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Q9D8B1 (AIG1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Androgen-induced gene 1 protein

Short name=AIG-1
Gene names
Name:Aig1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length262 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in androgen-regulated growth of hair follicles By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Induction

By dihydrotestosterone (DHT) By similarity.

Sequence similarities

Belongs to the AIG1 family.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9D8B1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9D8B1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     227-238: TKAPSCQDTQSS → SIEEEKEKPKLE
     239-262: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 262262Androgen-induced gene 1 protein
PRO_0000190099

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane39 – 5921Helical; Potential
Transmembrane90 – 11021Helical; Potential
Transmembrane124 – 14421Helical; Potential
Transmembrane159 – 17921Helical; Potential
Transmembrane197 – 21721Helical; Potential

Natural variations

Alternative sequence227 – 23812TKAPS…DTQSS → SIEEEKEKPKLE in isoform 2.
VSP_012319
Alternative sequence239 – 26224Missing in isoform 2.
VSP_012320

Experimental info

Sequence conflict1341H → N in BAB23957. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: DD73482C7A758EA4

FASTA26229,754
        10         20         30         40         50         60 
MALVPCQVLR VAILLSYCSI LCNYKAIEMP SHQTYGGSWK FLTFIDLVIQ AVFFGICVLT 

        70         80         90        100        110        120 
DLSSLLTRGS GNQEQERQLR KLISLRDWTL AVLAFPVGVF VVAVFWTIYA YDREMIYPRL 

       130        140        150        160        170        180 
LDNFIPGWLN HGMHTTVLPF ILIEMRTSHH QYPSRSSGLA AICTFSVGYI LWVCWIHHVT 

       190        200        210        220        230        240 
GMWVYPFLEH IGSGARIIFF GSTTILMNFL YLLGEVLNSY IWDTQRTKAP SCQDTQSSLS 

       250        260 
CAKPVQNLCK DTFMLEGGKA RA 

« Hide

Isoform 2 [UniParc].

Checksum: 23BAE63F35E0CF05
Show »

FASTA23827,397

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J.
Tissue: Cerebellum and Small intestine.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: FVB/N.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK005332 mRNA. Translation: BAB23957.1.
AK008210 mRNA. Translation: BAB25534.1.
BC035305 mRNA. Translation: AAH35305.1.
CCDSCCDS23703.1. [Q9D8B1-1]
RefSeqNP_079722.1. NM_025446.3. [Q9D8B1-1]
XP_006512874.1. XM_006512811.1. [Q9D8B1-2]
UniGeneMm.45755.

3D structure databases

ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9D8B1.

Proteomic databases

PRIDEQ9D8B1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000019942; ENSMUSP00000019942; ENSMUSG00000019806. [Q9D8B1-1]
ENSMUST00000162610; ENSMUSP00000125366; ENSMUSG00000019806. [Q9D8B1-2]
GeneID66253.
KEGGmmu:66253.
UCSCuc007elc.1. mouse. [Q9D8B1-1]

Organism-specific databases

CTD51390.
MGIMGI:1913503. Aig1.

Phylogenomic databases

eggNOGNOG311793.
GeneTreeENSGT00390000012526.
HOGENOMHOG000006895.
HOVERGENHBG050468.
InParanoidQ9D8B1.
OMAVFVVTMF.
OrthoDBEOG7288RV.
PhylomeDBQ9D8B1.
TreeFamTF318170.

Gene expression databases

ArrayExpressQ9D8B1.
BgeeQ9D8B1.
CleanExMM_AIG1.
GenevestigatorQ9D8B1.

Family and domain databases

InterProIPR006838. Far-17a_AIG1.
[Graphical view]
PfamPF04750. Far-17a_AIG1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSAIG1. mouse.
NextBio321095.
PROQ9D8B1.
SOURCESearch...

Entry information

Entry nameAIG1_MOUSE
AccessionPrimary (citable) accession number: Q9D8B1
Secondary accession number(s): Q8CI90, Q9CW23
Entry history
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot