Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Claudin-23

Gene

Cldn23

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-23
Gene namesi
Name:Cldn23
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1919158. Cldn23.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2CytoplasmicSequence analysis2
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Topological domaini24 – 81ExtracellularSequence analysisAdd BLAST58
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 111CytoplasmicSequence analysis9
Transmembranei112 – 132HelicalSequence analysisAdd BLAST21
Topological domaini133 – 160ExtracellularSequence analysisAdd BLAST28
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 296CytoplasmicSequence analysisAdd BLAST115

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447881 – 296Claudin-23Add BLAST296

Proteomic databases

PaxDbiQ9D7D7.
PRIDEiQ9D7D7.

PTM databases

iPTMnetiQ9D7D7.
PhosphoSitePlusiQ9D7D7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000055976.
CleanExiMM_CLDN23.
GenevisibleiQ9D7D7. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049725.

Structurei

3D structure databases

ProteinModelPortaliQ9D7D7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZ5H. Eukaryota.
ENOG4111S3E. LUCA.
GeneTreeiENSGT00390000006975.
HOGENOMiHOG000111788.
HOVERGENiHBG050988.
InParanoidiQ9D7D7.
KOiK06087.
OMAiSTVYVDW.
OrthoDBiEOG091G0O8D.
PhylomeDBiQ9D7D7.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 2 hits.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D7D7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTPVVMTLG MVLTPCGLLL NLVSTLAPGW RLVKGFLDQP VDVVLYQGLW
60 70 80 90 100
DICREQSSRE RECGQPDEWN YFQTQPVQVA RGLMITSLAT TALGLLLASL
110 120 130 140 150
GVRCWQDEPH YGLAGLSGVV FFVAGLFSLI PVSWYNHFLS DPDVLAAPSS
160 170 180 190 200
PVTVQVSYSL VLGYLGSCLL LLGGFSLALS FAPWCEERCR RCRKAPPAGP
210 220 230 240 250
RRSSISTVYV DWPEPALTPA IKYYSDGQHR PPPTAEHRDT SKLKVGFPMP
260 270 280 290
RPPPKSYTNP MDVLEGEEKK TATSQGGSSS RSTRPCQNSL PCDSDL
Length:296
Mass (Da):32,461
Last modified:June 1, 2001 - v1
Checksum:i33940F50D353927B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009330 mRNA. Translation: BAB26222.1.
AK037108 mRNA. Translation: BAC29706.1.
BC019534 mRNA. Translation: AAH19534.1.
BC085262 mRNA. Translation: AAH85262.1.
CCDSiCCDS22246.1.
RefSeqiNP_082274.1. NM_027998.4.
UniGeneiMm.37817.
Mm.486906.

Genome annotation databases

EnsembliENSMUST00000060128; ENSMUSP00000049725; ENSMUSG00000055976.
GeneIDi71908.
KEGGimmu:71908.
UCSCiuc009llc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009330 mRNA. Translation: BAB26222.1.
AK037108 mRNA. Translation: BAC29706.1.
BC019534 mRNA. Translation: AAH19534.1.
BC085262 mRNA. Translation: AAH85262.1.
CCDSiCCDS22246.1.
RefSeqiNP_082274.1. NM_027998.4.
UniGeneiMm.37817.
Mm.486906.

3D structure databases

ProteinModelPortaliQ9D7D7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049725.

PTM databases

iPTMnetiQ9D7D7.
PhosphoSitePlusiQ9D7D7.

Proteomic databases

PaxDbiQ9D7D7.
PRIDEiQ9D7D7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060128; ENSMUSP00000049725; ENSMUSG00000055976.
GeneIDi71908.
KEGGimmu:71908.
UCSCiuc009llc.2. mouse.

Organism-specific databases

CTDi137075.
MGIiMGI:1919158. Cldn23.

Phylogenomic databases

eggNOGiENOG410IZ5H. Eukaryota.
ENOG4111S3E. LUCA.
GeneTreeiENSGT00390000006975.
HOGENOMiHOG000111788.
HOVERGENiHBG050988.
InParanoidiQ9D7D7.
KOiK06087.
OMAiSTVYVDW.
OrthoDBiEOG091G0O8D.
PhylomeDBiQ9D7D7.
TreeFamiTF331936.

Miscellaneous databases

PROiQ9D7D7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055976.
CleanExiMM_CLDN23.
GenevisibleiQ9D7D7. MM.

Family and domain databases

InterProiIPR006187. Claudin.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 2 hits.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLD23_MOUSE
AccessioniPrimary (citable) accession number: Q9D7D7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.