP_006504568.1, XM_006504505.3 [Q9D8F1-2]
UniGeneiMm.294725
Mm.486605

Genome annotation databases

EnsembliENSMUST00000041100; ENSMUSP00000040403; ENSMUSG00000039754 [Q9D8F1-1]
ENSMUST00000100568; ENSMUSP00000098134; ENSMUSG00000039754 [Q9D8F1-2]
GeneIDi72041
KEGGimmu:72041
UCSCiuc009aaa.1 mouse [Q9D8F1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiALKB4_MOUSE
AccessioniPrimary (citable) accession number: Q9D8F1
Secondary accession number(s): Q8R1Y9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health