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Protein

Peptidyl-prolyl cis-trans isomerase-like 3

Gene

Ppil3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Rotamase
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase-like 3 (EC:5.2.1.8)
Short name:
PPIase
Alternative name(s):
CYP10L
Cyclophilin-like protein PPIL3
Rotamase PPIL3
Gene namesi
Name:Ppil3
Synonyms:Cyp10l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1917475 Ppil3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000641672 – 161Peptidyl-prolyl cis-trans isomerase-like 3Add BLAST160

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei61Omega-N-methylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

EPDiQ9D6L8
PaxDbiQ9D6L8
PeptideAtlasiQ9D6L8
PRIDEiQ9D6L8

PTM databases

iPTMnetiQ9D6L8
PhosphoSitePlusiQ9D6L8

Expressioni

Gene expression databases

BgeeiENSMUSG00000026035
CleanExiMM_PPIL3
ExpressionAtlasiQ9D6L8 baseline and differential
GenevisibleiQ9D6L8 MM

Interactioni

Subunit structurei

Identified in the spliceosome C complex.By similarity

Protein-protein interaction databases

IntActiQ9D6L8, 1 interactor
STRINGi10090.ENSMUSP00000080378

Structurei

3D structure databases

ProteinModelPortaliQ9D6L8
SMRiQ9D6L8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 154PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST153

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0884 Eukaryota
COG0652 LUCA
GeneTreeiENSGT00760000119072
HOGENOMiHOG000065981
HOVERGENiHBG001065
InParanoidiQ9D6L8
KOiK12734
OMAiEIFCDEV
OrthoDBiEOG091G05AW
PhylomeDBiQ9D6L8
TreeFamiTF352224

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PIRSFiPIRSF001467 Peptidylpro_ismrse, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D6L8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVTLHTDVG DIKIEVFCER TPKTCENFLA LCASNYYNGC VFHRNIKGFM
60 70 80 90 100
VQTGDPTGTG RGGSSIWAKK FEDEYSEYLK HNVRGVVSMA NNGPNTNGSQ
110 120 130 140 150
FFITYGKQPH LDMKYTVFGK VIDGLETLDE LEKLPVNEKT YRPLNDVHIK
160
DITIHANPFA Q
Length:161
Mass (Da):18,128
Last modified:June 1, 2001 - v1
Checksum:i913ED4C8CB839E2C
GO
Isoform 2 (identifier: Q9D6L8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-161: Missing.

Note: No experimental confirmation available.
Show »
Length:120
Mass (Da):13,445
Checksum:i66418755C7AC389D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23K → R in AAO32944 (Ref. 1) Curated1
Sequence conflicti103I → V in BAB27319 (PubMed:16141072).Curated1
Sequence conflicti144L → F in AAO32944 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015469121 – 161Missing in isoform 2. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF315803 mRNA Translation: AAO32944.1
AK010207 mRNA Translation: BAB26768.1
AK011000 mRNA Translation: BAB27319.1
BC060993 mRNA Translation: AAH60993.1
BC061645 mRNA Translation: AAH61645.1
CCDSiCCDS35579.1 [Q9D6L8-1]
CCDS35580.1 [Q9D6L8-2]
RefSeqiNP_001272755.1, NM_001285826.1 [Q9D6L8-1]
NP_001272756.1, NM_001285827.1 [Q9D6L8-1]
NP_081627.1, NM_027351.3 [Q9D6L8-1]
NP_081650.2, NM_027374.3 [Q9D6L8-2]
UniGeneiMm.340195

Genome annotation databases

EnsembliENSMUST00000081677; ENSMUSP00000080378; ENSMUSG00000026035 [Q9D6L8-1]
ENSMUST00000114345; ENSMUSP00000109984; ENSMUSG00000026035 [Q9D6L8-2]
ENSMUST00000114348; ENSMUSP00000109988; ENSMUSG00000026035 [Q9D6L8-1]
ENSMUST00000117069; ENSMUSP00000112947; ENSMUSG00000026035 [Q9D6L8-1]
GeneIDi70225
KEGGimmu:70225
UCSCiuc007bbv.2 mouse [Q9D6L8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPPIL3_MOUSE
AccessioniPrimary (citable) accession number: Q9D6L8
Secondary accession number(s): Q812D2, Q9CY23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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