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Protein

Cytochrome b-c1 complex subunit 7

Gene

Uqcrb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 7
Alternative name(s):
Complex III subunit 7
Complex III subunit VII
Ubiquinol-cytochrome c reductase complex 14 kDa protein
Gene namesi
Name:Uqcrb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1914780. Uqcrb.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: MGI
  • mitochondrial respiratory chain complex III Source: GO_Central
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 111110Cytochrome b-c1 complex subunit 7PRO_0000193525Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei12 – 121N6-acetyllysine; alternateCombined sources
Modified residuei12 – 121N6-succinyllysine; alternateCombined sources
Modified residuei19 – 191N6-acetyllysineCombined sources
Modified residuei78 – 781N6-acetyllysine; alternateCombined sources
Modified residuei78 – 781N6-succinyllysine; alternateCombined sources
Modified residuei83 – 831N6-acetyllysineCombined sources
Modified residuei88 – 881N6-acetyllysine; alternateCombined sources
Modified residuei88 – 881N6-succinyllysine; alternateCombined sources
Modified residuei96 – 961N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9D855.
MaxQBiQ9D855.
PaxDbiQ9D855.
PRIDEiQ9D855.
TopDownProteomicsiQ9D855.

PTM databases

iPTMnetiQ9D855.
PhosphoSiteiQ9D855.

Expressioni

Gene expression databases

CleanExiMM_UQCRB.

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).By similarity

Protein-protein interaction databases

IntActiQ9D855. 2 interactions.
MINTiMINT-1859815.
STRINGi10090.ENSMUSP00000021993.

Structurei

3D structure databases

ProteinModelPortaliQ9D855.
SMRiQ9D855. Positions 13-111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UQCRB/QCR7 family.Curated

Phylogenomic databases

eggNOGiKOG3440. Eukaryota.
ENOG4111V1G. LUCA.
HOGENOMiHOG000188221.
HOVERGENiHBG002984.
InParanoidiQ9D855.
PhylomeDBiQ9D855.

Family and domain databases

Gene3Di1.10.1090.10. 1 hit.
InterProiIPR003197. QCR7.
[Graphical view]
PANTHERiPTHR12022. PTHR12022. 1 hit.
PfamiPF02271. UCR_14kD. 1 hit.
[Graphical view]
PIRSFiPIRSF000022. Bc1_14K. 1 hit.
ProDomiPD008153. Cyt_bd_ubiquinol_oxidase_14kDa. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF81524. SSF81524. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D855-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRSAVSAS SKWLDGFRKW YYNAAGFNKL GLMRDDTLHE TEDVKEAIRR
60 70 80 90 100
LPEDLYNDRM LRIKRALDLT MRHQILPKDQ WTKYEEDKFY LEPYLKEVIR
110
ERKEREEWAK K
Length:111
Mass (Da):13,527
Last modified:January 23, 2007 - v3
Checksum:iA4C9BEFA39CBE94A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71V → F in AAH31607 (PubMed:15489334).Curated
Sequence conflicti61 – 611L → F in AAH31607 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008455 mRNA. Translation: BAB25678.1.
BC031607 mRNA. Translation: AAH31607.1.
CCDSiCCDS26610.1.
UniGeneiMm.379136.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008455 mRNA. Translation: BAB25678.1.
BC031607 mRNA. Translation: AAH31607.1.
CCDSiCCDS26610.1.
UniGeneiMm.379136.

3D structure databases

ProteinModelPortaliQ9D855.
SMRiQ9D855. Positions 13-111.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D855. 2 interactions.
MINTiMINT-1859815.
STRINGi10090.ENSMUSP00000021993.

PTM databases

iPTMnetiQ9D855.
PhosphoSiteiQ9D855.

Proteomic databases

EPDiQ9D855.
MaxQBiQ9D855.
PaxDbiQ9D855.
PRIDEiQ9D855.
TopDownProteomicsiQ9D855.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1914780. Uqcrb.

Phylogenomic databases

eggNOGiKOG3440. Eukaryota.
ENOG4111V1G. LUCA.
HOGENOMiHOG000188221.
HOVERGENiHBG002984.
InParanoidiQ9D855.
PhylomeDBiQ9D855.

Miscellaneous databases

PROiQ9D855.
SOURCEiSearch...

Gene expression databases

CleanExiMM_UQCRB.

Family and domain databases

Gene3Di1.10.1090.10. 1 hit.
InterProiIPR003197. QCR7.
[Graphical view]
PANTHERiPTHR12022. PTHR12022. 1 hit.
PfamiPF02271. UCR_14kD. 1 hit.
[Graphical view]
PIRSFiPIRSF000022. Bc1_14K. 1 hit.
ProDomiPD008153. Cyt_bd_ubiquinol_oxidase_14kDa. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF81524. SSF81524. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQCR7_MOUSE
AccessioniPrimary (citable) accession number: Q9D855
Secondary accession number(s): Q8K2E2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.