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Q9D7I9

- TGM5_MOUSE

UniProt

Q9D7I9 - TGM5_MOUSE

Protein

Protein-glutamine gamma-glutamyltransferase 5

Gene

Tgm5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes By similarity.By similarity

    Catalytic activityi

    Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

    Cofactori

    Binds 1 calcium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei283 – 2831PROSITE-ProRule annotation
    Active sitei342 – 3421PROSITE-ProRule annotation
    Active sitei365 – 3651PROSITE-ProRule annotation
    Metal bindingi405 – 4051CalciumBy similarity
    Metal bindingi407 – 4071CalciumBy similarity
    Metal bindingi453 – 4531CalciumBy similarity
    Metal bindingi458 – 4581CalciumBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. peptide cross-linking Source: InterPro

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein-glutamine gamma-glutamyltransferase 5 (EC:2.3.2.13)
    Alternative name(s):
    Transglutaminase-5
    Short name:
    TGase-5
    Gene namesi
    Name:Tgm5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1921426. Tgm5.

    Subcellular locationi

    Cytoplasm By similarity
    Note: Associated with intermediate filaments.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 724723Protein-glutamine gamma-glutamyltransferase 5PRO_0000213714Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiQ9D7I9.

    PTM databases

    PhosphoSiteiQ9D7I9.

    Expressioni

    Gene expression databases

    BgeeiQ9D7I9.
    CleanExiMM_TGM5.
    GenevestigatoriQ9D7I9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D7I9.
    SMRiQ9D7I9. Positions 9-720.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG293974.
    GeneTreeiENSGT00740000115034.
    HOGENOMiHOG000231695.
    HOVERGENiHBG004342.
    InParanoidiA2AQ62.
    KOiK05622.
    OMAiGVLNGNW.
    OrthoDBiEOG7WT40M.
    PhylomeDBiQ9D7I9.
    TreeFamiTF324278.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    3.90.260.10. 1 hit.
    InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002931. Transglutaminase-like.
    IPR008958. Transglutaminase_C.
    IPR013808. Transglutaminase_CS.
    IPR001102. Transglutaminase_N.
    [Graphical view]
    PANTHERiPTHR11590. PTHR11590. 1 hit.
    PfamiPF00927. Transglut_C. 2 hits.
    PF01841. Transglut_core. 1 hit.
    PF00868. Transglut_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
    SMARTiSM00460. TGc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49309. SSF49309. 2 hits.
    SSF81296. SSF81296. 1 hit.
    PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9D7I9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQGCPITGL EVALTDLQSS QNNVRHHTEE ISVDRLVVRR GQAFSITLYF    50
    KNRGFQPGMD SIMFVAETGP LPDLAKGTRA VFSFTGSGGP SPWIASLEAN 100
    RANSLEVSLC APPIAAVGRY LLKIRIDSYQ GFVTAYQLGE FILLFNPWCP 150
    ADSVYLESEP QRQEYVVNDY GFIYQGSKSW IRPCPWNYGQ FEENIIDICL 200
    ELLEKSLNFQ VDPSTDCALR GSPVYTSRVV CAMINSNDDN GVLNGNWSEN 250
    YVDGINPAEW TGSVAILKQW HATGCQPVRY GQCWVFAAVM CTVMRCLGIP 300
    TRVITNFDSG HDTDGNLIID EYYDNTGRIL ENMKKDTVWN FHVWNECWMA 350
    RKDLPPGYGG WQVLDATPQE TSNGLYCCGP ASVKAIKEGE IDLNYDTRFA 400
    FSMVNADCMS WLVYGGKEQK LHQDTATVGN FISTKSIQSD ERDDITESYK 450
    YEEGSLQERE VFLKALQKLQ ATRSQGPHQA NSNPFSSVPP RHNSARSPDS 500
    PSLQPSDVLQ VSLKFELLDS PKMGQDINFV LLAVNMSPQF KDLKLNLSAQ 550
    SLLHDGSPLV PFWQDTAFIT LFPEEEKSYP CKILYSQYSQ YLSTDKLIRI 600
    SALGEEKNSP EKILVNKIIT LTFPGIMINV LGAAFVNQPL TVQVVFSNPL 650
    SEPVEDCVLT LEGSGLFRKQ QRVLIGVLKP HHKASITLKT VPFKSGQRQI 700
    QANLRSNRFK DIKGYKNVYV DIGL 724
    Length:724
    Mass (Da):81,014
    Last modified:January 23, 2007 - v3
    Checksum:iFB6A22FDEB5F8329
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK009196 mRNA. Translation: BAB26133.1.
    AK132482 mRNA. Translation: BAE21192.1.
    AL844548 Genomic DNA. Translation: CAM19018.1.
    CCDSiCCDS16632.1.
    RefSeqiNP_083075.1. NM_028799.2.
    UniGeneiMm.20187.

    Genome annotation databases

    EnsembliENSMUST00000028721; ENSMUSP00000028721; ENSMUSG00000053675.
    GeneIDi74176.
    KEGGimmu:74176.
    UCSCiuc008lxl.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK009196 mRNA. Translation: BAB26133.1 .
    AK132482 mRNA. Translation: BAE21192.1 .
    AL844548 Genomic DNA. Translation: CAM19018.1 .
    CCDSi CCDS16632.1.
    RefSeqi NP_083075.1. NM_028799.2.
    UniGenei Mm.20187.

    3D structure databases

    ProteinModelPortali Q9D7I9.
    SMRi Q9D7I9. Positions 9-720.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9D7I9.

    Proteomic databases

    PRIDEi Q9D7I9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028721 ; ENSMUSP00000028721 ; ENSMUSG00000053675 .
    GeneIDi 74176.
    KEGGi mmu:74176.
    UCSCi uc008lxl.1. mouse.

    Organism-specific databases

    CTDi 9333.
    MGIi MGI:1921426. Tgm5.

    Phylogenomic databases

    eggNOGi NOG293974.
    GeneTreei ENSGT00740000115034.
    HOGENOMi HOG000231695.
    HOVERGENi HBG004342.
    InParanoidi A2AQ62.
    KOi K05622.
    OMAi GVLNGNW.
    OrthoDBi EOG7WT40M.
    PhylomeDBi Q9D7I9.
    TreeFami TF324278.

    Miscellaneous databases

    NextBioi 339996.
    PROi Q9D7I9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9D7I9.
    CleanExi MM_TGM5.
    Genevestigatori Q9D7I9.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    3.90.260.10. 1 hit.
    InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002931. Transglutaminase-like.
    IPR008958. Transglutaminase_C.
    IPR013808. Transglutaminase_CS.
    IPR001102. Transglutaminase_N.
    [Graphical view ]
    PANTHERi PTHR11590. PTHR11590. 1 hit.
    Pfami PF00927. Transglut_C. 2 hits.
    PF01841. Transglut_core. 1 hit.
    PF00868. Transglut_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
    SMARTi SM00460. TGc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49309. SSF49309. 2 hits.
    SSF81296. SSF81296. 1 hit.
    PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Skin and Tongue.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiTGM5_MOUSE
    AccessioniPrimary (citable) accession number: Q9D7I9
    Secondary accession number(s): A2AQ62, Q3V1F9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 102 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3