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Q9D8B1

- AIG1_MOUSE

UniProt

Q9D8B1 - AIG1_MOUSE

Protein

Androgen-induced gene 1 protein

Gene

Aig1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    May play a role in androgen-regulated growth of hair follicles.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Androgen-induced gene 1 protein
    Short name:
    AIG-1
    Gene namesi
    Name:Aig1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1913503. Aig1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 262262Androgen-induced gene 1 proteinPRO_0000190099Add
    BLAST

    Proteomic databases

    PRIDEiQ9D8B1.

    PTM databases

    PhosphoSiteiQ9D8B1.

    Expressioni

    Inductioni

    By dihydrotestosterone (DHT).By similarity

    Gene expression databases

    ArrayExpressiQ9D8B1.
    BgeeiQ9D8B1.
    CleanExiMM_AIG1.
    GenevestigatoriQ9D8B1.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei39 – 5921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei90 – 11021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei124 – 14421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIG1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG311793.
    GeneTreeiENSGT00390000012526.
    HOGENOMiHOG000006895.
    HOVERGENiHBG050468.
    InParanoidiQ9D8B1.
    OMAiVFVVTMF.
    OrthoDBiEOG7288RV.
    PhylomeDBiQ9D8B1.
    TreeFamiTF318170.

    Family and domain databases

    InterProiIPR006838. Far-17a_AIG1.
    [Graphical view]
    PfamiPF04750. Far-17a_AIG1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9D8B1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MALVPCQVLR VAILLSYCSI LCNYKAIEMP SHQTYGGSWK FLTFIDLVIQ    50
    AVFFGICVLT DLSSLLTRGS GNQEQERQLR KLISLRDWTL AVLAFPVGVF 100
    VVAVFWTIYA YDREMIYPRL LDNFIPGWLN HGMHTTVLPF ILIEMRTSHH 150
    QYPSRSSGLA AICTFSVGYI LWVCWIHHVT GMWVYPFLEH IGSGARIIFF 200
    GSTTILMNFL YLLGEVLNSY IWDTQRTKAP SCQDTQSSLS CAKPVQNLCK 250
    DTFMLEGGKA RA 262
    Length:262
    Mass (Da):29,754
    Last modified:June 1, 2001 - v1
    Checksum:iDD73482C7A758EA4
    GO
    Isoform 2 (identifier: Q9D8B1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         227-238: TKAPSCQDTQSS → SIEEEKEKPKLE
         239-262: Missing.

    Show »
    Length:238
    Mass (Da):27,397
    Checksum:i23BAE63F35E0CF05
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti134 – 1341H → N in BAB23957. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei227 – 23812TKAPS…DTQSS → SIEEEKEKPKLE in isoform 2. 2 PublicationsVSP_012319Add
    BLAST
    Alternative sequencei239 – 26224Missing in isoform 2. 2 PublicationsVSP_012320Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK005332 mRNA. Translation: BAB23957.1.
    AK008210 mRNA. Translation: BAB25534.1.
    BC035305 mRNA. Translation: AAH35305.1.
    CCDSiCCDS23703.1. [Q9D8B1-1]
    RefSeqiNP_079722.1. NM_025446.3. [Q9D8B1-1]
    XP_006512874.1. XM_006512811.1. [Q9D8B1-2]
    UniGeneiMm.45755.

    Genome annotation databases

    EnsembliENSMUST00000019942; ENSMUSP00000019942; ENSMUSG00000019806. [Q9D8B1-1]
    ENSMUST00000162610; ENSMUSP00000125366; ENSMUSG00000019806. [Q9D8B1-2]
    GeneIDi66253.
    KEGGimmu:66253.
    UCSCiuc007elc.1. mouse. [Q9D8B1-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK005332 mRNA. Translation: BAB23957.1 .
    AK008210 mRNA. Translation: BAB25534.1 .
    BC035305 mRNA. Translation: AAH35305.1 .
    CCDSi CCDS23703.1. [Q9D8B1-1 ]
    RefSeqi NP_079722.1. NM_025446.3. [Q9D8B1-1 ]
    XP_006512874.1. XM_006512811.1. [Q9D8B1-2 ]
    UniGenei Mm.45755.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9D8B1.

    Proteomic databases

    PRIDEi Q9D8B1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000019942 ; ENSMUSP00000019942 ; ENSMUSG00000019806 . [Q9D8B1-1 ]
    ENSMUST00000162610 ; ENSMUSP00000125366 ; ENSMUSG00000019806 . [Q9D8B1-2 ]
    GeneIDi 66253.
    KEGGi mmu:66253.
    UCSCi uc007elc.1. mouse. [Q9D8B1-1 ]

    Organism-specific databases

    CTDi 51390.
    MGIi MGI:1913503. Aig1.

    Phylogenomic databases

    eggNOGi NOG311793.
    GeneTreei ENSGT00390000012526.
    HOGENOMi HOG000006895.
    HOVERGENi HBG050468.
    InParanoidi Q9D8B1.
    OMAi VFVVTMF.
    OrthoDBi EOG7288RV.
    PhylomeDBi Q9D8B1.
    TreeFami TF318170.

    Miscellaneous databases

    ChiTaRSi AIG1. mouse.
    NextBioi 321095.
    PROi Q9D8B1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9D8B1.
    Bgeei Q9D8B1.
    CleanExi MM_AIG1.
    Genevestigatori Q9D8B1.

    Family and domain databases

    InterProi IPR006838. Far-17a_AIG1.
    [Graphical view ]
    Pfami PF04750. Far-17a_AIG1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Cerebellum and Small intestine.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: FVB/N.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiAIG1_MOUSE
    AccessioniPrimary (citable) accession number: Q9D8B1
    Secondary accession number(s): Q8CI90, Q9CW23
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 21, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3