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Protein

Chloride intracellular channel protein 3

Gene

Clic3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Can insert into membranes and form chloride ion channels. May participate in cellular growth control (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Names & Taxonomyi

Protein namesi
Recommended name:
Chloride intracellular channel protein 3
Gene namesi
Name:Clic3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1916704. Clic3.

Subcellular locationi

  • Nucleus By similarity
  • Membrane By similarity; Single-pass membrane protein By similarity
  • Cytoplasm By similarity

  • Note: Predominantly nuclear. Some protein was found in the cytoplasm. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity).By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001442081 – 237Chloride intracellular channel protein 3Add BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi23 ↔ 26In soluble formBy similarity
Modified residuei160PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiQ9D7P7.
PaxDbiQ9D7P7.
PRIDEiQ9D7P7.

PTM databases

PhosphoSitePlusiQ9D7P7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000015093.
CleanExiMM_CLIC3.
ExpressionAtlasiQ9D7P7. baseline and differential.
GenevisibleiQ9D7P7. MM.

Interactioni

Subunit structurei

Associated with the C-terminal of ERK7.By similarity

Protein-protein interaction databases

IntActiQ9D7P7. 1 interactor.
MINTiMINT-4091008.
STRINGi10090.ENSMUSP00000109904.

Structurei

3D structure databases

ProteinModelPortaliQ9D7P7.
SMRiQ9D7P7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 91GST N-terminalAdd BLAST79
Domaini92 – 236GST C-terminalAdd BLAST145

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 89Required for insertion into the membraneBy similarityAdd BLAST89

Domaini

Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity).By similarity

Sequence similaritiesi

Belongs to the chloride channel CLIC family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410INGY. Eukaryota.
ENOG4110FKA. LUCA.
GeneTreeiENSGT00550000074477.
HOVERGENiHBG050994.
InParanoidiQ9D7P7.
KOiK05023.
OMAiQDDALYQ.
OrthoDBiEOG091G0IHT.
TreeFamiTF315438.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR002946. CLIC.
IPR030261. CLIC-3.
IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11260:SF266. PTHR11260:SF266. 2 hits.
PfamiPF13417. GST_N_3. 1 hit.
[Graphical view]
PRINTSiPR01263. INTCLCHANNEL.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D7P7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAETTKLQLF VKASEDGESV GHCPSCQRLF MVLLLKGVPF TLTTVDTRRA
60 70 80 90 100
LDVLKDFAPG SQLPILLYDG DVKTDTLQIE EFLEETLGPP DFPSLAPRYR
110 120 130 140 150
ESNTAGNDIF HKFSAFIKNP VPTQDNALYQ QLLRALTRLD SYLRAPLDHE
160 170 180 190 200
LAQEPHLRES HRRFLDGDQF TLADCSLLPK LHIVDTVCAH FRQLPIPAEL
210 220 230
SCVRRYLDSA LQKKEFKYTC PHSAEILAAY QPAVHPR
Length:237
Mass (Da):26,846
Last modified:March 1, 2003 - v2
Checksum:iE1C3BA1754654191
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009020 mRNA. Translation: BAB26030.2.
CCDSiCCDS15774.1.
RefSeqiNP_081361.1. NM_027085.3.
UniGeneiMm.44194.

Genome annotation databases

EnsembliENSMUST00000114265; ENSMUSP00000109904; ENSMUSG00000015093.
GeneIDi69454.
KEGGimmu:69454.
UCSCiuc008isd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009020 mRNA. Translation: BAB26030.2.
CCDSiCCDS15774.1.
RefSeqiNP_081361.1. NM_027085.3.
UniGeneiMm.44194.

3D structure databases

ProteinModelPortaliQ9D7P7.
SMRiQ9D7P7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D7P7. 1 interactor.
MINTiMINT-4091008.
STRINGi10090.ENSMUSP00000109904.

PTM databases

PhosphoSitePlusiQ9D7P7.

Proteomic databases

MaxQBiQ9D7P7.
PaxDbiQ9D7P7.
PRIDEiQ9D7P7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114265; ENSMUSP00000109904; ENSMUSG00000015093.
GeneIDi69454.
KEGGimmu:69454.
UCSCiuc008isd.1. mouse.

Organism-specific databases

CTDi9022.
MGIiMGI:1916704. Clic3.

Phylogenomic databases

eggNOGiENOG410INGY. Eukaryota.
ENOG4110FKA. LUCA.
GeneTreeiENSGT00550000074477.
HOVERGENiHBG050994.
InParanoidiQ9D7P7.
KOiK05023.
OMAiQDDALYQ.
OrthoDBiEOG091G0IHT.
TreeFamiTF315438.

Miscellaneous databases

PROiQ9D7P7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015093.
CleanExiMM_CLIC3.
ExpressionAtlasiQ9D7P7. baseline and differential.
GenevisibleiQ9D7P7. MM.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR002946. CLIC.
IPR030261. CLIC-3.
IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11260:SF266. PTHR11260:SF266. 2 hits.
PfamiPF13417. GST_N_3. 1 hit.
[Graphical view]
PRINTSiPR01263. INTCLCHANNEL.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLIC3_MOUSE
AccessioniPrimary (citable) accession number: Q9D7P7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.