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Q9D799

- FMT_MOUSE

UniProt

Q9D799 - FMT_MOUSE

Protein

Methionyl-tRNA formyltransferase, mitochondrial

Gene

Mtfmt

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Formylates methionyl-tRNA in mitochondria. A single tRNA(Met) gene gives rise to both an initiator and an elongator species via an unknown mechanism By similarity.By similarity

    Catalytic activityi

    10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).

    GO - Molecular functioni

    1. methionyl-tRNA formyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Protein biosynthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methionyl-tRNA formyltransferase, mitochondrial (EC:2.1.2.9)
    Short name:
    MtFMT
    Gene namesi
    Name:Mtfmt
    Synonyms:Fmt
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1916856. Mtfmt.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 386Methionyl-tRNA formyltransferase, mitochondrialPRO_0000010094
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    PRIDEiQ9D799.

    PTM databases

    PhosphoSiteiQ9D799.

    Expressioni

    Gene expression databases

    BgeeiQ9D799.
    CleanExiMM_MTFMT.
    GenevestigatoriQ9D799.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D799.
    SMRiQ9D799. Positions 44-342.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    Composed of an N- and a C-terminal domain. The N-terminal domain carries the tetrahydrofolate (THF)-binding site and the C-terminal domain is presumably involved in positioning the Met-tRNA substrate for the formylation reaction.

    Sequence similaritiesi

    Belongs to the Fmt family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0223.
    GeneTreeiENSGT00390000017828.
    HOGENOMiHOG000261177.
    HOVERGENiHBG031552.
    InParanoidiQ9D799.
    KOiK00604.
    OMAiTHAPKIS.
    OrthoDBiEOG7CZK68.
    TreeFamiTF323405.

    Family and domain databases

    Gene3Di3.40.50.170. 1 hit.
    InterProiIPR005794. Fmt.
    IPR005793. Formyl_trans_C.
    IPR002376. Formyl_transf_N.
    IPR015518. Met_tRNA_Form_TA-like.
    [Graphical view]
    PANTHERiPTHR11138. PTHR11138. 1 hit.
    PfamiPF02911. Formyl_trans_C. 1 hit.
    PF00551. Formyl_trans_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF53328. SSF53328. 1 hit.
    TIGRFAMsiTIGR00460. fmt. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9D799-1 [UniParc]FASTAAdd to Basket

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    MLLPRCCWGR WLMGRRPRCS CQAPAGFDGK DGRGSRVREK PPWRVLFLGT    50
    DHFARETLRA LHAARDGKEE KLIEKLEVVT VPSLSPKGLP VKQYAIQSQL 100
    PVYEWPDVGS GEYDVGVVAS FGRLLSEALI LKFPYGILNV HPSCLPRWRG 150
    PAPIIHTVLH GDTVTGVTIM QIRPKRFDIG PILQQETIPV PPKSTSKELE 200
    AVLSKLGANM LISVLKNLPE SLNNGRPQPA EGVTYAPKVS AGTSCVKWEE 250
    QTSEQVLRLH LAIGDIVPLQ TLWMENTVKL LDLVEVNNSI LADPKLTGQT 300
    VTPGFVVYHR PSQMLLVRCK DGWIGVRSVM LKKTLTATDF YNGYLHAWYQ 350
    KNSHAHPSQC RFQTLRLPTK MQQKTKLLLC NSALSS 386
    Length:386
    Mass (Da):43,092
    Last modified:July 27, 2011 - v3
    Checksum:i74B0542C0ECA4D9D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti40 – 401K → M in BAB26282. (PubMed:16141072)Curated
    Sequence conflicti305 – 3051F → S in AAH19509. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK009430 mRNA. Translation: BAB26282.1.
    AC114645 Genomic DNA. No translation available.
    BC019509 mRNA. Translation: AAH19509.1.
    CCDSiCCDS23292.1.
    RefSeqiNP_081410.2. NM_027134.3.
    UniGeneiMm.287956.

    Genome annotation databases

    EnsembliENSMUST00000074792; ENSMUSP00000074347; ENSMUSG00000059183.
    GeneIDi69606.
    KEGGimmu:69606.
    UCSCiuc009qdh.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK009430 mRNA. Translation: BAB26282.1 .
    AC114645 Genomic DNA. No translation available.
    BC019509 mRNA. Translation: AAH19509.1 .
    CCDSi CCDS23292.1.
    RefSeqi NP_081410.2. NM_027134.3.
    UniGenei Mm.287956.

    3D structure databases

    ProteinModelPortali Q9D799.
    SMRi Q9D799. Positions 44-342.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9D799.

    Proteomic databases

    PRIDEi Q9D799.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000074792 ; ENSMUSP00000074347 ; ENSMUSG00000059183 .
    GeneIDi 69606.
    KEGGi mmu:69606.
    UCSCi uc009qdh.2. mouse.

    Organism-specific databases

    CTDi 123263.
    MGIi MGI:1916856. Mtfmt.

    Phylogenomic databases

    eggNOGi COG0223.
    GeneTreei ENSGT00390000017828.
    HOGENOMi HOG000261177.
    HOVERGENi HBG031552.
    InParanoidi Q9D799.
    KOi K00604.
    OMAi THAPKIS.
    OrthoDBi EOG7CZK68.
    TreeFami TF323405.

    Miscellaneous databases

    NextBioi 329900.
    PROi Q9D799.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9D799.
    CleanExi MM_MTFMT.
    Genevestigatori Q9D799.

    Family and domain databases

    Gene3Di 3.40.50.170. 1 hit.
    InterProi IPR005794. Fmt.
    IPR005793. Formyl_trans_C.
    IPR002376. Formyl_transf_N.
    IPR015518. Met_tRNA_Form_TA-like.
    [Graphical view ]
    PANTHERi PTHR11138. PTHR11138. 1 hit.
    Pfami PF02911. Formyl_trans_C. 1 hit.
    PF00551. Formyl_trans_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53328. SSF53328. 1 hit.
    TIGRFAMsi TIGR00460. fmt. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Tongue.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiFMT_MOUSE
    AccessioniPrimary (citable) accession number: Q9D799
    Secondary accession number(s): E9QKZ0, Q8VE89
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 105 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3