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Q9D7R7

- PEPC_MOUSE

UniProt

Q9D7R7 - PEPC_MOUSE

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Protein

Gastricsin

Gene

Pgc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Hydrolyzes a variety of proteins.

Catalytic activityi

More restricted specificity than pepsin A, but shows preferential cleavage at Tyr-|-Xaa bonds. High activity on hemoglobin.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei94 – 941PROSITE-ProRule annotation
Active sitei280 – 2801PROSITE-ProRule annotation

GO - Molecular functioni

  1. aspartic-type endopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. digestion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Keywords - Biological processi

Digestion

Protein family/group databases

MEROPSiA01.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Gastricsin (EC:3.4.23.3)
Alternative name(s):
Pepsinogen C
Gene namesi
Name:Pgc
Synonyms:Upg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:98909. Pgc.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Propeptidei17 – 6246Activation peptideBy similarityPRO_0000026063Add
BLAST
Chaini63 – 392330GastricsinPRO_0000026064Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi107 ↔ 112By similarity
Disulfide bondi270 ↔ 275By similarity
Disulfide bondi314 ↔ 347By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PRIDEiQ9D7R7.

PTM databases

PhosphoSiteiQ9D7R7.

Expressioni

Gene expression databases

BgeeiQ9D7R7.
CleanExiMM_PGC.
ExpressionAtlasiQ9D7R7. baseline and differential.
GenevestigatoriQ9D7R7.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024782.

Structurei

3D structure databases

ProteinModelPortaliQ9D7R7.
SMRiQ9D7R7. Positions 17-57, 63-391.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG248684.
GeneTreeiENSGT00760000118929.
HOGENOMiHOG000197681.
HOVERGENiHBG000482.
InParanoidiQ9D7R7.
KOiK01377.
OMAiASGWCSE.
OrthoDBiEOG7HQN88.
PhylomeDBiQ9D7R7.
TreeFamiTF314990.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiPF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D7R7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKWMVVALLC LPLLEAALIR VPLKKMKSIR ETMKEQGVLK DFLKNHKYDP
60 70 80 90 100
GQKYHFGKFG DYSVLYEPMA YMDASYYGEI SIGTPPQNFL VLFDTGSSNL
110 120 130 140 150
WVSSVYCQSE ACTTHTRYNP SKSSTYYTQG QTFSLQYGTG SLTGFFGYDT
160 170 180 190 200
LRVQSIQVPN QEFGLSENEP GTNFVYAQFD GIMGLAYPGL SSGGATTALQ
210 220 230 240 250
GMLGEGALSQ PLFGVYLGSQ QGSNGGQIVF GGVDENLYTG ELTWIPVTQE
260 270 280 290 300
LYWQITIDDF LIGNQASGWC SSSGCQGIVD TGTSLLVMPA QYLNELLQTI
310 320 330 340 350
GAQEGEYGQY FVSCDSVSSL PTLTFVLNGV QFPLSPSSYI IQEEGSCMVG
360 370 380 390
LESLSLNAES GQPLWILGDV FLRSYYAVFD MGNNRVGLAP SV
Length:392
Mass (Da):42,849
Last modified:June 1, 2001 - v1
Checksum:i0D19D87E4683C848
GO

Sequence cautioni

The sequence BAB25952.1 differs from that shown. Reason: Frameshift at position 378. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008959 mRNA. Translation: BAB25990.1.
AK008886 mRNA. Translation: BAB25952.1. Frameshift.
BC099409 mRNA. Translation: AAH99409.1.
CCDSiCCDS28855.1.
RefSeqiNP_080249.2. NM_025973.3.
UniGeneiMm.22957.

Genome annotation databases

EnsembliENSMUST00000024782; ENSMUSP00000024782; ENSMUSG00000023987.
GeneIDi109820.
KEGGimmu:109820.
UCSCiuc008cwb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008959 mRNA. Translation: BAB25990.1 .
AK008886 mRNA. Translation: BAB25952.1 . Frameshift.
BC099409 mRNA. Translation: AAH99409.1 .
CCDSi CCDS28855.1.
RefSeqi NP_080249.2. NM_025973.3.
UniGenei Mm.22957.

3D structure databases

ProteinModelPortali Q9D7R7.
SMRi Q9D7R7. Positions 17-57, 63-391.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000024782.

Protein family/group databases

MEROPSi A01.003.

PTM databases

PhosphoSitei Q9D7R7.

Proteomic databases

PRIDEi Q9D7R7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000024782 ; ENSMUSP00000024782 ; ENSMUSG00000023987 .
GeneIDi 109820.
KEGGi mmu:109820.
UCSCi uc008cwb.1. mouse.

Organism-specific databases

CTDi 5225.
MGIi MGI:98909. Pgc.

Phylogenomic databases

eggNOGi NOG248684.
GeneTreei ENSGT00760000118929.
HOGENOMi HOG000197681.
HOVERGENi HBG000482.
InParanoidi Q9D7R7.
KOi K01377.
OMAi ASGWCSE.
OrthoDBi EOG7HQN88.
PhylomeDBi Q9D7R7.
TreeFami TF314990.

Miscellaneous databases

ChiTaRSi Pgc. mouse.
NextBioi 362821.
PROi Q9D7R7.
SOURCEi Search...

Gene expression databases

Bgeei Q9D7R7.
CleanExi MM_PGC.
ExpressionAtlasi Q9D7R7. baseline and differential.
Genevestigatori Q9D7R7.

Family and domain databases

Gene3Di 2.40.70.10. 2 hits.
InterProi IPR001461. Aspartic_peptidase.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR021109. Peptidase_aspartic_dom.
[Graphical view ]
PANTHERi PTHR13683. PTHR13683. 1 hit.
Pfami PF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
[Graphical view ]
PRINTSi PR00792. PEPSIN.
SUPFAMi SSF50630. SSF50630. 1 hit.
PROSITEi PS00141. ASP_PROTEASE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Stomach.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiPEPC_MOUSE
AccessioniPrimary (citable) accession number: Q9D7R7
Secondary accession number(s): Q9D7T2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3