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Protein

Inorganic pyrophosphatase

Gene

Ppa1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.

Cofactori

Mg2+By similarityNote: Binds 4 Mg2+ ions per subunit. Other metal ions can support activity, but at a lower rate. Two Mg2+ ions are required for the activation of the enzyme and are present before substrate binds, two additional Mg2+ ions form complexes with substrate and product.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi116 – 1161Magnesium 1By similarity
Metal bindingi121 – 1211Magnesium 1By similarity
Metal bindingi121 – 1211Magnesium 2By similarity
Metal bindingi153 – 1531Magnesium 1By similarity

GO - Molecular functioni

GO - Biological processi

  • phosphate-containing compound metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-379716. Cytosolic tRNA aminoacylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Inorganic pyrophosphatase (EC:3.6.1.1)
Alternative name(s):
Pyrophosphate phospho-hydrolase
Short name:
PPase
Gene namesi
Name:Ppa1
Synonyms:Pp, Pyp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:97831. Ppa1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 289288Inorganic pyrophosphatasePRO_0000137569Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei57 – 571N6-acetyllysineBy similarity
Modified residuei228 – 2281N6-acetyllysineBy similarity
Modified residuei250 – 2501PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9D819.
MaxQBiQ9D819.
PaxDbiQ9D819.
PRIDEiQ9D819.

2D gel databases

REPRODUCTION-2DPAGEIPI00110684.
Q9D819.

PTM databases

iPTMnetiQ9D819.
PhosphoSiteiQ9D819.
SwissPalmiQ9D819.

Expressioni

Gene expression databases

BgeeiQ9D819.
CleanExiMM_PPA1.
ExpressionAtlasiQ9D819. baseline and differential.
GenevisibleiQ9D819. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi212519. 1 interaction.
IntActiQ9D819. 4 interactions.
MINTiMINT-4098757.
STRINGi10090.ENSMUSP00000020286.

Structurei

3D structure databases

ProteinModelPortaliQ9D819.
SMRiQ9D819. Positions 4-284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase family.Curated

Phylogenomic databases

eggNOGiKOG1626. Eukaryota.
COG0221. LUCA.
GeneTreeiENSGT00390000017004.
HOGENOMiHOG000195569.
HOVERGENiHBG000491.
InParanoidiQ9D819.
KOiK01507.
OMAiGHKDENT.
OrthoDBiEOG7R2BKH.
PhylomeDBiQ9D819.
TreeFamiTF300887.

Family and domain databases

Gene3Di3.90.80.10. 1 hit.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D819-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGFSSEERA APFTLEYRVF LKNEKGQYIS PFHDVPIYAD KDVFHMVVEV
60 70 80 90 100
PRWSNAKMEI ATKDPLNPIK QDVKKGKLRY VANLFPYKGY IWNYGAIPQT
110 120 130 140 150
WEDPGHSDKH TGCCGDNDPI DVCEIGSKVC ARGEIIRVKV LGILAMIDEG
160 170 180 190 200
ETDWKVIAIN VDDPDAANYK DISDVERLKP GYLEATVDWF RRYKVPDGKP
210 220 230 240 250
ENEFAFNAEF KNKDFAVDII KSTHDYWKAL VTKKTDGKGI SCMNTTVSES
260 270 280
PFKCDPDAAK AIVDALPPPC ESACSLPTDV DKWFHQQKN
Length:289
Mass (Da):32,667
Last modified:June 1, 2001 - v1
Checksum:i4E2D35387CCFED8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008575 mRNA. Translation: BAB25754.1.
BC010468 mRNA. Translation: AAH10468.1.
CCDSiCCDS23882.1.
RefSeqiNP_080714.2. NM_026438.4.
UniGeneiMm.28897.

Genome annotation databases

EnsembliENSMUST00000020286; ENSMUSP00000020286; ENSMUSG00000020089.
GeneIDi67895.
KEGGimmu:67895.
UCSCiuc007fge.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008575 mRNA. Translation: BAB25754.1.
BC010468 mRNA. Translation: AAH10468.1.
CCDSiCCDS23882.1.
RefSeqiNP_080714.2. NM_026438.4.
UniGeneiMm.28897.

3D structure databases

ProteinModelPortaliQ9D819.
SMRiQ9D819. Positions 4-284.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212519. 1 interaction.
IntActiQ9D819. 4 interactions.
MINTiMINT-4098757.
STRINGi10090.ENSMUSP00000020286.

PTM databases

iPTMnetiQ9D819.
PhosphoSiteiQ9D819.
SwissPalmiQ9D819.

2D gel databases

REPRODUCTION-2DPAGEIPI00110684.
Q9D819.

Proteomic databases

EPDiQ9D819.
MaxQBiQ9D819.
PaxDbiQ9D819.
PRIDEiQ9D819.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020286; ENSMUSP00000020286; ENSMUSG00000020089.
GeneIDi67895.
KEGGimmu:67895.
UCSCiuc007fge.1. mouse.

Organism-specific databases

CTDi5464.
MGIiMGI:97831. Ppa1.

Phylogenomic databases

eggNOGiKOG1626. Eukaryota.
COG0221. LUCA.
GeneTreeiENSGT00390000017004.
HOGENOMiHOG000195569.
HOVERGENiHBG000491.
InParanoidiQ9D819.
KOiK01507.
OMAiGHKDENT.
OrthoDBiEOG7R2BKH.
PhylomeDBiQ9D819.
TreeFamiTF300887.

Enzyme and pathway databases

ReactomeiR-MMU-379716. Cytosolic tRNA aminoacylation.

Miscellaneous databases

ChiTaRSiPpa1. mouse.
PROiQ9D819.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D819.
CleanExiMM_PPA1.
ExpressionAtlasiQ9D819. baseline and differential.
GenevisibleiQ9D819. MM.

Family and domain databases

Gene3Di3.90.80.10. 1 hit.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Small intestine.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. Lubec G., Klug S.
    Submitted (MAR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 26-41, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Hippocampus.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiIPYR_MOUSE
AccessioniPrimary (citable) accession number: Q9D819
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.