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Q9D6X5

- S52A3_MOUSE

UniProt

Q9D6X5 - S52A3_MOUSE

Protein

Solute carrier family 52, riboflavin transporter, member 3

Gene

Slc52a3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 3 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    Riboflavin transporter. Riboflavin transport is Na+-independent but moderately pH-sensitive. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin, flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), and to a lesser extent by amiloride By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. riboflavin transporter activity Source: UniProtKB

    GO - Biological processi

    1. cellular response to heat Source: MGI
    2. riboflavin transport Source: UniProtKB
    3. sensory perception of sound Source: UniProtKB

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    ReactomeiREACT_216155. Vitamin B2 (riboflavin) metabolism.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 52, riboflavin transporter, member 3
    Alternative name(s):
    Riboflavin transporter 2
    Short name:
    RFT2
    Gene namesi
    Name:Slc52a3
    Synonyms:Rft2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1916948. Slc52a3.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 460460Solute carrier family 52, riboflavin transporter, member 3PRO_0000042637Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9D6X5.
    PRIDEiQ9D6X5.

    PTM databases

    PhosphoSiteiQ9D6X5.

    Expressioni

    Gene expression databases

    BgeeiQ9D6X5.
    CleanExiMM_2310046K01RIK.
    GenevestigatoriQ9D6X5.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9D6X5. 1 interaction.
    MINTiMINT-218754.
    STRINGi10090.ENSMUSP00000072961.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D6X5.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei38 – 5821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei72 – 9221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei106 – 12621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei138 – 15821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei212 – 23221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei292 – 31221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei327 – 34721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei351 – 37121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei388 – 40821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei419 – 43921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the riboflavin transporter family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG326568.
    GeneTreeiENSGT00390000003774.
    HOGENOMiHOG000247012.
    HOVERGENiHBG051170.
    InParanoidiQ3U328.
    KOiK14620.
    OMAiWVLDGHH.
    OrthoDBiEOG7XDBFX.
    PhylomeDBiQ9D6X5.
    TreeFamiTF314820.

    Family and domain databases

    InterProiIPR009357. Endogenous_retrovirus_rcpt.
    [Graphical view]
    PANTHERiPTHR12929. PTHR12929. 1 hit.
    PfamiPF06237. DUF1011. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9D6X5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAFLTHLLVC VFGMGSWVAI NGLWVELPLL VTELPEAWYL PSYLTVVIQL    50
    ANIGPLLVTL MHRFRPGCLS EVPVIFLILC VGTAACILLA FLWNVTSWIQ 100
    GGQHSVAFIV LTFFLALVDC TSSVTFLPFM SQLPTYYLTT FFIGEGLSGL 150
    LPALVALVQG SGITTCVNVT ETPGTTLNTM ETPITQGNLS PSLPSPSWHQ 200
    ESRYLAPRFS PLLFFLLLSF LTGCCLVAFF LLQRQPWGRQ GSIEDLLHSQ 250
    VTLHSIRPRD TEDTSSLGAP VSSPGKGSVE ASVASLRPAQ LAFIYSVVAF 300
    VNALTNGVLP SVQTYSCLPY GPVAYHLSAT LSSVASPLAC FLPIFLPNRS 350
    LLFLGVLTVL GTGFGAYNMA MAAMSPCPVL QGHWGGEVLI VLSWVLFAAC 400
    LSYVKVMLGV ILRDRSRSAL LWCGAAVQLG SLIGALLMFP LVNVLKLFSS 450
    ADYCSLDCSV 460
    Length:460
    Mass (Da):49,559
    Last modified:October 5, 2010 - v3
    Checksum:i7F299163AD3C884E
    GO
    Isoform 2 (identifier: Q9D6X5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         187-250: GNLSPSLPSP...GSIEDLLHSQ → VAVIPGGAHS...CQGDAGCDLA
         251-460: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:250
    Mass (Da):26,770
    Checksum:iA10C6C43BBEF31C4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti81 – 811V → L in BAE41605. (PubMed:16141072)Curated
    Sequence conflicti182 – 1821T → N in BAB26542. (PubMed:16141072)Curated
    Sequence conflicti195 – 1951S → P in BAE41605. (PubMed:16141072)Curated
    Sequence conflicti223 – 2231G → C in BAB26542. (PubMed:16141072)Curated
    Sequence conflicti286 – 2861L → I in BAE41605. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei187 – 25064GNLSP…LLHSQ → VAVIPGGAHSVGDRLWGLQY GHGCYEPLPCPAGSLGWRSP YRALLGAVCSLSQLCQGDAG CDLA in isoform 2. 1 PublicationVSP_003816Add
    BLAST
    Alternative sequencei251 – 460210Missing in isoform 2. 1 PublicationVSP_003817Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK009850 mRNA. Translation: BAB26542.1.
    AK029091 mRNA. Translation: BAC26290.1.
    AK154970 mRNA. Translation: BAE32962.1.
    AK170158 mRNA. Translation: BAE41605.1.
    AL845161 Genomic DNA. Translation: CAM17705.1.
    AL845161 Genomic DNA. Translation: CAM17704.1.
    CH466551 Genomic DNA. Translation: EDL05945.1.
    BC016127 mRNA. Translation: AAH16127.1.
    CCDSiCCDS16876.1. [Q9D6X5-1]
    CCDS50749.1. [Q9D6X5-2]
    RefSeqiNP_001158291.1. NM_001164819.1. [Q9D6X5-1]
    NP_001158292.1. NM_001164820.1. [Q9D6X5-2]
    NP_081448.2. NM_027172.3. [Q9D6X5-1]
    UniGeneiMm.258262.

    Genome annotation databases

    EnsembliENSMUST00000073228; ENSMUSP00000072961; ENSMUSG00000027463. [Q9D6X5-1]
    ENSMUST00000109858; ENSMUSP00000105484; ENSMUSG00000027463. [Q9D6X5-2]
    ENSMUST00000109859; ENSMUSP00000105485; ENSMUSG00000027463. [Q9D6X5-2]
    ENSMUST00000109861; ENSMUSP00000105487; ENSMUSG00000027463. [Q9D6X5-1]
    GeneIDi69698.
    KEGGimmu:69698.
    UCSCiuc008neu.2. mouse. [Q9D6X5-1]
    uc012cga.1. mouse. [Q9D6X5-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK009850 mRNA. Translation: BAB26542.1 .
    AK029091 mRNA. Translation: BAC26290.1 .
    AK154970 mRNA. Translation: BAE32962.1 .
    AK170158 mRNA. Translation: BAE41605.1 .
    AL845161 Genomic DNA. Translation: CAM17705.1 .
    AL845161 Genomic DNA. Translation: CAM17704.1 .
    CH466551 Genomic DNA. Translation: EDL05945.1 .
    BC016127 mRNA. Translation: AAH16127.1 .
    CCDSi CCDS16876.1. [Q9D6X5-1 ]
    CCDS50749.1. [Q9D6X5-2 ]
    RefSeqi NP_001158291.1. NM_001164819.1. [Q9D6X5-1 ]
    NP_001158292.1. NM_001164820.1. [Q9D6X5-2 ]
    NP_081448.2. NM_027172.3. [Q9D6X5-1 ]
    UniGenei Mm.258262.

    3D structure databases

    ProteinModelPortali Q9D6X5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9D6X5. 1 interaction.
    MINTi MINT-218754.
    STRINGi 10090.ENSMUSP00000072961.

    PTM databases

    PhosphoSitei Q9D6X5.

    Proteomic databases

    PaxDbi Q9D6X5.
    PRIDEi Q9D6X5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000073228 ; ENSMUSP00000072961 ; ENSMUSG00000027463 . [Q9D6X5-1 ]
    ENSMUST00000109858 ; ENSMUSP00000105484 ; ENSMUSG00000027463 . [Q9D6X5-2 ]
    ENSMUST00000109859 ; ENSMUSP00000105485 ; ENSMUSG00000027463 . [Q9D6X5-2 ]
    ENSMUST00000109861 ; ENSMUSP00000105487 ; ENSMUSG00000027463 . [Q9D6X5-1 ]
    GeneIDi 69698.
    KEGGi mmu:69698.
    UCSCi uc008neu.2. mouse. [Q9D6X5-1 ]
    uc012cga.1. mouse. [Q9D6X5-2 ]

    Organism-specific databases

    CTDi 113278.
    MGIi MGI:1916948. Slc52a3.

    Phylogenomic databases

    eggNOGi NOG326568.
    GeneTreei ENSGT00390000003774.
    HOGENOMi HOG000247012.
    HOVERGENi HBG051170.
    InParanoidi Q3U328.
    KOi K14620.
    OMAi WVLDGHH.
    OrthoDBi EOG7XDBFX.
    PhylomeDBi Q9D6X5.
    TreeFami TF314820.

    Enzyme and pathway databases

    Reactomei REACT_216155. Vitamin B2 (riboflavin) metabolism.

    Miscellaneous databases

    NextBioi 330112.
    PROi Q9D6X5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9D6X5.
    CleanExi MM_2310046K01RIK.
    Genevestigatori Q9D6X5.

    Family and domain databases

    InterProi IPR009357. Endogenous_retrovirus_rcpt.
    [Graphical view ]
    PANTHERi PTHR12929. PTHR12929. 1 hit.
    Pfami PF06237. DUF1011. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J and NOD.
      Tissue: Skin and Tongue.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Salivary gland.

    Entry informationi

    Entry nameiS52A3_MOUSE
    AccessioniPrimary (citable) accession number: Q9D6X5
    Secondary accession number(s): A2AQU3
    , Q3TDJ6, Q3U328, Q8CE36, Q91WB9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2003
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 98 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3