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Q9D816

- CP255_MOUSE

UniProt

Q9D816 - CP255_MOUSE

Protein

Cytochrome P450 2C55

Gene

Cyp2c55

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Metabolizes arachidonic acid mainly to 19-hydroxyeicosatetraenoic acid (HETE).1 Publication

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.1 Publication

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi435 – 4351Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. arachidonic acid epoxygenase activity Source: MGI
    2. aromatase activity Source: UniProtKB-EC
    3. heme binding Source: InterPro
    4. iron ion binding Source: InterPro
    5. linoleic acid epoxygenase activity Source: MGI

    GO - Biological processi

    1. arachidonic acid metabolic process Source: MGI
    2. linoleic acid metabolic process Source: MGI

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
    REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2C55 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIC55
    Gene namesi
    Name:Cyp2c55Imported
    Synonyms:Cyp2c-55By similarity
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1919332. Cyp2c55.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 490490Cytochrome P450 2C55PRO_0000282959Add
    BLAST

    Proteomic databases

    MaxQBiQ9D816.
    PaxDbiQ9D816.
    PRIDEiQ9D816.

    PTM databases

    PhosphoSiteiQ9D816.

    Expressioni

    Tissue specificityi

    Highest level in colon. Low levels in liver and small intestine.1 Publication

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.Curated

    Gene expression databases

    BgeeiQ9D816.
    GenevestigatoriQ9D816.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-1870122.
    STRINGi10090.ENSMUSP00000025966.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D816.
    SMRiQ9D816. Positions 30-489.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Sequence Analysis

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00680000099783.
    HOGENOMiHOG000036992.
    HOVERGENiHBG015789.
    InParanoidiQ9D816.
    KOiK07413.
    OMAiIQEEASC.
    OrthoDBiEOG7RBZ85.
    PhylomeDBiQ9D816.
    TreeFamiTF352043.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9D816-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPVLVLVLT LSCLLLLSLW RQNSGRGKLP PGPTPFPIIG NILQIDIKNI    50
    SKSFNYFSKV YGPVFTLYFG SKPTVVVHGY EAVKEALDDL GEEFSGRGSF 100
    QIFERINNDL GVIFSNGTKW KELRRFSIMT LRSFGMGKRS IEDRIQEEAS 150
    CLVEELRKAN GSLCDPTFIL SCAPSNVICS VIFHNRFDYK DEKFLNLMER 200
    LNENFKILNS PWMQVYNALP TLINYLPGSH NKVIKNFTEI KSYILGRVKE 250
    HQETLDMDNP RDFIDCFLIK MEQEKHNPHS EFTIESLMAT VTDIFVAGTE 300
    TTNITLRYGL LLLLKHTEVT AKVQAEIDHV IGRHRSPCMQ DRTRMPYTDA 350
    MVHEIQRYID LIPNNVPHAA TCNVRFRSYF IPKGTELVTS LTSVLHDDKE 400
    FPNPEVFDPG HFLDENGNFK KSDYFMPFSI GKRMCVGEAL ARTELFLILT 450
    TILQNFNLKS LVDTKDIDTT PVANTFGRVP PSYQLYFIPR 490
    Length:490
    Mass (Da):56,096
    Last modified:June 1, 2001 - v1
    Checksum:i5CB0F771C0268FEC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY206875 mRNA. Translation: AAO52738.1.
    AK008580 mRNA. Translation: BAB25759.1.
    BC010824 mRNA. Translation: AAH10824.1.
    CCDSiCCDS29790.1.
    RefSeqiNP_082365.1. NM_028089.3.
    UniGeneiMm.142581.

    Genome annotation databases

    EnsembliENSMUST00000025966; ENSMUSP00000025966; ENSMUSG00000025002.
    GeneIDi72082.
    KEGGimmu:72082.
    UCSCiuc008hju.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY206875 mRNA. Translation: AAO52738.1 .
    AK008580 mRNA. Translation: BAB25759.1 .
    BC010824 mRNA. Translation: AAH10824.1 .
    CCDSi CCDS29790.1.
    RefSeqi NP_082365.1. NM_028089.3.
    UniGenei Mm.142581.

    3D structure databases

    ProteinModelPortali Q9D816.
    SMRi Q9D816. Positions 30-489.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1870122.
    STRINGi 10090.ENSMUSP00000025966.

    PTM databases

    PhosphoSitei Q9D816.

    Proteomic databases

    MaxQBi Q9D816.
    PaxDbi Q9D816.
    PRIDEi Q9D816.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025966 ; ENSMUSP00000025966 ; ENSMUSG00000025002 .
    GeneIDi 72082.
    KEGGi mmu:72082.
    UCSCi uc008hju.1. mouse.

    Organism-specific databases

    CTDi 72082.
    MGIi MGI:1919332. Cyp2c55.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00680000099783.
    HOGENOMi HOG000036992.
    HOVERGENi HBG015789.
    InParanoidi Q9D816.
    KOi K07413.
    OMAi IQEEASC.
    OrthoDBi EOG7RBZ85.
    PhylomeDBi Q9D816.
    TreeFami TF352043.

    Enzyme and pathway databases

    Reactomei REACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
    REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).

    Miscellaneous databases

    NextBioi 335388.
    PROi Q9D816.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9D816.
    Genevestigatori Q9D816.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, expression, and characterization of three new mouse cytochrome p450 enzymes and partial characterization of their fatty acid oxidation activities."
      Wang H., Zhao Y., Bradbury J.A., Graves J.P., Foley J., Blaisdell J.A., Goldstein J.A., Zeldin D.C.
      Mol. Pharmacol. 65:1148-1158(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Strain: C57BL/6Imported.
      Tissue: Colon1 Publication.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6JImported.
      Tissue: Small intestineImported.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/NImported.
      Tissue: ColonImported.

    Entry informationi

    Entry nameiCP255_MOUSE
    AccessioniPrimary (citable) accession number: Q9D816
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3