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Q9D7H3

- RTCA_MOUSE

UniProt

Q9D7H3 - RTCA_MOUSE

Protein

RNA 3'-terminal phosphate cyclase

Gene

RtcA

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing By similarity.By similarity

    Catalytic activityi

    ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei104 – 1041ATPBy similarity
    Active sitei320 – 3201Tele-AMP-histidine intermediateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi294 – 2985ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. RNA-3'-phosphate cyclase activity Source: UniProtKB-EC

    GO - Biological processi

    1. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA 3'-terminal phosphate cyclase (EC:6.5.1.4)
    Short name:
    RNA cyclase
    Short name:
    RNA-3'-phosphate cyclase
    Alternative name(s):
    RNA terminal phosphate cyclase domain-containing protein 1
    Gene namesi
    Name:RtcA
    Synonyms:Rpc1, Rtcd1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1913618. Rtca.

    Subcellular locationi

    Nucleusnucleoplasm By similarity

    GO - Cellular componenti

    1. nucleoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 366366RNA 3'-terminal phosphate cyclasePRO_0000156411Add
    BLAST

    Proteomic databases

    MaxQBiQ9D7H3.
    PaxDbiQ9D7H3.
    PRIDEiQ9D7H3.

    2D gel databases

    REPRODUCTION-2DPAGEQ9D7H3.

    PTM databases

    PhosphoSiteiQ9D7H3.

    Miscellaneous databases

    PMAP-CutDBQ9D7H3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9D7H3.
    BgeeiQ9D7H3.
    CleanExiMM_RTCD1.
    GenevestigatoriQ9D7H3.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D7H3.
    SMRiQ9D7H3. Positions 6-342.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0430.
    GeneTreeiENSGT00530000063404.
    HOGENOMiHOG000015264.
    HOVERGENiHBG017761.
    InParanoidiQ3TVV2.
    KOiK01974.
    OMAiAEMLLRN.
    OrthoDBiEOG780RMG.
    TreeFamiTF300831.

    Family and domain databases

    Gene3Di3.30.360.20. 1 hit.
    3.65.10.20. 2 hits.
    InterProiIPR013791. RNA3'-term_phos_cycl_insert.
    IPR023797. RNA3'_phos_cyclase_dom.
    IPR000228. RNA3'_term_phos_cyc.
    IPR017770. RNA3'_term_phos_cyc_type_1.
    IPR020719. RNA3'_term_phos_cycl-like_CS.
    IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
    [Graphical view]
    PANTHERiPTHR11096. PTHR11096. 1 hit.
    PfamiPF01137. RTC. 1 hit.
    PF05189. RTC_insert. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005378. RNA3'_term_phos_cycl_euk. 1 hit.
    SUPFAMiSSF52913. SSF52913. 1 hit.
    SSF55205. SSF55205. 2 hits.
    TIGRFAMsiTIGR03399. RNA_3prim_cycl. 1 hit.
    PROSITEiPS01287. RTC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9D7H3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGQRVEVDG GIMEGGGQIL RVSTALSCLL GLPLRVQKIR AGRSTPGLRP    50
    QHLSGLEMVR DLCGGHLEGA EIGSTEITFT PEKIRGGVHT ADTKTAGSVC 100
    LLMQVSMPCV LFAASPSELR LKGGTNAEMA PQIDYTMMVF KPIAEKFGFT 150
    FNCDIKTRGY YPKGGGEVIV RVSPVKRLDP INLTDRGSVT KIYGRAFVAG 200
    VLPLKVAKDM AAAAVRCIRK EIRDLYVSIQ PVQEARDQAF GNGSGIIIVA 250
    ETSTGCLFAG SSLGKRGVNA DKVGIEAAEM LLANLRHGGT VDEYLQDQLI 300
    IFMALANGIS RIKTGSVTLH TQTAIHFAEQ LAKAKFTVKK SEEEEDATKD 350
    TYVIECEGIG MANPHL 366
    Length:366
    Mass (Da):39,254
    Last modified:July 27, 2011 - v2
    Checksum:i28C7DADEBB86B9C5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti273 – 2731V → A in BAB26164. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK009245 mRNA. Translation: BAB26164.1.
    AK152129 mRNA. Translation: BAE30970.1.
    AK159961 mRNA. Translation: BAE35516.1.
    CH466532 Genomic DNA. Translation: EDL12384.1.
    CCDSiCCDS17786.1.
    RefSeqiNP_079793.2. NM_025517.3.
    UniGeneiMm.251228.

    Genome annotation databases

    EnsembliENSMUST00000000348; ENSMUSP00000000348; ENSMUSG00000000339.
    GeneIDi66368.
    KEGGimmu:66368.
    UCSCiuc008rcd.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK009245 mRNA. Translation: BAB26164.1 .
    AK152129 mRNA. Translation: BAE30970.1 .
    AK159961 mRNA. Translation: BAE35516.1 .
    CH466532 Genomic DNA. Translation: EDL12384.1 .
    CCDSi CCDS17786.1.
    RefSeqi NP_079793.2. NM_025517.3.
    UniGenei Mm.251228.

    3D structure databases

    ProteinModelPortali Q9D7H3.
    SMRi Q9D7H3. Positions 6-342.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9D7H3.

    2D gel databases

    REPRODUCTION-2DPAGE Q9D7H3.

    Proteomic databases

    MaxQBi Q9D7H3.
    PaxDbi Q9D7H3.
    PRIDEi Q9D7H3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000000348 ; ENSMUSP00000000348 ; ENSMUSG00000000339 .
    GeneIDi 66368.
    KEGGi mmu:66368.
    UCSCi uc008rcd.2. mouse.

    Organism-specific databases

    CTDi 8634.
    MGIi MGI:1913618. Rtca.

    Phylogenomic databases

    eggNOGi COG0430.
    GeneTreei ENSGT00530000063404.
    HOGENOMi HOG000015264.
    HOVERGENi HBG017761.
    InParanoidi Q3TVV2.
    KOi K01974.
    OMAi AEMLLRN.
    OrthoDBi EOG780RMG.
    TreeFami TF300831.

    Miscellaneous databases

    NextBioi 321465.
    PMAP-CutDB Q9D7H3.
    PROi Q9D7H3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9D7H3.
    Bgeei Q9D7H3.
    CleanExi MM_RTCD1.
    Genevestigatori Q9D7H3.

    Family and domain databases

    Gene3Di 3.30.360.20. 1 hit.
    3.65.10.20. 2 hits.
    InterProi IPR013791. RNA3'-term_phos_cycl_insert.
    IPR023797. RNA3'_phos_cyclase_dom.
    IPR000228. RNA3'_term_phos_cyc.
    IPR017770. RNA3'_term_phos_cyc_type_1.
    IPR020719. RNA3'_term_phos_cycl-like_CS.
    IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
    [Graphical view ]
    PANTHERi PTHR11096. PTHR11096. 1 hit.
    Pfami PF01137. RTC. 1 hit.
    PF05189. RTC_insert. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005378. RNA3'_term_phos_cycl_euk. 1 hit.
    SUPFAMi SSF52913. SSF52913. 1 hit.
    SSF55205. SSF55205. 2 hits.
    TIGRFAMsi TIGR03399. RNA_3prim_cycl. 1 hit.
    PROSITEi PS01287. RTC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone marrow and Tongue.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiRTCA_MOUSE
    AccessioniPrimary (citable) accession number: Q9D7H3
    Secondary accession number(s): Q3TVV2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3