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Protein

60S ribosomal protein L4

Gene

Rpl4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-MMU-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-MMU-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L4
Gene namesi
Name:Rpl4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1915141. Rpl4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001293512 – 41960S ribosomal protein L4Add BLAST418

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei14N6-acetyllysineBy similarity1
Modified residuei97Omega-N-methylarginineCombined sources1
Modified residuei106N6-acetyllysineBy similarity1
Modified residuei259N6-acetyllysineCombined sources1
Modified residuei266PhosphothreonineBy similarity1
Modified residuei290PhosphoserineBy similarity1
Modified residuei295PhosphoserineCombined sources1
Modified residuei300Citrulline1 Publication1
Modified residuei333N6-acetyllysineBy similarity1
Modified residuei353N6-acetyllysineCombined sources1
Modified residuei364N6-acetyllysine; alternateCombined sources1
Cross-linki364Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Modified residuei365PhosphoserineBy similarity1

Post-translational modificationi

Citrullinated by PADI4.1 Publication

Keywords - PTMi

Acetylation, Citrullination, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9D8E6.
MaxQBiQ9D8E6.
PaxDbiQ9D8E6.
PRIDEiQ9D8E6.

PTM databases

iPTMnetiQ9D8E6.
PhosphoSitePlusiQ9D8E6.
SwissPalmiQ9D8E6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032399.
CleanExiMM_RPL4.
ExpressionAtlasiQ9D8E6. baseline and differential.
GenevisibleiQ9D8E6. MM.

Interactioni

Subunit structurei

May bind IPO9 with low affinity. Interacts with RBM3 (By similarity).By similarity

Protein-protein interaction databases

BioGridi212515. 9 interactors.
IntActiQ9D8E6. 9 interactors.
MINTiMINT-1859608.
STRINGi10090.ENSMUSP00000034966.

Structurei

3D structure databases

ProteinModelPortaliQ9D8E6.
SMRiQ9D8E6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi307 – 419Lys-richAdd BLAST113

Sequence similaritiesi

Belongs to the ribosomal protein L4P family.Curated

Phylogenomic databases

eggNOGiKOG1475. Eukaryota.
COG0088. LUCA.
GeneTreeiENSGT00390000018145.
HOGENOMiHOG000107331.
HOVERGENiHBG001453.
InParanoidiQ9D8E6.
KOiK02930.
OMAiHAVNTKA.
OrthoDBiEOG091G0A2I.
PhylomeDBiQ9D8E6.
TreeFamiTF300593.

Family and domain databases

Gene3Di3.40.1370.10. 1 hit.
InterProiIPR025755. Ribos_L4_C_dom.
IPR002136. Ribosomal_L4/L1e.
IPR013000. Ribosomal_L4/L1e_euk/arc_CS.
IPR023574. Ribosomal_L4_dom.
[Graphical view]
PfamiPF14374. Ribos_L4_asso_C. 1 hit.
PF00573. Ribosomal_L4. 1 hit.
[Graphical view]
SUPFAMiSSF52166. SSF52166. 1 hit.
PROSITEiPS00939. RIBOSOMAL_L1E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D8E6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACARPLISV YSEKGESSGK NVTLPAVFKA PIRPDIVNFV HTNLRKNNRQ
60 70 80 90 100
PYAVSELAGH QTSAESWGTG RAVARIPRVR GGGTHRSGQG AFGNMCRGGR
110 120 130 140 150
MFAPTKTWRR WHRRVNTTQK RYAICSALAA SALPALVMSK GHRIEEVPEL
160 170 180 190 200
PLVVEDKVEG YKKTKEAVQL LKKLKAWNDI KKVYASQRMR AGKGKMRNRR
210 220 230 240 250
RIQRRGPCII YNEDNGIIKA FRNIPGITLL NVSKLNILKL APGGHVGRFC
260 270 280 290 300
IWTESAFRKL DELYGTWRKA ASLKSNYNLP MHKMMNTDLS RILKSPEIQR
310 320 330 340 350
ALRAPRKKIH RRVLKKNPLK NLRIMLKLNP YAKTMRRNTI LRQARNHKLR
360 370 380 390 400
VKKLEAAATA LATKSEKVVP EKGTADKKPA VGKKGKKVDA KKQKPAGKKV
410
VAKKPAEKKP TTEEKKPAA
Length:419
Mass (Da):47,154
Last modified:January 23, 2007 - v3
Checksum:iE736E656A60BE85B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti161Y → F in BAB27375 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008098 mRNA. Translation: BAB25458.1.
AK011068 mRNA. Translation: BAB27375.1.
BC003459 mRNA. Translation: AAH03459.1.
CCDSiCCDS40667.1.
RefSeqiNP_077174.1. NM_024212.4.
UniGeneiMm.280083.

Genome annotation databases

EnsembliENSMUST00000034966; ENSMUSP00000034966; ENSMUSG00000032399.
GeneIDi67891.
KEGGimmu:67891.
UCSCiuc009qbn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008098 mRNA. Translation: BAB25458.1.
AK011068 mRNA. Translation: BAB27375.1.
BC003459 mRNA. Translation: AAH03459.1.
CCDSiCCDS40667.1.
RefSeqiNP_077174.1. NM_024212.4.
UniGeneiMm.280083.

3D structure databases

ProteinModelPortaliQ9D8E6.
SMRiQ9D8E6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212515. 9 interactors.
IntActiQ9D8E6. 9 interactors.
MINTiMINT-1859608.
STRINGi10090.ENSMUSP00000034966.

PTM databases

iPTMnetiQ9D8E6.
PhosphoSitePlusiQ9D8E6.
SwissPalmiQ9D8E6.

Proteomic databases

EPDiQ9D8E6.
MaxQBiQ9D8E6.
PaxDbiQ9D8E6.
PRIDEiQ9D8E6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034966; ENSMUSP00000034966; ENSMUSG00000032399.
GeneIDi67891.
KEGGimmu:67891.
UCSCiuc009qbn.1. mouse.

Organism-specific databases

CTDi6124.
MGIiMGI:1915141. Rpl4.

Phylogenomic databases

eggNOGiKOG1475. Eukaryota.
COG0088. LUCA.
GeneTreeiENSGT00390000018145.
HOGENOMiHOG000107331.
HOVERGENiHBG001453.
InParanoidiQ9D8E6.
KOiK02930.
OMAiHAVNTKA.
OrthoDBiEOG091G0A2I.
PhylomeDBiQ9D8E6.
TreeFamiTF300593.

Enzyme and pathway databases

ReactomeiR-MMU-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-MMU-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-MMU-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRpl4. mouse.
PROiQ9D8E6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032399.
CleanExiMM_RPL4.
ExpressionAtlasiQ9D8E6. baseline and differential.
GenevisibleiQ9D8E6. MM.

Family and domain databases

Gene3Di3.40.1370.10. 1 hit.
InterProiIPR025755. Ribos_L4_C_dom.
IPR002136. Ribosomal_L4/L1e.
IPR013000. Ribosomal_L4/L1e_euk/arc_CS.
IPR023574. Ribosomal_L4_dom.
[Graphical view]
PfamiPF14374. Ribos_L4_asso_C. 1 hit.
PF00573. Ribosomal_L4. 1 hit.
[Graphical view]
SUPFAMiSSF52166. SSF52166. 1 hit.
PROSITEiPS00939. RIBOSOMAL_L1E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL4_MOUSE
AccessioniPrimary (citable) accession number: Q9D8E6
Secondary accession number(s): Q9CY08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.