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Protein

Gamma-glutamylcyclotransferase

Gene

Ggct

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis (By similarity).By similarity

Catalytic activityi

(Gamma-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei98 – 981Proton acceptorBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-174403. Glutathione synthesis and recycling.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamylcyclotransferase (EC:2.3.2.4)
Gene namesi
Name:Ggct
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:95700. Ggct.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188Gamma-glutamylcyclotransferasePRO_0000089581Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei173 – 1731PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9D7X8.
MaxQBiQ9D7X8.
PaxDbiQ9D7X8.
PeptideAtlasiQ9D7X8.
PRIDEiQ9D7X8.

2D gel databases

REPRODUCTION-2DPAGEQ66JQ5.
Q9D7X8.

PTM databases

iPTMnetiQ9D7X8.
PhosphoSiteiQ9D7X8.

Expressioni

Gene expression databases

BgeeiQ9D7X8.
CleanExiMM_A030007L17RIK.
ExpressionAtlasiQ9D7X8. baseline and differential.
GenevisibleiQ9D7X8. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000120154.

Structurei

3D structure databases

ProteinModelPortaliQ9D7X8.
SMRiQ9D7X8. Positions 15-183.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 224Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4059. Eukaryota.
ENOG4111IGG. LUCA.
GeneTreeiENSGT00500000044921.
HOGENOMiHOG000008049.
HOVERGENiHBG050922.
InParanoidiQ9D7X8.
KOiK00682.
OMAiRCPHSPM.
OrthoDBiEOG7H1JNT.
PhylomeDBiQ9D7X8.
TreeFamiTF314378.

Family and domain databases

Gene3Di3.10.490.10. 1 hit.
InterProiIPR013024. Butirosin_synth_BtrG-like.
IPR017939. G-Glutamylcylcotransferase.
[Graphical view]
PANTHERiPTHR12935. PTHR12935. 1 hit.
SUPFAMiSSF110857. SSF110857. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D7X8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSDCEGHA GQEGETFLYF AYGSNLLTER IHLRNPSAVF CCVARLQDFK
60 70 80 90 100
LDFGNFQGKM SERWHGGIAT IFQSPGDEVW GVVWRMNKSN ISSLDEQEGV
110 120 130 140 150
KSGVYVVIEI KVSTREGKEI TCRSYLMTNY ESAPPSPQYK KVICMGAKEN
160 170 180
GLPQEYQEKL KAIEPNEYKG KISDEMEDII KKGESKLS
Length:188
Mass (Da):21,166
Last modified:June 1, 2001 - v1
Checksum:iE03657B103BA7421
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti45 – 451R → C in EDK98717 (Ref. 2) Curated
Sequence conflicti45 – 451R → C in AAH80818 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008719 mRNA. Translation: BAB25854.1.
AK050049 mRNA. Translation: BAC34049.1.
AK079465 mRNA. Translation: BAC37656.1.
AK141474 mRNA. Translation: BAE24696.1.
CH466597 Genomic DNA. Translation: EDK98717.1.
BC080818 mRNA. Translation: AAH80818.1.
CCDSiCCDS20161.1.
RefSeqiNP_080913.1. NM_026637.3.
UniGeneiMm.294708.

Genome annotation databases

EnsembliENSMUST00000131475; ENSMUSP00000120154; ENSMUSG00000002797.
GeneIDi110175.
KEGGimmu:110175.
UCSCiuc009cah.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008719 mRNA. Translation: BAB25854.1.
AK050049 mRNA. Translation: BAC34049.1.
AK079465 mRNA. Translation: BAC37656.1.
AK141474 mRNA. Translation: BAE24696.1.
CH466597 Genomic DNA. Translation: EDK98717.1.
BC080818 mRNA. Translation: AAH80818.1.
CCDSiCCDS20161.1.
RefSeqiNP_080913.1. NM_026637.3.
UniGeneiMm.294708.

3D structure databases

ProteinModelPortaliQ9D7X8.
SMRiQ9D7X8. Positions 15-183.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000120154.

PTM databases

iPTMnetiQ9D7X8.
PhosphoSiteiQ9D7X8.

2D gel databases

REPRODUCTION-2DPAGEQ66JQ5.
Q9D7X8.

Proteomic databases

EPDiQ9D7X8.
MaxQBiQ9D7X8.
PaxDbiQ9D7X8.
PeptideAtlasiQ9D7X8.
PRIDEiQ9D7X8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000131475; ENSMUSP00000120154; ENSMUSG00000002797.
GeneIDi110175.
KEGGimmu:110175.
UCSCiuc009cah.1. mouse.

Organism-specific databases

CTDi79017.
MGIiMGI:95700. Ggct.

Phylogenomic databases

eggNOGiKOG4059. Eukaryota.
ENOG4111IGG. LUCA.
GeneTreeiENSGT00500000044921.
HOGENOMiHOG000008049.
HOVERGENiHBG050922.
InParanoidiQ9D7X8.
KOiK00682.
OMAiRCPHSPM.
OrthoDBiEOG7H1JNT.
PhylomeDBiQ9D7X8.
TreeFamiTF314378.

Enzyme and pathway databases

ReactomeiR-MMU-174403. Glutathione synthesis and recycling.

Miscellaneous databases

PROiQ9D7X8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D7X8.
CleanExiMM_A030007L17RIK.
ExpressionAtlasiQ9D7X8. baseline and differential.
GenevisibleiQ9D7X8. MM.

Family and domain databases

Gene3Di3.10.490.10. 1 hit.
InterProiIPR013024. Butirosin_synth_BtrG-like.
IPR017939. G-Glutamylcylcotransferase.
[Graphical view]
PANTHERiPTHR12935. PTHR12935. 1 hit.
SUPFAMiSSF110857. SSF110857. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Liver, Skin, Spinal cord and Stomach.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-173, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-173, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiGGCT_MOUSE
AccessioniPrimary (citable) accession number: Q9D7X8
Secondary accession number(s): Q3URJ2, Q66JQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.