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Q9D6X5 (S52A3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 52, riboflavin transporter, member 3
Alternative name(s):
Riboflavin transporter 2
Short name=RFT2
Gene names
Name:Slc52a3
Synonyms:Rft2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length460 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Riboflavin transporter. Riboflavin transport is Na+-independent but moderately pH-sensitive. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin, flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), and to a lesser extent by amiloride By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the riboflavin transporter family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9D6X5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9D6X5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     187-250: GNLSPSLPSP...GSIEDLLHSQ → VAVIPGGAHS...CQGDAGCDLA
     251-460: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 460460Solute carrier family 52, riboflavin transporter, member 3
PRO_0000042637

Regions

Transmembrane7 – 2721Helical; Potential
Transmembrane38 – 5821Helical; Potential
Transmembrane72 – 9221Helical; Potential
Transmembrane106 – 12621Helical; Potential
Transmembrane138 – 15821Helical; Potential
Transmembrane212 – 23221Helical; Potential
Transmembrane292 – 31221Helical; Potential
Transmembrane327 – 34721Helical; Potential
Transmembrane351 – 37121Helical; Potential
Transmembrane388 – 40821Helical; Potential
Transmembrane419 – 43921Helical; Potential

Amino acid modifications

Glycosylation941N-linked (GlcNAc...) Potential
Glycosylation1681N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence187 – 25064GNLSP…LLHSQ → VAVIPGGAHSVGDRLWGLQY GHGCYEPLPCPAGSLGWRSP YRALLGAVCSLSQLCQGDAG CDLA in isoform 2.
VSP_003816
Alternative sequence251 – 460210Missing in isoform 2.
VSP_003817

Experimental info

Sequence conflict811V → L in BAE41605. Ref.1
Sequence conflict1821T → N in BAB26542. Ref.1
Sequence conflict1951S → P in BAE41605. Ref.1
Sequence conflict2231G → C in BAB26542. Ref.1
Sequence conflict2861L → I in BAE41605. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 5, 2010. Version 3.
Checksum: 7F299163AD3C884E

FASTA46049,559
        10         20         30         40         50         60 
MAFLTHLLVC VFGMGSWVAI NGLWVELPLL VTELPEAWYL PSYLTVVIQL ANIGPLLVTL 

        70         80         90        100        110        120 
MHRFRPGCLS EVPVIFLILC VGTAACILLA FLWNVTSWIQ GGQHSVAFIV LTFFLALVDC 

       130        140        150        160        170        180 
TSSVTFLPFM SQLPTYYLTT FFIGEGLSGL LPALVALVQG SGITTCVNVT ETPGTTLNTM 

       190        200        210        220        230        240 
ETPITQGNLS PSLPSPSWHQ ESRYLAPRFS PLLFFLLLSF LTGCCLVAFF LLQRQPWGRQ 

       250        260        270        280        290        300 
GSIEDLLHSQ VTLHSIRPRD TEDTSSLGAP VSSPGKGSVE ASVASLRPAQ LAFIYSVVAF 

       310        320        330        340        350        360 
VNALTNGVLP SVQTYSCLPY GPVAYHLSAT LSSVASPLAC FLPIFLPNRS LLFLGVLTVL 

       370        380        390        400        410        420 
GTGFGAYNMA MAAMSPCPVL QGHWGGEVLI VLSWVLFAAC LSYVKVMLGV ILRDRSRSAL 

       430        440        450        460 
LWCGAAVQLG SLIGALLMFP LVNVLKLFSS ADYCSLDCSV 

« Hide

Isoform 2 [UniParc].

Checksum: A10C6C43BBEF31C4
Show »

FASTA25026,770

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J and NOD.
Tissue: Skin and Tongue.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Salivary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK009850 mRNA. Translation: BAB26542.1.
AK029091 mRNA. Translation: BAC26290.1.
AK154970 mRNA. Translation: BAE32962.1.
AK170158 mRNA. Translation: BAE41605.1.
AL845161 Genomic DNA. Translation: CAM17705.1.
AL845161 Genomic DNA. Translation: CAM17704.1.
CH466551 Genomic DNA. Translation: EDL05945.1.
BC016127 mRNA. Translation: AAH16127.1.
RefSeqNP_001158291.1. NM_001164819.1.
NP_001158292.1. NM_001164820.1.
NP_081448.2. NM_027172.3.
UniGeneMm.258262.

3D structure databases

ProteinModelPortalQ9D6X5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9D6X5. 1 interaction.
MINTMINT-218754.
STRING10090.ENSMUSP00000072961.

PTM databases

PhosphoSiteQ9D6X5.

Proteomic databases

PaxDbQ9D6X5.
PRIDEQ9D6X5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000073228; ENSMUSP00000072961; ENSMUSG00000027463. [Q9D6X5-1]
ENSMUST00000109858; ENSMUSP00000105484; ENSMUSG00000027463. [Q9D6X5-2]
ENSMUST00000109859; ENSMUSP00000105485; ENSMUSG00000027463. [Q9D6X5-2]
ENSMUST00000109861; ENSMUSP00000105487; ENSMUSG00000027463. [Q9D6X5-1]
GeneID69698.
KEGGmmu:69698.
UCSCuc008neu.2. mouse. [Q9D6X5-1]
uc012cga.1. mouse. [Q9D6X5-2]

Organism-specific databases

CTD113278.
MGIMGI:1916948. Slc52a3.

Phylogenomic databases

eggNOGNOG326568.
GeneTreeENSGT00390000003774.
HOGENOMHOG000247012.
HOVERGENHBG051170.
InParanoidQ3U328.
KOK14620.
OMAWVLDGHH.
OrthoDBEOG7XDBFX.
PhylomeDBQ9D6X5.
TreeFamTF314820.

Gene expression databases

BgeeQ9D6X5.
CleanExMM_2310046K01RIK.
GenevestigatorQ9D6X5.

Family and domain databases

InterProIPR009357. Endogenous_retrovirus_rcpt.
[Graphical view]
PANTHERPTHR12929. PTHR12929. 1 hit.
PfamPF06237. DUF1011. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio330112.
PROQ9D6X5.
SOURCESearch...

Entry information

Entry nameS52A3_MOUSE
AccessionPrimary (citable) accession number: Q9D6X5
Secondary accession number(s): A2AQU3 expand/collapse secondary AC list , Q3TDJ6, Q3U328, Q8CE36, Q91WB9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: October 5, 2010
Last modified: April 16, 2014
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot