Q9D786 (HAUS5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HAUS augmin-like complex subunit 5

Gene names

Name:	Haus5
Synonyms:	Kiaa0841

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	619 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex By similarity.
Subunit structure	Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly By similarity.
Subcellular location	Cytoplasm › cytoskeleton › centrosome By similarity. Cytoplasm › cytoskeleton › spindle By similarity. Note: Localizes to interphase centrosomes and to mitotic spindle microtubules By similarity.
Sequence similarities	Belongs to the HAUS5 family.
Sequence caution	The sequence AAH23723.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence AAH89002.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Cellular component	Cytoplasm Cytoskeleton Microtubule
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell division Inferred from electronic annotation. Source: UniProtKB-KW centrosome organization Inferred from sequence or structural similarity. Source: UniProtKB mitosis Inferred from electronic annotation. Source: UniProtKB-KW spindle assembly Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	HAUS complex Inferred from sequence or structural similarity. Source: UniProtKB centrosome Inferred from electronic annotation. Source: Compara cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW microtubule Inferred from electronic annotation. Source: UniProtKB-KW spindle Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9D786-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9D786-2)

The sequence of this isoform differs from the canonical sequence as follows:
     507-517: ASELLLPRAAS → TSWVSEEEISV
     518-619: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 619	619	HAUS augmin-like complex subunit 5		PRO_0000050777
Regions
	Coiled coil	73 – 108	36	Potential
	Coiled coil	310 – 395	86	Potential
	Coiled coil	550 – 590	41	Potential
Natural variations
	Alternative sequence	507 – 517	11	ASELLLPRAAS → TSWVSEEEISV in isoform 2.		VSP_013929
	Alternative sequence	518 – 619	102	Missing in isoform 2.		VSP_013930
Experimental info
	Sequence conflict	71 – 73	3	NPK → SYQ in BAC98038. Ref.4
	Sequence conflict	156	1	H → R in EDL24000. Ref.2
	Sequence conflict	156	1	H → R in AAI18935. Ref.3
	Sequence conflict	156	1	H → R in BAC98038. Ref.4
	Sequence conflict	321	1	R → H in EDL24000. Ref.2
	Sequence conflict	321	1	R → H in AAI18935. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 2D1201F6CB8CA28E	FASTA	619	69,572
	10 20 30 40 50 60 MELTQKEREL SRWAAEEMEV PLAARPREST LRRLCLSQGA DIWAYIVQHV RSQRNIKKIQ 70 80 90 100 110 120 GNLLWHAYQD NPKIHRKLEL EATVARLRAE NQELDQSLEL MDQESEAQDV AMTQTLQSLK 130 140 150 160 170 180 DTQHRALLLQ AQAGAVRRQQ RGLQDPMQRL QNQLKHLQDM QRKAKVDVTF GPVVSAAPAL 190 200 210 220 230 240 EPEVLGDVRA ACTLRTQFLQ NLLTPRARGG SILSPCDDHV GTSYQQWLTS VETLLTNHPA 250 260 270 280 290 300 GHVLAALEYL AAERESEIRS LCYGDGLKEE ELSRPQAPES SNSSQVLPST VHLIQEGWQA 310 320 330 340 350 360 VGALVTQRSA LLSERQVLTG RLQRLVEEVK RLLLGSSERK VLLLGLRHSG LLAELKALHA 370 380 390 400 410 420 QSQELESAVG QRHLLLRELQ AKRQRILQWR QLVEDRQEQI RLLIKGNSAS KTRLSRGPEE 430 440 450 460 470 480 VLALIDQKLV PTSEAVAPQS QELLRCLKEE AKHLPRVLLG PLLPYHVKGL KPLSRILPSI 490 500 510 520 530 540 HQLHPTNPRA SSLILLSHTL GLPVGKASEL LLPRAASLQQ DLLFLQDQLG LRRGNLCVKT 550 560 570 580 590 600 SLPPGPSTQE LLQMQVSQEK EQNENVGQTL KKLSNLLKQA LEQIPELQGI VQDWWEQPSQ 610 AALPEEICQG LSLPQCQLR
	Isoform 2 [UniParc]. Checksum: 595A0EBC76EC8177	FASTA	517	58,182
	10 20 30 40 50 60 MELTQKEREL SRWAAEEMEV PLAARPREST LRRLCLSQGA DIWAYIVQHV RSQRNIKKIQ 70 80 90 100 110 120 GNLLWHAYQD NPKIHRKLEL EATVARLRAE NQELDQSLEL MDQESEAQDV AMTQTLQSLK 130 140 150 160 170 180 DTQHRALLLQ AQAGAVRRQQ RGLQDPMQRL QNQLKHLQDM QRKAKVDVTF GPVVSAAPAL 190 200 210 220 230 240 EPEVLGDVRA ACTLRTQFLQ NLLTPRARGG SILSPCDDHV GTSYQQWLTS VETLLTNHPA 250 260 270 280 290 300 GHVLAALEYL AAERESEIRS LCYGDGLKEE ELSRPQAPES SNSSQVLPST VHLIQEGWQA 310 320 330 340 350 360 VGALVTQRSA LLSERQVLTG RLQRLVEEVK RLLLGSSERK VLLLGLRHSG LLAELKALHA 370 380 390 400 410 420 QSQELESAVG QRHLLLRELQ AKRQRILQWR QLVEDRQEQI RLLIKGNSAS KTRLSRGPEE 430 440 450 460 470 480 VLALIDQKLV PTSEAVAPQS QELLRCLKEE AKHLPRVLLG PLLPYHVKGL KPLSRILPSI 490 500 510 HQLHPTNPRA SSLILLSHTL GLPVGKTSWV SEEEISV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: C57BL/6J. Tissue: Tongue.
[2]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Strain: C57BL/6 and FVB/N. Tissue: Brain and Mammary tumor.
[4]	"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H. DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 71-619. Tissue: Embryonic tail.
[5]	Okazaki N., Kikuno R., Nagase T., Ohara O., Koga H. Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK009476 mRNA. Translation: BAB26314.1. CH466593 Genomic DNA. Translation: EDL24000.1. BC023723 mRNA. Translation: AAH23723.1. Different initiation. BC089002 mRNA. Translation: AAH89002.1. Different initiation. BC118934 mRNA. Translation: AAI18935.1. BC118935 mRNA. Translation: AAI18936.1. AK129228 Transcribed RNA. Translation: BAC98038.2.
IPI	IPI00109812. IPI00929869.
RefSeq	NP_082275.1. NM_027999.1.
UniGene	Mm.290410.
3D structure databases
ProteinModelPortal	Q9D786.
ModBase	Search...
PTM databases
PhosphoSite	Q9D786.
Proteomic databases
PaxDb	Q9D786.
PRIDE	Q9D786.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000019697; ENSMUSP00000019697; ENSMUSG00000078762. ENSMUST00000132862; ENSMUSP00000121739; ENSMUSG00000078762.
GeneID	71909.
KEGG	mmu:71909.
UCSC	uc009gfs.2. mouse.
Organism-specific databases
CTD	23354.
MGI	MGI:1919159. Haus5.
Rouge	Search...
Phylogenomic databases
eggNOG	NOG47858.
GeneTree	ENSGT00390000012508.
HOGENOM	HOG000112852.
HOVERGEN	HBG081829.
InParanoid	Q0VF86.
KO	K16588.
OMA	QQRILHW.
OrthoDB	EOG4K9BC5.
Gene expression databases
Bgee	Q9D786.
CleanEx	MM_2310022K01RIK.
Genevestigator	Q9D786.
GermOnline	ENSMUSG00000036733. Mus musculus.
Family and domain databases
InterPro	IPR026215. HAUS5. [Graphical view]
PRINTS	PR02091. HAUSAUGMINL5.
ProtoNet	Search...
Other
NextBio	334914.
SOURCE	Search...

Entry information

Entry name

HAUS5_MOUSE

Accession

Primary (citable) accession number: Q9D786
Secondary accession number(s): Q08EB3 , Q0VF86, Q5HZI7, Q6ZQ35, Q8CIK2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program