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Q9D8E6

- RL4_MOUSE

UniProt

Q9D8E6 - RL4_MOUSE

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Protein
60S ribosomal protein L4
Gene
Rpl4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: MGI
  2. structural constituent of ribosome Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_196445. SRP-dependent cotranslational protein targeting to membrane.
REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L4
Gene namesi
Name:Rpl4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1915141. Rpl4.

Subcellular locationi

GO - Cellular componenti

  1. cytosolic large ribosomal subunit Source: Ensembl
  2. nucleolus Source: Ensembl
  3. ribonucleoprotein complex Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 41941860S ribosomal protein L4
PRO_0000129351Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei14 – 141N6-acetyllysine By similarity
Modified residuei106 – 1061N6-acetyllysine By similarity
Modified residuei259 – 2591N6-acetyllysine1 Publication
Modified residuei295 – 2951Phosphoserine1 Publication
Modified residuei300 – 3001Citrulline
Modified residuei333 – 3331N6-acetyllysine By similarity
Modified residuei353 – 3531N6-acetyllysine1 Publication
Modified residuei364 – 3641N6-acetyllysine1 Publication
Modified residuei365 – 3651Phosphoserine By similarity

Post-translational modificationi

Citrullinated by PADI4.

Keywords - PTMi

Acetylation, Citrullination, Phosphoprotein

Proteomic databases

MaxQBiQ9D8E6.
PaxDbiQ9D8E6.
PRIDEiQ9D8E6.

PTM databases

PhosphoSiteiQ9D8E6.

Expressioni

Gene expression databases

ArrayExpressiQ9D8E6.
BgeeiQ9D8E6.
CleanExiMM_RPL4.
GenevestigatoriQ9D8E6.

Interactioni

Subunit structurei

May bind IPO9 with low affinity. Interacts with RBM3 By similarity.1 Publication

Protein-protein interaction databases

BioGridi212515. 14 interactions.
IntActiQ9D8E6. 9 interactions.
MINTiMINT-1859608.
STRINGi10090.ENSMUSP00000034966.

Structurei

3D structure databases

ProteinModelPortaliQ9D8E6.
SMRiQ9D8E6. Positions 4-367.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi307 – 419113Lys-rich
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0088.
GeneTreeiENSGT00390000018145.
HOGENOMiHOG000107331.
HOVERGENiHBG001453.
InParanoidiQ9D8E6.
KOiK02930.
OMAiVWADIQK.
OrthoDBiEOG73RBBP.
PhylomeDBiQ9D8E6.
TreeFamiTF300593.

Family and domain databases

Gene3Di3.40.1370.10. 1 hit.
InterProiIPR025755. Ribos_L4_C_dom.
IPR002136. Ribosomal_L4/L1e.
IPR013000. Ribosomal_L4/L1e_euk/arc_CS.
IPR023574. Ribosomal_L4_dom.
[Graphical view]
PfamiPF14374. Ribos_L4_asso_C. 1 hit.
PF00573. Ribosomal_L4. 1 hit.
[Graphical view]
SUPFAMiSSF52166. SSF52166. 1 hit.
PROSITEiPS00939. RIBOSOMAL_L1E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D8E6-1 [UniParc]FASTAAdd to Basket

« Hide

MACARPLISV YSEKGESSGK NVTLPAVFKA PIRPDIVNFV HTNLRKNNRQ    50
PYAVSELAGH QTSAESWGTG RAVARIPRVR GGGTHRSGQG AFGNMCRGGR 100
MFAPTKTWRR WHRRVNTTQK RYAICSALAA SALPALVMSK GHRIEEVPEL 150
PLVVEDKVEG YKKTKEAVQL LKKLKAWNDI KKVYASQRMR AGKGKMRNRR 200
RIQRRGPCII YNEDNGIIKA FRNIPGITLL NVSKLNILKL APGGHVGRFC 250
IWTESAFRKL DELYGTWRKA ASLKSNYNLP MHKMMNTDLS RILKSPEIQR 300
ALRAPRKKIH RRVLKKNPLK NLRIMLKLNP YAKTMRRNTI LRQARNHKLR 350
VKKLEAAATA LATKSEKVVP EKGTADKKPA VGKKGKKVDA KKQKPAGKKV 400
VAKKPAEKKP TTEEKKPAA 419
Length:419
Mass (Da):47,154
Last modified:January 23, 2007 - v3
Checksum:iE736E656A60BE85B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti161 – 1611Y → F in BAB27375. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK008098 mRNA. Translation: BAB25458.1.
AK011068 mRNA. Translation: BAB27375.1.
BC003459 mRNA. Translation: AAH03459.1.
CCDSiCCDS40667.1.
RefSeqiNP_077174.1. NM_024212.4.
UniGeneiMm.280083.

Genome annotation databases

EnsembliENSMUST00000034966; ENSMUSP00000034966; ENSMUSG00000032399.
GeneIDi67891.
KEGGimmu:67891.
UCSCiuc009qbn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK008098 mRNA. Translation: BAB25458.1 .
AK011068 mRNA. Translation: BAB27375.1 .
BC003459 mRNA. Translation: AAH03459.1 .
CCDSi CCDS40667.1.
RefSeqi NP_077174.1. NM_024212.4.
UniGenei Mm.280083.

3D structure databases

ProteinModelPortali Q9D8E6.
SMRi Q9D8E6. Positions 4-367.
ModBasei Search...

Protein-protein interaction databases

BioGridi 212515. 14 interactions.
IntActi Q9D8E6. 9 interactions.
MINTi MINT-1859608.
STRINGi 10090.ENSMUSP00000034966.

PTM databases

PhosphoSitei Q9D8E6.

Proteomic databases

MaxQBi Q9D8E6.
PaxDbi Q9D8E6.
PRIDEi Q9D8E6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034966 ; ENSMUSP00000034966 ; ENSMUSG00000032399 .
GeneIDi 67891.
KEGGi mmu:67891.
UCSCi uc009qbn.1. mouse.

Organism-specific databases

CTDi 6124.
MGIi MGI:1915141. Rpl4.

Phylogenomic databases

eggNOGi COG0088.
GeneTreei ENSGT00390000018145.
HOGENOMi HOG000107331.
HOVERGENi HBG001453.
InParanoidi Q9D8E6.
KOi K02930.
OMAi VWADIQK.
OrthoDBi EOG73RBBP.
PhylomeDBi Q9D8E6.
TreeFami TF300593.

Enzyme and pathway databases

Reactomei REACT_196445. SRP-dependent cotranslational protein targeting to membrane.
REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSi RPL4. mouse.
NextBioi 325862.
PROi Q9D8E6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9D8E6.
Bgeei Q9D8E6.
CleanExi MM_RPL4.
Genevestigatori Q9D8E6.

Family and domain databases

Gene3Di 3.40.1370.10. 1 hit.
InterProi IPR025755. Ribos_L4_C_dom.
IPR002136. Ribosomal_L4/L1e.
IPR013000. Ribosomal_L4/L1e_euk/arc_CS.
IPR023574. Ribosomal_L4_dom.
[Graphical view ]
Pfami PF14374. Ribos_L4_asso_C. 1 hit.
PF00573. Ribosomal_L4. 1 hit.
[Graphical view ]
SUPFAMi SSF52166. SSF52166. 1 hit.
PROSITEi PS00939. RIBOSOMAL_L1E. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryonic liver and Small intestine.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Kanor S., Quadroni M., Bienvenut W.V.
    Submitted (MAR-2006) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-13; 165-171 AND 353-363, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6J.
    Tissue: Skeletal muscle.
  4. "Importins fulfill a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains."
    Jaekel S., Mingot J.-M., Schwarzmaier P., Hartmann E., Goerlich D.
    EMBO J. 21:377-386(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IPO9.
  5. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  6. Cited for: CITRULLINATION AT ARG-300.
  7. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-259; LYS-353 AND LYS-364, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiRL4_MOUSE
AccessioniPrimary (citable) accession number: Q9D8E6
Secondary accession number(s): Q9CY08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi