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Protein

Androgen-induced gene 1 protein

Gene

Aig1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in androgen-regulated growth of hair follicles.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Androgen-induced gene 1 protein
Short name:
AIG-1
Gene namesi
Name:Aig1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1913503. Aig1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001900991 – 262Androgen-induced gene 1 proteinAdd BLAST262

Proteomic databases

PaxDbiQ9D8B1.
PRIDEiQ9D8B1.

PTM databases

PhosphoSitePlusiQ9D8B1.

Expressioni

Inductioni

By dihydrotestosterone (DHT).By similarity

Gene expression databases

BgeeiENSMUSG00000019806.
CleanExiMM_AIG1.
ExpressionAtlasiQ9D8B1. baseline and differential.
GenevisibleiQ9D8B1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019942.

Structurei

3D structure databases

ProteinModelPortaliQ9D8B1.
SMRiQ9D8B1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIG1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3989. Eukaryota.
ENOG4111HQA. LUCA.
GeneTreeiENSGT00390000012526.
HOGENOMiHOG000006895.
HOVERGENiHBG050468.
InParanoidiQ9D8B1.
OMAiWDTQRSK.
OrthoDBiEOG091G0LUO.
PhylomeDBiQ9D8B1.
TreeFamiTF318170.

Family and domain databases

InterProiIPR006838. Far-17a_AIG1.
[Graphical view]
PfamiPF04750. Far-17a_AIG1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D8B1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALVPCQVLR VAILLSYCSI LCNYKAIEMP SHQTYGGSWK FLTFIDLVIQ
60 70 80 90 100
AVFFGICVLT DLSSLLTRGS GNQEQERQLR KLISLRDWTL AVLAFPVGVF
110 120 130 140 150
VVAVFWTIYA YDREMIYPRL LDNFIPGWLN HGMHTTVLPF ILIEMRTSHH
160 170 180 190 200
QYPSRSSGLA AICTFSVGYI LWVCWIHHVT GMWVYPFLEH IGSGARIIFF
210 220 230 240 250
GSTTILMNFL YLLGEVLNSY IWDTQRTKAP SCQDTQSSLS CAKPVQNLCK
260
DTFMLEGGKA RA
Length:262
Mass (Da):29,754
Last modified:June 1, 2001 - v1
Checksum:iDD73482C7A758EA4
GO
Isoform 2 (identifier: Q9D8B1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-238: TKAPSCQDTQSS → SIEEEKEKPKLE
     239-262: Missing.

Show »
Length:238
Mass (Da):27,397
Checksum:i23BAE63F35E0CF05
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti134H → N in BAB23957 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012319227 – 238TKAPS…DTQSS → SIEEEKEKPKLE in isoform 2. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_012320239 – 262Missing in isoform 2. 2 PublicationsAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005332 mRNA. Translation: BAB23957.1.
AK008210 mRNA. Translation: BAB25534.1.
BC035305 mRNA. Translation: AAH35305.1.
CCDSiCCDS23703.1. [Q9D8B1-1]
RefSeqiNP_079722.1. NM_025446.3. [Q9D8B1-1]
XP_006512874.1. XM_006512811.3. [Q9D8B1-2]
UniGeneiMm.45755.

Genome annotation databases

EnsembliENSMUST00000019942; ENSMUSP00000019942; ENSMUSG00000019806. [Q9D8B1-1]
ENSMUST00000162610; ENSMUSP00000125366; ENSMUSG00000019806. [Q9D8B1-2]
GeneIDi66253.
KEGGimmu:66253.
UCSCiuc007elc.1. mouse. [Q9D8B1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005332 mRNA. Translation: BAB23957.1.
AK008210 mRNA. Translation: BAB25534.1.
BC035305 mRNA. Translation: AAH35305.1.
CCDSiCCDS23703.1. [Q9D8B1-1]
RefSeqiNP_079722.1. NM_025446.3. [Q9D8B1-1]
XP_006512874.1. XM_006512811.3. [Q9D8B1-2]
UniGeneiMm.45755.

3D structure databases

ProteinModelPortaliQ9D8B1.
SMRiQ9D8B1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019942.

PTM databases

PhosphoSitePlusiQ9D8B1.

Proteomic databases

PaxDbiQ9D8B1.
PRIDEiQ9D8B1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019942; ENSMUSP00000019942; ENSMUSG00000019806. [Q9D8B1-1]
ENSMUST00000162610; ENSMUSP00000125366; ENSMUSG00000019806. [Q9D8B1-2]
GeneIDi66253.
KEGGimmu:66253.
UCSCiuc007elc.1. mouse. [Q9D8B1-1]

Organism-specific databases

CTDi51390.
MGIiMGI:1913503. Aig1.

Phylogenomic databases

eggNOGiKOG3989. Eukaryota.
ENOG4111HQA. LUCA.
GeneTreeiENSGT00390000012526.
HOGENOMiHOG000006895.
HOVERGENiHBG050468.
InParanoidiQ9D8B1.
OMAiWDTQRSK.
OrthoDBiEOG091G0LUO.
PhylomeDBiQ9D8B1.
TreeFamiTF318170.

Miscellaneous databases

PROiQ9D8B1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019806.
CleanExiMM_AIG1.
ExpressionAtlasiQ9D8B1. baseline and differential.
GenevisibleiQ9D8B1. MM.

Family and domain databases

InterProiIPR006838. Far-17a_AIG1.
[Graphical view]
PfamiPF04750. Far-17a_AIG1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAIG1_MOUSE
AccessioniPrimary (citable) accession number: Q9D8B1
Secondary accession number(s): Q8CI90, Q9CW23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.