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Q9D777

- TNF13_MOUSE

UniProt

Q9D777 - TNF13_MOUSE

Protein

Tumor necrosis factor ligand superfamily member 13

Gene

Tnfsf13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei95 – 962Cleavage; by furinBy similarity

    GO - Biological processi

    1. immunoglobulin mediated immune response Source: MGI
    2. immunoglobulin production in mucosal tissue Source: MGI
    3. positive regulation of cell proliferation Source: MGI
    4. positive regulation of germinal center formation Source: MGI
    5. positive regulation of isotype switching to IgA isotypes Source: MGI
    6. regulation of immune response Source: MGI

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Immunity

    Enzyme and pathway databases

    ReactomeiREACT_198691. HuR stabilizes mRNA.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor ligand superfamily member 13
    Alternative name(s):
    A proliferation-inducing ligand
    Short name:
    APRIL
    CD_antigen: CD256
    Gene namesi
    Name:Tnfsf13
    Synonyms:April
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1916833. Tnfsf13.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. external side of plasma membrane Source: MGI
    2. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei1 – 9595By similarityPRO_0000034526Add
    BLAST
    Chaini96 – 241146Tumor necrosis factor ligand superfamily member 13PRO_0000034527Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi187 ↔ 2021 Publication

    Post-translational modificationi

    The soluble form derives from the membrane form by proteolytic processing.

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ9D777.

    PTM databases

    PhosphoSiteiQ9D777.

    Expressioni

    Gene expression databases

    BgeeiQ9D777.
    GenevestigatoriQ9D777.

    Interactioni

    Subunit structurei

    Homotrimer.Curated

    Protein-protein interaction databases

    IntActiQ9D777. 2 interactions.

    Structurei

    Secondary structure

    1
    241
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi108 – 11710
    Turni120 – 1223
    Beta strandi125 – 14218
    Beta strandi145 – 1484
    Beta strandi152 – 16211
    Beta strandi165 – 1673
    Beta strandi172 – 1765
    Beta strandi181 – 1866
    Turni195 – 1973
    Beta strandi200 – 21011
    Beta strandi215 – 2228
    Turni231 – 2333
    Beta strandi234 – 2407

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1U5XX-ray1.80A104-241[»]
    1U5YX-ray2.30A/B/D104-241[»]
    1U5ZX-ray2.40A104-241[»]
    1XU1X-ray1.90A/B/D104-241[»]
    1XU2X-ray2.35A/B/D104-241[»]
    3K48X-ray2.80A/B/D104-241[»]
    ProteinModelPortaliQ9D777.
    SMRiQ9D777. Positions 105-241.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9D777.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tumor necrosis factor family.Curated

    Phylogenomic databases

    HOGENOMiHOG000036810.
    HOVERGENiHBG104367.
    KOiK05475.
    PhylomeDBiQ9D777.

    Family and domain databases

    Gene3Di2.60.120.40. 1 hit.
    InterProiIPR021184. TNF_CS.
    IPR006052. TNF_dom.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PfamiPF00229. TNF. 1 hit.
    [Graphical view]
    SMARTiSM00207. TNF. 1 hit.
    [Graphical view]
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS00251. TNF_1. 1 hit.
    PS50049. TNF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9D777-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPASSPGHMG GSVREPALSV ALWLSWGAVL GAVTCAVALL IQQTELQSLR    50
    REVSRLQRSG GPSQKQGERP WQSLWEQSPD VLEAWKDGAK SRRRRAVLTQ 100
    KHKKKHSVLH LVPVNITSKA DSDVTEVMWQ PVLRRGRGLE AQGDIVRVWD 150
    TGIYLLYSQV LFHDVTFTMG QVVSREGQGR RETLFRCIRS MPSDPDRAYN 200
    SCYSAGVFHL HQGDIITVKI PRANAKLSLS PHGTFLGFVK L 241
    Length:241
    Mass (Da):26,889
    Last modified:June 1, 2001 - v1
    Checksum:i4B96D03BDBC712A4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti120 – 1201Missing in AAG22534. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF294825 mRNA. Translation: AAG22534.1.
    AK009514 mRNA. Translation: BAB26332.1.
    BC069900 mRNA. Translation: AAH69900.1.
    RefSeqiNP_001152977.1. NM_001159505.1.
    NP_076006.2. NM_023517.2.
    UniGeneiMm.8983.

    Genome annotation databases

    GeneIDi69583.
    KEGGimmu:69583.
    UCSCiuc007jrd.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF294825 mRNA. Translation: AAG22534.1 .
    AK009514 mRNA. Translation: BAB26332.1 .
    BC069900 mRNA. Translation: AAH69900.1 .
    RefSeqi NP_001152977.1. NM_001159505.1.
    NP_076006.2. NM_023517.2.
    UniGenei Mm.8983.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1U5X X-ray 1.80 A 104-241 [» ]
    1U5Y X-ray 2.30 A/B/D 104-241 [» ]
    1U5Z X-ray 2.40 A 104-241 [» ]
    1XU1 X-ray 1.90 A/B/D 104-241 [» ]
    1XU2 X-ray 2.35 A/B/D 104-241 [» ]
    3K48 X-ray 2.80 A/B/D 104-241 [» ]
    ProteinModelPortali Q9D777.
    SMRi Q9D777. Positions 105-241.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9D777. 2 interactions.

    PTM databases

    PhosphoSitei Q9D777.

    Proteomic databases

    PRIDEi Q9D777.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 69583.
    KEGGi mmu:69583.
    UCSCi uc007jrd.1. mouse.

    Organism-specific databases

    CTDi 8741.
    MGIi MGI:1916833. Tnfsf13.

    Phylogenomic databases

    HOGENOMi HOG000036810.
    HOVERGENi HBG104367.
    KOi K05475.
    PhylomeDBi Q9D777.

    Enzyme and pathway databases

    Reactomei REACT_198691. HuR stabilizes mRNA.

    Miscellaneous databases

    EvolutionaryTracei Q9D777.
    NextBioi 329846.
    PROi Q9D777.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9D777.
    Genevestigatori Q9D777.

    Family and domain databases

    Gene3Di 2.60.120.40. 1 hit.
    InterProi IPR021184. TNF_CS.
    IPR006052. TNF_dom.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    Pfami PF00229. TNF. 1 hit.
    [Graphical view ]
    SMARTi SM00207. TNF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS00251. TNF_1. 1 hit.
    PS50049. TNF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Tongue.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: 129.
      Tissue: Mammary gland.
    4. Cited for: FUNCTION, TRANSGENIC MICE.
    5. "Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding."
      Hymowitz S.G., Patel D.R., Wallweber H.J., Runyon S., Yan M., Yin J., Shriver S.K., Gordon N.C., Pan B., Skelton N.J., Kelley R.F., Starovasnik M.A.
      J. Biol. Chem. 280:7218-7227(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 104-241 IN COMPLEX WITH HUMAN TNFRSF17, DISULFIDE BONDS.

    Entry informationi

    Entry nameiTNF13_MOUSE
    AccessioniPrimary (citable) accession number: Q9D777
    Secondary accession number(s): Q9ERP1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 6, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Transgenic mice develop lymphoid tumors that originate from expansion of the peritoneal B-1 B-cell population. Aging transgenic mice develop progressive hyperplasia in mesenteric lymph nodes and Peyer patches, disorganization of affected lymphoid tissues, mucosal and capsular infiltration, and eventual tumor cell infiltration into non-lymphoid tissues such as kidney and liver (PubMed:15488762).1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3