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Q9D816

- CP255_MOUSE

UniProt

Q9D816 - CP255_MOUSE

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Protein

Cytochrome P450 2C55

Gene

Cyp2c55

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Metabolizes arachidonic acid mainly to 19-hydroxyeicosatetraenoic acid (HETE).1 Publication

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.1 Publication

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi435 – 4351Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. arachidonic acid epoxygenase activity Source: MGI
  2. aromatase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro
  5. linoleic acid epoxygenase activity Source: MGI

GO - Biological processi

  1. arachidonic acid metabolic process Source: MGI
  2. linoleic acid metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C55 (EC:1.14.14.1)
Alternative name(s):
CYPIIC55
Gene namesi
Name:Cyp2c55Imported
Synonyms:Cyp2c-55By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1919332. Cyp2c55.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Cytochrome P450 2C55PRO_0000282959Add
BLAST

Proteomic databases

MaxQBiQ9D816.
PaxDbiQ9D816.
PRIDEiQ9D816.

PTM databases

PhosphoSiteiQ9D816.

Expressioni

Tissue specificityi

Highest level in colon. Low levels in liver and small intestine.1 Publication

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.Curated

Gene expression databases

BgeeiQ9D816.
GenevestigatoriQ9D816.

Interactioni

Protein-protein interaction databases

MINTiMINT-1870122.
STRINGi10090.ENSMUSP00000025966.

Structurei

3D structure databases

ProteinModelPortaliQ9D816.
SMRiQ9D816. Positions 30-489.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Sequence Analysis

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiQ9D816.
KOiK07413.
OMAiIQEEASC.
OrthoDBiEOG7RBZ85.
PhylomeDBiQ9D816.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D816-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPVLVLVLT LSCLLLLSLW RQNSGRGKLP PGPTPFPIIG NILQIDIKNI
60 70 80 90 100
SKSFNYFSKV YGPVFTLYFG SKPTVVVHGY EAVKEALDDL GEEFSGRGSF
110 120 130 140 150
QIFERINNDL GVIFSNGTKW KELRRFSIMT LRSFGMGKRS IEDRIQEEAS
160 170 180 190 200
CLVEELRKAN GSLCDPTFIL SCAPSNVICS VIFHNRFDYK DEKFLNLMER
210 220 230 240 250
LNENFKILNS PWMQVYNALP TLINYLPGSH NKVIKNFTEI KSYILGRVKE
260 270 280 290 300
HQETLDMDNP RDFIDCFLIK MEQEKHNPHS EFTIESLMAT VTDIFVAGTE
310 320 330 340 350
TTNITLRYGL LLLLKHTEVT AKVQAEIDHV IGRHRSPCMQ DRTRMPYTDA
360 370 380 390 400
MVHEIQRYID LIPNNVPHAA TCNVRFRSYF IPKGTELVTS LTSVLHDDKE
410 420 430 440 450
FPNPEVFDPG HFLDENGNFK KSDYFMPFSI GKRMCVGEAL ARTELFLILT
460 470 480 490
TILQNFNLKS LVDTKDIDTT PVANTFGRVP PSYQLYFIPR
Length:490
Mass (Da):56,096
Last modified:June 1, 2001 - v1
Checksum:i5CB0F771C0268FEC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY206875 mRNA. Translation: AAO52738.1.
AK008580 mRNA. Translation: BAB25759.1.
BC010824 mRNA. Translation: AAH10824.1.
CCDSiCCDS29790.1.
RefSeqiNP_082365.1. NM_028089.3.
UniGeneiMm.142581.

Genome annotation databases

EnsembliENSMUST00000025966; ENSMUSP00000025966; ENSMUSG00000025002.
GeneIDi72082.
KEGGimmu:72082.
UCSCiuc008hju.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY206875 mRNA. Translation: AAO52738.1 .
AK008580 mRNA. Translation: BAB25759.1 .
BC010824 mRNA. Translation: AAH10824.1 .
CCDSi CCDS29790.1.
RefSeqi NP_082365.1. NM_028089.3.
UniGenei Mm.142581.

3D structure databases

ProteinModelPortali Q9D816.
SMRi Q9D816. Positions 30-489.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1870122.
STRINGi 10090.ENSMUSP00000025966.

PTM databases

PhosphoSitei Q9D816.

Proteomic databases

MaxQBi Q9D816.
PaxDbi Q9D816.
PRIDEi Q9D816.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025966 ; ENSMUSP00000025966 ; ENSMUSG00000025002 .
GeneIDi 72082.
KEGGi mmu:72082.
UCSCi uc008hju.1. mouse.

Organism-specific databases

CTDi 72082.
MGIi MGI:1919332. Cyp2c55.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00760000118775.
HOGENOMi HOG000036992.
HOVERGENi HBG015789.
InParanoidi Q9D816.
KOi K07413.
OMAi IQEEASC.
OrthoDBi EOG7RBZ85.
PhylomeDBi Q9D816.
TreeFami TF352043.

Enzyme and pathway databases

Reactomei REACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).

Miscellaneous databases

NextBioi 335388.
PROi Q9D816.
SOURCEi Search...

Gene expression databases

Bgeei Q9D816.
Genevestigatori Q9D816.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, expression, and characterization of three new mouse cytochrome p450 enzymes and partial characterization of their fatty acid oxidation activities."
    Wang H., Zhao Y., Bradbury J.A., Graves J.P., Foley J., Blaisdell J.A., Goldstein J.A., Zeldin D.C.
    Mol. Pharmacol. 65:1148-1158(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: C57BL/6Imported.
    Tissue: Colon1 Publication.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported.
    Tissue: Small intestineImported.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: ColonImported.

Entry informationi

Entry nameiCP255_MOUSE
AccessioniPrimary (citable) accession number: Q9D816
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3