Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable glutathione peroxidase 8

Gene

Gpx8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei79By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Enzyme and pathway databases

ReactomeiR-MMU-3299685. Detoxification of Reactive Oxygen Species.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione peroxidase 8 (EC:1.11.1.9)
Short name:
GPx-8
Short name:
GSHPx-8
Gene namesi
Name:Gpx8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1916840. Gpx8.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei18 – 40HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003177571 – 209Probable glutathione peroxidase 8Add BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9D7B7.
MaxQBiQ9D7B7.
PaxDbiQ9D7B7.
PeptideAtlasiQ9D7B7.
PRIDEiQ9D7B7.

PTM databases

PhosphoSitePlusiQ9D7B7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021760.
GenevisibleiQ9D7B7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022282.

Structurei

3D structure databases

ProteinModelPortaliQ9D7B7.
SMRiQ9D7B7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1651. Eukaryota.
COG0386. LUCA.
GeneTreeiENSGT00760000119230.
HOGENOMiHOG000277054.
HOVERGENiHBG004333.
InParanoidiQ9D7B7.
KOiK00432.
OMAiAYPLKCS.
OrthoDBiEOG091G0OJG.
PhylomeDBiQ9D7B7.
TreeFamiTF331942.

Family and domain databases

CDDicd00340. GSH_Peroxidase. 1 hit.
Gene3Di3.40.30.10. 1 hit.
InterProiIPR013376. Glut_perox_Gpx7.
IPR000889. Glutathione_peroxidase.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02540. gpx7. 1 hit.
PROSITEiPS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D7B7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPFAAYPLK CSGPKAKIFA VLLSMVLCTV MLFLLQLKFL KPRTNSFYSF
60 70 80 90 100
EVKDAKGRTV SLEKFKGKAS LVVNVASDCR FTDKSYQTLR ELHKEFGPYH
110 120 130 140 150
FNVLAFPCNQ FGESEPKSSK EVESFARQNY GVTFPIFHKI KILGPEAEPA
160 170 180 190 200
FRFIVDSSKK EPRWNFWKYL VNPEGQVVKF WRPEEPLEAI RPHVSQMIGQ

IILKKKEDL
Length:209
Mass (Da):24,148
Last modified:June 1, 2001 - v1
Checksum:i8DA93ED11B4ECF21
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88T → I in AAH19664 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009378 mRNA. Translation: BAB26254.1.
BC019664 mRNA. Translation: AAH19664.1.
CCDSiCCDS26781.1.
RefSeqiNP_081403.1. NM_027127.2.
UniGeneiMm.12715.

Genome annotation databases

EnsembliENSMUST00000022282; ENSMUSP00000022282; ENSMUSG00000021760.
GeneIDi69590.
KEGGimmu:69590.
UCSCiuc007rxb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009378 mRNA. Translation: BAB26254.1.
BC019664 mRNA. Translation: AAH19664.1.
CCDSiCCDS26781.1.
RefSeqiNP_081403.1. NM_027127.2.
UniGeneiMm.12715.

3D structure databases

ProteinModelPortaliQ9D7B7.
SMRiQ9D7B7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022282.

PTM databases

PhosphoSitePlusiQ9D7B7.

Proteomic databases

EPDiQ9D7B7.
MaxQBiQ9D7B7.
PaxDbiQ9D7B7.
PeptideAtlasiQ9D7B7.
PRIDEiQ9D7B7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022282; ENSMUSP00000022282; ENSMUSG00000021760.
GeneIDi69590.
KEGGimmu:69590.
UCSCiuc007rxb.1. mouse.

Organism-specific databases

CTDi493869.
MGIiMGI:1916840. Gpx8.

Phylogenomic databases

eggNOGiKOG1651. Eukaryota.
COG0386. LUCA.
GeneTreeiENSGT00760000119230.
HOGENOMiHOG000277054.
HOVERGENiHBG004333.
InParanoidiQ9D7B7.
KOiK00432.
OMAiAYPLKCS.
OrthoDBiEOG091G0OJG.
PhylomeDBiQ9D7B7.
TreeFamiTF331942.

Enzyme and pathway databases

ReactomeiR-MMU-3299685. Detoxification of Reactive Oxygen Species.

Miscellaneous databases

PROiQ9D7B7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021760.
GenevisibleiQ9D7B7. MM.

Family and domain databases

CDDicd00340. GSH_Peroxidase. 1 hit.
Gene3Di3.40.30.10. 1 hit.
InterProiIPR013376. Glut_perox_Gpx7.
IPR000889. Glutathione_peroxidase.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02540. gpx7. 1 hit.
PROSITEiPS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPX8_MOUSE
AccessioniPrimary (citable) accession number: Q9D7B7
Secondary accession number(s): Q8VE68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.