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Protein

Peroxisomal sarcosine oxidase

Gene

Pipox

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Metabolizes sarcosine, L-pipecolic acid and L-proline.By similarity

Catalytic activityi

Sarcosine + H2O + O2 = glycine + formaldehyde + H2O2.
L-pipecolate + O2 = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2.

Cofactori

FADNote: Binds 1 FAD per subunit.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 39FADSequence analysisAdd BLAST31

GO - Molecular functioni

  • L-pipecolate oxidase activity Source: UniProtKB
  • sarcosine oxidase activity Source: UniProtKB
  • signaling receptor binding Source: MGI

GO - Biological processi

  • L-lysine catabolic process to acetyl-CoA via L-pipecolate Source: UniProtKB
  • oxidation-reduction process Source: UniProtKB
  • tetrahydrofolate metabolic process Source: InterPro

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-MMU-71064 Lysine catabolism
R-MMU-9033241 Peroxisomal protein import

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal sarcosine oxidase (EC:1.5.3.1, EC:1.5.3.7)
Short name:
PSO
Alternative name(s):
L-pipecolate oxidase
L-pipecolic acid oxidase
Gene namesi
Name:Pipox
Synonyms:Pso
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1197006 Pipox

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002137741 – 390Peroxisomal sarcosine oxidaseAdd BLAST390

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei126N6-acetyllysineCombined sources1
Modified residuei287N6-acetyllysineCombined sources1
Modified residuei319S-8alpha-FAD cysteineCurated1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9D826
PaxDbiQ9D826
PRIDEiQ9D826

PTM databases

iPTMnetiQ9D826
PhosphoSitePlusiQ9D826
SwissPalmiQ9D826

Expressioni

Tissue specificityi

Kidney and liver.

Gene expression databases

BgeeiENSMUSG00000017453
CleanExiMM_PIPOX
ExpressionAtlasiQ9D826 baseline and differential
GenevisibleiQ9D826 MM

Interactioni

Subunit structurei

Monomer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9D826, 4 interactors
MINTiQ9D826
STRINGi10090.ENSMUSP00000017597

Structurei

3D structure databases

ProteinModelPortaliQ9D826
SMRiQ9D826
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi388 – 390Microbody targeting signalSequence analysis3

Sequence similaritiesi

Belongs to the MSOX/MTOX family.Curated

Phylogenomic databases

eggNOGiKOG2820 Eukaryota
COG0665 LUCA
GeneTreeiENSGT00390000011000
HOGENOMiHOG000236097
HOVERGENiHBG023161
InParanoidiQ9D826
KOiK00306
OMAiAHTEVEY
OrthoDBiEOG091G0DNX
PhylomeDBiQ9D826
TreeFamiTF313837

Family and domain databases

Gene3Di3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR006076 FAD-dep_OxRdtase
IPR036188 FAD/NAD-bd_sf
IPR006281 SoxA_mon
PfamiView protein in Pfam
PF01266 DAO, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
TIGRFAMsiTIGR01377 soxA_mon, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQTDFWDA IVIGAGIQGC FTAYHLAKHS KSVLLLEQFF LPHSRGSSHG
60 70 80 90 100
QSRIIRKAYP EDFYTMMMKE CYQTWAQLER EAGTQLHRQT ELLLLGTKEN
110 120 130 140 150
PGLKTIQATL SRQGIDHEYL SSVDLKQRFP NIRFTRGEVG LLDKTGGVLY
160 170 180 190 200
ADKALRALQH IICQLGGTVC DGEKVVEIRP GLPVTVKTTL KSYQANSLVI
210 220 230 240 250
TAGPWTNRLL HPLGIELPLQ TLRINVCYWR EKVPGSYGVS QAFPCILGLD
260 270 280 290 300
LAPHHIYGLP ASEYPGLMKI CYHHGDNVDP EERDCPKTFS DIQDVQILCH
310 320 330 340 350
FVRDHLPGLR AEPDIMERCM YTNTPDEHFI LDCHPKYDNI VIGAGFSGHG
360 370 380 390
FKLAPVVGKI LYELSMKLPP SYDLAPFRMS RFSTLSKAHL
Length:390
Mass (Da):43,847
Last modified:June 1, 2001 - v1
Checksum:i0C33A96A24731EE0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti164Q → H in AAC39948 (PubMed:9441754).Curated1
Sequence conflicti333C → W in AAC39948 (PubMed:9441754).Curated1
Sequence conflicti352K → T in AAC39948 (PubMed:9441754).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94700 mRNA Translation: AAC39948.1
AK008555 mRNA Translation: BAB25741.1
BC013525 mRNA Translation: AAH13525.1
CCDSiCCDS25086.1
RefSeqiNP_032978.2, NM_008952.2
UniGeneiMm.8543

Genome annotation databases

EnsembliENSMUST00000017597; ENSMUSP00000017597; ENSMUSG00000017453
GeneIDi19193
KEGGimmu:19193
UCSCiuc007khm.2 mouse

Similar proteinsi

Entry informationi

Entry nameiSOX_MOUSE
AccessioniPrimary (citable) accession number: Q9D826
Secondary accession number(s): O55223
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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