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Q9D8B1

- AIG1_MOUSE

UniProt

Q9D8B1 - AIG1_MOUSE

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Protein

Androgen-induced gene 1 protein

Gene

Aig1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in androgen-regulated growth of hair follicles.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Androgen-induced gene 1 protein
Short name:
AIG-1
Gene namesi
Name:Aig1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1913503. Aig1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalSequence AnalysisAdd
BLAST
Transmembranei39 – 5921HelicalSequence AnalysisAdd
BLAST
Transmembranei90 – 11021HelicalSequence AnalysisAdd
BLAST
Transmembranei124 – 14421HelicalSequence AnalysisAdd
BLAST
Transmembranei159 – 17921HelicalSequence AnalysisAdd
BLAST
Transmembranei197 – 21721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 262262Androgen-induced gene 1 proteinPRO_0000190099Add
BLAST

Proteomic databases

PRIDEiQ9D8B1.

PTM databases

PhosphoSiteiQ9D8B1.

Expressioni

Inductioni

By dihydrotestosterone (DHT).By similarity

Gene expression databases

BgeeiQ9D8B1.
CleanExiMM_AIG1.
ExpressionAtlasiQ9D8B1. baseline and differential.
GenevestigatoriQ9D8B1.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIG1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG311793.
GeneTreeiENSGT00390000012526.
HOGENOMiHOG000006895.
HOVERGENiHBG050468.
InParanoidiQ9D8B1.
OMAiVFVVTMF.
OrthoDBiEOG7288RV.
PhylomeDBiQ9D8B1.
TreeFamiTF318170.

Family and domain databases

InterProiIPR006838. Far-17a_AIG1.
[Graphical view]
PfamiPF04750. Far-17a_AIG1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9D8B1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALVPCQVLR VAILLSYCSI LCNYKAIEMP SHQTYGGSWK FLTFIDLVIQ
60 70 80 90 100
AVFFGICVLT DLSSLLTRGS GNQEQERQLR KLISLRDWTL AVLAFPVGVF
110 120 130 140 150
VVAVFWTIYA YDREMIYPRL LDNFIPGWLN HGMHTTVLPF ILIEMRTSHH
160 170 180 190 200
QYPSRSSGLA AICTFSVGYI LWVCWIHHVT GMWVYPFLEH IGSGARIIFF
210 220 230 240 250
GSTTILMNFL YLLGEVLNSY IWDTQRTKAP SCQDTQSSLS CAKPVQNLCK
260
DTFMLEGGKA RA
Length:262
Mass (Da):29,754
Last modified:June 1, 2001 - v1
Checksum:iDD73482C7A758EA4
GO
Isoform 2 (identifier: Q9D8B1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-238: TKAPSCQDTQSS → SIEEEKEKPKLE
     239-262: Missing.

Show »
Length:238
Mass (Da):27,397
Checksum:i23BAE63F35E0CF05
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti134 – 1341H → N in BAB23957. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei227 – 23812TKAPS…DTQSS → SIEEEKEKPKLE in isoform 2. 2 PublicationsVSP_012319Add
BLAST
Alternative sequencei239 – 26224Missing in isoform 2. 2 PublicationsVSP_012320Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005332 mRNA. Translation: BAB23957.1.
AK008210 mRNA. Translation: BAB25534.1.
BC035305 mRNA. Translation: AAH35305.1.
CCDSiCCDS23703.1. [Q9D8B1-1]
RefSeqiNP_079722.1. NM_025446.3. [Q9D8B1-1]
XP_006512874.1. XM_006512811.1. [Q9D8B1-2]
UniGeneiMm.45755.

Genome annotation databases

EnsembliENSMUST00000019942; ENSMUSP00000019942; ENSMUSG00000019806. [Q9D8B1-1]
ENSMUST00000162610; ENSMUSP00000125366; ENSMUSG00000019806. [Q9D8B1-2]
GeneIDi66253.
KEGGimmu:66253.
UCSCiuc007elc.1. mouse. [Q9D8B1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005332 mRNA. Translation: BAB23957.1 .
AK008210 mRNA. Translation: BAB25534.1 .
BC035305 mRNA. Translation: AAH35305.1 .
CCDSi CCDS23703.1. [Q9D8B1-1 ]
RefSeqi NP_079722.1. NM_025446.3. [Q9D8B1-1 ]
XP_006512874.1. XM_006512811.1. [Q9D8B1-2 ]
UniGenei Mm.45755.

3D structure databases

ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9D8B1.

Proteomic databases

PRIDEi Q9D8B1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000019942 ; ENSMUSP00000019942 ; ENSMUSG00000019806 . [Q9D8B1-1 ]
ENSMUST00000162610 ; ENSMUSP00000125366 ; ENSMUSG00000019806 . [Q9D8B1-2 ]
GeneIDi 66253.
KEGGi mmu:66253.
UCSCi uc007elc.1. mouse. [Q9D8B1-1 ]

Organism-specific databases

CTDi 51390.
MGIi MGI:1913503. Aig1.

Phylogenomic databases

eggNOGi NOG311793.
GeneTreei ENSGT00390000012526.
HOGENOMi HOG000006895.
HOVERGENi HBG050468.
InParanoidi Q9D8B1.
OMAi VFVVTMF.
OrthoDBi EOG7288RV.
PhylomeDBi Q9D8B1.
TreeFami TF318170.

Miscellaneous databases

NextBioi 321095.
PROi Q9D8B1.
SOURCEi Search...

Gene expression databases

Bgeei Q9D8B1.
CleanExi MM_AIG1.
ExpressionAtlasi Q9D8B1. baseline and differential.
Genevestigatori Q9D8B1.

Family and domain databases

InterProi IPR006838. Far-17a_AIG1.
[Graphical view ]
Pfami PF04750. Far-17a_AIG1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Cerebellum and Small intestine.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiAIG1_MOUSE
AccessioniPrimary (citable) accession number: Q9D8B1
Secondary accession number(s): Q8CI90, Q9CW23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3