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Protein

Carbonic anhydrase 13

Gene

Ca13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Reversible hydration of carbon dioxide.

Catalytic activityi

H2CO3 = CO2 + H2O.

Cofactori

Zn2+By similarity

Enzyme regulationi

Inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA) and Foscarnet (phosphonoformate trisodium salt).3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65Proton acceptorBy similarity1
Active sitei68By similarity1
Metal bindingi95Zinc; catalyticBy similarity1
Metal bindingi97Zinc; catalyticBy similarity1
Metal bindingi120Zinc; catalyticBy similarity1
Active sitei129By similarity1

GO - Molecular functioni

  • carbonate dehydratase activity Source: MGI
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDAi4.2.1.1 3474
ReactomeiR-MMU-1475029 Reversible hydration of carbon dioxide

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonic anhydrase 13 (EC:4.2.1.1)
Alternative name(s):
Carbonate dehydratase XIII
Carbonic anhydrase XIII
Short name:
CA-XIII
Gene namesi
Name:Ca13
Synonyms:Car13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1931322 Car13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2186
GuidetoPHARMACOLOGYi2748

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000774411 – 262Carbonic anhydrase 13Add BLAST262

Proteomic databases

MaxQBiQ9D6N1
PaxDbiQ9D6N1
PeptideAtlasiQ9D6N1
PRIDEiQ9D6N1

PTM databases

iPTMnetiQ9D6N1
PhosphoSitePlusiQ9D6N1

Expressioni

Tissue specificityi

Expressed in spleen, lung, kidney, heart, brain, skeletal muscle and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000027555
CleanExiMM_CAR13
GenevisibleiQ9D6N1 MM

Interactioni

Chemistry databases

BindingDBiQ9D6N1

Structurei

3D structure databases

ProteinModelPortaliQ9D6N1
SMRiQ9D6N1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 261Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST258

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni200 – 201Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the alpha-carbonic anhydrase family.Curated

Phylogenomic databases

eggNOGiKOG0382 Eukaryota
COG3338 LUCA
GeneTreeiENSGT00760000118915
HOGENOMiHOG000112637
HOVERGENiHBG002837
InParanoidiQ9D6N1
KOiK01672
OMAiNGPIHWN
OrthoDBiEOG091G0XFM
PhylomeDBiQ9D6N1
TreeFamiTF316425

Family and domain databases

Gene3Di3.10.200.10, 1 hit
InterProiView protein in InterPro
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR023561 Carbonic_anhydrase_a-class
IPR018338 Carbonic_anhydrase_a-class_CS
PANTHERiPTHR18952 PTHR18952, 1 hit
PfamiView protein in Pfam
PF00194 Carb_anhydrase, 1 hit
SMARTiView protein in SMART
SM01057 Carb_anhydrase, 1 hit
SUPFAMiSSF51069 SSF51069, 1 hit
PROSITEiView protein in PROSITE
PS00162 ALPHA_CA_1, 1 hit
PS51144 ALPHA_CA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D6N1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARLSWGYGE HNGPIHWNEL FPIADGDQQS PIEIKTKEVK YDSSLRPLSI
60 70 80 90 100
KYDPASAKII SNSGHSFNVD FDDTEDKSVL RGGPLTGNYR LRQFHLHWGS
110 120 130 140 150
ADDHGSEHVV DGVRYAAELH VVHWNSDKYP SFVEAAHESD GLAVLGVFLQ
160 170 180 190 200
IGEHNPQLQK ITDILDSIKE KGKQTRFTNF DPLCLLPSSW DYWTYPGSLT
210 220 230 240 250
VPPLLESVTW IVLKQPISIS SQQLARFRSL LCTAEGESAA FLLSNHRPPQ
260
PLKGRRVRAS FY
Length:262
Mass (Da):29,522
Last modified:June 1, 2001 - v1
Checksum:iE3CA4674C1CF4A12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231123 mRNA Translation: AAK16672.1
AK010166 mRNA Translation: BAB26742.1
AK150871 mRNA Translation: BAE29922.1
AK150897 mRNA Translation: BAE29942.1
AK151519 mRNA Translation: BAE30468.1
AK151978 mRNA Translation: BAE30845.1
AK153080 mRNA Translation: BAE31705.1
AK153258 mRNA Translation: BAE31849.1
AK153353 mRNA Translation: BAE31927.1
AK162621 mRNA Translation: BAE36996.1
BC064050 mRNA Translation: AAH64050.1
CCDSiCCDS17247.1
RefSeqiNP_078771.1, NM_024495.5
UniGeneiMm.158776

Genome annotation databases

EnsembliENSMUST00000029071; ENSMUSP00000029071; ENSMUSG00000027555
GeneIDi71934
KEGGimmu:71934
UCSCiuc008oqo.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCAH13_MOUSE
AccessioniPrimary (citable) accession number: Q9D6N1
Secondary accession number(s): Q3UBM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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