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Protein

Zinc transporter ZIP5

Gene

Slc39a5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in polarized cells by carrying out serosal-to-mucosal zinc transport. Plays a role in eye development. Could regulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera (PubMed:24891338). Seems to play a central role in controlling organismal zinc status.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • BMP signaling pathway Source: UniProtKB
  • cellular response to zinc ion starvation Source: MGI
  • cellular zinc ion homeostasis Source: MGI
  • eye development Source: UniProtKB
  • positive regulation of mRNA splicing, via spliceosome Source: MGI
  • zinc II ion transmembrane import Source: GO_Central
  • zinc II ion transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiR-MMU-442380. Zinc influx into cells by the SLC39 gene family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP5
Alternative name(s):
Solute carrier family 39 member 5
Zrt- and Irt-like protein 5
Short name:
ZIP-5
Gene namesi
Name:Slc39a5
Synonyms:Zip5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1919336. Slc39a5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 210191Extracellular1 PublicationAdd
BLAST
Transmembranei211 – 23121HelicalSequence analysisAdd
BLAST
Topological domaini232 – 24211CytoplasmicSequence analysisAdd
BLAST
Transmembranei243 – 26321HelicalSequence analysisAdd
BLAST
Topological domaini264 – 28522ExtracellularSequence analysisAdd
BLAST
Transmembranei286 – 30621HelicalSequence analysisAdd
BLAST
Topological domaini307 – 439133CytoplasmicSequence analysisAdd
BLAST
Transmembranei440 – 46021HelicalSequence analysisAdd
BLAST
Topological domaini461 – 4655ExtracellularSequence analysis
Transmembranei466 – 48621HelicalSequence analysisAdd
BLAST
Topological domaini487 – 50317CytoplasmicSequence analysisAdd
BLAST
Transmembranei504 – 52421HelicalSequence analysisAdd
BLAST
Topological domaini525 – 53511Extracellular1 PublicationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 535516Zinc transporter ZIP5PRO_0000045796Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi49 – 491N-linked (GlcNAc...)Sequence analysis
Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence analysis
Modified residuei333 – 3331PhosphoserineCombined sources

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9D856.
PRIDEiQ9D856.

PTM databases

iPTMnetiQ9D856.
PhosphoSiteiQ9D856.

Expressioni

Tissue specificityi

Expressed in all stages of eye development and primarily in the sclera and several layers of the retina, including the inner segment, outer plexiform layer and ganglion cell layer.1 Publication

Developmental stagei

Expressed at embryonic day E10, postnatal day P0, P13 and adult.1 Publication

Gene expression databases

BgeeiQ9D856.
GenevisibleiQ9D856. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037753.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi135 – 528394Leu-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
GeneTreeiENSGT00760000119115.
HOGENOMiHOG000132930.
HOVERGENiHBG084379.
InParanoidiQ9D856.
KOiK14711.
OMAiENGSGMA.
OrthoDBiEOG7Q5HDD.
PhylomeDBiQ9D856.
TreeFamiTF318470.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D856-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPPVHHLLT GLCVGVALGW VGGSVPNLGP AEQEQNHYLA QLFGLYGENG
60 70 80 90 100
TLTAGGLARL LHSLGLGRVQ GLRLGHHEPP TGRAAPTSGD NFTHRLQEPE
110 120 130 140 150
LSVDIWAGMP LGPSGWGDQE ESKAPDLHGS GPSSLDLFQR LLLLDHSLAD
160 170 180 190 200
HLNEDCLNGS QLLVNFGLSP VAPLTPRQFA LLCPALLYQI DSRVCIKTPA
210 220 230 240 250
PAPPGDVLSA LLHSGLAVLF LSLPAPLSLL LLRLLGPRLL RPVLGFLGAL
260 270 280 290 300
AVGTLCGDAL LHLLPHAQGG RHTGPSEQSE EDLGPGLSVL GGLFLLFMLE
310 320 330 340 350
NTLGLVRHRG LRPRCCRNKR DLGEPNPDPE DGSGMVLRPL QAASEPEVQG
360 370 380 390 400
QRENRQSSPS LAPPGHQGHS HEHRGGSIAW MVLLGDCLHN LTDGLALGAA
410 420 430 440 450
FSDGFSSGLS TTLAVFCHEL PHELGDFAML LQEGLSFRKL LLLSLVSGAL
460 470 480 490 500
GLGGAALGVG LSLGPVPLTP WVFGTTAGVF LYVALVDMLP TLLRPPEPLP
510 520 530
VFHVLLQGLG LLLGGSLMFT IALLEEQLVP TVPDG
Length:535
Mass (Da):56,275
Last modified:June 1, 2001 - v1
Checksum:i272204D17B2E66CD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti137 – 1371L → R in BAB25054 (PubMed:16141072).Curated
Sequence conflicti332 – 3321G → V in BAB25054 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007473 mRNA. Translation: BAB25054.1.
AK008448 mRNA. Translation: BAB25675.1.
BC028990 mRNA. Translation: AAH28990.1.
CCDSiCCDS24275.1.
RefSeqiNP_001129709.1. NM_001136237.1.
NP_082327.2. NM_028051.3.
NP_082368.1. NM_028092.3.
XP_006514235.1. XM_006514172.2.
XP_006514236.1. XM_006514173.2.
UniGeneiMm.22983.

Genome annotation databases

EnsembliENSMUST00000042666; ENSMUSP00000037753; ENSMUSG00000039878.
ENSMUST00000167859; ENSMUSP00000131736; ENSMUSG00000039878.
GeneIDi72002.
KEGGimmu:72002.
UCSCiuc007hmn.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007473 mRNA. Translation: BAB25054.1.
AK008448 mRNA. Translation: BAB25675.1.
BC028990 mRNA. Translation: AAH28990.1.
CCDSiCCDS24275.1.
RefSeqiNP_001129709.1. NM_001136237.1.
NP_082327.2. NM_028051.3.
NP_082368.1. NM_028092.3.
XP_006514235.1. XM_006514172.2.
XP_006514236.1. XM_006514173.2.
UniGeneiMm.22983.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037753.

PTM databases

iPTMnetiQ9D856.
PhosphoSiteiQ9D856.

Proteomic databases

PaxDbiQ9D856.
PRIDEiQ9D856.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042666; ENSMUSP00000037753; ENSMUSG00000039878.
ENSMUST00000167859; ENSMUSP00000131736; ENSMUSG00000039878.
GeneIDi72002.
KEGGimmu:72002.
UCSCiuc007hmn.3. mouse.

Organism-specific databases

CTDi283375.
MGIiMGI:1919336. Slc39a5.

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
GeneTreeiENSGT00760000119115.
HOGENOMiHOG000132930.
HOVERGENiHBG084379.
InParanoidiQ9D856.
KOiK14711.
OMAiENGSGMA.
OrthoDBiEOG7Q5HDD.
PhylomeDBiQ9D856.
TreeFamiTF318470.

Enzyme and pathway databases

ReactomeiR-MMU-442380. Zinc influx into cells by the SLC39 gene family.

Miscellaneous databases

PROiQ9D856.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D856.
GenevisibleiQ9D856. MM.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pancreas and Small intestine.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.
  3. "The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells."
    Wang F., Kim B.-E., Petris M.J., Eide D.J.
    J. Biol. Chem. 279:51433-51441(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TOPOLOGY, GLYCOSYLATION, SUBCELLULAR LOCATION.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-333, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Pancreas.
  5. Cited for: DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.

Entry informationi

Entry nameiS39A5_MOUSE
AccessioniPrimary (citable) accession number: Q9D856
Secondary accession number(s): Q9D909
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.