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Protein

Charged multivesicular body protein 5

Gene

Chmp5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cell separation after cytokinesis Source: MGI
  • endosome to lysosome transport Source: MGI
  • lysosome organization Source: MGI
  • mitotic metaphase plate congression Source: MGI
  • multivesicular body-lysosome fusion Source: ParkinsonsUK-UCL
  • multivesicular body sorting pathway Source: MGI
  • nucleus organization Source: MGI
  • protein transport Source: UniProtKB-KW
  • regulation of centrosome duplication Source: MGI
  • regulation of mitotic spindle assembly Source: MGI
  • regulation of receptor recycling Source: MGI
  • viral budding Source: MGI

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

Names & Taxonomyi

Protein namesi
Recommended name:
Charged multivesicular body protein 5
Alternative name(s):
Chromatin-modifying protein 5
SNF7 domain-containing protein 2
Gene namesi
Name:Chmp5
Synonyms:Snf7dc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1924209 Chmp5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002115011 – 219Charged multivesicular body protein 5Add BLAST219

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei86PhosphoserineBy similarity1

Post-translational modificationi

ISGylated. Isgylation inhibits its interaction with VTA1 (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9D7S9
MaxQBiQ9D7S9
PaxDbiQ9D7S9
PeptideAtlasiQ9D7S9
PRIDEiQ9D7S9

PTM databases

iPTMnetiQ9D7S9
PhosphoSitePlusiQ9D7S9

Expressioni

Gene expression databases

BgeeiENSMUSG00000028419
CleanExiMM_CHMP5
GenevisibleiQ9D7S9 MM

Interactioni

Subunit structurei

Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentially. Interacts with VTA1. Interacts with CHMP2A. Interacts with VTA1; the interaction involves soluble CHMP5 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi218428, 2 interactors
STRINGi10090.ENSMUSP00000030128

Structurei

3D structure databases

ProteinModelPortaliQ9D7S9
SMRiQ9D7S9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili26 – 179Sequence analysisAdd BLAST154

Sequence similaritiesi

Belongs to the SNF7 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1655 Eukaryota
ENOG410XPDA LUCA
GeneTreeiENSGT00550000074817
HOGENOMiHOG000191086
HOVERGENiHBG055759
InParanoidiQ9D7S9
KOiK12198
OMAiAKMRDGP
OrthoDBiEOG091G0LIN
PhylomeDBiQ9D7S9
TreeFamiTF300122

Family and domain databases

InterProiView protein in InterPro
IPR005024 Snf7_fam
PfamiView protein in Pfam
PF03357 Snf7, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D7S9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRFFGKAKP KAPPPSLTDC IGTVDSRAES IDKKISRLDA ELVKYKDQIK
60 70 80 90 100
KMREGPAKNM VKQKALRVLK QKRMYEQQRD NLAQQSFNME QANYTIQSLK
110 120 130 140 150
DTKTTVDAMK LGVKEMKKAY KEVKIDQIED LQDQLEDMME DANEIQEALG
160 170 180 190 200
RSYGTPELDE DDLEAELDAL GDELLADEDS SYLDEAASAP AIPEGVPTDT
210
KNKDGVLVDE FGLPQIPAS
Length:219
Mass (Da):24,576
Last modified:June 1, 2001 - v1
Checksum:i38D13A6AD601A040
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008911 mRNA Translation: BAB25962.1
AK147058 mRNA Translation: BAE27642.1
BC006947 mRNA Translation: AAH06947.1
CCDSiCCDS18053.1
RefSeqiNP_084090.1, NM_029814.1
UniGeneiMm.212763

Genome annotation databases

EnsembliENSMUST00000030128; ENSMUSP00000030128; ENSMUSG00000028419
GeneIDi76959
KEGGimmu:76959
UCSCiuc008sia.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCHMP5_MOUSE
AccessioniPrimary (citable) accession number: Q9D7S9
Secondary accession number(s): Q3UI64
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health