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Protein

Tetraspanin-13

Gene

Tspan13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • calcium channel regulator activity Source: MGI

GO - Biological processi

  • regulation of calcium ion transmembrane transport Source: MGI
Complete GO annotation...

Protein family/group databases

TCDBi8.A.40.1.8. the tetraspanin (tetraspanin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-13
Short name:
Tspan-13
Alternative name(s):
Transmembrane 4 superfamily member 13
Gene namesi
Name:Tspan13
Synonyms:Tm4sf13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1913359. Tspan13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei20 – 4021HelicalSequence AnalysisAdd
BLAST
Topological domaini41 – 444ExtracellularSequence Analysis
Transmembranei45 – 6521HelicalSequence AnalysisAdd
BLAST
Topological domaini66 – 727CytoplasmicSequence Analysis
Transmembranei73 – 9321HelicalSequence AnalysisAdd
BLAST
Topological domaini94 – 16774ExtracellularSequence AnalysisAdd
BLAST
Transmembranei168 – 18821HelicalSequence AnalysisAdd
BLAST
Topological domaini189 – 20416CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 204204Tetraspanin-13PRO_0000219259Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi113 – 1131N-linked (GlcNAc...)By similarity
Glycosylationi137 – 1371N-linked (GlcNAc...)By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9D8C2.
PaxDbiQ9D8C2.
PRIDEiQ9D8C2.

PTM databases

PhosphoSiteiQ9D8C2.

Expressioni

Gene expression databases

BgeeiQ9D8C2.
CleanExiMM_TSPAN13.
ExpressionAtlasiQ9D8C2. baseline and differential.
GenevisibleiQ9D8C2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020896.

Structurei

3D structure databases

ProteinModelPortaliQ9D8C2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG279074.
GeneTreeiENSGT00500000044851.
HOGENOMiHOG000005650.
HOVERGENiHBG009195.
InParanoidiQ9D8C2.
KOiK17356.
OMAiHRYRNLK.
OrthoDBiEOG7D2FFF.
PhylomeDBiQ9D8C2.
TreeFamiTF323367.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D8C2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVCGGFSCSK NCLCALNLLY TLVSLLLIGI AAWGIGFGLI SSLRVVGVVI
60 70 80 90 100
AVGIFLFLIA LVGLIGAVKH HQVLLFFYMI ILLLVFIVQF SVSCACLALN
110 120 130 140 150
REQQGQLLEV GWNNTASARN DIQRNLNCCG FRSYNPNDTC PASCAKSTQK
160 170 180 190 200
CSSCAPIIGE YAGEVLRFVG GIGLFFSFTE ILGVWLTYRY RNQKDPRANP

SAFL
Length:204
Mass (Da):22,219
Last modified:June 1, 2001 - v1
Checksum:i76B95421EBCAE5F0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti97 – 971L → S in BAC41170 (PubMed:16141072).Curated
Sequence conflicti157 – 1571I → M in BAC41170 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008175 mRNA. Translation: BAB25510.1.
AK090217 mRNA. Translation: BAC41139.1.
AK090322 mRNA. Translation: BAC41170.1.
AK158761 mRNA. Translation: BAE34648.1.
AK165768 mRNA. Translation: BAE38371.1.
AK167495 mRNA. Translation: BAE39572.1.
AK167979 mRNA. Translation: BAE39971.1.
CT030196 Genomic DNA. Translation: CAO91837.1.
BC018317 mRNA. Translation: AAH18317.1.
CCDSiCCDS25882.1.
RefSeqiNP_079635.1. NM_025359.3.
UniGeneiMm.254663.

Genome annotation databases

EnsembliENSMUST00000020896; ENSMUSP00000020896; ENSMUSG00000020577.
GeneIDi66109.
KEGGimmu:66109.
UCSCiuc007njn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008175 mRNA. Translation: BAB25510.1.
AK090217 mRNA. Translation: BAC41139.1.
AK090322 mRNA. Translation: BAC41170.1.
AK158761 mRNA. Translation: BAE34648.1.
AK165768 mRNA. Translation: BAE38371.1.
AK167495 mRNA. Translation: BAE39572.1.
AK167979 mRNA. Translation: BAE39971.1.
CT030196 Genomic DNA. Translation: CAO91837.1.
BC018317 mRNA. Translation: AAH18317.1.
CCDSiCCDS25882.1.
RefSeqiNP_079635.1. NM_025359.3.
UniGeneiMm.254663.

3D structure databases

ProteinModelPortaliQ9D8C2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020896.

Protein family/group databases

TCDBi8.A.40.1.8. the tetraspanin (tetraspanin) family.

PTM databases

PhosphoSiteiQ9D8C2.

Proteomic databases

MaxQBiQ9D8C2.
PaxDbiQ9D8C2.
PRIDEiQ9D8C2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020896; ENSMUSP00000020896; ENSMUSG00000020577.
GeneIDi66109.
KEGGimmu:66109.
UCSCiuc007njn.1. mouse.

Organism-specific databases

CTDi27075.
MGIiMGI:1913359. Tspan13.

Phylogenomic databases

eggNOGiNOG279074.
GeneTreeiENSGT00500000044851.
HOGENOMiHOG000005650.
HOVERGENiHBG009195.
InParanoidiQ9D8C2.
KOiK17356.
OMAiHRYRNLK.
OrthoDBiEOG7D2FFF.
PhylomeDBiQ9D8C2.
TreeFamiTF323367.

Miscellaneous databases

NextBioi320654.
PROiQ9D8C2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D8C2.
CleanExiMM_TSPAN13.
ExpressionAtlasiQ9D8C2. baseline and differential.
GenevisibleiQ9D8C2. MM.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and DBA/2.
    Tissue: Brain, Placenta, Seminal vesicle and Visual cortex.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.

Entry informationi

Entry nameiTSN13_MOUSE
AccessioniPrimary (citable) accession number: Q9D8C2
Secondary accession number(s): A7NSH9, Q3TMS0, Q8BTH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: June 24, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.