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Protein

Mitochondrial peptide methionine sulfoxide reductase

Gene

Msra

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).By similarity

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.

GO - Molecular functioni

  • peptide-methionine (S)-S-oxide reductase activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BRENDAi1.8.4.11. 3474.
ReactomeiR-MMU-5676934. Protein repair.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial peptide methionine sulfoxide reductase (EC:1.8.4.11)
Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name:
Peptide Met(O) reductase
Protein-methionine-S-oxide reductase
Short name:
PMSR
Gene namesi
Name:Msra
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:106916. Msra.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: MGI
  • cytoplasm Source: MGI
  • extracellular exosome Source: MGI
  • membrane Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
  • nucleoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2020MitochondrionBy similarityAdd
BLAST
Chaini21 – 233213Mitochondrial peptide methionine sulfoxide reductasePRO_0000138627Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei104 – 1041N6-acetyllysine; alternateCombined sources
Modified residuei104 – 1041N6-succinyllysine; alternateCombined sources
Modified residuei183 – 1831N6-acetyllysine; alternateCombined sources
Modified residuei183 – 1831N6-succinyllysine; alternateCombined sources
Isoform 2 (identifier: Q9D6Y7-2)
Lipidationi2 – 21N-myristoyl glycine

Keywords - PTMi

Acetylation, Lipoprotein, Myristate

Proteomic databases

MaxQBiQ9D6Y7.
PaxDbiQ9D6Y7.
PeptideAtlasiQ9D6Y7.
PRIDEiQ9D6Y7.

PTM databases

iPTMnetiQ9D6Y7.
PhosphoSiteiQ9D6Y7.
SwissPalmiQ9D6Y7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000054733.
CleanExiMM_MSRA.
GenevisibleiQ9D6Y7. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9D6Y7. 4 interactions.
MINTiMINT-1854772.
STRINGi10090.ENSMUSP00000065754.

Structurei

Secondary structure

1
233
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi24 – 263Combined sources
Turni31 – 333Combined sources
Turni49 – 513Combined sources
Beta strandi55 – 584Combined sources
Beta strandi64 – 696Combined sources
Helixi73 – 819Combined sources
Beta strandi83 – 9513Combined sources
Helixi103 – 1064Combined sources
Beta strandi114 – 1218Combined sources
Turni123 – 1253Combined sources
Helixi128 – 13710Combined sources
Beta strandi144 – 1474Combined sources
Beta strandi150 – 1523Combined sources
Beta strandi158 – 1603Combined sources
Helixi164 – 18219Combined sources
Turni183 – 1853Combined sources
Helixi204 – 2063Combined sources
Helixi209 – 2124Combined sources
Turni228 – 2303Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2L90NMR-A22-233[»]
ProteinModelPortaliQ9D6Y7.
SMRiQ9D6Y7. Positions 22-232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1635. Eukaryota.
COG0225. LUCA.
GeneTreeiENSGT00390000003823.
HOGENOMiHOG000263862.
HOVERGENiHBG006401.
InParanoidiQ9D6Y7.
KOiK07304.
OMAiMVLRSEI.
OrthoDBiEOG091G0MD8.
PhylomeDBiQ9D6Y7.
TreeFamiTF353884.

Family and domain databases

Gene3Di3.30.1060.10. 1 hit.
HAMAPiMF_01401. MsrA. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMiSSF55068. SSF55068. 1 hit.
TIGRFAMsiTIGR00401. msrA. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

Note: Only about 25% of mRNAs are initiated at the mitochondrial isoform 1 codon. According to PubMed:15924425, differential subcellular targeting is not due alternative initiation.1 Publication
Isoform 1 (identifier: Q9D6Y7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSASRRALQ LLSSANPVRR MGDSASKVIS AEEALPGRTE PIPVTAKHHV
60 70 80 90 100
SGNRTVEPFP EGTQMAVFGM GCFWGAERKF WVLKGVYSTQ VGFAGGHTRN
110 120 130 140 150
PTYKEVCSEK TGHAEVVRVV YRPEHISFEE LLKVFWENHD PTQGMRQGND
160 170 180 190 200
FGTQYRSAVY PTSAVQMEAA LRSKEEYQKV LSKHNFGPIT TDIREGQVFY
210 220 230
YAEDYHQQYL SKNPDGYCGL GGTGVSCPMA IKK
Note: Mitochondrial.
Length:233
Mass (Da):25,988
Last modified:June 1, 2001 - v1
Checksum:iB16EFE01BE751242
GO
Isoform 2 (identifier: Q9D6Y7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.

Note: Cytoplasmic. Produced by alternative initiation.
Show »
Length:213
Mass (Da):23,780
Checksum:i016CA48DFF31A154
GO
Isoform 3 (identifier: Q9D6Y7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-108: Missing.

Show »
Length:193
Mass (Da):21,550
Checksum:iBF6451CEEF2B8C7E
GO
Isoform 4 (identifier: Q9D6Y7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: MLSASRRALQLLSSANPVRRMGDSASKVISAEEALPGRTEPIPVT → MSK

Show »
Length:191
Mass (Da):21,588
Checksum:i05A91F2966016833
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201R → G in BAB22035 (PubMed:16141072).Curated
Sequence conflicti156 – 1561R → P in AK018338 (PubMed:16141072).Curated
Sequence conflicti187 – 1871G → V in BAB22035 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4545MLSAS…PIPVT → MSK in isoform 4. 1 PublicationVSP_041408Add
BLAST
Alternative sequencei1 – 2020Missing in isoform 2. CuratedVSP_042133Add
BLAST
Alternative sequencei69 – 10840Missing in isoform 3. 1 PublicationVSP_041409Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002356 mRNA. Translation: BAB22035.1.
AK009822 mRNA. Translation: BAB26522.1.
AK049714 mRNA. Translation: BAC33889.1.
AK018338 mRNA. No translation available.
CH466535 Genomic DNA. Translation: EDL36048.1.
BC014738 mRNA. Translation: AAH14738.1.
BC089311 mRNA. Translation: AAH89311.1.
CCDSiCCDS27209.1. [Q9D6Y7-1]
RefSeqiNP_001240641.1. NM_001253712.1. [Q9D6Y7-1]
NP_001240643.1. NM_001253714.1.
NP_001240644.1. NM_001253715.1. [Q9D6Y7-3]
NP_001240645.1. NM_001253716.1. [Q9D6Y7-4]
NP_080598.2. NM_026322.4. [Q9D6Y7-1]
UniGeneiMm.26713.

Genome annotation databases

EnsembliENSMUST00000067927; ENSMUSP00000065754; ENSMUSG00000054733. [Q9D6Y7-1]
GeneIDi110265.
KEGGimmu:110265.
UCSCiuc007uig.2. mouse. [Q9D6Y7-4]
uc007uih.2. mouse. [Q9D6Y7-3]
uc007uii.2. mouse. [Q9D6Y7-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002356 mRNA. Translation: BAB22035.1.
AK009822 mRNA. Translation: BAB26522.1.
AK049714 mRNA. Translation: BAC33889.1.
AK018338 mRNA. No translation available.
CH466535 Genomic DNA. Translation: EDL36048.1.
BC014738 mRNA. Translation: AAH14738.1.
BC089311 mRNA. Translation: AAH89311.1.
CCDSiCCDS27209.1. [Q9D6Y7-1]
RefSeqiNP_001240641.1. NM_001253712.1. [Q9D6Y7-1]
NP_001240643.1. NM_001253714.1.
NP_001240644.1. NM_001253715.1. [Q9D6Y7-3]
NP_001240645.1. NM_001253716.1. [Q9D6Y7-4]
NP_080598.2. NM_026322.4. [Q9D6Y7-1]
UniGeneiMm.26713.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2L90NMR-A22-233[»]
ProteinModelPortaliQ9D6Y7.
SMRiQ9D6Y7. Positions 22-232.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D6Y7. 4 interactions.
MINTiMINT-1854772.
STRINGi10090.ENSMUSP00000065754.

PTM databases

iPTMnetiQ9D6Y7.
PhosphoSiteiQ9D6Y7.
SwissPalmiQ9D6Y7.

Proteomic databases

MaxQBiQ9D6Y7.
PaxDbiQ9D6Y7.
PeptideAtlasiQ9D6Y7.
PRIDEiQ9D6Y7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067927; ENSMUSP00000065754; ENSMUSG00000054733. [Q9D6Y7-1]
GeneIDi110265.
KEGGimmu:110265.
UCSCiuc007uig.2. mouse. [Q9D6Y7-4]
uc007uih.2. mouse. [Q9D6Y7-3]
uc007uii.2. mouse. [Q9D6Y7-1]

Organism-specific databases

CTDi4482.
MGIiMGI:106916. Msra.

Phylogenomic databases

eggNOGiKOG1635. Eukaryota.
COG0225. LUCA.
GeneTreeiENSGT00390000003823.
HOGENOMiHOG000263862.
HOVERGENiHBG006401.
InParanoidiQ9D6Y7.
KOiK07304.
OMAiMVLRSEI.
OrthoDBiEOG091G0MD8.
PhylomeDBiQ9D6Y7.
TreeFamiTF353884.

Enzyme and pathway databases

BRENDAi1.8.4.11. 3474.
ReactomeiR-MMU-5676934. Protein repair.

Miscellaneous databases

ChiTaRSiMsra. mouse.
PROiQ9D6Y7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054733.
CleanExiMM_MSRA.
GenevisibleiQ9D6Y7. MM.

Family and domain databases

Gene3Di3.30.1060.10. 1 hit.
HAMAPiMF_01401. MsrA. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMiSSF55068. SSF55068. 1 hit.
TIGRFAMsiTIGR00401. msrA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMSRA_MOUSE
AccessioniPrimary (citable) accession number: Q9D6Y7
Secondary accession number(s): Q5EBQ7, Q91WK9, Q9DCY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.