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Q9D6Y9

- GLGB_MOUSE

UniProt

Q9D6Y9 - GLGB_MOUSE

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Protein
1,4-alpha-glucan-branching enzyme
Gene
Gbe1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Required for sufficient glycogen accumulation. The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule and, consequently, in reducing the osmotic pressure within cells By similarity.

Catalytic activityi

Transfers a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei357 – 3571Nucleophile By similarity
Active sitei412 – 4121Proton donor By similarity

GO - Molecular functioni

  1. 1,4-alpha-glucan branching enzyme activity Source: UniProtKB-EC
  2. cation binding Source: InterPro
  3. hydrolase activity, hydrolyzing O-glycosyl compounds Source: InterPro

GO - Biological processi

  1. glycogen biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Glycogen biosynthesis

Enzyme and pathway databases

ReactomeiREACT_188939. Glycogen synthesis.
UniPathwayiUPA00164.

Protein family/group databases

CAZyiCBM48. Carbohydrate-Binding Module Family 48.
GH13. Glycoside Hydrolase Family 13.

Names & Taxonomyi

Protein namesi
Recommended name:
1,4-alpha-glucan-branching enzyme (EC:2.4.1.18)
Alternative name(s):
Brancher enzyme
Glycogen-branching enzyme
Gene namesi
Name:Gbe1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1921435. Gbe1.

Pathology & Biotechi

Keywords - Diseasei

Glycogen storage disease

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 7027011,4-alpha-glucan-branching enzyme
PRO_0000188776Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei173 – 1731Phosphotyrosine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9D6Y9.
PaxDbiQ9D6Y9.
PRIDEiQ9D6Y9.

PTM databases

PhosphoSiteiQ9D6Y9.

Expressioni

Gene expression databases

BgeeiQ9D6Y9.
CleanExiMM_GBE1.
GenevestigatoriQ9D6Y9.

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

IntActiQ9D6Y9. 1 interaction.
MINTiMINT-4127309.

Structurei

3D structure databases

ProteinModelPortaliQ9D6Y9.
SMRiQ9D6Y9. Positions 44-699.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0296.
GeneTreeiENSGT00390000017040.
HOGENOMiHOG000175159.
HOVERGENiHBG051734.
InParanoidiQ9D6Y9.
KOiK00700.
OMAiGPRGTHD.
OrthoDBiEOG7Q5HCP.
PhylomeDBiQ9D6Y9.
TreeFamiTF300783.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR006048. A-amylase_b_C.
IPR006407. GlgB.
IPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR004193. Glyco_hydro_13_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 1 hit.
PfamiPF00128. Alpha-amylase. 1 hit.
PF02806. Alpha-amylase_C. 1 hit.
PF02922. CBM_48. 1 hit.
[Graphical view]
PIRSFiPIRSF000463. GlgB. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D6Y9-1 [UniParc]FASTAAdd to Basket

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MAAPAAPAAG ETGPDARLEA ALADVPELAR LLEIDPYLKP FAADFQRRYK    50
KFSQVLHDIG ENEGGIDKFS RGYESFGIHR CSDGGIYCKE WAPGAEGVFL 100
TGEFSGWNPF SHPYKKLEYG KWELYIPPKQ NKSPLIPHGS KLKVVITSKS 150
GEILYRISPW AKYVVRENNN VNYDWIHWAP EDPYKFKHSR PKKPRSLRIY 200
ESHVGISSHE GKIASYKHFT SNVLPRIKDL GYNCIQLMAI MEHAYYASFG 250
YQITSFFAAS SRYGTPEELK ELVDTAHSMG IVVLLDVVHS HASKNSEDGL 300
NMFDGTDSCY FHSGPRGTHD LWDSRLFIYS SWEVLRFLLS NIRWWLEEYC 350
FDGFRFDGVT SMLYHHHGMG QGFSGDYNEY FGLQVDEDAL IYLMLANHLA 400
HTLYPDSITI AEDVSGMPAL CSPTSQGGGG FDYRLAMAIP DKWIQLLKEF 450
KDEDWNMGNI VYTLTNRRYL EKCVAYAESH DQALVGDKTL AFWLMDAEMY 500
TNMSVLAPFT PVIDRGIQLH KMIRLITHGL GGEGYLNFMG NEFGHPEWLD 550
FPRKGNNESY HYARRQFNLT DDDLLRYKFL NNFDRDMNRL EERCGWLSAP 600
QAYVSEKHEA NKTITFERAG LLFIFNFHPS KSYTDYRVGT ATPGKFKIVL 650
DSDAAEYGGH QRLDHNTNYF AEAFEHNGRP YSLLVYIPSR VALILQNVDL 700
QN 702
Length:702
Mass (Da):80,364
Last modified:June 1, 2001 - v1
Checksum:iBE2284A5CED7C060
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK009815 mRNA. Translation: BAB26519.1.
AK050365 mRNA. Translation: BAC34210.1.
BC017541 mRNA. Translation: AAH17541.1.
RefSeqiNP_083079.1. NM_028803.4.
UniGeneiMm.396102.

Genome annotation databases

EnsembliENSMUST00000163832; ENSMUSP00000132603; ENSMUSG00000022707.
GeneIDi74185.
KEGGimmu:74185.
UCSCiuc007zqu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK009815 mRNA. Translation: BAB26519.1 .
AK050365 mRNA. Translation: BAC34210.1 .
BC017541 mRNA. Translation: AAH17541.1 .
RefSeqi NP_083079.1. NM_028803.4.
UniGenei Mm.396102.

3D structure databases

ProteinModelPortali Q9D6Y9.
SMRi Q9D6Y9. Positions 44-699.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9D6Y9. 1 interaction.
MINTi MINT-4127309.

Protein family/group databases

CAZyi CBM48. Carbohydrate-Binding Module Family 48.
GH13. Glycoside Hydrolase Family 13.

PTM databases

PhosphoSitei Q9D6Y9.

Proteomic databases

MaxQBi Q9D6Y9.
PaxDbi Q9D6Y9.
PRIDEi Q9D6Y9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000163832 ; ENSMUSP00000132603 ; ENSMUSG00000022707 .
GeneIDi 74185.
KEGGi mmu:74185.
UCSCi uc007zqu.1. mouse.

Organism-specific databases

CTDi 2632.
MGIi MGI:1921435. Gbe1.

Phylogenomic databases

eggNOGi COG0296.
GeneTreei ENSGT00390000017040.
HOGENOMi HOG000175159.
HOVERGENi HBG051734.
InParanoidi Q9D6Y9.
KOi K00700.
OMAi GPRGTHD.
OrthoDBi EOG7Q5HCP.
PhylomeDBi Q9D6Y9.
TreeFami TF300783.

Enzyme and pathway databases

UniPathwayi UPA00164 .
Reactomei REACT_188939. Glycogen synthesis.

Miscellaneous databases

NextBioi 340028.
PROi Q9D6Y9.
SOURCEi Search...

Gene expression databases

Bgeei Q9D6Y9.
CleanExi MM_GBE1.
Genevestigatori Q9D6Y9.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR006048. A-amylase_b_C.
IPR006407. GlgB.
IPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR004193. Glyco_hydro_13_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view ]
PANTHERi PTHR10357. PTHR10357. 1 hit.
Pfami PF00128. Alpha-amylase. 1 hit.
PF02806. Alpha-amylase_C. 1 hit.
PF02922. CBM_48. 1 hit.
[Graphical view ]
PIRSFi PIRSF000463. GlgB. 1 hit.
SUPFAMi SSF51445. SSF51445. 1 hit.
SSF81296. SSF81296. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Liver and Tongue.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiGLGB_MOUSE
AccessioniPrimary (citable) accession number: Q9D6Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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