Reviewed, UniProtKB/Swiss-Prot Q9D826 (SOX_MOUSE)

Names and origin

Protein names

Recommended name:
    Peroxisomal sarcosine oxidase
      Short name=PSO
    EC=1.5.3.1
    EC=1.5.3.7
Alternative name(s):
    L-pipecolate oxidase
    L-pipecolic acid oxidase

Gene names

Name:	Pipox
Synonyms:	Pso

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	390 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Metabolizes sarcosine, L-pipecolic acid and L-proline By similarity.
Catalytic activity	Sarcosine + H2O + O2 = glycine + formaldehyde + H2O2. L-pipecolate + O2 = 2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2.
Cofactor	Binds 1 FAD per subunit.
Subunit structure	Monomer By similarity.
Subcellular location	Peroxisome By similarity.
Tissue specificity	Kidney and liver.
Sequence similarities	Belongs to the MSOX/MTOX family.

Ontologies

Keywords
Cellular component	Peroxisome
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tetrahydrofolate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	peroxisome Inferred from direct assay. Source: HGNC
Molecular function	L-pipecolate oxidase activity Inferred from electronic annotation. Source: EC sarcosine oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 390	390	Peroxisomal sarcosine oxidase		PRO_0000213774
Regions
	Nucleotide binding	9 – 39	31	FAD Potential
	Motif	388 – 390	3	Microbody targeting signal Potential
Amino acid modifications
	Modified residue	319	1	S-8alpha-FAD cysteine Probable
Experimental info
	Sequence conflict	164	1	Q → H in AAC39948. Ref.1
	Sequence conflict	333	1	C → W in AAC39948. Ref.1
	Sequence conflict	352	1	K → T in AAC39948. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9D826-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 0C33A96A24731EE0	FASTA	390	43,847
	10 20 30 40 50 60 MAAQTDFWDA IVIGAGIQGC FTAYHLAKHS KSVLLLEQFF LPHSRGSSHG QSRIIRKAYP 70 80 90 100 110 120 EDFYTMMMKE CYQTWAQLER EAGTQLHRQT ELLLLGTKEN PGLKTIQATL SRQGIDHEYL 130 140 150 160 170 180 SSVDLKQRFP NIRFTRGEVG LLDKTGGVLY ADKALRALQH IICQLGGTVC DGEKVVEIRP 190 200 210 220 230 240 GLPVTVKTTL KSYQANSLVI TAGPWTNRLL HPLGIELPLQ TLRINVCYWR EKVPGSYGVS 250 260 270 280 290 300 QAFPCILGLD LAPHHIYGLP ASEYPGLMKI CYHHGDNVDP EERDCPKTFS DIQDVQILCH 310 320 330 340 350 360 FVRDHLPGLR AEPDIMERCM YTNTPDEHFI LDCHPKYDNI VIGAGFSGHG FKLAPVVGKI 370 380 390 LYELSMKLPP SYDLAPFRMS RFSTLSKAHL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A mammalian homolog of the bacterial monomeric sarcosine oxidases maps to mouse chromosome 11, close to Cryba1." Herbst R., Barton J.L., Nicklin M.J.H. Genomics 46:480-482(1997) [PubMed: 9441754] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Embryo.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Small intestine.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U94700 mRNA. Translation: AAC39948.1. AK008555 mRNA. Translation: BAB25741.1. BC013525 mRNA. Translation: AAH13525.1.
IPI	IPI00110719.
RefSeq	NP_032978.2.
UniGene	Mm.8543
3D structure databases
HSSP	HSSP built from PDB template 1EL5 based on UniProtKB P40859.
ModBase	Search...
Proteomic databases
PRIDE	Q9D826.
Genome annotation databases
Ensembl	ENSMUSG00000017453. Mus musculus. [Contig view]
GeneID	19193.
KEGG	mmu:19193.
Organism-specific databases
MGI	MGI:1197006. Pipox.
Phylogenomic databases
HOGENOM	Q9D826.
HOVERGEN	Q9D826.
OMA	Q9D826. ERDCPEA.
Enzyme and pathway databases
BRENDA	1.5.3.1. 244. 1.5.3.7. 244.
Gene expression databases
ArrayExpress	Q9D826.
Bgee	Q9D826.
CleanEx	MM_PIPOX.
GermOnline	ENSMUSG00000017453. Mus musculus.
Family and domain databases
InterPro	IPR006076. FAD-dep_OxRdtase. IPR006281. SoxA_mon. [Graphical view]
Pfam	PF01266. DAO. 1 hit. [Graphical view]
TIGRFAMs	TIGR01377. soxA_mon. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	295904.
SOURCE	Search...

Entry information

Entry name

SOX_MOUSE

Accession

Primary (citable) accession number: Q9D826
Secondary accession number(s): O55223

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	June 1, 2001
Last modified:	June 16, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)