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Protein

39S ribosomal protein L2, mitochondrial

Gene

Mrpl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-5389840. Mitochondrial translation elongation.
R-MMU-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L2, mitochondrial
Short name:
L2mt
Short name:
MRP-L2
Gene namesi
Name:Mrpl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1351622. Mrpl2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial large ribosomal subunit Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 6060MitochondrionSequence analysisAdd
BLAST
Chaini61 – 30624639S ribosomal protein L2, mitochondrialPRO_0000261641Add
BLAST

Proteomic databases

EPDiQ9D773.
MaxQBiQ9D773.
PaxDbiQ9D773.
PRIDEiQ9D773.

PTM databases

PhosphoSiteiQ9D773.

Expressioni

Gene expression databases

BgeeiQ9D773.
CleanExiMM_MRPL2.
ExpressionAtlasiQ9D773. baseline and differential.
GenevisibleiQ9D773. MM.

Interactioni

Protein-protein interaction databases

BioGridi205205. 1 interaction.
IntActiQ9D773. 1 interaction.
MINTiMINT-4127375.
STRINGi10090.ENSMUSP00000002844.

Structurei

3D structure databases

ProteinModelPortaliQ9D773.
SMRiQ9D773. Positions 61-297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi127 – 1304Poly-Val

Sequence similaritiesi

Belongs to the ribosomal protein L2P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0438. Eukaryota.
COG0090. LUCA.
GeneTreeiENSGT00390000000189.
HOGENOMiHOG000046229.
HOVERGENiHBG057412.
InParanoidiQ9D773.
KOiK02886.
OMAiKWVRDGP.
OrthoDBiEOG7VX8Z8.
PhylomeDBiQ9D773.
TreeFamiTF314647.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
2.40.50.140. 1 hit.
4.10.950.10. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR022666. Rbsml_prot_L2_RNA-bd_dom.
IPR014722. Rib_L2_dom2.
IPR002171. Ribosomal_L2.
IPR005880. Ribosomal_L2_bac/org-type.
IPR022669. Ribosomal_L2_C.
IPR014726. Ribosomal_L2_dom3.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR13691. PTHR13691. 1 hit.
PTHR13691:SF5. PTHR13691:SF5. 1 hit.
PfamiPF00181. Ribosomal_L2. 1 hit.
PF03947. Ribosomal_L2_C. 1 hit.
[Graphical view]
SMARTiSM01383. Ribosomal_L2. 1 hit.
SM01382. Ribosomal_L2_C. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D773-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALCALTSAL RSLSLASAAI TARVPTLLPA AQIQSNVLLQ LPPALVSPSY
60 70 80 90 100
RPVHMSADRS AKFVSWKSRT KYTVKPVKMR KSGGRDHTGR IRVHGIGGGH
110 120 130 140 150
KQNYRMIDFL RFRPEKEKAP EPFEEKVVVV RYDPCRSADI ALVAGGSRKR
160 170 180 190 200
WIIATENMKA GDTILNSNHI GRMAVAAQEG DAHPLGALPV GTLINNVESE
210 220 230 240 250
PGRGAQYIRA AGTCGVLLRK VNGTAIIQLP SKRQMQVLES CTATVGRVSN
260 270 280 290 300
VNHNQRVIGK AGRNRWLGKR PNSGLWQRKG GWAGRKIRPL PPMKSYVKLP

SAAAQN
Length:306
Mass (Da):33,341
Last modified:June 1, 2001 - v1
Checksum:iF18049E789E2FB87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009521 mRNA. Translation: BAB26336.1.
BC027762 mRNA. Translation: AAH27762.1.
CCDSiCCDS37638.1.
RefSeqiNP_001303671.1. NM_001316742.1.
NP_079578.1. NM_025302.4.
UniGeneiMm.391007.

Genome annotation databases

EnsembliENSMUST00000002844; ENSMUSP00000002844; ENSMUSG00000002767.
GeneIDi27398.
KEGGimmu:27398.
UCSCiuc008ctm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009521 mRNA. Translation: BAB26336.1.
BC027762 mRNA. Translation: AAH27762.1.
CCDSiCCDS37638.1.
RefSeqiNP_001303671.1. NM_001316742.1.
NP_079578.1. NM_025302.4.
UniGeneiMm.391007.

3D structure databases

ProteinModelPortaliQ9D773.
SMRiQ9D773. Positions 61-297.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205205. 1 interaction.
IntActiQ9D773. 1 interaction.
MINTiMINT-4127375.
STRINGi10090.ENSMUSP00000002844.

PTM databases

PhosphoSiteiQ9D773.

Proteomic databases

EPDiQ9D773.
MaxQBiQ9D773.
PaxDbiQ9D773.
PRIDEiQ9D773.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002844; ENSMUSP00000002844; ENSMUSG00000002767.
GeneIDi27398.
KEGGimmu:27398.
UCSCiuc008ctm.1. mouse.

Organism-specific databases

CTDi51069.
MGIiMGI:1351622. Mrpl2.

Phylogenomic databases

eggNOGiKOG0438. Eukaryota.
COG0090. LUCA.
GeneTreeiENSGT00390000000189.
HOGENOMiHOG000046229.
HOVERGENiHBG057412.
InParanoidiQ9D773.
KOiK02886.
OMAiKWVRDGP.
OrthoDBiEOG7VX8Z8.
PhylomeDBiQ9D773.
TreeFamiTF314647.

Enzyme and pathway databases

ReactomeiR-MMU-5389840. Mitochondrial translation elongation.
R-MMU-5419276. Mitochondrial translation termination.

Miscellaneous databases

NextBioi305380.
PROiQ9D773.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D773.
CleanExiMM_MRPL2.
ExpressionAtlasiQ9D773. baseline and differential.
GenevisibleiQ9D773. MM.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
2.40.50.140. 1 hit.
4.10.950.10. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR022666. Rbsml_prot_L2_RNA-bd_dom.
IPR014722. Rib_L2_dom2.
IPR002171. Ribosomal_L2.
IPR005880. Ribosomal_L2_bac/org-type.
IPR022669. Ribosomal_L2_C.
IPR014726. Ribosomal_L2_dom3.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR13691. PTHR13691. 1 hit.
PTHR13691:SF5. PTHR13691:SF5. 1 hit.
PfamiPF00181. Ribosomal_L2. 1 hit.
PF03947. Ribosomal_L2_C. 1 hit.
[Graphical view]
SMARTiSM01383. Ribosomal_L2. 1 hit.
SM01382. Ribosomal_L2_C. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Tongue.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung and Spleen.

Entry informationi

Entry nameiRM02_MOUSE
AccessioniPrimary (citable) accession number: Q9D773
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.