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Protein
Submitted name:

Putative uncharacterized protein

Gene

Rac1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. enzyme binding Source: MGI
  2. GTPase activity Source: MGI
  3. GTP binding Source: MGI
  4. thioesterase binding Source: MGI

GO - Biological processi

  1. actin cytoskeleton organization Source: MGI
  2. actin filament polymerization Source: MGI
  3. anatomical structure arrangement Source: MGI
  4. auditory receptor cell morphogenesis Source: MGI
  5. axon guidance Source: MGI
  6. cell adhesion Source: MGI
  7. cell-cell junction organization Source: MGI
  8. cell migration Source: MGI
  9. cell motility Source: MGI
  10. cerebral cortex radially oriented cell migration Source: MGI
  11. cochlea morphogenesis Source: MGI
  12. cytoskeleton organization Source: MGI
  13. dendrite development Source: MGI
  14. dendrite morphogenesis Source: MGI
  15. dopaminergic neuron differentiation Source: MGI
  16. embryonic olfactory bulb interneuron precursor migration Source: MGI
  17. endocytosis Source: MGI
  18. epithelial cell morphogenesis Source: MGI
  19. G-protein coupled receptor signaling pathway Source: MGI
  20. hyperosmotic response Source: MGI
  21. lamellipodium assembly Source: MGI
  22. localization within membrane Source: MGI
  23. metabolic process Source: GOC
  24. negative regulation of interleukin-23 production Source: MGI
  25. positive regulation of actin filament polymerization Source: MGI
  26. positive regulation of cell-substrate adhesion Source: MGI
  27. positive regulation of focal adhesion assembly Source: MGI
  28. positive regulation of lamellipodium assembly Source: MGI
  29. positive regulation of neutrophil chemotaxis Source: MGI
  30. positive regulation of phosphatidylinositol 3-kinase activity Source: MGI
  31. positive regulation of protein phosphorylation Source: MGI
  32. positive regulation of stress fiber assembly Source: MGI
  33. positive regulation of substrate adhesion-dependent cell spreading Source: MGI
  34. protein localization to plasma membrane Source: MGI
  35. regulation of cell migration Source: MGI
  36. regulation of respiratory burst Source: MGI
  37. ruffle organization Source: MGI
  38. small GTPase mediated signal transduction Source: MGI
  39. substrate adhesion-dependent cell spreading Source: MGI
  40. Wnt signaling pathway, planar cell polarity pathway Source: MGI
Complete GO annotation...

Keywords - Ligandi

GTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Rac1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:97845. Rac1.

Subcellular locationi

GO - Cellular componenti

  1. cell projection Source: MGI
  2. cytoplasm Source: MGI
  3. cytoplasmic membrane-bounded vesicle Source: MGI
  4. cytoplasmic ribonucleoprotein granule Source: MGI
  5. extracellular vesicular exosome Source: MGI
  6. extrinsic component of plasma membrane Source: MGI
  7. focal adhesion Source: MGI
  8. lamellipodium Source: MGI
  9. membrane Source: MGI
  10. trans-Golgi network Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

MembraneSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiQ9D859.

Expressioni

Gene expression databases

GenevestigatoriQ9D859.

Interactioni

Protein-protein interaction databases

MINTiMINT-1517323.
STRINGi10090.ENSMUSP00000098058.

Structurei

3D structure databases

ProteinModelPortaliQ9D859.
SMRiQ9D859. Positions 1-192.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG009351.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00174. RHO. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D859-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDGKP
60 70 80 90 100
VNLGLWDTAG QEDYERLRPL SYPQTDVFLI CFSLVSPASF ENVRAKWYPE
110 120 130 140 150
VRHHCPNTPI ILVGTKLDLR DDKDTIEKLK EKKLTPITYP QGLAMAKEIG
160 170 180 190
AVKYLECSAL TQRGLKTVFD EAIRAVLCPP PVKKRKRKCL LL
Length:192
Mass (Da):21,464
Last modified:June 1, 2001 - v1
Checksum:i59EC483A45E45A67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008435 mRNA. Translation: BAB25667.1.
UniGeneiMm.292510.
Mm.469963.
Mm.475073.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008435 mRNA. Translation: BAB25667.1.
UniGeneiMm.292510.
Mm.469963.
Mm.475073.

3D structure databases

ProteinModelPortaliQ9D859.
SMRiQ9D859. Positions 1-192.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1517323.
STRINGi10090.ENSMUSP00000098058.

Proteomic databases

PRIDEiQ9D859.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:97845. Rac1.

Phylogenomic databases

HOVERGENiHBG009351.

Miscellaneous databases

ChiTaRSiRac1. mouse.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ9D859.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00174. RHO. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Small intestineImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Small intestineImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Small intestineImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Small intestineImported.
  5. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Small intestineImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Small intestineImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Small intestineImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Small intestineImported.

Entry informationi

Entry nameiQ9D859_MOUSE
AccessioniPrimary (citable) accession number: Q9D859
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: March 4, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.