ID ISCU_MOUSE Reviewed; 168 AA. AC Q9D7P6; Q4VBC7; Q8K344; DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2001, sequence version 1. DT 16-SEP-2015, entry version 110. DE RecName: Full=Iron-sulfur cluster assembly enzyme ISCU, mitochondrial; DE AltName: Full=NifU-like N-terminal domain-containing protein; DE AltName: Full=NifU-like protein; DE Flags: Precursor; GN Name=Iscu; Synonyms=Nifun; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; TISSUE=Hippocampus, Thymus, and Tongue; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=FVB/N-3; TISSUE=Mammary gland, and Mammary tumor; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, RC Spleen, and Testis; RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). RN [4] RP STRUCTURE BY NMR OF 45-161. RG RIKEN structural genomics initiative (RSGI); RT "Solution structure of iron-sulfur cluster protein (ISCU)."; RL Submitted (NOV-2004) to the PDB data bank. CC -!- FUNCTION: Involved in the assembly or repair of [Fe-S] clusters CC that are present in iron-sulfur proteins. Binds iron (By CC similarity). {ECO:0000250}. CC -!- SUBUNIT: Binds NFS1. Interacts with HSCB (By similarity). CC {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}. CC -!- SIMILARITY: Belongs to the NifU family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK009021; BAB26031.1; -; mRNA. DR EMBL; AK039834; BAC30464.1; -; mRNA. DR EMBL; AK083247; BAC38830.1; -; mRNA. DR EMBL; BC028800; AAH28800.1; -; mRNA. DR EMBL; BC048409; AAH48409.1; -; mRNA. DR EMBL; BC096049; AAH96049.1; -; mRNA. DR CCDS; CCDS19553.1; -. DR RefSeq; NP_079802.1; NM_025526.4. DR UniGene; Mm.29497; -. DR PDB; 1WFZ; NMR; -; A=45-161. DR PDBsum; 1WFZ; -. DR ProteinModelPortal; Q9D7P6; -. DR SMR; Q9D7P6; 45-161. DR IntAct; Q9D7P6; 1. DR MINT; MINT-1848781; -. DR STRING; 10090.ENSMUSP00000026937; -. DR PhosphoSite; Q9D7P6; -. DR MaxQB; Q9D7P6; -. DR PaxDb; Q9D7P6; -. DR PRIDE; Q9D7P6; -. DR Ensembl; ENSMUST00000026937; ENSMUSP00000026937; ENSMUSG00000025825. DR GeneID; 66383; -. DR KEGG; mmu:66383; -. DR UCSC; uc008yyp.1; mouse. DR CTD; 23479; -. DR MGI; MGI:1913633; Iscu. DR eggNOG; COG0822; -. DR GeneTree; ENSGT00390000015813; -. DR HOGENOM; HOG000069228; -. DR HOVERGEN; HBG052621; -. DR InParanoid; Q9D7P6; -. DR OMA; HVGENPM; -. DR OrthoDB; EOG7JMGGC; -. DR PhylomeDB; Q9D7P6; -. DR TreeFam; TF105422; -. DR Reactome; R-MMU-1362409; Mitochondrial iron-sulfur cluster biogenesis. DR EvolutionaryTrace; Q9D7P6; -. DR NextBio; 321509; -. DR PRO; PR:Q9D7P6; -. DR Proteomes; UP000000589; Chromosome 5. DR Bgee; Q9D7P6; -. DR ExpressionAtlas; Q9D7P6; baseline and differential. DR Genevisible; Q9D7P6; MM. DR GO; GO:0005737; C:cytoplasm; ISO:MGI. DR GO; GO:0005829; C:cytosol; ISO:MGI. DR GO; GO:0005759; C:mitochondrial matrix; IBA:GO_Central. DR GO; GO:0005739; C:mitochondrion; IDA:MGI. DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IBA:GO_Central. DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IBA:GO_Central. DR GO; GO:0008198; F:ferrous iron binding; IBA:GO_Central. DR GO; GO:0036455; F:iron-sulfur transferase activity; IBA:GO_Central. DR GO; GO:0032947; F:protein complex scaffold; ISO:MGI. DR GO; GO:0044571; P:[2Fe-2S] cluster assembly; IBA:GO_Central. DR GO; GO:0006879; P:cellular iron ion homeostasis; IBA:GO_Central. DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IBA:GO_Central. DR InterPro; IPR011339; ISC_FeS_clus_asmbl_IscU. DR InterPro; IPR002871; NIF_FeS_clus_asmbl_NifU_N. DR Pfam; PF01592; NifU_N; 1. DR TIGRFAMs; TIGR01999; iscU; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Iron; Metal-binding; Mitochondrion; KW Reference proteome; Transit peptide. FT TRANSIT 1 35 Mitochondrion. {ECO:0000255}. FT CHAIN 36 168 Iron-sulfur cluster assembly enzyme ISCU, FT mitochondrial. FT /FTId=PRO_0000019693. FT STRAND 58 67 {ECO:0000244|PDB:1WFZ}. FT TURN 68 71 {ECO:0000244|PDB:1WFZ}. FT STRAND 72 80 {ECO:0000244|PDB:1WFZ}. FT STRAND 82 92 {ECO:0000244|PDB:1WFZ}. FT HELIX 97 110 {ECO:0000244|PDB:1WFZ}. FT HELIX 115 120 {ECO:0000244|PDB:1WFZ}. FT HELIX 123 130 {ECO:0000244|PDB:1WFZ}. FT HELIX 134 136 {ECO:0000244|PDB:1WFZ}. FT HELIX 137 159 {ECO:0000244|PDB:1WFZ}. SQ SEQUENCE 168 AA; 18098 MW; 06B6350434FEAAF6 CRC64; MAAATGAGRL RRAASALLLR SPRLPARELS APARLYHKKV VDHYENPRNV GSLDKTSKNV GTGLVGAPAC GDVMKLQIQV DEKGKIVDAR FKTFGCGSAI ASSSLATEWV KGKTVEEALT IKNTDIAKEL CLPPVKLHCS MLAEDAIKAA LADYKLKQES KKEEPEKQ //