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Q9D8C2 (TSN13_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tetraspanin-13

Short name=Tspan-13
Alternative name(s):
Transmembrane 4 superfamily member 13
Gene names
Name:Tspan13
Synonyms:Tm4sf13
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length204 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Probable.

Sequence similarities

Belongs to the tetraspanin (TM4SF) family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 204204Tetraspanin-13
PRO_0000219259

Regions

Topological domain1 – 1919Cytoplasmic Potential
Transmembrane20 – 4021Helical; Potential
Topological domain41 – 444Extracellular Potential
Transmembrane45 – 6521Helical; Potential
Topological domain66 – 727Cytoplasmic Potential
Transmembrane73 – 9321Helical; Potential
Topological domain94 – 16774Extracellular Potential
Transmembrane168 – 18821Helical; Potential
Topological domain189 – 20416Cytoplasmic Potential

Amino acid modifications

Glycosylation1131N-linked (GlcNAc...) By similarity
Glycosylation1371N-linked (GlcNAc...) By similarity

Experimental info

Sequence conflict971L → S in BAC41170. Ref.1
Sequence conflict1571I → M in BAC41170. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9D8C2 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 76B95421EBCAE5F0

FASTA20422,219
        10         20         30         40         50         60 
MVCGGFSCSK NCLCALNLLY TLVSLLLIGI AAWGIGFGLI SSLRVVGVVI AVGIFLFLIA 

        70         80         90        100        110        120 
LVGLIGAVKH HQVLLFFYMI ILLLVFIVQF SVSCACLALN REQQGQLLEV GWNNTASARN 

       130        140        150        160        170        180 
DIQRNLNCCG FRSYNPNDTC PASCAKSTQK CSSCAPIIGE YAGEVLRFVG GIGLFFSFTE 

       190        200 
ILGVWLTYRY RNQKDPRANP SAFL 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and DBA/2.
Tissue: Brain, Placenta, Seminal vesicle and Visual cortex.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Salivary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK008175 mRNA. Translation: BAB25510.1.
AK090217 mRNA. Translation: BAC41139.1.
AK090322 mRNA. Translation: BAC41170.1.
AK158761 mRNA. Translation: BAE34648.1.
AK165768 mRNA. Translation: BAE38371.1.
AK167495 mRNA. Translation: BAE39572.1.
AK167979 mRNA. Translation: BAE39971.1.
CT030196 Genomic DNA. Translation: CAO91837.1.
BC018317 mRNA. Translation: AAH18317.1.
RefSeqNP_079635.1. NM_025359.3.
UniGeneMm.254663.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000020896.

Protein family/group databases

TCDB8.A.40.1.8. the tetraspanin (tetraspanin) family.

PTM databases

PhosphoSiteQ9D8C2.

Proteomic databases

PaxDbQ9D8C2.
PRIDEQ9D8C2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000020896; ENSMUSP00000020896; ENSMUSG00000020577.
GeneID66109.
KEGGmmu:66109.
UCSCuc007njn.1. mouse.

Organism-specific databases

CTD27075.
MGIMGI:1913359. Tspan13.

Phylogenomic databases

eggNOGNOG279074.
GeneTreeENSGT00500000044851.
HOGENOMHOG000005650.
HOVERGENHBG009195.
InParanoidA7NSH9.
KOK17356.
OMADTCPASC.
OrthoDBEOG7D2FFF.
PhylomeDBQ9D8C2.
TreeFamTF323367.

Gene expression databases

ArrayExpressQ9D8C2.
BgeeQ9D8C2.
CleanExMM_TSPAN13.
GenevestigatorQ9D8C2.

Family and domain databases

InterProIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFPIRSF002419. Tetraspanin. 1 hit.
PRINTSPR00259. TMFOUR.
SUPFAMSSF48652. SSF48652. 1 hit.
ProtoNetSearch...

Other

NextBio320654.
PROQ9D8C2.
SOURCESearch...

Entry information

Entry nameTSN13_MOUSE
AccessionPrimary (citable) accession number: Q9D8C2
Secondary accession number(s): A7NSH9, Q3TMS0, Q8BTH3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot