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Protein

Actin-related protein 2/3 complex subunit 5-like protein

Gene

Arpc5l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 5-like protein
Alternative name(s):
Arp2/3 complex 16 kDa subunit 2
Short name:
ARC16-2
Gene namesi
Name:Arpc5l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1921442. Arpc5l.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 153153Actin-related protein 2/3 complex subunit 5-like proteinPRO_0000279481Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei64 – 641PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9D898.
MaxQBiQ9D898.
PaxDbiQ9D898.
PRIDEiQ9D898.
TopDownProteomicsiQ9D898.

2D gel databases

REPRODUCTION-2DPAGEQ9D898.

PTM databases

iPTMnetiQ9D898.
PhosphoSiteiQ9D898.

Expressioni

Gene expression databases

BgeeiQ9D898.
CleanExiMM_ARPC5L.
ExpressionAtlasiQ9D898. baseline and differential.
GenevisibleiQ9D898. MM.

Interactioni

Subunit structurei

May be a component of the Arp2/3 complex in which it may replace ARPC5.

Protein-protein interaction databases

BioGridi216564. 2 interactions.
IntActiQ9D898. 3 interactions.
MINTiMINT-4127578.
STRINGi10090.ENSMUSP00000088516.

Structurei

3D structure databases

ProteinModelPortaliQ9D898.
SMRiQ9D898. Positions 13-153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC5 family.Curated

Phylogenomic databases

eggNOGiKOG3380. Eukaryota.
ENOG4111FGV. LUCA.
GeneTreeiENSGT00390000014806.
HOGENOMiHOG000197215.
HOVERGENiHBG050583.
InParanoidiQ9D898.
KOiK05754.

Family and domain databases

Gene3Di1.25.40.190. 1 hit.
InterProiIPR006789. ARPC5.
IPR030075. ARPC5L.
[Graphical view]
PANTHERiPTHR12644. PTHR12644. 1 hit.
PTHR12644:SF2. PTHR12644:SF2. 1 hit.
PfamiPF04699. P16-Arc. 1 hit.
[Graphical view]
PIRSFiPIRSF039096. p16-ARC. 1 hit.
SUPFAMiSSF69103. SSF69103. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D898-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARNTLSSRF RRVDIDEFDE NKFVDEHEEA AAAAGEPGPD PCEVDGLLRQ
60 70 80 90 100
GDMLRAFHAA LRNSPINTKN QAVKERAQGV VLKVLTNFKS SEIEQAVQSL
110 120 130 140 150
DRNGIDLLMK YIYKGFEKPT ENSSAVLLQW HEKALAVGGL GSIIRVLTAR

KTV
Length:153
Mass (Da):16,980
Last modified:June 1, 2001 - v1
Checksum:iF01A86DC009ECEC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008255 mRNA. Translation: BAB25561.1.
BC024482 mRNA. Translation: AAH24482.1.
CCDSiCCDS38120.1.
RefSeqiNP_083085.1. NM_028809.1.
UniGeneiMm.38155.
Mm.440770.

Genome annotation databases

EnsembliENSMUST00000112862; ENSMUSP00000108483; ENSMUSG00000026755.
GeneIDi74192.
KEGGimmu:74192.
UCSCiuc008joa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008255 mRNA. Translation: BAB25561.1.
BC024482 mRNA. Translation: AAH24482.1.
CCDSiCCDS38120.1.
RefSeqiNP_083085.1. NM_028809.1.
UniGeneiMm.38155.
Mm.440770.

3D structure databases

ProteinModelPortaliQ9D898.
SMRiQ9D898. Positions 13-153.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216564. 2 interactions.
IntActiQ9D898. 3 interactions.
MINTiMINT-4127578.
STRINGi10090.ENSMUSP00000088516.

PTM databases

iPTMnetiQ9D898.
PhosphoSiteiQ9D898.

2D gel databases

REPRODUCTION-2DPAGEQ9D898.

Proteomic databases

EPDiQ9D898.
MaxQBiQ9D898.
PaxDbiQ9D898.
PRIDEiQ9D898.
TopDownProteomicsiQ9D898.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112862; ENSMUSP00000108483; ENSMUSG00000026755.
GeneIDi74192.
KEGGimmu:74192.
UCSCiuc008joa.1. mouse.

Organism-specific databases

CTDi81873.
MGIiMGI:1921442. Arpc5l.

Phylogenomic databases

eggNOGiKOG3380. Eukaryota.
ENOG4111FGV. LUCA.
GeneTreeiENSGT00390000014806.
HOGENOMiHOG000197215.
HOVERGENiHBG050583.
InParanoidiQ9D898.
KOiK05754.

Miscellaneous databases

ChiTaRSiArpc5l. mouse.
PROiQ9D898.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D898.
CleanExiMM_ARPC5L.
ExpressionAtlasiQ9D898. baseline and differential.
GenevisibleiQ9D898. MM.

Family and domain databases

Gene3Di1.25.40.190. 1 hit.
InterProiIPR006789. ARPC5.
IPR030075. ARPC5L.
[Graphical view]
PANTHERiPTHR12644. PTHR12644. 1 hit.
PTHR12644:SF2. PTHR12644:SF2. 1 hit.
PfamiPF04699. P16-Arc. 1 hit.
[Graphical view]
PIRSFiPIRSF039096. p16-ARC. 1 hit.
SUPFAMiSSF69103. SSF69103. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Small intestine.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. Lubec G., Klug S.
    Submitted (MAR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 90-102, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Hippocampus.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiARP5L_MOUSE
AccessioniPrimary (citable) accession number: Q9D898
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.