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Q9D7R7

- PEPC_MOUSE

UniProt

Q9D7R7 - PEPC_MOUSE

Protein

Gastricsin

Gene

Pgc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Hydrolyzes a variety of proteins.

    Catalytic activityi

    More restricted specificity than pepsin A, but shows preferential cleavage at Tyr-|-Xaa bonds. High activity on hemoglobin.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei94 – 941PROSITE-ProRule annotation
    Active sitei280 – 2801PROSITE-ProRule annotation

    GO - Molecular functioni

    1. aspartic-type endopeptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. digestion Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aspartyl protease, Hydrolase, Protease

    Keywords - Biological processi

    Digestion

    Protein family/group databases

    MEROPSiA01.003.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gastricsin (EC:3.4.23.3)
    Alternative name(s):
    Pepsinogen C
    Gene namesi
    Name:Pgc
    Synonyms:Upg1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:98909. Pgc.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. nucleolus Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Propeptidei17 – 6246Activation peptideBy similarityPRO_0000026063Add
    BLAST
    Chaini63 – 392330GastricsinPRO_0000026064Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi107 ↔ 112By similarity
    Disulfide bondi270 ↔ 275By similarity
    Disulfide bondi314 ↔ 347By similarity

    Keywords - PTMi

    Disulfide bond, Zymogen

    Proteomic databases

    PRIDEiQ9D7R7.

    PTM databases

    PhosphoSiteiQ9D7R7.

    Expressioni

    Gene expression databases

    BgeeiQ9D7R7.
    CleanExiMM_PGC.
    GenevestigatoriQ9D7R7.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000024782.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D7R7.
    SMRiQ9D7R7. Positions 17-57, 63-391.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase A1 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG248684.
    GeneTreeiENSGT00670000097830.
    HOGENOMiHOG000197681.
    HOVERGENiHBG000482.
    InParanoidiQ9D7R7.
    KOiK01377.
    OMAiASGWCSE.
    OrthoDBiEOG7HQN88.
    PhylomeDBiQ9D7R7.
    TreeFamiTF314990.

    Family and domain databases

    Gene3Di2.40.70.10. 2 hits.
    InterProiIPR001461. Aspartic_peptidase.
    IPR001969. Aspartic_peptidase_AS.
    IPR012848. Aspartic_peptidase_N.
    IPR021109. Peptidase_aspartic_dom.
    [Graphical view]
    PANTHERiPTHR13683. PTHR13683. 1 hit.
    PfamiPF07966. A1_Propeptide. 1 hit.
    PF00026. Asp. 1 hit.
    [Graphical view]
    PRINTSiPR00792. PEPSIN.
    SUPFAMiSSF50630. SSF50630. 1 hit.
    PROSITEiPS00141. ASP_PROTEASE. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9D7R7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKWMVVALLC LPLLEAALIR VPLKKMKSIR ETMKEQGVLK DFLKNHKYDP    50
    GQKYHFGKFG DYSVLYEPMA YMDASYYGEI SIGTPPQNFL VLFDTGSSNL 100
    WVSSVYCQSE ACTTHTRYNP SKSSTYYTQG QTFSLQYGTG SLTGFFGYDT 150
    LRVQSIQVPN QEFGLSENEP GTNFVYAQFD GIMGLAYPGL SSGGATTALQ 200
    GMLGEGALSQ PLFGVYLGSQ QGSNGGQIVF GGVDENLYTG ELTWIPVTQE 250
    LYWQITIDDF LIGNQASGWC SSSGCQGIVD TGTSLLVMPA QYLNELLQTI 300
    GAQEGEYGQY FVSCDSVSSL PTLTFVLNGV QFPLSPSSYI IQEEGSCMVG 350
    LESLSLNAES GQPLWILGDV FLRSYYAVFD MGNNRVGLAP SV 392
    Length:392
    Mass (Da):42,849
    Last modified:June 1, 2001 - v1
    Checksum:i0D19D87E4683C848
    GO

    Sequence cautioni

    The sequence BAB25952.1 differs from that shown. Reason: Frameshift at position 378.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK008959 mRNA. Translation: BAB25990.1.
    AK008886 mRNA. Translation: BAB25952.1. Frameshift.
    BC099409 mRNA. Translation: AAH99409.1.
    CCDSiCCDS28855.1.
    RefSeqiNP_080249.2. NM_025973.3.
    UniGeneiMm.22957.

    Genome annotation databases

    EnsembliENSMUST00000024782; ENSMUSP00000024782; ENSMUSG00000023987.
    GeneIDi109820.
    KEGGimmu:109820.
    UCSCiuc008cwb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK008959 mRNA. Translation: BAB25990.1 .
    AK008886 mRNA. Translation: BAB25952.1 . Frameshift.
    BC099409 mRNA. Translation: AAH99409.1 .
    CCDSi CCDS28855.1.
    RefSeqi NP_080249.2. NM_025973.3.
    UniGenei Mm.22957.

    3D structure databases

    ProteinModelPortali Q9D7R7.
    SMRi Q9D7R7. Positions 17-57, 63-391.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000024782.

    Protein family/group databases

    MEROPSi A01.003.

    PTM databases

    PhosphoSitei Q9D7R7.

    Proteomic databases

    PRIDEi Q9D7R7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000024782 ; ENSMUSP00000024782 ; ENSMUSG00000023987 .
    GeneIDi 109820.
    KEGGi mmu:109820.
    UCSCi uc008cwb.1. mouse.

    Organism-specific databases

    CTDi 5225.
    MGIi MGI:98909. Pgc.

    Phylogenomic databases

    eggNOGi NOG248684.
    GeneTreei ENSGT00670000097830.
    HOGENOMi HOG000197681.
    HOVERGENi HBG000482.
    InParanoidi Q9D7R7.
    KOi K01377.
    OMAi ASGWCSE.
    OrthoDBi EOG7HQN88.
    PhylomeDBi Q9D7R7.
    TreeFami TF314990.

    Miscellaneous databases

    ChiTaRSi PGC. mouse.
    NextBioi 362821.
    PROi Q9D7R7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9D7R7.
    CleanExi MM_PGC.
    Genevestigatori Q9D7R7.

    Family and domain databases

    Gene3Di 2.40.70.10. 2 hits.
    InterProi IPR001461. Aspartic_peptidase.
    IPR001969. Aspartic_peptidase_AS.
    IPR012848. Aspartic_peptidase_N.
    IPR021109. Peptidase_aspartic_dom.
    [Graphical view ]
    PANTHERi PTHR13683. PTHR13683. 1 hit.
    Pfami PF07966. A1_Propeptide. 1 hit.
    PF00026. Asp. 1 hit.
    [Graphical view ]
    PRINTSi PR00792. PEPSIN.
    SUPFAMi SSF50630. SSF50630. 1 hit.
    PROSITEi PS00141. ASP_PROTEASE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Stomach.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.

    Entry informationi

    Entry nameiPEPC_MOUSE
    AccessioniPrimary (citable) accession number: Q9D7R7
    Secondary accession number(s): Q9D7T2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3