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Protein

Mitochondrial glutamate carrier 1

Gene

Slc25a22

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H+ (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-428643. Organic anion transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial glutamate carrier 1
Short name:
GC-1
Alternative name(s):
Glutamate/H(+) symporter 1
Solute carrier family 25 member 22
Gene namesi
Name:Slc25a22
Synonyms:Gc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1915517. Slc25a22.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei62 – 82Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei107 – 127Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei189 – 209Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei223 – 243Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei292 – 312Helical; Name=6Sequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906201 – 323Mitochondrial glutamate carrier 1Add BLAST323

Proteomic databases

EPDiQ9D6M3.
MaxQBiQ9D6M3.
PeptideAtlasiQ9D6M3.
PRIDEiQ9D6M3.

PTM databases

iPTMnetiQ9D6M3.
PhosphoSitePlusiQ9D6M3.
SwissPalmiQ9D6M3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000019082.
ExpressionAtlasiQ9D6M3. baseline and differential.
GenevisibleiQ9D6M3. MM.

Interactioni

Protein-protein interaction databases

BioGridi212770. 3 interactors.
IntActiQ9D6M3. 8 interactors.
MINTiMINT-1839997.

Structurei

3D structure databases

ProteinModelPortaliQ9D6M3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 93Solcar 1Add BLAST88
Repeati101 – 214Solcar 2Add BLAST114
Repeati223 – 312Solcar 3Add BLAST90

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000062944.
HOGENOMiHOG000168308.
HOVERGENiHBG039469.
InParanoidiQ9D6M3.
KOiK15107.
OMAiAQRKLMP.
OrthoDBiEOG091G08GT.
PhylomeDBiQ9D6M3.
TreeFamiTF313209.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D6M3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKQISLPA KLINGGIAGL IGVTCVFPID LAKTRLQNQQ NGQRMYASMS
60 70 80 90 100
DCLIKTIRSE GYFGMYRGAA VNLTLVTPEK AIKLAANDFF RHQLSKDGQK
110 120 130 140 150
LTLPKEMLAG CGAGTCQVIV TTPMEMLKIQ LQDAGRIAAQ RKILAAQAQL
160 170 180 190 200
SAQGGAQPSV EAPAPPRPTA TQLTRDLLRN HGIAGLYKGL GATLLRDVPF
210 220 230 240 250
SIVYFPLFAN LNQLGRPSSE EKSPFYVSFL AGCVAGSAAA VAVNPCDVVK
260 270 280 290 300
TRLQSLERGV NEDTYSGFLD CARKIWRHEG PSAFLKGAYC RALVIAPLFG
310 320
IAQVVYFLGI AESLLGLLQE PQA
Length:323
Mass (Da):34,670
Last modified:June 1, 2001 - v1
Checksum:iCCAED09AB4CF73AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010193 mRNA. Translation: BAB26760.1.
AK046874 mRNA. Translation: BAC32903.1.
AK048389 mRNA. Translation: BAC33318.1.
AK049313 mRNA. Translation: BAC33676.1.
AK155276 mRNA. Translation: BAE33159.1.
AK162400 mRNA. Translation: BAE36895.1.
BC037949 mRNA. Translation: AAH37949.1.
CCDSiCCDS22013.1.
RefSeqiNP_001171047.1. NM_001177576.1.
NP_080922.1. NM_026646.3.
XP_006536295.1. XM_006536232.1.
XP_006536296.1. XM_006536233.3.
UniGeneiMm.33729.

Genome annotation databases

EnsembliENSMUST00000019226; ENSMUSP00000019226; ENSMUSG00000019082.
ENSMUST00000106007; ENSMUSP00000101629; ENSMUSG00000019082.
ENSMUST00000201710; ENSMUSP00000144231; ENSMUSG00000019082.
GeneIDi68267.
KEGGimmu:68267.
UCSCiuc009kkz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010193 mRNA. Translation: BAB26760.1.
AK046874 mRNA. Translation: BAC32903.1.
AK048389 mRNA. Translation: BAC33318.1.
AK049313 mRNA. Translation: BAC33676.1.
AK155276 mRNA. Translation: BAE33159.1.
AK162400 mRNA. Translation: BAE36895.1.
BC037949 mRNA. Translation: AAH37949.1.
CCDSiCCDS22013.1.
RefSeqiNP_001171047.1. NM_001177576.1.
NP_080922.1. NM_026646.3.
XP_006536295.1. XM_006536232.1.
XP_006536296.1. XM_006536233.3.
UniGeneiMm.33729.

3D structure databases

ProteinModelPortaliQ9D6M3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212770. 3 interactors.
IntActiQ9D6M3. 8 interactors.
MINTiMINT-1839997.

PTM databases

iPTMnetiQ9D6M3.
PhosphoSitePlusiQ9D6M3.
SwissPalmiQ9D6M3.

Proteomic databases

EPDiQ9D6M3.
MaxQBiQ9D6M3.
PeptideAtlasiQ9D6M3.
PRIDEiQ9D6M3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019226; ENSMUSP00000019226; ENSMUSG00000019082.
ENSMUST00000106007; ENSMUSP00000101629; ENSMUSG00000019082.
ENSMUST00000201710; ENSMUSP00000144231; ENSMUSG00000019082.
GeneIDi68267.
KEGGimmu:68267.
UCSCiuc009kkz.2. mouse.

Organism-specific databases

CTDi79751.
MGIiMGI:1915517. Slc25a22.

Phylogenomic databases

GeneTreeiENSGT00530000062944.
HOGENOMiHOG000168308.
HOVERGENiHBG039469.
InParanoidiQ9D6M3.
KOiK15107.
OMAiAQRKLMP.
OrthoDBiEOG091G08GT.
PhylomeDBiQ9D6M3.
TreeFamiTF313209.

Enzyme and pathway databases

ReactomeiR-MMU-428643. Organic anion transporters.

Miscellaneous databases

PROiQ9D6M3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019082.
ExpressionAtlasiQ9D6M3. baseline and differential.
GenevisibleiQ9D6M3. MM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGHC1_MOUSE
AccessioniPrimary (citable) accession number: Q9D6M3
Secondary accession number(s): Q3TRY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.