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Q9D808

- KCNE2_MOUSE

UniProt

Q9D808 - KCNE2_MOUSE

Protein

Potassium voltage-gated channel subfamily E member 2

Gene

Kcne2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with KCNQ1/KCLQT1 and elicit a voltage-independent current By similarity.By similarity

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: Ensembl
    2. inward rectifier potassium channel activity Source: Ensembl
    3. potassium channel regulator activity Source: Ensembl
    4. protein binding Source: MGI
    5. voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization Source: Ensembl

    GO - Biological processi

    1. aging Source: Ensembl
    2. cellular protein localization Source: MGI
    3. cellular response to drug Source: Ensembl
    4. positive regulation of proteasomal protein catabolic process Source: Ensembl
    5. potassium ion export Source: Ensembl
    6. potassium ion import Source: Ensembl
    7. potassium ion transmembrane transport Source: MGI
    8. regulation of cyclic nucleotide-gated ion channel activity Source: Ensembl
    9. regulation of delayed rectifier potassium channel activity Source: Ensembl
    10. regulation of heart rate by cardiac conduction Source: Ensembl
    11. regulation of inward rectifier potassium channel activity Source: Ensembl
    12. regulation of ventricular cardiac muscle cell membrane repolarization Source: MGI
    13. tongue development Source: Ensembl
    14. ventricular cardiac muscle cell action potential Source: MGI

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Protein family/group databases

    TCDBi8.A.10.2.1. the slow voltage-gated k+) channel accessory protein (mink) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily E member 2
    Alternative name(s):
    MinK-related peptide 1
    Minimum potassium ion channel-related peptide 1
    Potassium channel subunit beta MiRP1
    Gene namesi
    Name:Kcne2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1891123. Kcne2.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. lysosome Source: Ensembl
    3. membrane Source: MGI
    4. voltage-gated potassium channel complex Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 123123Potassium voltage-gated channel subfamily E member 2PRO_0000144286Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ9D808.

    PTM databases

    PhosphoSiteiQ9D808.

    Expressioni

    Gene expression databases

    BgeeiQ9D808.
    GenevestigatoriQ9D808.

    Interactioni

    Subunit structurei

    Associates with KCNH2/ERG1 By similarity. May associate with KCNQ1/KVLQT1, KCNQ2 and KCNQ3. Associates with HCN1 and probably HCN2 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D808.
    SMRiQ9D808. Positions 51-100.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini70 – 12354CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei49 – 6921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the potassium channel KCNE family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG43841.
    GeneTreeiENSGT00510000048894.
    HOGENOMiHOG000113208.
    HOVERGENiHBG052227.
    InParanoidiQ9D808.
    KOiK04896.
    OrthoDBiEOG7WDN4J.
    PhylomeDBiQ9D808.
    TreeFamiTF336058.

    Family and domain databases

    InterProiIPR000369. K_chnl_volt-dep_bsu_KCNE.
    IPR005424. K_chnl_volt-dep_bsu_KCNE1.
    IPR005425. K_chnl_volt-dep_bsu_KCNE2.
    [Graphical view]
    PANTHERiPTHR17028. PTHR17028. 1 hit.
    PfamiPF02060. ISK_Channel. 1 hit.
    [Graphical view]
    PRINTSiPR01605. KCNE2CHANNEL.

    Sequencei

    Sequence statusi: Complete.

    Q9D808-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATLANLTQT LEDAFKKIFI TYMDSWRRNT TAEEQALQAR VDAENFYYVI    50
    LYLMVMIGMF SFIVVAILVS TVKSKRREHS QHPYHQYIVE DWQEKYKSQI 100
    LHLEDSKATI HENMGATGFT VSP 123
    Length:123
    Mass (Da):14,370
    Last modified:November 28, 2002 - v2
    Checksum:i0A52784967FD741C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti82 – 821H → D in BAB25781. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK008619 mRNA. Translation: BAB25781.1.
    BC022699 mRNA. Translation: AAH22699.1.
    CCDSiCCDS28333.1.
    RefSeqiNP_598871.1. NM_134110.3.
    XP_006523096.1. XM_006523033.1.
    UniGeneiMm.156736.

    Genome annotation databases

    EnsembliENSMUST00000047383; ENSMUSP00000048849; ENSMUSG00000039672.
    ENSMUST00000113971; ENSMUSP00000109604; ENSMUSG00000039672.
    GeneIDi246133.
    KEGGimmu:246133.
    UCSCiuc007zyw.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK008619 mRNA. Translation: BAB25781.1 .
    BC022699 mRNA. Translation: AAH22699.1 .
    CCDSi CCDS28333.1.
    RefSeqi NP_598871.1. NM_134110.3.
    XP_006523096.1. XM_006523033.1.
    UniGenei Mm.156736.

    3D structure databases

    ProteinModelPortali Q9D808.
    SMRi Q9D808. Positions 51-100.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 8.A.10.2.1. the slow voltage-gated k+) channel accessory protein (mink) family.

    PTM databases

    PhosphoSitei Q9D808.

    Proteomic databases

    PRIDEi Q9D808.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000047383 ; ENSMUSP00000048849 ; ENSMUSG00000039672 .
    ENSMUST00000113971 ; ENSMUSP00000109604 ; ENSMUSG00000039672 .
    GeneIDi 246133.
    KEGGi mmu:246133.
    UCSCi uc007zyw.2. mouse.

    Organism-specific databases

    CTDi 9992.
    MGIi MGI:1891123. Kcne2.

    Phylogenomic databases

    eggNOGi NOG43841.
    GeneTreei ENSGT00510000048894.
    HOGENOMi HOG000113208.
    HOVERGENi HBG052227.
    InParanoidi Q9D808.
    KOi K04896.
    OrthoDBi EOG7WDN4J.
    PhylomeDBi Q9D808.
    TreeFami TF336058.

    Miscellaneous databases

    NextBioi 387099.
    PROi Q9D808.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9D808.
    Genevestigatori Q9D808.

    Family and domain databases

    InterProi IPR000369. K_chnl_volt-dep_bsu_KCNE.
    IPR005424. K_chnl_volt-dep_bsu_KCNE1.
    IPR005425. K_chnl_volt-dep_bsu_KCNE2.
    [Graphical view ]
    PANTHERi PTHR17028. PTHR17028. 1 hit.
    Pfami PF02060. ISK_Channel. 1 hit.
    [Graphical view ]
    PRINTSi PR01605. KCNE2CHANNEL.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Stomach.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.

    Entry informationi

    Entry nameiKCNE2_MOUSE
    AccessioniPrimary (citable) accession number: Q9D808
    Secondary accession number(s): Q8R1Z7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2002
    Last sequence update: November 28, 2002
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3