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Protein

Potassium voltage-gated channel subfamily E member 2

Gene

Kcne2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with KCNQ1/KCLQT1 and elicit a voltage-independent current (By similarity).By similarity

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: Ensembl
  2. inward rectifier potassium channel activity Source: Ensembl
  3. ion channel binding Source: MGI
  4. potassium channel regulator activity Source: MGI
  5. voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization Source: MGI

GO - Biological processi

  1. aging Source: Ensembl
  2. cardiac muscle cell action potential involved in contraction Source: MGI
  3. cellular protein localization Source: MGI
  4. cellular response to drug Source: MGI
  5. membrane repolarization Source: MGI
  6. membrane repolarization during action potential Source: MGI
  7. positive regulation of proteasomal protein catabolic process Source: MGI
  8. potassium ion export Source: MGI
  9. potassium ion import Source: MGI
  10. potassium ion transmembrane transport Source: MGI
  11. regulation of cyclic nucleotide-gated ion channel activity Source: Ensembl
  12. regulation of delayed rectifier potassium channel activity Source: MGI
  13. regulation of heart rate by cardiac conduction Source: MGI
  14. regulation of inward rectifier potassium channel activity Source: MGI
  15. regulation of membrane repolarization Source: MGI
  16. regulation of potassium ion transmembrane transport Source: MGI
  17. regulation of ventricular cardiac muscle cell membrane repolarization Source: MGI
  18. tongue development Source: Ensembl
  19. ventricular cardiac muscle cell action potential Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Protein family/group databases

TCDBi8.A.10.2.1. the slow voltage-gated k+) channel accessory protein (mink) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily E member 2
Alternative name(s):
MinK-related peptide 1
Minimum potassium ion channel-related peptide 1
Potassium channel subunit beta MiRP1
Gene namesi
Name:Kcne2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1891123. Kcne2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei49 – 6921HelicalSequence AnalysisAdd
BLAST
Topological domaini70 – 12354CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: MGI
  2. lysosome Source: MGI
  3. membrane Source: MGI
  4. plasma membrane Source: MGI
  5. voltage-gated potassium channel complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 123123Potassium voltage-gated channel subfamily E member 2PRO_0000144286Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9D808.

PTM databases

PhosphoSiteiQ9D808.

Expressioni

Gene expression databases

BgeeiQ9D808.
GenevestigatoriQ9D808.

Interactioni

Subunit structurei

Associates with KCNH2/ERG1 (By similarity). May associate with KCNQ1/KVLQT1, KCNQ2 and KCNQ3. Associates with HCN1 and probably HCN2 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9D808.
SMRiQ9D808. Positions 1-123.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the potassium channel KCNE family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43841.
HOGENOMiHOG000113208.
HOVERGENiHBG052227.
InParanoidiQ9D808.
KOiK04896.
OrthoDBiEOG7WDN4J.
PhylomeDBiQ9D808.
TreeFamiTF336058.

Family and domain databases

InterProiIPR000369. K_chnl_volt-dep_bsu_KCNE.
IPR005424. K_chnl_volt-dep_bsu_KCNE1.
IPR005425. K_chnl_volt-dep_bsu_KCNE2.
[Graphical view]
PANTHERiPTHR17028. PTHR17028. 1 hit.
PfamiPF02060. ISK_Channel. 1 hit.
[Graphical view]
PRINTSiPR01605. KCNE2CHANNEL.

Sequencei

Sequence statusi: Complete.

Q9D808-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATLANLTQT LEDAFKKIFI TYMDSWRRNT TAEEQALQAR VDAENFYYVI
60 70 80 90 100
LYLMVMIGMF SFIVVAILVS TVKSKRREHS QHPYHQYIVE DWQEKYKSQI
110 120
LHLEDSKATI HENMGATGFT VSP
Length:123
Mass (Da):14,370
Last modified:November 27, 2002 - v2
Checksum:i0A52784967FD741C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti82 – 821H → D in BAB25781 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008619 mRNA. Translation: BAB25781.1.
BC022699 mRNA. Translation: AAH22699.1.
CCDSiCCDS28333.1.
RefSeqiNP_598871.1. NM_134110.3.
XP_006523096.1. XM_006523033.2.
UniGeneiMm.156736.

Genome annotation databases

GeneIDi246133.
KEGGimmu:246133.
UCSCiuc007zyw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008619 mRNA. Translation: BAB25781.1.
BC022699 mRNA. Translation: AAH22699.1.
CCDSiCCDS28333.1.
RefSeqiNP_598871.1. NM_134110.3.
XP_006523096.1. XM_006523033.2.
UniGeneiMm.156736.

3D structure databases

ProteinModelPortaliQ9D808.
SMRiQ9D808. Positions 1-123.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi8.A.10.2.1. the slow voltage-gated k+) channel accessory protein (mink) family.

PTM databases

PhosphoSiteiQ9D808.

Proteomic databases

PRIDEiQ9D808.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi246133.
KEGGimmu:246133.
UCSCiuc007zyw.2. mouse.

Organism-specific databases

CTDi9992.
MGIiMGI:1891123. Kcne2.

Phylogenomic databases

eggNOGiNOG43841.
HOGENOMiHOG000113208.
HOVERGENiHBG052227.
InParanoidiQ9D808.
KOiK04896.
OrthoDBiEOG7WDN4J.
PhylomeDBiQ9D808.
TreeFamiTF336058.

Miscellaneous databases

NextBioi387099.
PROiQ9D808.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D808.
GenevestigatoriQ9D808.

Family and domain databases

InterProiIPR000369. K_chnl_volt-dep_bsu_KCNE.
IPR005424. K_chnl_volt-dep_bsu_KCNE1.
IPR005425. K_chnl_volt-dep_bsu_KCNE2.
[Graphical view]
PANTHERiPTHR17028. PTHR17028. 1 hit.
PfamiPF02060. ISK_Channel. 1 hit.
[Graphical view]
PRINTSiPR01605. KCNE2CHANNEL.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Stomach.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiKCNE2_MOUSE
AccessioniPrimary (citable) accession number: Q9D808
Secondary accession number(s): Q8R1Z7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 27, 2002
Last sequence update: November 27, 2002
Last modified: March 31, 2015
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.