Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Actin-related protein 6

Gene

Actr6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 6
Short name:
mArp6
Gene namesi
Name:Actr6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1914269. Actr6.

Subcellular locationi

  • Cytoplasmcytoskeleton By similarity
  • Nucleus By similarity

  • Note: Colocalizes with HP1 family proteins at pericentric heterochromatin.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 396395Actin-related protein 6PRO_0000089106Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylthreonineBy similarity
Modified residuei260 – 2601N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9D864.
MaxQBiQ9D864.
PaxDbiQ9D864.
PRIDEiQ9D864.

PTM databases

PhosphoSiteiQ9D864.

Expressioni

Gene expression databases

BgeeiQ9D864.
CleanExiMM_ACTR6.

Interactioni

Subunit structurei

Interacts with CBX1, CBX3 and CBX5.By similarity

Protein-protein interaction databases

IntActiQ9D864. 1 interaction.
STRINGi10090.ENSMUSP00000020109.

Structurei

3D structure databases

ProteinModelPortaliQ9D864.
SMRiQ9D864. Positions 4-386.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family. ARP6 subfamily.Curated

Phylogenomic databases

eggNOGiKOG0680. Eukaryota.
ENOG410XPT5. LUCA.
HOGENOMiHOG000170496.
HOVERGENiHBG097980.
InParanoidiQ9D864.
KOiK11662.
OrthoDBiEOG7P2XRZ.
PhylomeDBiQ9D864.
TreeFamiTF105780.

Family and domain databases

InterProiIPR004000. Actin.
IPR030054. Arp6.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 2 hits.
PTHR11937:SF47. PTHR11937:SF47. 2 hits.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D864-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTLVLDNGA YNAKIGYSHD SVSVIPNCQF RSKTARLKTF TANQIDEIKD
60 70 80 90 100
PSGLFYILPF QKGYLVNWDV QRQVWDYLFG KEMYQVDFLD TNIIITEPYF
110 120 130 140 150
NFTSIQESMN EILFEEYQFQ AVLRVNAGAL SAHRYFRDNP SELCCIIVDS
160 170 180 190 200
GYSFTHIVPY CRSKKKKEAI IRINVGGKLL TNHLKEIISY RQLHVMDETH
210 220 230 240 250
VINQVKEDVC YVSQDFYRDM DIAKLKGEDN TVMIDYVLPD FSTIKKGFCK
260 270 280 290 300
PREEMVLSGK YKSGEQILRL ANERFAVPEI LFNPSDIGIQ EMGIPEAIVY
310 320 330 340 350
SIQNLPEEMQ PHFFKNIVLT GGNSLFPGFR ERVYSEVRCL TPTDYDVSVV
360 370 380 390
LPENPITYSW EGGKLISEND DFEDMVVTRE DYEENGHSVC EEKFDI
Length:396
Mass (Da):45,785
Last modified:May 10, 2004 - v2
Checksum:i550B68A2CBEAC82C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261P → T in BAC40429 (PubMed:16141072).Curated
Sequence conflicti263 – 2631S → F in BAB25654 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008409 mRNA. Translation: BAB25654.1.
AK088571 mRNA. Translation: BAC40429.1.
BC062137 mRNA. Translation: AAH62137.1.
CCDSiCCDS24118.1.
RefSeqiNP_080190.1. NM_025914.2.
UniGeneiMm.335292.

Genome annotation databases

GeneIDi67019.
KEGGimmu:67019.
UCSCiuc007gss.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008409 mRNA. Translation: BAB25654.1.
AK088571 mRNA. Translation: BAC40429.1.
BC062137 mRNA. Translation: AAH62137.1.
CCDSiCCDS24118.1.
RefSeqiNP_080190.1. NM_025914.2.
UniGeneiMm.335292.

3D structure databases

ProteinModelPortaliQ9D864.
SMRiQ9D864. Positions 4-386.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D864. 1 interaction.
STRINGi10090.ENSMUSP00000020109.

PTM databases

PhosphoSiteiQ9D864.

Proteomic databases

EPDiQ9D864.
MaxQBiQ9D864.
PaxDbiQ9D864.
PRIDEiQ9D864.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi67019.
KEGGimmu:67019.
UCSCiuc007gss.1. mouse.

Organism-specific databases

CTDi64431.
MGIiMGI:1914269. Actr6.

Phylogenomic databases

eggNOGiKOG0680. Eukaryota.
ENOG410XPT5. LUCA.
HOGENOMiHOG000170496.
HOVERGENiHBG097980.
InParanoidiQ9D864.
KOiK11662.
OrthoDBiEOG7P2XRZ.
PhylomeDBiQ9D864.
TreeFamiTF105780.

Miscellaneous databases

NextBioi323326.
PROiQ9D864.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D864.
CleanExiMM_ACTR6.

Family and domain databases

InterProiIPR004000. Actin.
IPR030054. Arp6.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 2 hits.
PTHR11937:SF47. PTHR11937:SF47. 2 hits.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Small intestine and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Limb.
  3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-260, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiARP6_MOUSE
AccessioniPrimary (citable) accession number: Q9D864
Secondary accession number(s): Q8BTV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: May 10, 2004
Last modified: March 16, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.