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Protein

Ribosome-recycling factor, mitochondrial

Gene

Mrrf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-MMU-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome-recycling factor, mitochondrial
Short name:
RRF
Alternative name(s):
Ribosome-releasing factor, mitochondrial
Gene namesi
Name:Mrrf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1915121 Mrrf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 55MitochondrionSequence analysisAdd BLAST55
ChainiPRO_000003108156 – 262Ribosome-recycling factor, mitochondrialAdd BLAST207

Proteomic databases

EPDiQ9D6S7
MaxQBiQ9D6S7
PaxDbiQ9D6S7
PeptideAtlasiQ9D6S7
PRIDEiQ9D6S7

PTM databases

iPTMnetiQ9D6S7
PhosphoSitePlusiQ9D6S7

Expressioni

Gene expression databases

BgeeiENSMUSG00000026887
CleanExiMM_MRRF
ExpressionAtlasiQ9D6S7 baseline and differential
GenevisibleiQ9D6S7 MM

Interactioni

Protein-protein interaction databases

BioGridi212498, 1 interactor
STRINGi10090.ENSMUSP00000028250

Structurei

Secondary structure

1262
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi120 – 123Combined sources4
Beta strandi126 – 129Combined sources4
Helixi130 – 133Combined sources4
Beta strandi134 – 140Combined sources7
Beta strandi143 – 147Combined sources5
Helixi155 – 163Combined sources9
Turni164 – 166Combined sources3
Beta strandi172 – 174Combined sources3
Beta strandi177 – 181Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WIHNMR-A116-186[»]
ProteinModelPortaliQ9D6S7
SMRiQ9D6S7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9D6S7

Family & Domainsi

Sequence similaritiesi

Belongs to the RRF family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4759 Eukaryota
COG0233 LUCA
GeneTreeiENSGT00390000005084
HOGENOMiHOG000007351
HOVERGENiHBG061516
InParanoidiQ9D6S7
KOiK02838
OMAiRTNAMNK
OrthoDBiEOG091G0HBC
PhylomeDBiQ9D6S7
TreeFamiTF323691

Family and domain databases

InterProiView protein in InterPro
IPR002661 Ribosome_recyc_fac
IPR023584 Ribosome_recyc_fac_dom
IPR036191 RRF_sf
PANTHERiPTHR20982 PTHR20982, 1 hit
PfamiView protein in Pfam
PF01765 RRF, 1 hit
SUPFAMiSSF55194 SSF55194, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D6S7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGIRCFRL LHPAFRSYHA ALTRPVSEVS MKTVSGRQHG HRQYSAYPAV
60 70 80 90 100
PVRHFATKKA KAKGKGQPQA RVTVNRALVE DIISLEEVDE DMKSVVEALK
110 120 130 140 150
DNFNKTLNIR TAPGSLDHIT VVTADGKVAL NQIGQISMKS PQVILVNMAS
160 170 180 190 200
FPECTAAAIK AIRESGMNLN PEVEGTLIRV PIPKVTREHR EMLVKLAKQN
210 220 230 240 250
TNKAKENLRK VRTNAMNKLK KSKDKTSEDT IRLIEKQISQ MADDTVAELD
260
QHLAAKTKEL LG
Length:262
Mass (Da):29,051
Last modified:June 1, 2001 - v1
Checksum:i52C3315B0886C850
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010018 mRNA Translation: BAB26646.1
AK032371 mRNA Translation: BAC27839.1
BX293557 Genomic DNA No translation available.
BC019787 mRNA Translation: AAH19787.1
CCDSiCCDS38114.1
RefSeqiNP_080698.1, NM_026422.2
UniGeneiMm.378232

Genome annotation databases

EnsembliENSMUST00000028250; ENSMUSP00000028250; ENSMUSG00000026887
GeneIDi67871
KEGGimmu:67871
UCSCiuc008jlj.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRRFM_MOUSE
AccessioniPrimary (citable) accession number: Q9D6S7
Secondary accession number(s): B1B055
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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