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Protein

SH2 domain-containing protein 4A

Gene

Sh2d4a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation (By similarity). May play a role in T-cell development and function.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
SH2 domain-containing protein 4A
Gene namesi
Name:Sh2d4a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1919531. Sh2d4a.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 421421SH2 domain-containing protein 4APRO_0000233134Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei117 – 1171PhosphoserineCombined sources
Modified residuei123 – 1231PhosphoserineBy similarity
Modified residuei232 – 2321PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9D7V1.
PaxDbiQ9D7V1.
PRIDEiQ9D7V1.

PTM databases

iPTMnetiQ9D7V1.

Expressioni

Tissue specificityi

In the kidney, expressed only in the glomerulus. Expressed in T-cells, B-cells, macrophages and dendritic cells (at protein level). In adult, highest levels are found in muscle and lung with lower levels in kidney.2 Publications

Inductioni

Upon CD3/CD28 stimulation in CD4 T-cells.1 Publication

Gene expression databases

BgeeiQ9D7V1.
CleanExiMM_SH2D4A.
GenevisibleiQ9D7V1. MM.

Interactioni

Subunit structurei

Interacts with ESR1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070825.

Structurei

3D structure databases

ProteinModelPortaliQ9D7V1.
SMRiQ9D7V1. Positions 306-414.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini315 – 40793SH2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiENOG410IEFY. Eukaryota.
ENOG410XPPJ. LUCA.
GeneTreeiENSGT00570000079047.
HOGENOMiHOG000031527.
HOVERGENiHBG057918.
InParanoidiQ9D7V1.
KOiK17577.
OMAiPYDVLCN.
OrthoDBiEOG71P2BD.
PhylomeDBiQ9D7V1.
TreeFamiTF336893.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D7V1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRQILSDMF IDPDLLAELS EEQKQILFYK MREEQIRRWK EREAAMERKE
60 70 80 90 100
SLPVKSRPKK ENGKSVHWKL GADKQVWVWV MGEHHLDKPY DVLCDEILAE
110 120 130 140 150
REHLRAAKDS ELRKTQSLEL ANSLKIKSQN CDLQAMKKTE PQNVTRKAAS
160 170 180 190 200
EEASGQGPRA IPTRKDDKAQ TKPVKEKDHE EMKQTEDEKT KQIYKSWKED
210 220 230 240 250
SEWQASLRKS KAADEKRRSL AKQAREDYKR LSQRGRSGDG LQNPLTGPQK
260 270 280 290 300
PRRPPLPPKP QFLQPLGIPP KSLGNQGVIR TEISSAQMDT IRWFKEEQLP
310 320 330 340 350
FRAGYQKNSD TIAPWFHGIL TLKKANELLS TGVPGSFLIR VSEKIKGYAL
360 370 380 390 400
SYLSEEGCKH FLIDASANSY SFLGVDQLQH ATLADLVEYH KEEPITSLGK
410 420
ELLLYPCGQQ DKLPDYLELF Q
Length:421
Mass (Da):48,460
Last modified:June 1, 2001 - v1
Checksum:iEED076D6A1AE32D8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti283 – 2831I → T in AAI16683 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008803 mRNA. Translation: BAB25905.1.
BC116682 mRNA. Translation: AAI16683.1.
CCDSiCCDS52564.1.
RefSeqiNP_082458.1. NM_028182.1.
XP_006509814.1. XM_006509751.2.
UniGeneiMm.40974.

Genome annotation databases

EnsembliENSMUST00000066594; ENSMUSP00000070825; ENSMUSG00000053886.
GeneIDi72281.
KEGGimmu:72281.
UCSCiuc009lwe.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008803 mRNA. Translation: BAB25905.1.
BC116682 mRNA. Translation: AAI16683.1.
CCDSiCCDS52564.1.
RefSeqiNP_082458.1. NM_028182.1.
XP_006509814.1. XM_006509751.2.
UniGeneiMm.40974.

3D structure databases

ProteinModelPortaliQ9D7V1.
SMRiQ9D7V1. Positions 306-414.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070825.

PTM databases

iPTMnetiQ9D7V1.

Proteomic databases

MaxQBiQ9D7V1.
PaxDbiQ9D7V1.
PRIDEiQ9D7V1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066594; ENSMUSP00000070825; ENSMUSG00000053886.
GeneIDi72281.
KEGGimmu:72281.
UCSCiuc009lwe.2. mouse.

Organism-specific databases

CTDi63898.
MGIiMGI:1919531. Sh2d4a.

Phylogenomic databases

eggNOGiENOG410IEFY. Eukaryota.
ENOG410XPPJ. LUCA.
GeneTreeiENSGT00570000079047.
HOGENOMiHOG000031527.
HOVERGENiHBG057918.
InParanoidiQ9D7V1.
KOiK17577.
OMAiPYDVLCN.
OrthoDBiEOG71P2BD.
PhylomeDBiQ9D7V1.
TreeFamiTF336893.

Miscellaneous databases

ChiTaRSiSh2d4a. mouse.
PROiQ9D7V1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D7V1.
CleanExiMM_SH2D4A.
GenevisibleiQ9D7V1. MM.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Stomach.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Expression and subcellular distribution of novel glomerulus-associated proteins Dendrin, Ehd3, Sh2d4a, Plekhh2, and 2310066E14Rik."
    Patrakka J., Xiao Z., Nukui M., Takemoto M., He L., Oddsson A., Perisic L., Kaukinen A., Szigyarto C.A.-K., Uhlen M., Jalanko H., Betsholtz C., Tryggvason K.
    J. Am. Soc. Nephrol. 18:689-697(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  4. "Genetic analysis of SH2D4A, a novel adapter protein related to T cell-specific adapter and adapter protein in lymphocytes of unknown function, reveals a redundant function in T cells."
    Lapinski P.E., Oliver J.A., Kamen L.A., Hughes E.D., Saunders T.L., King P.D.
    J. Immunol. 181:2019-2027(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung, Pancreas and Spleen.

Entry informationi

Entry nameiSH24A_MOUSE
AccessioniPrimary (citable) accession number: Q9D7V1
Secondary accession number(s): Q14AV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.