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Protein

Protein-glutamine gamma-glutamyltransferase 5

Gene

Tgm5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes (By similarity).By similarity

Catalytic activityi

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei283 – 2831PROSITE-ProRule annotation
Active sitei342 – 3421PROSITE-ProRule annotation
Active sitei365 – 3651PROSITE-ProRule annotation
Metal bindingi405 – 4051CalciumBy similarity
Metal bindingi407 – 4071CalciumBy similarity
Metal bindingi453 – 4531CalciumBy similarity
Metal bindingi458 – 4581CalciumBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-glutamine gamma-glutamyltransferase 5 (EC:2.3.2.13)
Alternative name(s):
Transglutaminase-5
Short name:
TGase-5
Gene namesi
Name:Tgm5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1921426. Tgm5.

Subcellular locationi

  • Cytoplasm By similarity

  • Note: Associated with intermediate filaments.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 724723Protein-glutamine gamma-glutamyltransferase 5PRO_0000213714Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ9D7I9.

PTM databases

PhosphoSiteiQ9D7I9.

Expressioni

Gene expression databases

BgeeiQ9D7I9.
CleanExiMM_TGM5.
GenevisibleiQ9D7I9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028721.

Structurei

3D structure databases

ProteinModelPortaliQ9D7I9.
SMRiQ9D7I9. Positions 9-720.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG293974.
GeneTreeiENSGT00760000119108.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiQ9D7I9.
KOiK05622.
OMAiGVLNGNW.
OrthoDBiEOG7WT40M.
PhylomeDBiQ9D7I9.
TreeFamiTF324278.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D7I9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQGCPITGL EVALTDLQSS QNNVRHHTEE ISVDRLVVRR GQAFSITLYF
60 70 80 90 100
KNRGFQPGMD SIMFVAETGP LPDLAKGTRA VFSFTGSGGP SPWIASLEAN
110 120 130 140 150
RANSLEVSLC APPIAAVGRY LLKIRIDSYQ GFVTAYQLGE FILLFNPWCP
160 170 180 190 200
ADSVYLESEP QRQEYVVNDY GFIYQGSKSW IRPCPWNYGQ FEENIIDICL
210 220 230 240 250
ELLEKSLNFQ VDPSTDCALR GSPVYTSRVV CAMINSNDDN GVLNGNWSEN
260 270 280 290 300
YVDGINPAEW TGSVAILKQW HATGCQPVRY GQCWVFAAVM CTVMRCLGIP
310 320 330 340 350
TRVITNFDSG HDTDGNLIID EYYDNTGRIL ENMKKDTVWN FHVWNECWMA
360 370 380 390 400
RKDLPPGYGG WQVLDATPQE TSNGLYCCGP ASVKAIKEGE IDLNYDTRFA
410 420 430 440 450
FSMVNADCMS WLVYGGKEQK LHQDTATVGN FISTKSIQSD ERDDITESYK
460 470 480 490 500
YEEGSLQERE VFLKALQKLQ ATRSQGPHQA NSNPFSSVPP RHNSARSPDS
510 520 530 540 550
PSLQPSDVLQ VSLKFELLDS PKMGQDINFV LLAVNMSPQF KDLKLNLSAQ
560 570 580 590 600
SLLHDGSPLV PFWQDTAFIT LFPEEEKSYP CKILYSQYSQ YLSTDKLIRI
610 620 630 640 650
SALGEEKNSP EKILVNKIIT LTFPGIMINV LGAAFVNQPL TVQVVFSNPL
660 670 680 690 700
SEPVEDCVLT LEGSGLFRKQ QRVLIGVLKP HHKASITLKT VPFKSGQRQI
710 720
QANLRSNRFK DIKGYKNVYV DIGL
Length:724
Mass (Da):81,014
Last modified:January 23, 2007 - v3
Checksum:iFB6A22FDEB5F8329
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009196 mRNA. Translation: BAB26133.1.
AK132482 mRNA. Translation: BAE21192.1.
AL844548 Genomic DNA. Translation: CAM19018.1.
CCDSiCCDS16632.1.
RefSeqiNP_083075.1. NM_028799.2.
UniGeneiMm.20187.

Genome annotation databases

EnsembliENSMUST00000028721; ENSMUSP00000028721; ENSMUSG00000053675.
GeneIDi74176.
KEGGimmu:74176.
UCSCiuc008lxl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009196 mRNA. Translation: BAB26133.1.
AK132482 mRNA. Translation: BAE21192.1.
AL844548 Genomic DNA. Translation: CAM19018.1.
CCDSiCCDS16632.1.
RefSeqiNP_083075.1. NM_028799.2.
UniGeneiMm.20187.

3D structure databases

ProteinModelPortaliQ9D7I9.
SMRiQ9D7I9. Positions 9-720.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028721.

PTM databases

PhosphoSiteiQ9D7I9.

Proteomic databases

PRIDEiQ9D7I9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028721; ENSMUSP00000028721; ENSMUSG00000053675.
GeneIDi74176.
KEGGimmu:74176.
UCSCiuc008lxl.1. mouse.

Organism-specific databases

CTDi9333.
MGIiMGI:1921426. Tgm5.

Phylogenomic databases

eggNOGiNOG293974.
GeneTreeiENSGT00760000119108.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiQ9D7I9.
KOiK05622.
OMAiGVLNGNW.
OrthoDBiEOG7WT40M.
PhylomeDBiQ9D7I9.
TreeFamiTF324278.

Miscellaneous databases

NextBioi339996.
PROiQ9D7I9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D7I9.
CleanExiMM_TGM5.
GenevisibleiQ9D7I9. MM.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Skin and Tongue.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiTGM5_MOUSE
AccessioniPrimary (citable) accession number: Q9D7I9
Secondary accession number(s): A2AQ62, Q3V1F9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: January 23, 2007
Last modified: June 24, 2015
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.