Q9D7P7 (CLIC3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chloride intracellular channel protein 3

Gene names

Name:

Clic3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	237 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Can insert into membranes and form chloride ion channels. May participate in cellular growth control By similarity.
Subunit structure	Associated with the C-terminal of ERK7 By similarity.
Subcellular location	Nucleus By similarity. Membrane; Single-pass membrane protein By similarity. Cytoplasm By similarity. Note: Predominantly nuclear. Some protein was found in the cytoplasm. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain By similarity.
Domain	Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion By similarity.
Sequence similarities	Belongs to the chloride channel CLIC family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cytoplasm Membrane Nucleus
Domain	Transmembrane Transmembrane helix
Ligand	Chloride
Molecular function	Chloride channel Ion channel Voltage-gated channel
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	chloride channel complex Inferred from electronic annotation. Source: UniProtKB-KW cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB nucleus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	chloride channel activity Inferred from sequence or structural similarity. Source: UniProtKB voltage-gated chloride channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 237	237	Chloride intracellular channel protein 3		PRO_0000144208
Regions
	Transmembrane	25 – 45	21	Helical; Potential
	Domain	13 – 91	79	GST N-terminal
	Domain	92 – 236	145	GST C-terminal
	Region	1 – 89	89	Required for insertion into the membrane By similarity
Amino acid modifications
	Disulfide bond	23 ↔ 26		In soluble form By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9D7P7 [UniParc]. Last modified March 1, 2003. Version 2. Checksum: E1C3BA1754654191	FASTA	237	26,846
	10 20 30 40 50 60 MAETTKLQLF VKASEDGESV GHCPSCQRLF MVLLLKGVPF TLTTVDTRRA LDVLKDFAPG 70 80 90 100 110 120 SQLPILLYDG DVKTDTLQIE EFLEETLGPP DFPSLAPRYR ESNTAGNDIF HKFSAFIKNP 130 140 150 160 170 180 VPTQDNALYQ QLLRALTRLD SYLRAPLDHE LAQEPHLRES HRRFLDGDQF TLADCSLLPK 190 200 210 220 230 LHIVDTVCAH FRQLPIPAEL SCVRRYLDSA LQKKEFKYTC PHSAEILAAY QPAVHPR

References

[1]

"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Tongue.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK009020 mRNA. Translation: BAB26030.2.
IPI	IPI00988809.
RefSeq	NP_081361.1. NM_027085.3.
UniGene	Mm.44194.
3D structure databases
ProteinModelPortal	Q9D7P7.
SMR	Q9D7P7. Positions 5-231.
ModBase	Search...
PTM databases
PhosphoSite	Q9D7P7.
Proteomic databases
PaxDb	Q9D7P7.
PRIDE	Q9D7P7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000114265; ENSMUSP00000109904; ENSMUSG00000015093.
GeneID	69454.
KEGG	mmu:69454.
Organism-specific databases
CTD	9022.
MGI	MGI:1916704. Clic3.
Phylogenomic databases
eggNOG	NOG325572.
GeneTree	ENSGT00550000074477.
HOVERGEN	HBG050994.
InParanoid	Q9D7P7.
KO	K05023.
OMA	FHKFSAF.
OrthoDB	EOG4MCX15.
Gene expression databases
ArrayExpress	Q9D7P7.
Bgee	Q9D7P7.
CleanEx	MM_CLIC3.
Genevestigator	Q9D7P7.
GermOnline	ENSMUSG00000015093. Mus musculus.
Family and domain databases
Gene3D	1.20.1050.10. 1 hit. 3.40.30.10. 1 hit.
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR002946. Int_Cl_channel. IPR012336. Thioredoxin-like_fold. [Graphical view]
PRINTS	PR01263. INTCLCHANNEL.
SUPFAM	SSF47616. GST_C_like. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	329494.
SOURCE	Search...

Entry information

Entry name

CLIC3_MOUSE

Accession

Primary (citable) accession number: Q9D7P7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	March 1, 2003
Last modified:	April 3, 2013
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program