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Protein

Calcineurin B homologous protein 2

Gene

Chp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na+/H+ exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi124 – 1351PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi165 – 1762PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcineurin B homologous protein 2
Alternative name(s):
Hepatocellular carcinoma-associated antigen 520 homolog
Gene namesi
Name:Chp2
Synonyms:Hca520
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1917511 Chp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00000738492 – 196Calcineurin B homologous protein 2Add BLAST195

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1
Modified residuei27PhosphoserineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

MaxQBiQ9D869
PaxDbiQ9D869
PRIDEiQ9D869

PTM databases

iPTMnetiQ9D869
PhosphoSitePlusiQ9D869

Expressioni

Gene expression databases

BgeeiENSMUSG00000030865
CleanExiMM_2010110P09RIK
GenevisibleiQ9D869 MM

Interactioni

Subunit structurei

Interacts with PPP3CA. Interacts with SLC9A1/NHE1; the interaction occurs in a calcium-dependent manner. Interacts with SLC9A1/NHE1 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9D869, 1 interactor
STRINGi10090.ENSMUSP00000033152

Structurei

3D structure databases

ProteinModelPortaliQ9D869
SMRiQ9D869
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 61EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini71 – 106EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini111 – 146EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini152 – 187EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi137 – 148Nuclear export signalBy similarityAdd BLAST12

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0034 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00860000133729
HOGENOMiHOG000233019
HOVERGENiHBG105307
InParanoidiQ9D869
KOiK17611
OMAiHFRPVDE
OrthoDBiEOG091G0LZ1
TreeFamiTF354284

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13202 EF-hand_5, 1 hit
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D869-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSRSSHIAL IPDVEHIRRE TGFSQASLLR LYHRFQALDR DEKGFLSRLD
60 70 80 90 100
LQQIGALAVN PLGDRIIDSF FPNGSQRLYF AGFARVLAYF RPIDEEDATL
110 120 130 140 150
RDPKQPEPLN SRMNKLRFAF QLYDLDRDGK ISRNEMLQVL RLMVGVQVTD
160 170 180 190
EQLESITDRT VQEADEDGDG AVSFLEFTKS LEKMNIEQKM SIRILK
Length:196
Mass (Da):22,567
Last modified:September 18, 2013 - v4
Checksum:i49195FE3DF608286
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti191S → G in BAB25644 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008392 mRNA Translation: BAB25644.1
AC122232 Genomic DNA No translation available.
CH466531 Genomic DNA Translation: EDL17277.1
BC119202 mRNA Translation: AAI19203.1
BC119204 mRNA Translation: AAI19205.1
CCDSiCCDS21814.1
RefSeqiNP_081639.1, NM_027363.1
XP_011240201.1, XM_011241899.1
UniGeneiMm.96997

Genome annotation databases

EnsembliENSMUST00000033152; ENSMUSP00000033152; ENSMUSG00000030865
GeneIDi70261
KEGGimmu:70261
UCSCiuc009jos.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCHP2_MOUSE
AccessioniPrimary (citable) accession number: Q9D869
Secondary accession number(s): Q0VEK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: September 18, 2013
Last modified: March 28, 2018
This is version 114 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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