Q9D859 (Q9D859_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative uncharacterized protein EMBL BAB25667.1

Gene names

Name:

Rac1 MGI 97845

Organism

Mus musculus (Mouse) EMBL BAB25667.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	192 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the small GTPase superfamily. Rho family. RuleBase RU003317

Ontologies

Keywords
Cellular component	Membrane SAAS SAAS003578
Ligand	GTP-binding SAAS SAAS003578 RuleBase RU003312 Nucleotide-binding
Gene Ontology (GO)
Biological_process	Wnt receptor signaling pathway, planar cell polarity pathway Inferred from genetic interaction PubMed 18953410. Source: MGI anatomical structure arrangement Inferred from mutant phenotype PubMed 20016102. Source: MGI auditory receptor cell morphogenesis Inferred from mutant phenotype PubMed 20016102. Source: MGI axon guidance Inferred from mutant phenotype PubMed 17409253. Source: MGI cell-cell junction organization Inferred from mutant phenotype PubMed 20016102. Source: MGI cerebral cortex radially oriented cell migration Inferred from mutant phenotype PubMed 17409253. Source: MGI cochlea morphogenesis Inferred from mutant phenotype PubMed 20016102. Source: MGI cytoskeleton organization Inferred from direct assay PubMed 14657280. Source: MGI dendrite morphogenesis Inferred from genetic interaction PubMed 20335472. Source: MGI dopaminergic neuron differentiation Inferred from genetic interaction PubMed 18953410. Source: MGI embryonic olfactory bulb interneuron precursor migration Inferred from mutant phenotype PubMed 17409253. Source: MGI endocytosis Inferred from direct assay PubMed 12446704. Source: MGI epithelial cell morphogenesis Inferred from mutant phenotype PubMed 20016102. Source: MGI hyperosmotic response Inferred from direct assay PubMed 12783890. Source: MGI lamellipodium assembly Inferred from direct assay PubMed 15728191. Source: MGI positive regulation of actin filament polymerization Inferred from direct assay PubMed 12853475. Source: MGI positive regulation of lamellipodium assembly Inferred from sequence orthology PubMed 15467718. Source: MGI positive regulation of phosphatidylinositol 3-kinase activity Inferred from mutant phenotype PubMed 15728722. Source: MGI regulation of cell migration Inferred from mutant phenotype PubMed 17409253. Source: MGI ruffle organization Inferred from sequence orthology PubMed 15467718. Source: MGI small GTPase mediated signal transduction Inferred from direct assay PubMed 12525493. Source: MGI substrate adhesion-dependent cell spreading Inferred from direct assay PubMed 18156211. Source: MGI
Cellular_component	cytoplasmic membrane-bounded vesicle Inferred from direct assay PubMed 12783890PubMed 14516655. Source: MGI extrinsic to plasma membrane Inferred from direct assay PubMed 14516655. Source: MGI lamellipodium Inferred from direct assay PubMed 12783890PubMed 14657280. Source: MGI
Molecular_function	GTP binding Inferred from direct assay PubMed 12783890PubMed 14580336PubMed 15728191. Source: MGI GTPase activity Inferred from direct assay PubMed 10699171PubMed 12525493PubMed 15249579. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9D859 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 59EC483A45E45A67	FASTA	192	21,464
	10 20 30 40 50 60 MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDGKP VNLGLWDTAG 70 80 90 100 110 120 QEDYERLRPL SYPQTDVFLI CFSLVSPASF ENVRAKWYPE VRHHCPNTPI ILVGTKLDLR 130 140 150 160 170 180 DDKDTIEKLK EKKLTPITYP QGLAMAKEIG AVKYLECSAL TQRGLKTVFD EAIRAVLCPP 190 PVKKRKRKCL LL

References

[1]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB25667.1. Tissue: Small intestine EMBL BAB25667.1.
[2]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB25667.1. Tissue: Small intestine EMBL BAB25667.1.
[3]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB25667.1. Tissue: Small intestine EMBL BAB25667.1.
[4]	Adachi J., Aizawa K., Akahira S., Akimura T., Arai A., Aono H., Arakawa T., Bono H., Carninci P., Fukuda S., Fukunishi Y., Furuno M., Hanagaki T., Hara A., Hayatsu N., Hiramoto K., Hiraoka T., Hori F. , Imotani K., Ishii Y., Itoh M., Izawa M., Kasukawa T., Kato H., Kawai J., Kojima Y., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Nishi K., Nomura K., Numazaki R., Ohno M., Okazaki Y., Okido T., Owa C., Saito H., Saito R., Sakai C., Sakai K., Sano H., Sasaki D., Shibata K., Shibata Y., Shinagawa A., Shiraki T., Sogabe Y., Suzuki H., Tagami M., Tagawa A., Takahashi F., Tanaka T., Tejima Y., Toya T., Yamamura T., Yasunishi A., Yoshida K., Yoshino M., Muramatsu M., Hayashizaki Y. Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB25667.1. Tissue: Small intestine EMBL BAB25667.1.
[5]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB25667.1. Tissue: Small intestine EMBL BAB25667.1.
[6]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB25667.1. Tissue: Small intestine EMBL BAB25667.1.
[7]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB25667.1. Tissue: Small intestine EMBL BAB25667.1.
[8]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB25667.1. Tissue: Small intestine EMBL BAB25667.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK008435 mRNA. Translation: BAB25667.1.
IPI	IPI00761613.
UniGene	Mm.292510. Mm.469963. Mm.475073.
3D structure databases
ProteinModelPortal	Q9D859.
SMR	Q9D859. Positions 1-192.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1517323.
STRING	10090.ENSMUSP00000098058.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:97845. Rac1.
Phylogenomic databases
HOVERGEN	HBG009351.
Gene expression databases
Genevestigator	Q9D859.
Family and domain databases
InterPro	IPR027417. P-loop_NTPase. IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003578. Small_GTPase_Rho. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00174. RHO. 1 hit. [Graphical view]
SUPFAM	SSF52540. SSF52540. 1 hit.
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51420. RHO. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RAC1. mouse.
SOURCE	Search...

Entry information

Entry name

Q9D859_MOUSE

Accession

Primary (citable) accession number: Q9D859

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2001
Last sequence update:	June 1, 2001
Last modified:	May 29, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)