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Protein

Adipocyte plasma membrane-associated protein

Gene

Apmap

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate (By similarity). May play a role in adipocyte differentiation.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Adipocyte plasma membrane-associated protein
Alternative name(s):
Protein DD16
Gene namesi
Name:Apmap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1919131. Apmap.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 3938CytoplasmicSequence analysisAdd
BLAST
Transmembranei40 – 6021Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini61 – 415355ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 415414Adipocyte plasma membrane-associated proteinPRO_0000205946Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei19 – 191PhosphothreonineBy similarity
Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Glycosylated in vitro.

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9D7N9.
MaxQBiQ9D7N9.
PaxDbiQ9D7N9.
PeptideAtlasiQ9D7N9.
PRIDEiQ9D7N9.

PTM databases

PhosphoSiteiQ9D7N9.
SwissPalmiQ9D7N9.

Expressioni

Tissue specificityi

Strongly expressed in adipose tissue. Highly expressed in liver, heart, and kidney. Expressed at intermediate level in brain and lung. Weakly expressed in spleen, skeletal muscle and testis.

Developmental stagei

Expressed during adipocyte differentiation. Expression appears 3 days following induction of adipose conversion.

Gene expression databases

BgeeiQ9D7N9.
CleanExiMM_2310001A20RIK.
GenevisibleiQ9D7N9. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9D7N9. 3 interactions.
MINTiMINT-1846053.
STRINGi10090.ENSMUSP00000040840.

Structurei

3D structure databases

ProteinModelPortaliQ9D7N9.
SMRiQ9D7N9. Positions 111-320.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the strictosidine synthase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1520. Eukaryota.
COG3386. LUCA.
GeneTreeiENSGT00440000039984.
HOGENOMiHOG000223914.
HOVERGENiHBG050543.
InParanoidiQ9D7N9.
OMAiAHIGDVM.
OrthoDBiEOG7TJ3HT.
PhylomeDBiQ9D7N9.
TreeFamiTF316475.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR018119. Strictosidine_synth_cons-reg.
IPR004141. Strictosidine_synthase.
[Graphical view]
PANTHERiPTHR10426. PTHR10426. 1 hit.
PfamiPF03088. Str_synth. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D7N9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEADGLRQR RPLRPQVVTD DGQVPEVKEG SSFSGRVFRM TFLMLAVSLA
60 70 80 90 100
IPLLGAMMLL ESPIDPQSFS FKEPPFMFGV LHPNTKLRQA ERLFENQLSG
110 120 130 140 150
PESIVNIGDV LFTGTADGRV VKLENGEIET IARFGSGPCK TRDDEPTCGR
160 170 180 190 200
PLGIRAGPNG TLFVVDAYKG LFEVNPQKRS VKLLLSSETP IEGKKMSFVN
210 220 230 240 250
DLTVTRDGRK IYFTDSSSKW QRRDYLLLVM EATDDGRLLE YDTVTKEVKV
260 270 280 290 300
LLDQLQFPNG VQLSPEEDFV LVAETTMARI RRVYVSGLMK GGADMFVENM
310 320 330 340 350
PGFPDNIRPS SSGGYWVAAA TIRANPGFSM LDFLSDKPFI KRMIFKMFSQ
360 370 380 390 400
ETVMKFVPRY SLVLEVSDSG AFRRSLHDPD GQVVTYVSEA HEHDGYLYLG
410
SFRSPFICRL SLQSI
Length:415
Mass (Da):46,434
Last modified:June 1, 2001 - v1
Checksum:i10BA522364CC03D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310638 mRNA. Translation: CAC83967.1.
AK009057 mRNA. Translation: BAB26050.1.
AK154266 mRNA. Translation: BAE32477.1.
AL845174 Genomic DNA. Translation: CAM15679.1.
CH466519 Genomic DNA. Translation: EDL28569.1.
BC055706 mRNA. Translation: AAH55706.1.
CCDSiCCDS16858.1.
RefSeqiNP_082253.1. NM_027977.2.
UniGeneiMm.26599.

Genome annotation databases

EnsembliENSMUST00000046399; ENSMUSP00000040840; ENSMUSG00000033096.
GeneIDi71881.
KEGGimmu:71881.
UCSCiuc008mud.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310638 mRNA. Translation: CAC83967.1.
AK009057 mRNA. Translation: BAB26050.1.
AK154266 mRNA. Translation: BAE32477.1.
AL845174 Genomic DNA. Translation: CAM15679.1.
CH466519 Genomic DNA. Translation: EDL28569.1.
BC055706 mRNA. Translation: AAH55706.1.
CCDSiCCDS16858.1.
RefSeqiNP_082253.1. NM_027977.2.
UniGeneiMm.26599.

3D structure databases

ProteinModelPortaliQ9D7N9.
SMRiQ9D7N9. Positions 111-320.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D7N9. 3 interactions.
MINTiMINT-1846053.
STRINGi10090.ENSMUSP00000040840.

PTM databases

PhosphoSiteiQ9D7N9.
SwissPalmiQ9D7N9.

Proteomic databases

EPDiQ9D7N9.
MaxQBiQ9D7N9.
PaxDbiQ9D7N9.
PeptideAtlasiQ9D7N9.
PRIDEiQ9D7N9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046399; ENSMUSP00000040840; ENSMUSG00000033096.
GeneIDi71881.
KEGGimmu:71881.
UCSCiuc008mud.1. mouse.

Organism-specific databases

CTDi57136.
MGIiMGI:1919131. Apmap.

Phylogenomic databases

eggNOGiKOG1520. Eukaryota.
COG3386. LUCA.
GeneTreeiENSGT00440000039984.
HOGENOMiHOG000223914.
HOVERGENiHBG050543.
InParanoidiQ9D7N9.
OMAiAHIGDVM.
OrthoDBiEOG7TJ3HT.
PhylomeDBiQ9D7N9.
TreeFamiTF316475.

Miscellaneous databases

PROiQ9D7N9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D7N9.
CleanExiMM_2310001A20RIK.
GenevisibleiQ9D7N9. MM.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR018119. Strictosidine_synth_cons-reg.
IPR004141. Strictosidine_synthase.
[Graphical view]
PANTHERiPTHR10426. PTHR10426. 1 hit.
PfamiPF03088. Str_synth. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel integral plasma membrane protein induced during adipocyte differentiation."
    Albrektsen T., Richter H.E., Clausen J.T., Fleckner J.
    Biochem. J. 359:393-402(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Tongue.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  6. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 170-178; 183-194; 196-206 AND 324-341, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6J.
    Tissue: Brain.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiAPMAP_MOUSE
AccessioniPrimary (citable) accession number: Q9D7N9
Secondary accession number(s): A2AQX3, Q3U4F4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.