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Q9D6X5

- S52A3_MOUSE

UniProt

Q9D6X5 - S52A3_MOUSE

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Protein

Solute carrier family 52, riboflavin transporter, member 3

Gene
Slc52a3, Rft2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Riboflavin transporter. Riboflavin transport is Na+-independent but moderately pH-sensitive. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin, flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), and to a lesser extent by amiloride By similarity.

GO - Molecular functioni

  1. protein binding Source: MGI
  2. riboflavin transporter activity Source: UniProtKB

GO - Biological processi

  1. cellular response to heat Source: MGI
  2. riboflavin transport Source: UniProtKB
  3. sensory perception of sound Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_216155. Vitamin B2 (riboflavin) metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 52, riboflavin transporter, member 3
Alternative name(s):
Riboflavin transporter 2
Short name:
RFT2
Gene namesi
Name:Slc52a3
Synonyms:Rft2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1916948. Slc52a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721Helical; Reviewed predictionAdd
BLAST
Transmembranei38 – 5821Helical; Reviewed predictionAdd
BLAST
Transmembranei72 – 9221Helical; Reviewed predictionAdd
BLAST
Transmembranei106 – 12621Helical; Reviewed predictionAdd
BLAST
Transmembranei138 – 15821Helical; Reviewed predictionAdd
BLAST
Transmembranei212 – 23221Helical; Reviewed predictionAdd
BLAST
Transmembranei292 – 31221Helical; Reviewed predictionAdd
BLAST
Transmembranei327 – 34721Helical; Reviewed predictionAdd
BLAST
Transmembranei351 – 37121Helical; Reviewed predictionAdd
BLAST
Transmembranei388 – 40821Helical; Reviewed predictionAdd
BLAST
Transmembranei419 – 43921Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 460460Solute carrier family 52, riboflavin transporter, member 3PRO_0000042637Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi94 – 941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi168 – 1681N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9D6X5.
PRIDEiQ9D6X5.

PTM databases

PhosphoSiteiQ9D6X5.

Expressioni

Gene expression databases

BgeeiQ9D6X5.
CleanExiMM_2310046K01RIK.
GenevestigatoriQ9D6X5.

Interactioni

Protein-protein interaction databases

IntActiQ9D6X5. 1 interaction.
MINTiMINT-218754.
STRINGi10090.ENSMUSP00000072961.

Structurei

3D structure databases

ProteinModelPortaliQ9D6X5.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG326568.
GeneTreeiENSGT00390000003774.
HOGENOMiHOG000247012.
HOVERGENiHBG051170.
InParanoidiQ3U328.
KOiK14620.
OMAiWVLDGHH.
OrthoDBiEOG7XDBFX.
PhylomeDBiQ9D6X5.
TreeFamiTF314820.

Family and domain databases

InterProiIPR009357. Endogenous_retrovirus_rcpt.
[Graphical view]
PANTHERiPTHR12929. PTHR12929. 1 hit.
PfamiPF06237. DUF1011. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9D6X5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAFLTHLLVC VFGMGSWVAI NGLWVELPLL VTELPEAWYL PSYLTVVIQL    50
ANIGPLLVTL MHRFRPGCLS EVPVIFLILC VGTAACILLA FLWNVTSWIQ 100
GGQHSVAFIV LTFFLALVDC TSSVTFLPFM SQLPTYYLTT FFIGEGLSGL 150
LPALVALVQG SGITTCVNVT ETPGTTLNTM ETPITQGNLS PSLPSPSWHQ 200
ESRYLAPRFS PLLFFLLLSF LTGCCLVAFF LLQRQPWGRQ GSIEDLLHSQ 250
VTLHSIRPRD TEDTSSLGAP VSSPGKGSVE ASVASLRPAQ LAFIYSVVAF 300
VNALTNGVLP SVQTYSCLPY GPVAYHLSAT LSSVASPLAC FLPIFLPNRS 350
LLFLGVLTVL GTGFGAYNMA MAAMSPCPVL QGHWGGEVLI VLSWVLFAAC 400
LSYVKVMLGV ILRDRSRSAL LWCGAAVQLG SLIGALLMFP LVNVLKLFSS 450
ADYCSLDCSV 460
Length:460
Mass (Da):49,559
Last modified:October 5, 2010 - v3
Checksum:i7F299163AD3C884E
GO
Isoform 2 (identifier: Q9D6X5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     187-250: GNLSPSLPSP...GSIEDLLHSQ → VAVIPGGAHS...CQGDAGCDLA
     251-460: Missing.

Note: No experimental confirmation available.

Show »
Length:250
Mass (Da):26,770
Checksum:iA10C6C43BBEF31C4
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei187 – 25064GNLSP…LLHSQ → VAVIPGGAHSVGDRLWGLQY GHGCYEPLPCPAGSLGWRSP YRALLGAVCSLSQLCQGDAG CDLA in isoform 2. VSP_003816Add
BLAST
Alternative sequencei251 – 460210Missing in isoform 2. VSP_003817Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti81 – 811V → L in BAE41605. 1 Publication
Sequence conflicti182 – 1821T → N in BAB26542. 1 Publication
Sequence conflicti195 – 1951S → P in BAE41605. 1 Publication
Sequence conflicti223 – 2231G → C in BAB26542. 1 Publication
Sequence conflicti286 – 2861L → I in BAE41605. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK009850 mRNA. Translation: BAB26542.1.
AK029091 mRNA. Translation: BAC26290.1.
AK154970 mRNA. Translation: BAE32962.1.
AK170158 mRNA. Translation: BAE41605.1.
AL845161 Genomic DNA. Translation: CAM17705.1.
AL845161 Genomic DNA. Translation: CAM17704.1.
CH466551 Genomic DNA. Translation: EDL05945.1.
BC016127 mRNA. Translation: AAH16127.1.
CCDSiCCDS16876.1. [Q9D6X5-1]
CCDS50749.1. [Q9D6X5-2]
RefSeqiNP_001158291.1. NM_001164819.1. [Q9D6X5-1]
NP_001158292.1. NM_001164820.1. [Q9D6X5-2]
NP_081448.2. NM_027172.3. [Q9D6X5-1]
UniGeneiMm.258262.

Genome annotation databases

EnsembliENSMUST00000073228; ENSMUSP00000072961; ENSMUSG00000027463. [Q9D6X5-1]
ENSMUST00000109858; ENSMUSP00000105484; ENSMUSG00000027463. [Q9D6X5-2]
ENSMUST00000109859; ENSMUSP00000105485; ENSMUSG00000027463. [Q9D6X5-2]
ENSMUST00000109861; ENSMUSP00000105487; ENSMUSG00000027463. [Q9D6X5-1]
GeneIDi69698.
KEGGimmu:69698.
UCSCiuc008neu.2. mouse. [Q9D6X5-1]
uc012cga.1. mouse. [Q9D6X5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK009850 mRNA. Translation: BAB26542.1 .
AK029091 mRNA. Translation: BAC26290.1 .
AK154970 mRNA. Translation: BAE32962.1 .
AK170158 mRNA. Translation: BAE41605.1 .
AL845161 Genomic DNA. Translation: CAM17705.1 .
AL845161 Genomic DNA. Translation: CAM17704.1 .
CH466551 Genomic DNA. Translation: EDL05945.1 .
BC016127 mRNA. Translation: AAH16127.1 .
CCDSi CCDS16876.1. [Q9D6X5-1 ]
CCDS50749.1. [Q9D6X5-2 ]
RefSeqi NP_001158291.1. NM_001164819.1. [Q9D6X5-1 ]
NP_001158292.1. NM_001164820.1. [Q9D6X5-2 ]
NP_081448.2. NM_027172.3. [Q9D6X5-1 ]
UniGenei Mm.258262.

3D structure databases

ProteinModelPortali Q9D6X5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9D6X5. 1 interaction.
MINTi MINT-218754.
STRINGi 10090.ENSMUSP00000072961.

PTM databases

PhosphoSitei Q9D6X5.

Proteomic databases

PaxDbi Q9D6X5.
PRIDEi Q9D6X5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000073228 ; ENSMUSP00000072961 ; ENSMUSG00000027463 . [Q9D6X5-1 ]
ENSMUST00000109858 ; ENSMUSP00000105484 ; ENSMUSG00000027463 . [Q9D6X5-2 ]
ENSMUST00000109859 ; ENSMUSP00000105485 ; ENSMUSG00000027463 . [Q9D6X5-2 ]
ENSMUST00000109861 ; ENSMUSP00000105487 ; ENSMUSG00000027463 . [Q9D6X5-1 ]
GeneIDi 69698.
KEGGi mmu:69698.
UCSCi uc008neu.2. mouse. [Q9D6X5-1 ]
uc012cga.1. mouse. [Q9D6X5-2 ]

Organism-specific databases

CTDi 113278.
MGIi MGI:1916948. Slc52a3.

Phylogenomic databases

eggNOGi NOG326568.
GeneTreei ENSGT00390000003774.
HOGENOMi HOG000247012.
HOVERGENi HBG051170.
InParanoidi Q3U328.
KOi K14620.
OMAi WVLDGHH.
OrthoDBi EOG7XDBFX.
PhylomeDBi Q9D6X5.
TreeFami TF314820.

Enzyme and pathway databases

Reactomei REACT_216155. Vitamin B2 (riboflavin) metabolism.

Miscellaneous databases

NextBioi 330112.
PROi Q9D6X5.
SOURCEi Search...

Gene expression databases

Bgeei Q9D6X5.
CleanExi MM_2310046K01RIK.
Genevestigatori Q9D6X5.

Family and domain databases

InterProi IPR009357. Endogenous_retrovirus_rcpt.
[Graphical view ]
PANTHERi PTHR12929. PTHR12929. 1 hit.
Pfami PF06237. DUF1011. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J and NOD.
    Tissue: Skin and Tongue.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Salivary gland.

Entry informationi

Entry nameiS52A3_MOUSE
AccessioniPrimary (citable) accession number: Q9D6X5
Secondary accession number(s): A2AQU3
, Q3TDJ6, Q3U328, Q8CE36, Q91WB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: October 5, 2010
Last modified: September 3, 2014
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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