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Protein

Gamma-glutamylcyclotransferase

Gene

Ggct

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis.By similarity

Catalytic activityi

Alpha-(gamma-L-glutamyl)-L-amino acid = alpha-L-amino acid + 5-oxo-L-proline.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei98Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase

Enzyme and pathway databases

ReactomeiR-MMU-174403 Glutathione synthesis and recycling

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamylcyclotransferase (EC:4.3.2.9)
Gene namesi
Name:Ggct
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:95700 Ggct

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000895811 – 188Gamma-glutamylcyclotransferaseAdd BLAST188

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei173PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9D7X8
MaxQBiQ9D7X8
PaxDbiQ9D7X8
PeptideAtlasiQ9D7X8
PRIDEiQ9D7X8

2D gel databases

REPRODUCTION-2DPAGEiQ66JQ5
Q9D7X8

PTM databases

iPTMnetiQ9D7X8
PhosphoSitePlusiQ9D7X8

Expressioni

Gene expression databases

BgeeiENSMUSG00000002797
CleanExiMM_A030007L17RIK
ExpressionAtlasiQ9D7X8 baseline and differential
GenevisibleiQ9D7X8 MM

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000120154

Structurei

3D structure databases

ProteinModelPortaliQ9D7X8
SMRiQ9D7X8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni19 – 22Substrate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4059 Eukaryota
ENOG4111IGG LUCA
GeneTreeiENSGT00500000044921
HOGENOMiHOG000008049
HOVERGENiHBG050922
InParanoidiQ9D7X8
KOiK00682
OMAiAPHDYVM
OrthoDBiEOG091G0NMM
PhylomeDBiQ9D7X8
TreeFamiTF314378

Family and domain databases

CDDicd06661 GGCT_like, 1 hit
InterProiView protein in InterPro
IPR017939 G-Glutamylcylcotransferase
IPR013024 GGCT-like
IPR036568 GGCT-like_sf
PANTHERiPTHR12935 PTHR12935, 1 hit
SUPFAMiSSF110857 SSF110857, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D7X8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSDCEGHA GQEGETFLYF AYGSNLLTER IHLRNPSAVF CCVARLQDFK
60 70 80 90 100
LDFGNFQGKM SERWHGGIAT IFQSPGDEVW GVVWRMNKSN ISSLDEQEGV
110 120 130 140 150
KSGVYVVIEI KVSTREGKEI TCRSYLMTNY ESAPPSPQYK KVICMGAKEN
160 170 180
GLPQEYQEKL KAIEPNEYKG KISDEMEDII KKGESKLS
Length:188
Mass (Da):21,166
Last modified:June 1, 2001 - v1
Checksum:iE03657B103BA7421
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45R → C in EDK98717 (Ref. 2) Curated1
Sequence conflicti45R → C in AAH80818 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008719 mRNA Translation: BAB25854.1
AK050049 mRNA Translation: BAC34049.1
AK079465 mRNA Translation: BAC37656.1
AK141474 mRNA Translation: BAE24696.1
CH466597 Genomic DNA Translation: EDK98717.1
BC080818 mRNA Translation: AAH80818.1
CCDSiCCDS20161.1
RefSeqiNP_080913.1, NM_026637.3
UniGeneiMm.294708

Genome annotation databases

EnsembliENSMUST00000131475; ENSMUSP00000120154; ENSMUSG00000002797
GeneIDi110175
KEGGimmu:110175
UCSCiuc009cah.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGGCT_MOUSE
AccessioniPrimary (citable) accession number: Q9D7X8
Secondary accession number(s): Q3URJ2, Q66JQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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