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Q9D7I9

- TGM5_MOUSE

UniProt

Q9D7I9 - TGM5_MOUSE

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Protein
Protein-glutamine gamma-glutamyltransferase 5
Gene
Tgm5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes By similarity.

Catalytic activityi

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.

Cofactori

Binds 1 calcium ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei283 – 2831 By similarity
Active sitei342 – 3421 By similarity
Active sitei365 – 3651 By similarity
Metal bindingi405 – 4051Calcium By similarity
Metal bindingi407 – 4071Calcium By similarity
Metal bindingi453 – 4531Calcium By similarity
Metal bindingi458 – 4581Calcium By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. peptide cross-linking Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-glutamine gamma-glutamyltransferase 5 (EC:2.3.2.13)
Alternative name(s):
Transglutaminase-5
Short name:
TGase-5
Gene namesi
Name:Tgm5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1921426. Tgm5.

Subcellular locationi

Cytoplasm By similarity
Note: Associated with intermediate filaments By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 724723Protein-glutamine gamma-glutamyltransferase 5
PRO_0000213714Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ9D7I9.

PTM databases

PhosphoSiteiQ9D7I9.

Expressioni

Gene expression databases

BgeeiQ9D7I9.
CleanExiMM_TGM5.
GenevestigatoriQ9D7I9.

Structurei

3D structure databases

ProteinModelPortaliQ9D7I9.
SMRiQ9D7I9. Positions 9-720.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG293974.
GeneTreeiENSGT00740000115034.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiA2AQ62.
KOiK05622.
OMAiGVLNGNW.
OrthoDBiEOG7WT40M.
PhylomeDBiQ9D7I9.
TreeFamiTF324278.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D7I9-1 [UniParc]FASTAAdd to Basket

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MAQGCPITGL EVALTDLQSS QNNVRHHTEE ISVDRLVVRR GQAFSITLYF    50
KNRGFQPGMD SIMFVAETGP LPDLAKGTRA VFSFTGSGGP SPWIASLEAN 100
RANSLEVSLC APPIAAVGRY LLKIRIDSYQ GFVTAYQLGE FILLFNPWCP 150
ADSVYLESEP QRQEYVVNDY GFIYQGSKSW IRPCPWNYGQ FEENIIDICL 200
ELLEKSLNFQ VDPSTDCALR GSPVYTSRVV CAMINSNDDN GVLNGNWSEN 250
YVDGINPAEW TGSVAILKQW HATGCQPVRY GQCWVFAAVM CTVMRCLGIP 300
TRVITNFDSG HDTDGNLIID EYYDNTGRIL ENMKKDTVWN FHVWNECWMA 350
RKDLPPGYGG WQVLDATPQE TSNGLYCCGP ASVKAIKEGE IDLNYDTRFA 400
FSMVNADCMS WLVYGGKEQK LHQDTATVGN FISTKSIQSD ERDDITESYK 450
YEEGSLQERE VFLKALQKLQ ATRSQGPHQA NSNPFSSVPP RHNSARSPDS 500
PSLQPSDVLQ VSLKFELLDS PKMGQDINFV LLAVNMSPQF KDLKLNLSAQ 550
SLLHDGSPLV PFWQDTAFIT LFPEEEKSYP CKILYSQYSQ YLSTDKLIRI 600
SALGEEKNSP EKILVNKIIT LTFPGIMINV LGAAFVNQPL TVQVVFSNPL 650
SEPVEDCVLT LEGSGLFRKQ QRVLIGVLKP HHKASITLKT VPFKSGQRQI 700
QANLRSNRFK DIKGYKNVYV DIGL 724
Length:724
Mass (Da):81,014
Last modified:January 23, 2007 - v3
Checksum:iFB6A22FDEB5F8329
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK009196 mRNA. Translation: BAB26133.1.
AK132482 mRNA. Translation: BAE21192.1.
AL844548 Genomic DNA. Translation: CAM19018.1.
CCDSiCCDS16632.1.
RefSeqiNP_083075.1. NM_028799.2.
UniGeneiMm.20187.

Genome annotation databases

EnsembliENSMUST00000028721; ENSMUSP00000028721; ENSMUSG00000053675.
GeneIDi74176.
KEGGimmu:74176.
UCSCiuc008lxl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK009196 mRNA. Translation: BAB26133.1 .
AK132482 mRNA. Translation: BAE21192.1 .
AL844548 Genomic DNA. Translation: CAM19018.1 .
CCDSi CCDS16632.1.
RefSeqi NP_083075.1. NM_028799.2.
UniGenei Mm.20187.

3D structure databases

ProteinModelPortali Q9D7I9.
SMRi Q9D7I9. Positions 9-720.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9D7I9.

Proteomic databases

PRIDEi Q9D7I9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028721 ; ENSMUSP00000028721 ; ENSMUSG00000053675 .
GeneIDi 74176.
KEGGi mmu:74176.
UCSCi uc008lxl.1. mouse.

Organism-specific databases

CTDi 9333.
MGIi MGI:1921426. Tgm5.

Phylogenomic databases

eggNOGi NOG293974.
GeneTreei ENSGT00740000115034.
HOGENOMi HOG000231695.
HOVERGENi HBG004342.
InParanoidi A2AQ62.
KOi K05622.
OMAi GVLNGNW.
OrthoDBi EOG7WT40M.
PhylomeDBi Q9D7I9.
TreeFami TF324278.

Miscellaneous databases

NextBioi 339996.
PROi Q9D7I9.
SOURCEi Search...

Gene expression databases

Bgeei Q9D7I9.
CleanExi MM_TGM5.
Genevestigatori Q9D7I9.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view ]
PANTHERi PTHR11590. PTHR11590. 1 hit.
Pfami PF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
SMARTi SM00460. TGc. 1 hit.
[Graphical view ]
SUPFAMi SSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Skin and Tongue.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiTGM5_MOUSE
AccessioniPrimary (citable) accession number: Q9D7I9
Secondary accession number(s): A2AQ62, Q3V1F9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi