Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peroxisomal sarcosine oxidase

Gene

Pipox

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Metabolizes sarcosine, L-pipecolic acid and L-proline.By similarity

Catalytic activityi

Sarcosine + H2O + O2 = glycine + formaldehyde + H2O2.
L-pipecolate + O2 = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2.

Cofactori

FADNote: Binds 1 FAD per subunit.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 3931FADSequence analysisAdd
BLAST

GO - Molecular functioni

  • L-pipecolate oxidase activity Source: UniProtKB
  • receptor binding Source: MGI
  • sarcosine oxidase activity Source: UniProtKB

GO - Biological processi

  • L-lysine catabolic process to acetyl-CoA via L-pipecolate Source: UniProtKB
  • oxidation-reduction process Source: UniProtKB
  • tetrahydrofolate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-MMU-71064. Lysine catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal sarcosine oxidase (EC:1.5.3.1, EC:1.5.3.7)
Short name:
PSO
Alternative name(s):
L-pipecolate oxidase
L-pipecolic acid oxidase
Gene namesi
Name:Pipox
Synonyms:Pso
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1197006. Pipox.

Subcellular locationi

GO - Cellular componenti

  • peroxisome Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 390390Peroxisomal sarcosine oxidasePRO_0000213774Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei126 – 1261N6-acetyllysineCombined sources
Modified residuei287 – 2871N6-acetyllysineCombined sources
Modified residuei319 – 3191S-8alpha-FAD cysteineCurated

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9D826.
PaxDbiQ9D826.
PRIDEiQ9D826.

PTM databases

iPTMnetiQ9D826.
PhosphoSiteiQ9D826.
SwissPalmiQ9D826.

Expressioni

Tissue specificityi

Kidney and liver.

Gene expression databases

BgeeiENSMUSG00000017453.
CleanExiMM_PIPOX.
ExpressionAtlasiQ9D826. baseline and differential.
GenevisibleiQ9D826. MM.

Interactioni

Subunit structurei

Monomer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9D826. 4 interactions.
MINTiMINT-1850149.
STRINGi10090.ENSMUSP00000017597.

Structurei

3D structure databases

ProteinModelPortaliQ9D826.
SMRiQ9D826. Positions 5-381.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi388 – 3903Microbody targeting signalSequence analysis

Sequence similaritiesi

Belongs to the MSOX/MTOX family.Curated

Phylogenomic databases

eggNOGiKOG2820. Eukaryota.
COG0665. LUCA.
GeneTreeiENSGT00390000011000.
HOGENOMiHOG000236097.
HOVERGENiHBG023161.
InParanoidiQ9D826.
KOiK00306.
OMAiPAVMESC.
OrthoDBiEOG091G0DNX.
PhylomeDBiQ9D826.
TreeFamiTF313837.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
InterProiIPR006076. FAD-dep_OxRdtase.
IPR023753. FAD/NAD-binding_dom.
IPR006281. SoxA_mon.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR01377. soxA_mon. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQTDFWDA IVIGAGIQGC FTAYHLAKHS KSVLLLEQFF LPHSRGSSHG
60 70 80 90 100
QSRIIRKAYP EDFYTMMMKE CYQTWAQLER EAGTQLHRQT ELLLLGTKEN
110 120 130 140 150
PGLKTIQATL SRQGIDHEYL SSVDLKQRFP NIRFTRGEVG LLDKTGGVLY
160 170 180 190 200
ADKALRALQH IICQLGGTVC DGEKVVEIRP GLPVTVKTTL KSYQANSLVI
210 220 230 240 250
TAGPWTNRLL HPLGIELPLQ TLRINVCYWR EKVPGSYGVS QAFPCILGLD
260 270 280 290 300
LAPHHIYGLP ASEYPGLMKI CYHHGDNVDP EERDCPKTFS DIQDVQILCH
310 320 330 340 350
FVRDHLPGLR AEPDIMERCM YTNTPDEHFI LDCHPKYDNI VIGAGFSGHG
360 370 380 390
FKLAPVVGKI LYELSMKLPP SYDLAPFRMS RFSTLSKAHL
Length:390
Mass (Da):43,847
Last modified:June 1, 2001 - v1
Checksum:i0C33A96A24731EE0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti164 – 1641Q → H in AAC39948 (PubMed:9441754).Curated
Sequence conflicti333 – 3331C → W in AAC39948 (PubMed:9441754).Curated
Sequence conflicti352 – 3521K → T in AAC39948 (PubMed:9441754).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94700 mRNA. Translation: AAC39948.1.
AK008555 mRNA. Translation: BAB25741.1.
BC013525 mRNA. Translation: AAH13525.1.
CCDSiCCDS25086.1.
RefSeqiNP_032978.2. NM_008952.2.
UniGeneiMm.8543.

Genome annotation databases

EnsembliENSMUST00000017597; ENSMUSP00000017597; ENSMUSG00000017453.
GeneIDi19193.
KEGGimmu:19193.
UCSCiuc007khm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94700 mRNA. Translation: AAC39948.1.
AK008555 mRNA. Translation: BAB25741.1.
BC013525 mRNA. Translation: AAH13525.1.
CCDSiCCDS25086.1.
RefSeqiNP_032978.2. NM_008952.2.
UniGeneiMm.8543.

3D structure databases

ProteinModelPortaliQ9D826.
SMRiQ9D826. Positions 5-381.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D826. 4 interactions.
MINTiMINT-1850149.
STRINGi10090.ENSMUSP00000017597.

PTM databases

iPTMnetiQ9D826.
PhosphoSiteiQ9D826.
SwissPalmiQ9D826.

Proteomic databases

MaxQBiQ9D826.
PaxDbiQ9D826.
PRIDEiQ9D826.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000017597; ENSMUSP00000017597; ENSMUSG00000017453.
GeneIDi19193.
KEGGimmu:19193.
UCSCiuc007khm.2. mouse.

Organism-specific databases

CTDi51268.
MGIiMGI:1197006. Pipox.

Phylogenomic databases

eggNOGiKOG2820. Eukaryota.
COG0665. LUCA.
GeneTreeiENSGT00390000011000.
HOGENOMiHOG000236097.
HOVERGENiHBG023161.
InParanoidiQ9D826.
KOiK00306.
OMAiPAVMESC.
OrthoDBiEOG091G0DNX.
PhylomeDBiQ9D826.
TreeFamiTF313837.

Enzyme and pathway databases

ReactomeiR-MMU-71064. Lysine catabolism.

Miscellaneous databases

PROiQ9D826.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000017453.
CleanExiMM_PIPOX.
ExpressionAtlasiQ9D826. baseline and differential.
GenevisibleiQ9D826. MM.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
InterProiIPR006076. FAD-dep_OxRdtase.
IPR023753. FAD/NAD-binding_dom.
IPR006281. SoxA_mon.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR01377. soxA_mon. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSOX_MOUSE
AccessioniPrimary (citable) accession number: Q9D826
Secondary accession number(s): O55223
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.