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Q9D777 (TNF13_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tumor necrosis factor ligand superfamily member 13
Alternative name(s):
A proliferation-inducing ligand
Short name=APRIL
CD_antigen=CD256
Gene names
Name:Tnfsf13
Synonyms:April
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length241 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. Ref.4

Subunit structure

Homotrimer Potential.

Subcellular location

Secreted By similarity.

Post-translational modification

The soluble form derives from the membrane form by proteolytic processing.

Miscellaneous

Transgenic mice develop lymphoid tumors that originate from expansion of the peritoneal B-1 B-cell population. Aging transgenic mice develop progressive hyperplasia in mesenteric lymph nodes and Peyer patches, disorganization of affected lymphoid tissues, mucosal and capsular infiltration, and eventual tumor cell infiltration into non-lymphoid tissues such as kidney and liver (Ref.4).

Sequence similarities

Belongs to the tumor necrosis factor family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide1 – 9595 By similarity
PRO_0000034526
Chain96 – 241146Tumor necrosis factor ligand superfamily member 13
PRO_0000034527

Sites

Site95 – 962Cleavage; by furin By similarity

Amino acid modifications

Glycosylation1151N-linked (GlcNAc...) Potential
Disulfide bond187 ↔ 202 Ref.5

Experimental info

Sequence conflict1201Missing in AAG22534. Ref.2

Secondary structure

.......................... 241
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9D777 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 4B96D03BDBC712A4

FASTA24126,889
        10         20         30         40         50         60 
MPASSPGHMG GSVREPALSV ALWLSWGAVL GAVTCAVALL IQQTELQSLR REVSRLQRSG 

        70         80         90        100        110        120 
GPSQKQGERP WQSLWEQSPD VLEAWKDGAK SRRRRAVLTQ KHKKKHSVLH LVPVNITSKA 

       130        140        150        160        170        180 
DSDVTEVMWQ PVLRRGRGLE AQGDIVRVWD TGIYLLYSQV LFHDVTFTMG QVVSREGQGR 

       190        200        210        220        230        240 
RETLFRCIRS MPSDPDRAYN SCYSAGVFHL HQGDIITVKI PRANAKLSLS PHGTFLGFVK 


L 

« Hide

References

« Hide 'large scale' references
[1]"APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity."
Yu G., Boone T., Delaney J., Hawkins N., Kelley M.J., Ramakrishnan M., McCabe S., Qiu W.R., Kornuc M., Xia X.-Z., Guo J., Stolina M., Boyle W.J., Sarosi I., Hsu H., Senaldi G., Theill L.E.
Nat. Immunol. 1:252-256(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Tongue.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: 129.
Tissue: Mammary gland.
[4]"APRIL promotes B-1 cell-associated neoplasm."
Planelles L., Carvalho-Pinto C.E., Hardenberg G., Smaniotto S., Savino W., Gomez-Caro R., Alvarez-Mon M., de Jong J., Eldering E., Martinez-A C., Medema J.P., Hahne M.
Cancer Cell 6:399-408(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TRANSGENIC MICE.
[5]"Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding."
Hymowitz S.G., Patel D.R., Wallweber H.J., Runyon S., Yan M., Yin J., Shriver S.K., Gordon N.C., Pan B., Skelton N.J., Kelley R.F., Starovasnik M.A.
J. Biol. Chem. 280:7218-7227(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 104-241 IN COMPLEX WITH HUMAN TNFRSF17, DISULFIDE BONDS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF294825 mRNA. Translation: AAG22534.1.
AK009514 mRNA. Translation: BAB26332.1.
BC069900 mRNA. Translation: AAH69900.1.
RefSeqNP_001152977.1. NM_001159505.1.
NP_076006.2. NM_023517.2.
UniGeneMm.8983.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1U5XX-ray1.80A104-241[»]
1U5YX-ray2.30A/B/D104-241[»]
1U5ZX-ray2.40A104-241[»]
1XU1X-ray1.90A/B/D104-241[»]
1XU2X-ray2.35A/B/D104-241[»]
3K48X-ray2.80A/B/D104-241[»]
ProteinModelPortalQ9D777.
SMRQ9D777. Positions 105-241.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9D777. 2 interactions.

PTM databases

PhosphoSiteQ9D777.

Proteomic databases

PRIDEQ9D777.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID69583.
KEGGmmu:69583.
UCSCuc007jrd.1. mouse.

Organism-specific databases

CTD8741.
MGIMGI:1916833. Tnfsf13.

Phylogenomic databases

HOGENOMHOG000036810.
HOVERGENHBG104367.
KOK05475.
PhylomeDBQ9D777.

Gene expression databases

BgeeQ9D777.
GenevestigatorQ9D777.

Family and domain databases

Gene3D2.60.120.40. 1 hit.
InterProIPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamPF00229. TNF. 1 hit.
[Graphical view]
SMARTSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMSSF49842. SSF49842. 1 hit.
PROSITEPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9D777.
NextBio329846.
PROQ9D777.
SOURCESearch...

Entry information

Entry nameTNF13_MOUSE
AccessionPrimary (citable) accession number: Q9D777
Secondary accession number(s): Q9ERP1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot