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Protein

Tetraspanin-13

Gene

Tspan13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • calcium channel regulator activity Source: MGI

GO - Biological processi

Complete GO annotation...

Protein family/group databases

TCDBi8.A.40.1.8. the tetraspanin (tetraspanin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-13
Short name:
Tspan-13
Alternative name(s):
Transmembrane 4 superfamily member 13
Gene namesi
Name:Tspan13
Synonyms:Tm4sf13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1913359. Tspan13.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Topological domaini41 – 44ExtracellularSequence analysis4
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Topological domaini66 – 72CytoplasmicSequence analysis7
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Topological domaini94 – 167ExtracellularSequence analysisAdd BLAST74
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189 – 204CytoplasmicSequence analysisAdd BLAST16

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192591 – 204Tetraspanin-13Add BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi113N-linked (GlcNAc...)By similarity1
Glycosylationi137N-linked (GlcNAc...)By similarity1
Modified residuei143PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9D8C2.
MaxQBiQ9D8C2.
PaxDbiQ9D8C2.
PRIDEiQ9D8C2.

PTM databases

iPTMnetiQ9D8C2.
PhosphoSitePlusiQ9D8C2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020577.
CleanExiMM_TSPAN13.
ExpressionAtlasiQ9D8C2. baseline and differential.
GenevisibleiQ9D8C2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020896.

Structurei

3D structure databases

ProteinModelPortaliQ9D8C2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00500000044851.
HOGENOMiHOG000005650.
HOVERGENiHBG009195.
InParanoidiQ9D8C2.
KOiK17356.
OMAiCGFNATG.
OrthoDBiEOG091G0PBF.
PhylomeDBiQ9D8C2.
TreeFamiTF323367.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D8C2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVCGGFSCSK NCLCALNLLY TLVSLLLIGI AAWGIGFGLI SSLRVVGVVI
60 70 80 90 100
AVGIFLFLIA LVGLIGAVKH HQVLLFFYMI ILLLVFIVQF SVSCACLALN
110 120 130 140 150
REQQGQLLEV GWNNTASARN DIQRNLNCCG FRSYNPNDTC PASCAKSTQK
160 170 180 190 200
CSSCAPIIGE YAGEVLRFVG GIGLFFSFTE ILGVWLTYRY RNQKDPRANP

SAFL
Length:204
Mass (Da):22,219
Last modified:June 1, 2001 - v1
Checksum:i76B95421EBCAE5F0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97L → S in BAC41170 (PubMed:16141072).Curated1
Sequence conflicti157I → M in BAC41170 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008175 mRNA. Translation: BAB25510.1.
AK090217 mRNA. Translation: BAC41139.1.
AK090322 mRNA. Translation: BAC41170.1.
AK158761 mRNA. Translation: BAE34648.1.
AK165768 mRNA. Translation: BAE38371.1.
AK167495 mRNA. Translation: BAE39572.1.
AK167979 mRNA. Translation: BAE39971.1.
CT030196 Genomic DNA. Translation: CAO91837.1.
BC018317 mRNA. Translation: AAH18317.1.
CCDSiCCDS25882.1.
RefSeqiNP_079635.1. NM_025359.3.
UniGeneiMm.254663.

Genome annotation databases

EnsembliENSMUST00000020896; ENSMUSP00000020896; ENSMUSG00000020577.
GeneIDi66109.
KEGGimmu:66109.
UCSCiuc007njn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008175 mRNA. Translation: BAB25510.1.
AK090217 mRNA. Translation: BAC41139.1.
AK090322 mRNA. Translation: BAC41170.1.
AK158761 mRNA. Translation: BAE34648.1.
AK165768 mRNA. Translation: BAE38371.1.
AK167495 mRNA. Translation: BAE39572.1.
AK167979 mRNA. Translation: BAE39971.1.
CT030196 Genomic DNA. Translation: CAO91837.1.
BC018317 mRNA. Translation: AAH18317.1.
CCDSiCCDS25882.1.
RefSeqiNP_079635.1. NM_025359.3.
UniGeneiMm.254663.

3D structure databases

ProteinModelPortaliQ9D8C2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020896.

Protein family/group databases

TCDBi8.A.40.1.8. the tetraspanin (tetraspanin) family.

PTM databases

iPTMnetiQ9D8C2.
PhosphoSitePlusiQ9D8C2.

Proteomic databases

EPDiQ9D8C2.
MaxQBiQ9D8C2.
PaxDbiQ9D8C2.
PRIDEiQ9D8C2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020896; ENSMUSP00000020896; ENSMUSG00000020577.
GeneIDi66109.
KEGGimmu:66109.
UCSCiuc007njn.1. mouse.

Organism-specific databases

CTDi27075.
MGIiMGI:1913359. Tspan13.

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00500000044851.
HOGENOMiHOG000005650.
HOVERGENiHBG009195.
InParanoidiQ9D8C2.
KOiK17356.
OMAiCGFNATG.
OrthoDBiEOG091G0PBF.
PhylomeDBiQ9D8C2.
TreeFamiTF323367.

Miscellaneous databases

PROiQ9D8C2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020577.
CleanExiMM_TSPAN13.
ExpressionAtlasiQ9D8C2. baseline and differential.
GenevisibleiQ9D8C2. MM.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTSN13_MOUSE
AccessioniPrimary (citable) accession number: Q9D8C2
Secondary accession number(s): A7NSH9, Q3TMS0, Q8BTH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.