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Protein

Ankyrin repeat and SOCS box protein 12

Gene

Asb12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 12
Short name:
ASB-12
Gene namesi
Name:Asb12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1917642. Asb12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Ankyrin repeat and SOCS box protein 12PRO_0000066948Add
BLAST

Proteomic databases

PaxDbiQ9D738.
PRIDEiQ9D738.

Expressioni

Gene expression databases

BgeeiQ9D738.
CleanExiMM_ASB12.
ExpressionAtlasiQ9D738. baseline and differential.
GenevisibleiQ9D738. MM.

Interactioni

Subunit structurei

Interacts with CUL5 and RNF7.By similarity

Protein-protein interaction databases

BioGridi214021. 3 interactions.
STRINGi10090.ENSMUSP00000033549.

Structurei

3D structure databases

ProteinModelPortaliQ9D738.
SMRiQ9D738. Positions 26-307.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati63 – 9230ANK 1Add
BLAST
Repeati96 – 12530ANK 2Add
BLAST
Repeati129 – 15830ANK 3Add
BLAST
Repeati171 – 20030ANK 4Add
BLAST
Repeati213 – 24331ANK 5Add
BLAST
Domaini268 – 30841SOCS boxAdd
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated
Contains 5 ANK repeats.PROSITE-ProRule annotation
Contains 1 SOCS box domain.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00730000110500.
HOGENOMiHOG000034084.
HOVERGENiHBG107089.
InParanoidiQ9D738.
KOiK10334.
OMAiEVCLRYG.
OrthoDBiEOG7TXKGW.
PhylomeDBiQ9D738.
TreeFamiTF331945.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 5 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D738-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLMDIAKIF SLLQPEKEEE DTGTGEKQAL NQAVYDNDSC TLDHLLHQER
60 70 80 90 100
YKRFINSRSG WGIPGTPLRL AASYGHLNCV KVLLEHGADV DSLDVKAQTP
110 120 130 140 150
LFTAVSHGHL ECVRMLLEAG ACPSGSIYNN CSPVLTASRD GAFAILQELL
160 170 180 190 200
GHGAEANVKA KLPVWASNIA SCSGPLYLAA VYGHLDCFRL LLLYGADPDY
210 220 230 240 250
NCTDQGLLSR VPQPRTLLEI CLHHNCEPEY IQLLIDFGAN IYLPSLPVDP
260 270 280 290 300
TSQDDKGIKL LLQARATPRS LLSQTRLVIR RSLCRANQSQ ATDQLDIPPV

LISYLKHQ
Length:308
Mass (Da):33,912
Last modified:June 1, 2001 - v1
Checksum:i49824EE6616DB961
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009644 mRNA. Translation: BAB26410.1.
AF403040 mRNA. Translation: AAL57359.1.
CCDSiCCDS30283.1.
RefSeqiNP_001300672.1. NM_001313743.1.
NP_543134.1. NM_080858.3.
XP_011245976.1. XM_011247674.1.
XP_011245977.1. XM_011247675.1.
UniGeneiMm.79122.

Genome annotation databases

EnsembliENSMUST00000033549; ENSMUSP00000033549; ENSMUSG00000031204.
GeneIDi70392.
KEGGimmu:70392.
UCSCiuc009tty.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009644 mRNA. Translation: BAB26410.1.
AF403040 mRNA. Translation: AAL57359.1.
CCDSiCCDS30283.1.
RefSeqiNP_001300672.1. NM_001313743.1.
NP_543134.1. NM_080858.3.
XP_011245976.1. XM_011247674.1.
XP_011245977.1. XM_011247675.1.
UniGeneiMm.79122.

3D structure databases

ProteinModelPortaliQ9D738.
SMRiQ9D738. Positions 26-307.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214021. 3 interactions.
STRINGi10090.ENSMUSP00000033549.

Proteomic databases

PaxDbiQ9D738.
PRIDEiQ9D738.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033549; ENSMUSP00000033549; ENSMUSG00000031204.
GeneIDi70392.
KEGGimmu:70392.
UCSCiuc009tty.1. mouse.

Organism-specific databases

CTDi142689.
MGIiMGI:1917642. Asb12.

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00730000110500.
HOGENOMiHOG000034084.
HOVERGENiHBG107089.
InParanoidiQ9D738.
KOiK10334.
OMAiEVCLRYG.
OrthoDBiEOG7TXKGW.
PhylomeDBiQ9D738.
TreeFamiTF331945.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ9D738.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D738.
CleanExiMM_ASB12.
ExpressionAtlasiQ9D738. baseline and differential.
GenevisibleiQ9D738. MM.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 5 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "SOCS box proteins."
    Kile B.T., Nicola N.A.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Tongue.

Entry informationi

Entry nameiASB12_MOUSE
AccessioniPrimary (citable) accession number: Q9D738
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.