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Protein

FUN14 domain-containing protein 2

Gene

Fundc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. mitochondrion degradation Source: GO_Central
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
FUN14 domain-containing protein 2
Alternative name(s):
Hepatitis C virus core-binding protein 6
Gene namesi
Name:Fundc2
Synonyms:Hcbp6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1914641. Fundc2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of mitochondrial outer membrane Source: GO_Central
  2. mitochondrion Source: MGI
  3. nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 151151FUN14 domain-containing protein 2PRO_0000314617Add
BLAST

Proteomic databases

MaxQBiQ9D6K8.
PaxDbiQ9D6K8.
PRIDEiQ9D6K8.

PTM databases

PhosphoSiteiQ9D6K8.

Expressioni

Gene expression databases

BgeeiQ9D6K8.
CleanExiMM_FUNDC2.
GenevestigatoriQ9D6K8.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033541.

Family & Domainsi

Sequence similaritiesi

Belongs to the FUN14 family.Curated

Phylogenomic databases

eggNOGiNOG249575.
GeneTreeiENSGT00390000003926.
HOGENOMiHOG000232100.
HOVERGENiHBG054805.
InParanoidiQ9D6K8.
OMAiTKKQPWW.
OrthoDBiEOG7PCJJT.
PhylomeDBiQ9D6K8.
TreeFamiTF300280.

Family and domain databases

InterProiIPR007014. FUN14.
[Graphical view]
PfamiPF04930. FUN14. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D6K8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAANSQGNFD GKFEALDLAE LTKKQPWWRK LFGQESGPSA EKYSVATQLV
60 70 80 90 100
IGGVTGWCTG FVFQKVGKLA ATAVGGGFFL LQLANHTGYI KVDWQRVEKD
110 120 130 140 150
MKKAKEQLKI RKNKQIPTEV KSKAEEVVSF VKKNVLVTGG FFGGFLLGMA

S
Length:151
Mass (Da):16,564
Last modified:June 1, 2001 - v1
Checksum:i7EC4C8B9301D64ED
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti30 – 312KL → NS in BAB29513 (PubMed:16141072).Curated
Sequence conflicti73 – 731A → D in BAC27304 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY234858 mRNA. Translation: AAO89275.1.
AK013460 mRNA. Translation: BAB28867.1.
AK014705 mRNA. Translation: BAB29513.1.
AK031214 mRNA. Translation: BAC27304.1.
AL731844 Genomic DNA. Translation: CAM15582.1.
BC042794 mRNA. Translation: AAH42794.1.
BC049566 mRNA. Translation: AAH49566.2.
BC061464 mRNA. Translation: AAH61464.1.
CCDSiCCDS30239.1.
RefSeqiNP_080402.3. NM_026126.4.
UniGeneiMm.126404.

Genome annotation databases

EnsembliENSMUST00000033541; ENSMUSP00000033541; ENSMUSG00000031198.
GeneIDi67391.
KEGGimmu:67391.
UCSCiuc009tpu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY234858 mRNA. Translation: AAO89275.1.
AK013460 mRNA. Translation: BAB28867.1.
AK014705 mRNA. Translation: BAB29513.1.
AK031214 mRNA. Translation: BAC27304.1.
AL731844 Genomic DNA. Translation: CAM15582.1.
BC042794 mRNA. Translation: AAH42794.1.
BC049566 mRNA. Translation: AAH49566.2.
BC061464 mRNA. Translation: AAH61464.1.
CCDSiCCDS30239.1.
RefSeqiNP_080402.3. NM_026126.4.
UniGeneiMm.126404.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033541.

PTM databases

PhosphoSiteiQ9D6K8.

Proteomic databases

MaxQBiQ9D6K8.
PaxDbiQ9D6K8.
PRIDEiQ9D6K8.

Protocols and materials databases

DNASUi67391.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033541; ENSMUSP00000033541; ENSMUSG00000031198.
GeneIDi67391.
KEGGimmu:67391.
UCSCiuc009tpu.2. mouse.

Organism-specific databases

CTDi65991.
MGIiMGI:1914641. Fundc2.

Phylogenomic databases

eggNOGiNOG249575.
GeneTreeiENSGT00390000003926.
HOGENOMiHOG000232100.
HOVERGENiHBG054805.
InParanoidiQ9D6K8.
OMAiTKKQPWW.
OrthoDBiEOG7PCJJT.
PhylomeDBiQ9D6K8.
TreeFamiTF300280.

Miscellaneous databases

NextBioi324436.
PROiQ9D6K8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D6K8.
CleanExiMM_FUNDC2.
GenevestigatoriQ9D6K8.

Family and domain databases

InterProiIPR007014. FUN14.
[Graphical view]
PfamiPF04930. FUN14. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and sequence analysis of a mouse homologous gene HCBP6."
    Cheng J., Li K., Wang L.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Forelimb, Head and Hippocampus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain, Eye and Testis.

Entry informationi

Entry nameiFUND2_MOUSE
AccessioniPrimary (citable) accession number: Q9D6K8
Secondary accession number(s): Q80VT2
, Q80YD9, Q8BSM8, Q9D617
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2001
Last modified: February 4, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.