Reviewed, UniProtKB/Swiss-Prot Q9D6N1 (CAH13_MOUSE)

Names and origin

Protein names

Recommended name:
    Carbonic anhydrase 13
    EC=4.2.1.1
Alternative name(s):
    Carbonic anhydrase XIII
      Short name=CA-XIII
    Carbonate dehydratase XIII

Gene names

Name:	Ca13
Synonyms:	Car13

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	262 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Reversible hydration of carbon dioxide.
Catalytic activity	H2CO3 = CO2 + H2O.
Cofactor	Zinc By similarity.
Tissue specificity	Expressed in spleen, lung, kidney, heart, brain, skeletal muscle and testis. Ref.4
Sequence similarities	Belongs to the alpha-carbonic anhydrase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Lyase
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	carbonate dehydratase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 262	262	Carbonic anhydrase 13		PRO_0000077441
Sites
	Metal binding	95	1	Zinc; catalytic By similarity
	Metal binding	97	1	Zinc; catalytic By similarity
	Metal binding	120	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9D6N1-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: E3CA4674C1CF4A12	FASTA	262	29,522
	10 20 30 40 50 60 MARLSWGYGE HNGPIHWNEL FPIADGDQQS PIEIKTKEVK YDSSLRPLSI KYDPASAKII 70 80 90 100 110 120 SNSGHSFNVD FDDTEDKSVL RGGPLTGNYR LRQFHLHWGS ADDHGSEHVV DGVRYAAELH 130 140 150 160 170 180 VVHWNSDKYP SFVEAAHESD GLAVLGVFLQ IGEHNPQLQK ITDILDSIKE KGKQTRFTNF 190 200 210 220 230 240 DPLCLLPSSW DYWTYPGSLT VPPLLESVTW IVLKQPISIS SQQLARFRSL LCTAEGESAA 250 260 FLLSNHRPPQ PLKGRRVRAS FY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization and evolution of two new members of the alpha-carbonic anhydrase gene family in mouse: Car13 and Car15." Hewett-Emmett D., Shimmin L.C. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C3H.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Bone, Bone marrow and Tongue.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Mammary gland.
[4]	"Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family." Lehtonen J., Shen B., Vihinen M., Casini A., Scozzafava A., Supuran C.T., Parkkila A.-K., Saarnio J., Kivelae A.J., Waheed A., Sly W.S., Parkkila S. J. Biol. Chem. 279:2719-2727(2004) [PubMed: 14600151] [Abstract] Cited for: CHARACTERIZATION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF231123 mRNA. Translation: AAK16672.1. AK010166 mRNA. Translation: BAB26742.1. AK150871 mRNA. Translation: BAE29922.1. AK150897 mRNA. Translation: BAE29942.1. AK151519 mRNA. Translation: BAE30468.1. AK151978 mRNA. Translation: BAE30845.1. AK153080 mRNA. Translation: BAE31705.1. AK153258 mRNA. Translation: BAE31849.1. AK153353 mRNA. Translation: BAE31927.1. AK162621 mRNA. Translation: BAE36996.1. BC064050 mRNA. Translation: AAH64050.1.
IPI	IPI00109304.
RefSeq	NP_078771.1.
UniGene	Mm.158776
3D structure databases
HSSP	HSSP built from PDB template 1CIM based on UniProtKB P00918.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9D6N1.
Proteomic databases
PRIDE	Q9D6N1.
Genome annotation databases
Ensembl	ENSMUST00000029071; ENSMUSP00000029071; ENSMUSG00000027555; Mus musculus. [Genome view]
GeneID	71934.
KEGG	mmu:71934.
UCSC	uc008oqo.1. mouse.
Organism-specific databases
CTD	71934.
MGI	MGI:1931322. Car13.
Phylogenomic databases
HOGENOM	Q9D6N1.
HOVERGEN	Q9D6N1.
OMA	MSRLSWG.
Enzyme and pathway databases
BRENDA	4.2.1.1. 244.
Gene expression databases
ArrayExpress	Q9D6N1.
Bgee	Q9D6N1.
CleanEx	MM_CAR13.
Genevestigator	Q9D6N1.
GermOnline	ENSMUSG00000027555. Mus musculus.
Family and domain databases
InterPro	IPR001148. Carbonic_anhydrase_a-class_cat. IPR018338. Carbonic_anhydrase_a-class_CS. IPR018443. Carbonic_anhydrase_CA13. [Graphical view]
Gene3D	G3DSA:3.10.200.10. Euk_COanhd. 1 hit.
PANTHER	PTHR18952:SF31. Carbonic_anhydrase_CA13. 1 hit. PTHR18952. Euk_COanhd. 1 hit.
Pfam	PF00194. Carb_anhydrase. 1 hit. [Graphical view]
ProDom	PD000865. Euk_COanhd. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00162. ALPHA_CA_1. 1 hit. PS51144. ALPHA_CA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
BindingDB	Q9D6N1.
NextBio	334994.
SOURCE	Search...

Entry information

Entry name

CAH13_MOUSE

Accession

Primary (citable) accession number: Q9D6N1
Secondary accession number(s): Q3UBM2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 9, 2003
Last sequence update:	June 1, 2001
Last modified:	November 3, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)