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Protein

Deoxyribonuclease-1-like 1

Gene

Dnase1l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei113By similarity1
Active sitei164By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribonuclease-1-like 1 (EC:3.1.21.-)
Alternative name(s):
DNase X
Deoxyribonuclease I-like 1
Short name:
DNase I-like 1
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:109628. Dnase1l1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 37Sequence analysisAdd BLAST37
ChainiPRO_000000728538 – 314Deoxyribonuclease-1-like 1Add BLAST277

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi102N-linked (GlcNAc...)Sequence analysis1
Glycosylationi133N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi203 ↔ 240Essential for enzymatic activityBy similarity
Glycosylationi239N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9D7J6.
PaxDbiQ9D7J6.
PRIDEiQ9D7J6.

PTM databases

PhosphoSitePlusiQ9D7J6.

Expressioni

Tissue specificityi

Highly expressed in heart and skeletal muscles. Low expression in brain and thymus. Intermediated expression in other tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000019088.
CleanExiMM_DNASE1L1.
ExpressionAtlasiQ9D7J6. baseline and differential.
GenevisibleiQ9D7J6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019232.

Structurei

3D structure databases

ProteinModelPortaliQ9D7J6.
SMRiQ9D7J6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNase I family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IH3K. Eukaryota.
ENOG410Z4MV. LUCA.
GeneTreeiENSGT00390000013146.
HOGENOMiHOG000059570.
HOVERGENiHBG051368.
InParanoidiQ9D7J6.
KOiK11995.
OMAiETIFHWA.
OrthoDBiEOG091G0I0B.
PhylomeDBiQ9D7J6.
TreeFamiTF329541.

Family and domain databases

Gene3Di3.60.10.10. 1 hit.
InterProiIPR018057. Deoxyribonuclease-1_AS.
IPR016202. DNase_I.
IPR033125. DNASE_I_2.
IPR005135. Endo/exonuclease/phosphatase.
[Graphical view]
PANTHERiPTHR11371. PTHR11371. 1 hit.
PfamiPF03372. Exo_endo_phos. 1 hit.
[Graphical view]
PIRSFiPIRSF000988. DNase_I_euk. 1 hit.
PRINTSiPR00130. DNASEI.
SMARTiSM00476. DNaseIc. 1 hit.
[Graphical view]
SUPFAMiSSF56219. SSF56219. 1 hit.
PROSITEiPS00919. DNASE_I_1. 1 hit.
PS00918. DNASE_I_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D7J6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFGQPGFLW RVPDAHIAMR GLVMAPLLIL LVGGTEAFRI CAFNAHRLTL
60 70 80 90 100
AKLTKESVMD TLVQILARCD IMVLQEVVDS SQNTVPFLLQ KLKSSRSYSF
110 120 130 140 150
LNSSLLGRST YKEKYVYIYR SDKTQVLNFY QYNDTDDIFA REPFVAHFTL
160 170 180 190 200
PSKTLPSVVL VPLHTTPKDV EKELNALYDV FLDVYQRWQN ENVILLGDFN
210 220 230 240 250
ADCASLTKKR LKSLLLRTKA GFHWVIPDGE DTTVRASTNC TYDRIVVHGQ
260 270 280 290 300
GCQMLLKAAA TFDFPKRFQL TEEEALRISD HYPVEVELSQ ATPLSIPPHY
310
LAALLLSLLP SQLD
Length:314
Mass (Da):35,604
Last modified:April 4, 2006 - v3
Checksum:i61888D72FF13E3F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ116784 mRNA. Translation: AAZ94277.1.
AK009174 mRNA. Translation: BAB26122.1.
AK150242 mRNA. Translation: BAE29406.1.
BC023246 mRNA. Translation: AAH23246.1.
CCDSiCCDS30223.1.
RefSeqiNP_001165625.1. NM_001172154.1.
NP_081385.1. NM_027109.2.
UniGeneiMm.20169.

Genome annotation databases

EnsembliENSMUST00000019232; ENSMUSP00000019232; ENSMUSG00000019088.
ENSMUST00000075821; ENSMUSP00000075218; ENSMUSG00000019088.
GeneIDi69537.
KEGGimmu:69537.
UCSCiuc009tof.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ116784 mRNA. Translation: AAZ94277.1.
AK009174 mRNA. Translation: BAB26122.1.
AK150242 mRNA. Translation: BAE29406.1.
BC023246 mRNA. Translation: AAH23246.1.
CCDSiCCDS30223.1.
RefSeqiNP_001165625.1. NM_001172154.1.
NP_081385.1. NM_027109.2.
UniGeneiMm.20169.

3D structure databases

ProteinModelPortaliQ9D7J6.
SMRiQ9D7J6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019232.

PTM databases

PhosphoSitePlusiQ9D7J6.

Proteomic databases

MaxQBiQ9D7J6.
PaxDbiQ9D7J6.
PRIDEiQ9D7J6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019232; ENSMUSP00000019232; ENSMUSG00000019088.
ENSMUST00000075821; ENSMUSP00000075218; ENSMUSG00000019088.
GeneIDi69537.
KEGGimmu:69537.
UCSCiuc009tof.2. mouse.

Organism-specific databases

CTDi1774.
MGIiMGI:109628. Dnase1l1.

Phylogenomic databases

eggNOGiENOG410IH3K. Eukaryota.
ENOG410Z4MV. LUCA.
GeneTreeiENSGT00390000013146.
HOGENOMiHOG000059570.
HOVERGENiHBG051368.
InParanoidiQ9D7J6.
KOiK11995.
OMAiETIFHWA.
OrthoDBiEOG091G0I0B.
PhylomeDBiQ9D7J6.
TreeFamiTF329541.

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiQ9D7J6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019088.
CleanExiMM_DNASE1L1.
ExpressionAtlasiQ9D7J6. baseline and differential.
GenevisibleiQ9D7J6. MM.

Family and domain databases

Gene3Di3.60.10.10. 1 hit.
InterProiIPR018057. Deoxyribonuclease-1_AS.
IPR016202. DNase_I.
IPR033125. DNASE_I_2.
IPR005135. Endo/exonuclease/phosphatase.
[Graphical view]
PANTHERiPTHR11371. PTHR11371. 1 hit.
PfamiPF03372. Exo_endo_phos. 1 hit.
[Graphical view]
PIRSFiPIRSF000988. DNase_I_euk. 1 hit.
PRINTSiPR00130. DNASEI.
SMARTiSM00476. DNaseIc. 1 hit.
[Graphical view]
SUPFAMiSSF56219. SSF56219. 1 hit.
PROSITEiPS00919. DNASE_I_1. 1 hit.
PS00918. DNASE_I_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNSL1_MOUSE
AccessioniPrimary (citable) accession number: Q9D7J6
Secondary accession number(s): Q3UD56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: April 4, 2006
Last modified: November 30, 2016
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.