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Q9D7I9

- TGM5_MOUSE

UniProt

Q9D7I9 - TGM5_MOUSE

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Protein

Protein-glutamine gamma-glutamyltransferase 5

Gene

Tgm5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes (By similarity).By similarity

Catalytic activityi

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

Cofactori

Binds 1 calcium ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei283 – 2831PROSITE-ProRule annotation
Active sitei342 – 3421PROSITE-ProRule annotation
Active sitei365 – 3651PROSITE-ProRule annotation
Metal bindingi405 – 4051CalciumBy similarity
Metal bindingi407 – 4071CalciumBy similarity
Metal bindingi453 – 4531CalciumBy similarity
Metal bindingi458 – 4581CalciumBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. peptide cross-linking Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-glutamine gamma-glutamyltransferase 5 (EC:2.3.2.13)
Alternative name(s):
Transglutaminase-5
Short name:
TGase-5
Gene namesi
Name:Tgm5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1921426. Tgm5.

Subcellular locationi

Cytoplasm By similarity
Note: Associated with intermediate filaments.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 724723Protein-glutamine gamma-glutamyltransferase 5PRO_0000213714Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ9D7I9.

PTM databases

PhosphoSiteiQ9D7I9.

Expressioni

Gene expression databases

BgeeiQ9D7I9.
CleanExiMM_TGM5.
GenevestigatoriQ9D7I9.

Structurei

3D structure databases

ProteinModelPortaliQ9D7I9.
SMRiQ9D7I9. Positions 9-720.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG293974.
GeneTreeiENSGT00760000119108.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiQ9D7I9.
KOiK05622.
OMAiGVLNGNW.
OrthoDBiEOG7WT40M.
PhylomeDBiQ9D7I9.
TreeFamiTF324278.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D7I9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQGCPITGL EVALTDLQSS QNNVRHHTEE ISVDRLVVRR GQAFSITLYF
60 70 80 90 100
KNRGFQPGMD SIMFVAETGP LPDLAKGTRA VFSFTGSGGP SPWIASLEAN
110 120 130 140 150
RANSLEVSLC APPIAAVGRY LLKIRIDSYQ GFVTAYQLGE FILLFNPWCP
160 170 180 190 200
ADSVYLESEP QRQEYVVNDY GFIYQGSKSW IRPCPWNYGQ FEENIIDICL
210 220 230 240 250
ELLEKSLNFQ VDPSTDCALR GSPVYTSRVV CAMINSNDDN GVLNGNWSEN
260 270 280 290 300
YVDGINPAEW TGSVAILKQW HATGCQPVRY GQCWVFAAVM CTVMRCLGIP
310 320 330 340 350
TRVITNFDSG HDTDGNLIID EYYDNTGRIL ENMKKDTVWN FHVWNECWMA
360 370 380 390 400
RKDLPPGYGG WQVLDATPQE TSNGLYCCGP ASVKAIKEGE IDLNYDTRFA
410 420 430 440 450
FSMVNADCMS WLVYGGKEQK LHQDTATVGN FISTKSIQSD ERDDITESYK
460 470 480 490 500
YEEGSLQERE VFLKALQKLQ ATRSQGPHQA NSNPFSSVPP RHNSARSPDS
510 520 530 540 550
PSLQPSDVLQ VSLKFELLDS PKMGQDINFV LLAVNMSPQF KDLKLNLSAQ
560 570 580 590 600
SLLHDGSPLV PFWQDTAFIT LFPEEEKSYP CKILYSQYSQ YLSTDKLIRI
610 620 630 640 650
SALGEEKNSP EKILVNKIIT LTFPGIMINV LGAAFVNQPL TVQVVFSNPL
660 670 680 690 700
SEPVEDCVLT LEGSGLFRKQ QRVLIGVLKP HHKASITLKT VPFKSGQRQI
710 720
QANLRSNRFK DIKGYKNVYV DIGL
Length:724
Mass (Da):81,014
Last modified:January 23, 2007 - v3
Checksum:iFB6A22FDEB5F8329
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK009196 mRNA. Translation: BAB26133.1.
AK132482 mRNA. Translation: BAE21192.1.
AL844548 Genomic DNA. Translation: CAM19018.1.
CCDSiCCDS16632.1.
RefSeqiNP_083075.1. NM_028799.2.
UniGeneiMm.20187.

Genome annotation databases

EnsembliENSMUST00000028721; ENSMUSP00000028721; ENSMUSG00000053675.
GeneIDi74176.
KEGGimmu:74176.
UCSCiuc008lxl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK009196 mRNA. Translation: BAB26133.1 .
AK132482 mRNA. Translation: BAE21192.1 .
AL844548 Genomic DNA. Translation: CAM19018.1 .
CCDSi CCDS16632.1.
RefSeqi NP_083075.1. NM_028799.2.
UniGenei Mm.20187.

3D structure databases

ProteinModelPortali Q9D7I9.
SMRi Q9D7I9. Positions 9-720.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9D7I9.

Proteomic databases

PRIDEi Q9D7I9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028721 ; ENSMUSP00000028721 ; ENSMUSG00000053675 .
GeneIDi 74176.
KEGGi mmu:74176.
UCSCi uc008lxl.1. mouse.

Organism-specific databases

CTDi 9333.
MGIi MGI:1921426. Tgm5.

Phylogenomic databases

eggNOGi NOG293974.
GeneTreei ENSGT00760000119108.
HOGENOMi HOG000231695.
HOVERGENi HBG004342.
InParanoidi Q9D7I9.
KOi K05622.
OMAi GVLNGNW.
OrthoDBi EOG7WT40M.
PhylomeDBi Q9D7I9.
TreeFami TF324278.

Miscellaneous databases

NextBioi 339996.
PROi Q9D7I9.
SOURCEi Search...

Gene expression databases

Bgeei Q9D7I9.
CleanExi MM_TGM5.
Genevestigatori Q9D7I9.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view ]
PANTHERi PTHR11590. PTHR11590. 1 hit.
Pfami PF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
SMARTi SM00460. TGc. 1 hit.
[Graphical view ]
SUPFAMi SSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Skin and Tongue.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiTGM5_MOUSE
AccessioniPrimary (citable) accession number: Q9D7I9
Secondary accession number(s): A2AQ62, Q3V1F9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3