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Protein

Potassium voltage-gated channel subfamily E member 2

Gene

Kcne2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with HCN1 and HCN2 and increase potassium current (By similarity). Interacts with KCNQ1; forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Protein family/group databases

TCDBi8.A.10.2.1. the slow voltage-gated k+) channel accessory protein (mink) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily E member 2
Alternative name(s):
MinK-related peptide 1
Minimum potassium ion channel-related peptide 1
Potassium channel subunit beta MiRP1
Gene namesi
Name:Kcne2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1891123. Kcne2.

Subcellular locationi

  • Cell membrane By similarity; Single-pass type I membrane protein By similarity

  • Note: Colocalizes with KCNB1 at the plasma membrane.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Topological domaini70 – 123CytoplasmicSequence analysisAdd BLAST54

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001442861 – 123Potassium voltage-gated channel subfamily E member 2Add BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...)Sequence analysis1
Glycosylationi29N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9D808.
PRIDEiQ9D808.

PTM databases

iPTMnetiQ9D808.
PhosphoSitePlusiQ9D808.

Expressioni

Gene expression databases

BgeeiENSMUSG00000039672.

Interactioni

Subunit structurei

Interacts with KCNB1. Associates with KCNH2/ERG1. May associate with KCNQ2 and KCNQ3. Associates with HCN1 and probably HCN2. Heteromultimer with KCNC2. Interacts with KCNC2 (By similarity). Interacts with KCNQ1; forms a heterooligomer complex that targets to the membrane raft and leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048849.

Structurei

3D structure databases

ProteinModelPortaliQ9D808.
SMRiQ9D808.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the potassium channel KCNE family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IX4Y. Eukaryota.
ENOG411297Y. LUCA.
HOGENOMiHOG000113208.
HOVERGENiHBG052227.
InParanoidiQ9D808.
KOiK04896.
PhylomeDBiQ9D808.
TreeFamiTF336058.

Family and domain databases

InterProiIPR000369. K_chnl_KCNE.
IPR005425. K_chnl_volt-dep_bsu_KCNE2.
[Graphical view]
PfamiPF02060. ISK_Channel. 1 hit.
[Graphical view]
PRINTSiPR01605. KCNE2CHANNEL.

Sequencei

Sequence statusi: Complete.

Q9D808-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATLANLTQT LEDAFKKIFI TYMDSWRRNT TAEEQALQAR VDAENFYYVI
60 70 80 90 100
LYLMVMIGMF SFIVVAILVS TVKSKRREHS QHPYHQYIVE DWQEKYKSQI
110 120
LHLEDSKATI HENMGATGFT VSP
Length:123
Mass (Da):14,370
Last modified:November 28, 2002 - v2
Checksum:i0A52784967FD741C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82H → D in BAB25781 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008619 mRNA. Translation: BAB25781.1.
BC022699 mRNA. Translation: AAH22699.1.
CCDSiCCDS28333.1.
RefSeqiNP_598871.1. NM_134110.3.
XP_006523096.1. XM_006523033.3.
UniGeneiMm.156736.

Genome annotation databases

GeneIDi246133.
KEGGimmu:246133.
UCSCiuc007zyw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008619 mRNA. Translation: BAB25781.1.
BC022699 mRNA. Translation: AAH22699.1.
CCDSiCCDS28333.1.
RefSeqiNP_598871.1. NM_134110.3.
XP_006523096.1. XM_006523033.3.
UniGeneiMm.156736.

3D structure databases

ProteinModelPortaliQ9D808.
SMRiQ9D808.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048849.

Protein family/group databases

TCDBi8.A.10.2.1. the slow voltage-gated k+) channel accessory protein (mink) family.

PTM databases

iPTMnetiQ9D808.
PhosphoSitePlusiQ9D808.

Proteomic databases

PaxDbiQ9D808.
PRIDEiQ9D808.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi246133.
KEGGimmu:246133.
UCSCiuc007zyw.2. mouse.

Organism-specific databases

CTDi9992.
MGIiMGI:1891123. Kcne2.

Phylogenomic databases

eggNOGiENOG410IX4Y. Eukaryota.
ENOG411297Y. LUCA.
HOGENOMiHOG000113208.
HOVERGENiHBG052227.
InParanoidiQ9D808.
KOiK04896.
PhylomeDBiQ9D808.
TreeFamiTF336058.

Miscellaneous databases

PROiQ9D808.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039672.

Family and domain databases

InterProiIPR000369. K_chnl_KCNE.
IPR005425. K_chnl_volt-dep_bsu_KCNE2.
[Graphical view]
PfamiPF02060. ISK_Channel. 1 hit.
[Graphical view]
PRINTSiPR01605. KCNE2CHANNEL.
ProtoNetiSearch...

Entry informationi

Entry nameiKCNE2_MOUSE
AccessioniPrimary (citable) accession number: Q9D808
Secondary accession number(s): Q8R1Z7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: November 28, 2002
Last modified: November 2, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.