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Protein

Mitochondrial glutamate carrier 1

Gene

Slc25a22

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H+ (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial glutamate carrier 1
Short name:
GC-1
Alternative name(s):
Glutamate/H(+) symporter 1
Solute carrier family 25 member 22
Gene namesi
Name:Slc25a22
Synonyms:Gc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1915517. Slc25a22.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei62 – 8221Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei107 – 12721Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei189 – 20921Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei223 – 24321Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei292 – 31221Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Mitochondrial glutamate carrier 1PRO_0000090620Add
BLAST

Proteomic databases

EPDiQ9D6M3.
MaxQBiQ9D6M3.
PRIDEiQ9D6M3.

PTM databases

iPTMnetiQ9D6M3.
PhosphoSiteiQ9D6M3.
SwissPalmiQ9D6M3.

Expressioni

Gene expression databases

BgeeiQ9D6M3.
ExpressionAtlasiQ9D6M3. baseline and differential.
GenevisibleiQ9D6M3. MM.

Interactioni

Protein-protein interaction databases

BioGridi212770. 2 interactions.
IntActiQ9D6M3. 7 interactions.
MINTiMINT-1839997.

Structurei

3D structure databases

ProteinModelPortaliQ9D6M3.
SMRiQ9D6M3. Positions 3-316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati6 – 9388Solcar 1Add
BLAST
Repeati101 – 214114Solcar 2Add
BLAST
Repeati223 – 31290Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000062944.
HOGENOMiHOG000168308.
HOVERGENiHBG039469.
InParanoidiQ9D6M3.
KOiK15107.
OMAiAQRKLMP.
OrthoDBiEOG7KM5TK.
PhylomeDBiQ9D6M3.
TreeFamiTF313209.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D6M3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKQISLPA KLINGGIAGL IGVTCVFPID LAKTRLQNQQ NGQRMYASMS
60 70 80 90 100
DCLIKTIRSE GYFGMYRGAA VNLTLVTPEK AIKLAANDFF RHQLSKDGQK
110 120 130 140 150
LTLPKEMLAG CGAGTCQVIV TTPMEMLKIQ LQDAGRIAAQ RKILAAQAQL
160 170 180 190 200
SAQGGAQPSV EAPAPPRPTA TQLTRDLLRN HGIAGLYKGL GATLLRDVPF
210 220 230 240 250
SIVYFPLFAN LNQLGRPSSE EKSPFYVSFL AGCVAGSAAA VAVNPCDVVK
260 270 280 290 300
TRLQSLERGV NEDTYSGFLD CARKIWRHEG PSAFLKGAYC RALVIAPLFG
310 320
IAQVVYFLGI AESLLGLLQE PQA
Length:323
Mass (Da):34,670
Last modified:June 1, 2001 - v1
Checksum:iCCAED09AB4CF73AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010193 mRNA. Translation: BAB26760.1.
AK046874 mRNA. Translation: BAC32903.1.
AK048389 mRNA. Translation: BAC33318.1.
AK049313 mRNA. Translation: BAC33676.1.
AK155276 mRNA. Translation: BAE33159.1.
AK162400 mRNA. Translation: BAE36895.1.
BC037949 mRNA. Translation: AAH37949.1.
CCDSiCCDS22013.1.
RefSeqiNP_001171047.1. NM_001177576.1.
NP_080922.1. NM_026646.3.
XP_006536295.1. XM_006536232.1.
XP_006536296.1. XM_006536233.2.
UniGeneiMm.33729.

Genome annotation databases

EnsembliENSMUST00000019226; ENSMUSP00000019226; ENSMUSG00000019082.
ENSMUST00000106007; ENSMUSP00000101629; ENSMUSG00000019082.
ENSMUST00000201710; ENSMUSP00000144231; ENSMUSG00000019082.
GeneIDi68267.
KEGGimmu:68267.
UCSCiuc009kkz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010193 mRNA. Translation: BAB26760.1.
AK046874 mRNA. Translation: BAC32903.1.
AK048389 mRNA. Translation: BAC33318.1.
AK049313 mRNA. Translation: BAC33676.1.
AK155276 mRNA. Translation: BAE33159.1.
AK162400 mRNA. Translation: BAE36895.1.
BC037949 mRNA. Translation: AAH37949.1.
CCDSiCCDS22013.1.
RefSeqiNP_001171047.1. NM_001177576.1.
NP_080922.1. NM_026646.3.
XP_006536295.1. XM_006536232.1.
XP_006536296.1. XM_006536233.2.
UniGeneiMm.33729.

3D structure databases

ProteinModelPortaliQ9D6M3.
SMRiQ9D6M3. Positions 3-316.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212770. 2 interactions.
IntActiQ9D6M3. 7 interactions.
MINTiMINT-1839997.

PTM databases

iPTMnetiQ9D6M3.
PhosphoSiteiQ9D6M3.
SwissPalmiQ9D6M3.

Proteomic databases

EPDiQ9D6M3.
MaxQBiQ9D6M3.
PRIDEiQ9D6M3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019226; ENSMUSP00000019226; ENSMUSG00000019082.
ENSMUST00000106007; ENSMUSP00000101629; ENSMUSG00000019082.
ENSMUST00000201710; ENSMUSP00000144231; ENSMUSG00000019082.
GeneIDi68267.
KEGGimmu:68267.
UCSCiuc009kkz.2. mouse.

Organism-specific databases

CTDi79751.
MGIiMGI:1915517. Slc25a22.

Phylogenomic databases

GeneTreeiENSGT00530000062944.
HOGENOMiHOG000168308.
HOVERGENiHBG039469.
InParanoidiQ9D6M3.
KOiK15107.
OMAiAQRKLMP.
OrthoDBiEOG7KM5TK.
PhylomeDBiQ9D6M3.
TreeFamiTF313209.

Miscellaneous databases

NextBioi326862.
PROiQ9D6M3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D6M3.
ExpressionAtlasiQ9D6M3. baseline and differential.
GenevisibleiQ9D6M3. MM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Diencephalon, Head, Medulla oblongata and Tongue.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  3. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 12-33; 59-80; 84-91; 129-136; 180-196; 259-273 AND 278-286, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6J.
    Tissue: Brain.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas and Spleen.

Entry informationi

Entry nameiGHC1_MOUSE
AccessioniPrimary (citable) accession number: Q9D6M3
Secondary accession number(s): Q3TRY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.