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Protein

Claudin-22

Gene

Cldn22

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-22
Gene namesi
Name:Cldn22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1922927. Cldn22.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 81ExtracellularSequence analysisAdd BLAST50
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 120CytoplasmicSequence analysisAdd BLAST18
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Topological domaini142 – 164ExtracellularSequence analysisAdd BLAST23
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Topological domaini186 – 220CytoplasmicSequence analysisAdd BLAST35

GO - Cellular componenti

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447861 – 220Claudin-22Add BLAST220

Proteomic databases

PaxDbiQ9D7U6.
PRIDEiQ9D7U6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000038064.
CleanExiMM_CLDN22.
GenevisibleiQ9D7U6. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041676.

Structurei

3D structure databases

ProteinModelPortaliQ9D7U6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410INS5. Eukaryota.
ENOG4111QE3. LUCA.
GeneTreeiENSGT00760000119222.
HOGENOMiHOG000220937.
HOVERGENiHBG104065.
InParanoidiQ9D7U6.
KOiK06087.
OMAiEGGMQCK.
OrthoDBiEOG091G0QQ0.
PhylomeDBiQ9D7U6.
TreeFamiTF331936.

Family and domain databases

InterProiView protein in InterPro
IPR006187. Claudin.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiView protein in Pfam
PF00822. PMP22_Claudin. 1 hit.
PROSITEiView protein in PROSITE
PS01346. CLAUDIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D7U6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLVFRTATQ AAALLLSLLG WVLSCLTNYL PHWKNLNLEL NEMENWTMGL
60 70 80 90 100
WKSCVIQEEV GRQCKDFDSF LALPAELQVS RVLMSLCNGL GLLGLLASGC
110 120 130 140 150
GLDCLRLGET QEGLKKRLLT LGGTLLWTSG VMVLVPVSWV AHKTVREFWD
160 170 180 190 200
ETMPEIVPRW EFGEALFLGW FAGFCLVLGG CVLHCAACWS PAPAASSHYA
210 220
VAGPRDHQQH LELKQANPEI
Length:220
Mass (Da):24,310
Last modified:June 1, 2001 - v1
Checksum:iAA4EDB4959E3108E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008821 mRNA. Translation: BAB25914.1.
CCDSiCCDS52550.1.
RefSeqiNP_083659.1. NM_029383.1.
UniGeneiMm.390033.

Genome annotation databases

EnsembliENSMUST00000038693; ENSMUSP00000041676; ENSMUSG00000038064.
GeneIDi75677.
KEGGimmu:75677.
UCSCiuc012gdq.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCLD22_MOUSE
AccessioniPrimary (citable) accession number: Q9D7U6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: June 1, 2001
Last modified: June 7, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families