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Q9D859 (Q9D859_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Rac1 MGI 97845
OrganismMus musculus (Mouse) EMBL BAB25667.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length192 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the small GTPase superfamily. Rho family. RuleBase RU003317

Ontologies

Keywords
   Cellular componentMembrane SAAS SAAS003578
   LigandGTP-binding SAAS SAAS003578 RuleBase RU003312
Nucleotide-binding
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Inferred from genetic interaction PubMed 21178006. Source: MGI

GTP catabolic process

Inferred from direct assay PubMed 10699171PubMed 12525493PubMed 15249579. Source: GOC

Wnt signaling pathway, planar cell polarity pathway

Inferred from genetic interaction PubMed 18953410. Source: MGI

anatomical structure arrangement

Inferred from mutant phenotype PubMed 20016102. Source: MGI

auditory receptor cell morphogenesis

Inferred from mutant phenotype PubMed 20016102. Source: MGI

axon guidance

Inferred from mutant phenotype PubMed 17409253. Source: MGI

cell adhesion

Inferred from direct assay PubMed 14657280. Source: MGI

cell migration

Inferred from direct assay PubMed 15728191. Source: MGI

cell-cell junction organization

Inferred from mutant phenotype PubMed 20016102. Source: MGI

cerebral cortex radially oriented cell migration

Inferred from mutant phenotype PubMed 17409253. Source: MGI

cochlea morphogenesis

Inferred from mutant phenotype PubMed 20016102. Source: MGI

cytoskeleton organization

Inferred from direct assay PubMed 14657280. Source: MGI

dendrite development

Inferred from direct assay PubMed 12213441. Source: MGI

dendrite morphogenesis

Inferred from genetic interaction PubMed 20335472. Source: MGI

dopaminergic neuron differentiation

Inferred from genetic interaction PubMed 18953410. Source: MGI

embryonic olfactory bulb interneuron precursor migration

Inferred from mutant phenotype PubMed 17409253. Source: MGI

endocytosis

Inferred from direct assay PubMed 12446704. Source: MGI

epithelial cell morphogenesis

Inferred from mutant phenotype PubMed 20016102. Source: MGI

hyperosmotic response

Inferred from direct assay PubMed 12783890. Source: MGI

lamellipodium assembly

Inferred from direct assay PubMed 15728191. Source: MGI

positive regulation of actin filament polymerization

Inferred from direct assay PubMed 12853475. Source: MGI

positive regulation of lamellipodium assembly

Inferred from sequence orthology PubMed 15467718. Source: MGI

positive regulation of phosphatidylinositol 3-kinase activity

Inferred from mutant phenotype PubMed 15728722. Source: MGI

protein localization to plasma membrane

Inferred from direct assay PubMed 23184663. Source: MGI

regulation of cell migration

Inferred from mutant phenotype PubMed 17409253. Source: MGI

ruffle organization

Inferred from sequence orthology PubMed 15467718. Source: MGI

small GTPase mediated signal transduction

Inferred from direct assay PubMed 12525493. Source: MGI

substrate adhesion-dependent cell spreading

Inferred from direct assay PubMed 18156211. Source: MGI

   Cellular_componentcell projection

Inferred from direct assay PubMed 15728722. Source: MGI

cytoplasm

Inferred from direct assay PubMed 12213441. Source: MGI

cytoplasmic membrane-bounded vesicle

Inferred from direct assay PubMed 12783890PubMed 14516655. Source: MGI

extrinsic component of plasma membrane

Inferred from direct assay PubMed 14516655. Source: MGI

lamellipodium

Inferred from direct assay PubMed 12783890PubMed 14657280. Source: MGI

membrane

Inferred from direct assay PubMed 14657280. Source: MGI

   Molecular_functionGTP binding

Inferred from direct assay PubMed 12783890PubMed 14580336PubMed 15728191PubMed 23528453. Source: MGI

GTPase activity

Inferred from direct assay PubMed 10699171PubMed 12525493PubMed 15249579. Source: MGI

protein binding

Inferred from physical interaction PubMed 14573547PubMed 17227220PubMed 18604197PubMed 8464478. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q9D859 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 59EC483A45E45A67

FASTA19221,464
        10         20         30         40         50         60 
MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDGKP VNLGLWDTAG 

        70         80         90        100        110        120 
QEDYERLRPL SYPQTDVFLI CFSLVSPASF ENVRAKWYPE VRHHCPNTPI ILVGTKLDLR 

       130        140        150        160        170        180 
DDKDTIEKLK EKKLTPITYP QGLAMAKEIG AVKYLECSAL TQRGLKTVFD EAIRAVLCPP 

       190 
PVKKRKRKCL LL 

« Hide

References

[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB25667.1.
Tissue: Small intestine EMBL BAB25667.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB25667.1.
Tissue: Small intestine EMBL BAB25667.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB25667.1.
Tissue: Small intestine EMBL BAB25667.1.
[4]Adachi J., Aizawa K., Akahira S., Akimura T., Arai A., Aono H., Arakawa T., Bono H., Carninci P., Fukuda S., Fukunishi Y., Furuno M., Hanagaki T., Hara A., Hayatsu N., Hiramoto K., Hiraoka T., Hori F. expand/collapse author list , Imotani K., Ishii Y., Itoh M., Izawa M., Kasukawa T., Kato H., Kawai J., Kojima Y., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Nishi K., Nomura K., Numazaki R., Ohno M., Okazaki Y., Okido T., Owa C., Saito H., Saito R., Sakai C., Sakai K., Sano H., Sasaki D., Shibata K., Shibata Y., Shinagawa A., Shiraki T., Sogabe Y., Suzuki H., Tagami M., Tagawa A., Takahashi F., Tanaka T., Tejima Y., Toya T., Yamamura T., Yasunishi A., Yoshida K., Yoshino M., Muramatsu M., Hayashizaki Y.
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB25667.1.
Tissue: Small intestine EMBL BAB25667.1.
[5]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB25667.1.
Tissue: Small intestine EMBL BAB25667.1.
[6]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB25667.1.
Tissue: Small intestine EMBL BAB25667.1.
[7]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB25667.1.
Tissue: Small intestine EMBL BAB25667.1.
[8]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB25667.1.
Tissue: Small intestine EMBL BAB25667.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK008435 mRNA. Translation: BAB25667.1.
UniGeneMm.292510.
Mm.469963.
Mm.475073.

3D structure databases

ProteinModelPortalQ9D859.
SMRQ9D859. Positions 1-192.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-1517323.
STRING10090.ENSMUSP00000098058.

Proteomic databases

PRIDEQ9D859.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:97845. Rac1.

Phylogenomic databases

HOVERGENHBG009351.

Gene expression databases

GenevestigatorQ9D859.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00174. RHO. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRAC1. mouse.
SOURCESearch...

Entry information

Entry nameQ9D859_MOUSE
AccessionPrimary (citable) accession number: Q9D859
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: June 11, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)