Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tumor necrosis factor ligand superfamily member 13

Gene

Tnfsf13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.1 Publication

GO - Biological processi

  • immunoglobulin mediated immune response Source: MGI
  • immunoglobulin production in mucosal tissue Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of germinal center formation Source: MGI
  • positive regulation of isotype switching to IgA isotypes Source: MGI
  • regulation of immune response Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 13
Alternative name(s):
A proliferation-inducing ligand
Short name:
APRIL
CD_antigen: CD256
Gene namesi
Name:Tnfsf13
Synonyms:April
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1916833. Tnfsf13.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000345261 – 95By similarityAdd BLAST95
ChainiPRO_000003452796 – 241Tumor necrosis factor ligand superfamily member 13Add BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi115N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi187 ↔ 2021 Publication

Post-translational modificationi

The soluble form derives from the membrane form by proteolytic processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei95 – 96Cleavage; by furinBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9D777.
PaxDbiQ9D777.
PRIDEiQ9D777.

PTM databases

PhosphoSitePlusiQ9D777.

Expressioni

Gene expression databases

BgeeiENSMUSG00000089669.

Interactioni

Subunit structurei

Homotrimer.Curated

Protein-protein interaction databases

IntActiQ9D777. 2 interactors.
STRINGi10090.ENSMUSP00000018896.

Structurei

Secondary structure

1241
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi108 – 117Combined sources10
Turni120 – 122Combined sources3
Beta strandi125 – 142Combined sources18
Beta strandi145 – 148Combined sources4
Beta strandi152 – 162Combined sources11
Beta strandi165 – 167Combined sources3
Beta strandi172 – 176Combined sources5
Beta strandi181 – 186Combined sources6
Turni195 – 197Combined sources3
Beta strandi200 – 210Combined sources11
Beta strandi215 – 222Combined sources8
Turni231 – 233Combined sources3
Beta strandi234 – 240Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1U5XX-ray1.80A104-241[»]
1U5YX-ray2.30A/B/D104-241[»]
1U5ZX-ray2.40A104-241[»]
1XU1X-ray1.90A/B/D104-241[»]
1XU2X-ray2.35A/B/D104-241[»]
3K48X-ray2.80A/B/D104-241[»]
ProteinModelPortaliQ9D777.
SMRiQ9D777.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9D777.

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Phylogenomic databases

eggNOGiENOG410II60. Eukaryota.
ENOG410Y4KC. LUCA.
HOGENOMiHOG000036810.
HOVERGENiHBG104367.
InParanoidiQ9D777.
KOiK05475.
PhylomeDBiQ9D777.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D777-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPASSPGHMG GSVREPALSV ALWLSWGAVL GAVTCAVALL IQQTELQSLR
60 70 80 90 100
REVSRLQRSG GPSQKQGERP WQSLWEQSPD VLEAWKDGAK SRRRRAVLTQ
110 120 130 140 150
KHKKKHSVLH LVPVNITSKA DSDVTEVMWQ PVLRRGRGLE AQGDIVRVWD
160 170 180 190 200
TGIYLLYSQV LFHDVTFTMG QVVSREGQGR RETLFRCIRS MPSDPDRAYN
210 220 230 240
SCYSAGVFHL HQGDIITVKI PRANAKLSLS PHGTFLGFVK L
Length:241
Mass (Da):26,889
Last modified:June 1, 2001 - v1
Checksum:i4B96D03BDBC712A4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120Missing in AAG22534 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF294825 mRNA. Translation: AAG22534.1.
AK009514 mRNA. Translation: BAB26332.1.
BC069900 mRNA. Translation: AAH69900.1.
RefSeqiNP_001152977.1. NM_001159505.1.
NP_076006.2. NM_023517.2.
UniGeneiMm.8983.

Genome annotation databases

GeneIDi69583.
KEGGimmu:69583.
UCSCiuc007jrd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF294825 mRNA. Translation: AAG22534.1.
AK009514 mRNA. Translation: BAB26332.1.
BC069900 mRNA. Translation: AAH69900.1.
RefSeqiNP_001152977.1. NM_001159505.1.
NP_076006.2. NM_023517.2.
UniGeneiMm.8983.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1U5XX-ray1.80A104-241[»]
1U5YX-ray2.30A/B/D104-241[»]
1U5ZX-ray2.40A104-241[»]
1XU1X-ray1.90A/B/D104-241[»]
1XU2X-ray2.35A/B/D104-241[»]
3K48X-ray2.80A/B/D104-241[»]
ProteinModelPortaliQ9D777.
SMRiQ9D777.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D777. 2 interactors.
STRINGi10090.ENSMUSP00000018896.

PTM databases

PhosphoSitePlusiQ9D777.

Proteomic databases

MaxQBiQ9D777.
PaxDbiQ9D777.
PRIDEiQ9D777.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi69583.
KEGGimmu:69583.
UCSCiuc007jrd.1. mouse.

Organism-specific databases

CTDi8741.
MGIiMGI:1916833. Tnfsf13.

Phylogenomic databases

eggNOGiENOG410II60. Eukaryota.
ENOG410Y4KC. LUCA.
HOGENOMiHOG000036810.
HOVERGENiHBG104367.
InParanoidiQ9D777.
KOiK05475.
PhylomeDBiQ9D777.

Miscellaneous databases

EvolutionaryTraceiQ9D777.
PROiQ9D777.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000089669.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNF13_MOUSE
AccessioniPrimary (citable) accession number: Q9D777
Secondary accession number(s): Q9ERP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Transgenic mice develop lymphoid tumors that originate from expansion of the peritoneal B-1 B-cell population. Aging transgenic mice develop progressive hyperplasia in mesenteric lymph nodes and Peyer patches, disorganization of affected lymphoid tissues, mucosal and capsular infiltration, and eventual tumor cell infiltration into non-lymphoid tissues such as kidney and liver (PubMed:15488762).1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.