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Protein

Ribosome-recycling factor, mitochondrial

Gene

Mrrf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

ReactomeiR-MMU-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome-recycling factor, mitochondrial
Short name:
RRF
Alternative name(s):
Ribosome-releasing factor, mitochondrial
Gene namesi
Name:Mrrf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1915121. Mrrf.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5555MitochondrionSequence analysisAdd
BLAST
Chaini56 – 262207Ribosome-recycling factor, mitochondrialPRO_0000031081Add
BLAST

Proteomic databases

EPDiQ9D6S7.
MaxQBiQ9D6S7.
PaxDbiQ9D6S7.
PRIDEiQ9D6S7.

PTM databases

iPTMnetiQ9D6S7.

Expressioni

Gene expression databases

BgeeiQ9D6S7.
CleanExiMM_MRRF.
ExpressionAtlasiQ9D6S7. baseline and differential.
GenevisibleiQ9D6S7. MM.

Interactioni

Protein-protein interaction databases

BioGridi212498. 1 interaction.
STRINGi10090.ENSMUSP00000028250.

Structurei

Secondary structure

1
262
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi120 – 1234Combined sources
Beta strandi126 – 1294Combined sources
Helixi130 – 1334Combined sources
Beta strandi134 – 1407Combined sources
Beta strandi143 – 1475Combined sources
Helixi155 – 1639Combined sources
Turni164 – 1663Combined sources
Beta strandi172 – 1743Combined sources
Beta strandi177 – 1815Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WIHNMR-A116-186[»]
ProteinModelPortaliQ9D6S7.
SMRiQ9D6S7. Positions 86-261.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9D6S7.

Family & Domainsi

Sequence similaritiesi

Belongs to the RRF family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4759. Eukaryota.
COG0233. LUCA.
GeneTreeiENSGT00390000005084.
HOGENOMiHOG000007351.
HOVERGENiHBG061516.
InParanoidiQ9D6S7.
KOiK02838.
OMAiPIPQVTR.
OrthoDBiEOG7G4QGH.
PhylomeDBiQ9D6S7.
TreeFamiTF323691.

Family and domain databases

Gene3Di3.30.1360.40. 1 hit.
InterProiIPR024946. Arg_repress_C-like.
IPR002661. Ribosome_recyc_fac.
IPR023584. Ribosome_recyc_fac_dom.
[Graphical view]
PANTHERiPTHR20982. PTHR20982. 1 hit.
PfamiPF01765. RRF. 1 hit.
[Graphical view]
SUPFAMiSSF55194. SSF55194. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D6S7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGIRCFRL LHPAFRSYHA ALTRPVSEVS MKTVSGRQHG HRQYSAYPAV
60 70 80 90 100
PVRHFATKKA KAKGKGQPQA RVTVNRALVE DIISLEEVDE DMKSVVEALK
110 120 130 140 150
DNFNKTLNIR TAPGSLDHIT VVTADGKVAL NQIGQISMKS PQVILVNMAS
160 170 180 190 200
FPECTAAAIK AIRESGMNLN PEVEGTLIRV PIPKVTREHR EMLVKLAKQN
210 220 230 240 250
TNKAKENLRK VRTNAMNKLK KSKDKTSEDT IRLIEKQISQ MADDTVAELD
260
QHLAAKTKEL LG
Length:262
Mass (Da):29,051
Last modified:June 1, 2001 - v1
Checksum:i52C3315B0886C850
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010018 mRNA. Translation: BAB26646.1.
AK032371 mRNA. Translation: BAC27839.1.
BX293557 Genomic DNA. Translation: CAM20861.1.
BC019787 mRNA. Translation: AAH19787.1.
CCDSiCCDS38114.1.
RefSeqiNP_080698.1. NM_026422.2.
UniGeneiMm.378232.

Genome annotation databases

EnsembliENSMUST00000028250; ENSMUSP00000028250; ENSMUSG00000026887.
GeneIDi67871.
KEGGimmu:67871.
UCSCiuc008jlj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010018 mRNA. Translation: BAB26646.1.
AK032371 mRNA. Translation: BAC27839.1.
BX293557 Genomic DNA. Translation: CAM20861.1.
BC019787 mRNA. Translation: AAH19787.1.
CCDSiCCDS38114.1.
RefSeqiNP_080698.1. NM_026422.2.
UniGeneiMm.378232.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WIHNMR-A116-186[»]
ProteinModelPortaliQ9D6S7.
SMRiQ9D6S7. Positions 86-261.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212498. 1 interaction.
STRINGi10090.ENSMUSP00000028250.

PTM databases

iPTMnetiQ9D6S7.

Proteomic databases

EPDiQ9D6S7.
MaxQBiQ9D6S7.
PaxDbiQ9D6S7.
PRIDEiQ9D6S7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028250; ENSMUSP00000028250; ENSMUSG00000026887.
GeneIDi67871.
KEGGimmu:67871.
UCSCiuc008jlj.2. mouse.

Organism-specific databases

CTDi92399.
MGIiMGI:1915121. Mrrf.

Phylogenomic databases

eggNOGiKOG4759. Eukaryota.
COG0233. LUCA.
GeneTreeiENSGT00390000005084.
HOGENOMiHOG000007351.
HOVERGENiHBG061516.
InParanoidiQ9D6S7.
KOiK02838.
OMAiPIPQVTR.
OrthoDBiEOG7G4QGH.
PhylomeDBiQ9D6S7.
TreeFamiTF323691.

Enzyme and pathway databases

ReactomeiR-MMU-5419276. Mitochondrial translation termination.

Miscellaneous databases

EvolutionaryTraceiQ9D6S7.
PROiQ9D6S7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D6S7.
CleanExiMM_MRRF.
ExpressionAtlasiQ9D6S7. baseline and differential.
GenevisibleiQ9D6S7. MM.

Family and domain databases

Gene3Di3.30.1360.40. 1 hit.
InterProiIPR024946. Arg_repress_C-like.
IPR002661. Ribosome_recyc_fac.
IPR023584. Ribosome_recyc_fac_dom.
[Graphical view]
PANTHERiPTHR20982. PTHR20982. 1 hit.
PfamiPF01765. RRF. 1 hit.
[Graphical view]
SUPFAMiSSF55194. SSF55194. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Olfactory bulb and Tongue.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung and Testis.
  5. "Solution structure of ribosome recycling factor."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2004) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 116-186.

Entry informationi

Entry nameiRRFM_MOUSE
AccessioniPrimary (citable) accession number: Q9D6S7
Secondary accession number(s): B1B055
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.