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Protein

Probable palmitoyltransferase ZDHHC4

Gene

Zdhhc4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei179S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC4 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 4
Short name:
DHHC-4
Gene namesi
Name:Zdhhc4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1920131. Zdhhc4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128661 – 343Probable palmitoyltransferase ZDHHC4Add BLAST343

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ9D6H5.
PeptideAtlasiQ9D6H5.
PRIDEiQ9D6H5.

PTM databases

PhosphoSitePlusiQ9D6H5.
SwissPalmiQ9D6H5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000001844.
CleanExiMM_ZDHHC4.
ExpressionAtlasiQ9D6H5. baseline and differential.
GenevisibleiQ9D6H5. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9D6H5. 1 interactor.
STRINGi10090.ENSMUSP00000001900.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini149 – 199DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1312. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00870000136460.
HOGENOMiHOG000253024.
HOVERGENiHBG054775.
InParanoidiQ9D6H5.
KOiK20003.
OMAiGAWNIRY.
OrthoDBiEOG091G0BJJ.
PhylomeDBiQ9D6H5.
TreeFamiTF330931.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. zf-DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D6H5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFLVLFLFY LAFLLICVVL ICIFTKSQRL KAVVLGGAQV CSRVIPQCLQ
60 70 80 90 100
RAVQTLLHQL FHTRHPTFIV LHLLLQGLVY AEYTCEVFGY CRELEFSLPY
110 120 130 140 150
LLLPYVLLSV NLVFFTLTCA ANPGTITKAN ESFLLQVYKF DDVMFPKNSR
160 170 180 190 200
CPTCDLRKPA RSKHCRLCDR CVHRFDHHCV WVNNCIGAWN TRYFLIYLLT
210 220 230 240 250
LTASAATIAT VTAAFLLRLV TVSDLYQETY LDDVGHFQAV DTVFLIQHLF
260 270 280 290 300
LAFPRIVFLL GFVIVLSMLL AGYLCFALYL AATNQTTNEW YKGDWAWCQR
310 320 330 340
WPLVAWSPSA EPRIHQNIHS HGFRSNLREI FLPATPSYKK KEK
Length:343
Mass (Da):39,528
Last modified:June 1, 2001 - v1
Checksum:i1EAB40177DDD218C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013609 mRNA. Translation: BAB28929.1.
BC019523 mRNA. Translation: AAH19523.1.
BC022770 mRNA. Translation: AAH22770.1.
CCDSiCCDS19840.1.
RefSeqiNP_082655.1. NM_028379.5.
XP_006504794.1. XM_006504731.1.
XP_006504796.1. XM_006504733.1.
XP_006504797.1. XM_006504734.1.
XP_006504798.1. XM_006504735.1.
XP_006504799.1. XM_006504736.3.
UniGeneiMm.261606.
Mm.489693.

Genome annotation databases

EnsembliENSMUST00000001900; ENSMUSP00000001900; ENSMUSG00000001844.
ENSMUST00000161915; ENSMUSP00000124813; ENSMUSG00000001844.
GeneIDi72881.
KEGGimmu:72881.
UCSCiuc009ajz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013609 mRNA. Translation: BAB28929.1.
BC019523 mRNA. Translation: AAH19523.1.
BC022770 mRNA. Translation: AAH22770.1.
CCDSiCCDS19840.1.
RefSeqiNP_082655.1. NM_028379.5.
XP_006504794.1. XM_006504731.1.
XP_006504796.1. XM_006504733.1.
XP_006504797.1. XM_006504734.1.
XP_006504798.1. XM_006504735.1.
XP_006504799.1. XM_006504736.3.
UniGeneiMm.261606.
Mm.489693.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D6H5. 1 interactor.
STRINGi10090.ENSMUSP00000001900.

PTM databases

PhosphoSitePlusiQ9D6H5.
SwissPalmiQ9D6H5.

Proteomic databases

PaxDbiQ9D6H5.
PeptideAtlasiQ9D6H5.
PRIDEiQ9D6H5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001900; ENSMUSP00000001900; ENSMUSG00000001844.
ENSMUST00000161915; ENSMUSP00000124813; ENSMUSG00000001844.
GeneIDi72881.
KEGGimmu:72881.
UCSCiuc009ajz.2. mouse.

Organism-specific databases

CTDi55146.
MGIiMGI:1920131. Zdhhc4.

Phylogenomic databases

eggNOGiKOG1312. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00870000136460.
HOGENOMiHOG000253024.
HOVERGENiHBG054775.
InParanoidiQ9D6H5.
KOiK20003.
OMAiGAWNIRY.
OrthoDBiEOG091G0BJJ.
PhylomeDBiQ9D6H5.
TreeFamiTF330931.

Miscellaneous databases

PROiPR:Q9D6H5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001844.
CleanExiMM_ZDHHC4.
ExpressionAtlasiQ9D6H5. baseline and differential.
GenevisibleiQ9D6H5. MM.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. zf-DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZDHC4_MOUSE
AccessioniPrimary (citable) accession number: Q9D6H5
Secondary accession number(s): Q8R5E0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: June 1, 2001
Last modified: April 12, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.