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Q9D8C2

- TSN13_MOUSE

UniProt

Q9D8C2 - TSN13_MOUSE

Protein

Tetraspanin-13

Gene

Tspan13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Protein family/group databases

    TCDBi8.A.40.1.8. the tetraspanin (tetraspanin) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tetraspanin-13
    Short name:
    Tspan-13
    Alternative name(s):
    Transmembrane 4 superfamily member 13
    Gene namesi
    Name:Tspan13
    Synonyms:Tm4sf13
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1913359. Tspan13.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 204204Tetraspanin-13PRO_0000219259Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi113 – 1131N-linked (GlcNAc...)By similarity
    Glycosylationi137 – 1371N-linked (GlcNAc...)By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9D8C2.
    PRIDEiQ9D8C2.

    PTM databases

    PhosphoSiteiQ9D8C2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9D8C2.
    BgeeiQ9D8C2.
    CleanExiMM_TSPAN13.
    GenevestigatoriQ9D8C2.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000020896.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D8C2.
    SMRiQ9D8C2. Positions 114-165.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini41 – 444ExtracellularSequence Analysis
    Topological domaini66 – 727CytoplasmicSequence Analysis
    Topological domaini94 – 16774ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini189 – 20416CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei20 – 4021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei45 – 6521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei73 – 9321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei168 – 18821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tetraspanin (TM4SF) family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG279074.
    GeneTreeiENSGT00500000044851.
    HOGENOMiHOG000005650.
    HOVERGENiHBG009195.
    InParanoidiA7NSH9.
    KOiK17356.
    OMAiDTCPASC.
    OrthoDBiEOG7D2FFF.
    PhylomeDBiQ9D8C2.
    TreeFamiTF323367.

    Family and domain databases

    InterProiIPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR008952. Tetraspanin_EC2.
    [Graphical view]
    PfamiPF00335. Tetraspannin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002419. Tetraspanin. 1 hit.
    PRINTSiPR00259. TMFOUR.
    SUPFAMiSSF48652. SSF48652. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9D8C2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVCGGFSCSK NCLCALNLLY TLVSLLLIGI AAWGIGFGLI SSLRVVGVVI    50
    AVGIFLFLIA LVGLIGAVKH HQVLLFFYMI ILLLVFIVQF SVSCACLALN 100
    REQQGQLLEV GWNNTASARN DIQRNLNCCG FRSYNPNDTC PASCAKSTQK 150
    CSSCAPIIGE YAGEVLRFVG GIGLFFSFTE ILGVWLTYRY RNQKDPRANP 200
    SAFL 204
    Length:204
    Mass (Da):22,219
    Last modified:June 1, 2001 - v1
    Checksum:i76B95421EBCAE5F0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti97 – 971L → S in BAC41170. (PubMed:16141072)Curated
    Sequence conflicti157 – 1571I → M in BAC41170. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK008175 mRNA. Translation: BAB25510.1.
    AK090217 mRNA. Translation: BAC41139.1.
    AK090322 mRNA. Translation: BAC41170.1.
    AK158761 mRNA. Translation: BAE34648.1.
    AK165768 mRNA. Translation: BAE38371.1.
    AK167495 mRNA. Translation: BAE39572.1.
    AK167979 mRNA. Translation: BAE39971.1.
    CT030196 Genomic DNA. Translation: CAO91837.1.
    BC018317 mRNA. Translation: AAH18317.1.
    CCDSiCCDS25882.1.
    RefSeqiNP_079635.1. NM_025359.3.
    UniGeneiMm.254663.

    Genome annotation databases

    EnsembliENSMUST00000020896; ENSMUSP00000020896; ENSMUSG00000020577.
    GeneIDi66109.
    KEGGimmu:66109.
    UCSCiuc007njn.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK008175 mRNA. Translation: BAB25510.1 .
    AK090217 mRNA. Translation: BAC41139.1 .
    AK090322 mRNA. Translation: BAC41170.1 .
    AK158761 mRNA. Translation: BAE34648.1 .
    AK165768 mRNA. Translation: BAE38371.1 .
    AK167495 mRNA. Translation: BAE39572.1 .
    AK167979 mRNA. Translation: BAE39971.1 .
    CT030196 Genomic DNA. Translation: CAO91837.1 .
    BC018317 mRNA. Translation: AAH18317.1 .
    CCDSi CCDS25882.1.
    RefSeqi NP_079635.1. NM_025359.3.
    UniGenei Mm.254663.

    3D structure databases

    ProteinModelPortali Q9D8C2.
    SMRi Q9D8C2. Positions 114-165.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000020896.

    Protein family/group databases

    TCDBi 8.A.40.1.8. the tetraspanin (tetraspanin) family.

    PTM databases

    PhosphoSitei Q9D8C2.

    Proteomic databases

    PaxDbi Q9D8C2.
    PRIDEi Q9D8C2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020896 ; ENSMUSP00000020896 ; ENSMUSG00000020577 .
    GeneIDi 66109.
    KEGGi mmu:66109.
    UCSCi uc007njn.1. mouse.

    Organism-specific databases

    CTDi 27075.
    MGIi MGI:1913359. Tspan13.

    Phylogenomic databases

    eggNOGi NOG279074.
    GeneTreei ENSGT00500000044851.
    HOGENOMi HOG000005650.
    HOVERGENi HBG009195.
    InParanoidi A7NSH9.
    KOi K17356.
    OMAi DTCPASC.
    OrthoDBi EOG7D2FFF.
    PhylomeDBi Q9D8C2.
    TreeFami TF323367.

    Miscellaneous databases

    NextBioi 320654.
    PROi Q9D8C2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9D8C2.
    Bgeei Q9D8C2.
    CleanExi MM_TSPAN13.
    Genevestigatori Q9D8C2.

    Family and domain databases

    InterProi IPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR008952. Tetraspanin_EC2.
    [Graphical view ]
    Pfami PF00335. Tetraspannin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002419. Tetraspanin. 1 hit.
    PRINTSi PR00259. TMFOUR.
    SUPFAMi SSF48652. SSF48652. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and DBA/2.
      Tissue: Brain, Placenta, Seminal vesicle and Visual cortex.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Salivary gland.

    Entry informationi

    Entry nameiTSN13_MOUSE
    AccessioniPrimary (citable) accession number: Q9D8C2
    Secondary accession number(s): A7NSH9, Q3TMS0, Q8BTH3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3