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Q9D6H5 (ZDHC4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable palmitoyltransferase ZDHHC4
EC=2.3.1.-
Alternative name(s):
Zinc finger DHHC domain-containing protein 4
Short name=DHHC-4
Gene names
Name:Zdhhc4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Domain

The DHHC domain is required for palmitoyltransferase activity By similarity.

Sequence similarities

Belongs to the DHHC palmitoyltransferase family.

Contains 1 DHHC-type zinc finger.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
Zinc-finger
   LigandMetal-binding
Zinc
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functiontransferase activity, transferring acyl groups

Inferred from electronic annotation. Source: UniProtKB-KW

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 343343Probable palmitoyltransferase ZDHHC4
PRO_0000212866

Regions

Transmembrane3 – 2321Helical; Potential
Transmembrane68 – 8821Helical; Potential
Transmembrane101 – 12121Helical; Potential
Transmembrane194 – 21421Helical; Potential
Transmembrane256 – 27621Helical; Potential
Zinc finger149 – 19951DHHC-type

Sites

Active site1791S-palmitoyl cysteine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9D6H5 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 1EAB40177DDD218C

FASTA34339,528
        10         20         30         40         50         60 
MDFLVLFLFY LAFLLICVVL ICIFTKSQRL KAVVLGGAQV CSRVIPQCLQ RAVQTLLHQL 

        70         80         90        100        110        120 
FHTRHPTFIV LHLLLQGLVY AEYTCEVFGY CRELEFSLPY LLLPYVLLSV NLVFFTLTCA 

       130        140        150        160        170        180 
ANPGTITKAN ESFLLQVYKF DDVMFPKNSR CPTCDLRKPA RSKHCRLCDR CVHRFDHHCV 

       190        200        210        220        230        240 
WVNNCIGAWN TRYFLIYLLT LTASAATIAT VTAAFLLRLV TVSDLYQETY LDDVGHFQAV 

       250        260        270        280        290        300 
DTVFLIQHLF LAFPRIVFLL GFVIVLSMLL AGYLCFALYL AATNQTTNEW YKGDWAWCQR 

       310        320        330        340 
WPLVAWSPSA EPRIHQNIHS HGFRSNLREI FLPATPSYKK KEK

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Hippocampus.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK013609 mRNA. Translation: BAB28929.1.
BC019523 mRNA. Translation: AAH19523.1.
BC022770 mRNA. Translation: AAH22770.1.
IPIIPI00109120.
RefSeqNP_082655.1. NM_028379.5.
UniGeneMm.261606.
Mm.489693.

3D structure databases

ModBaseSearch...

PTM databases

PhosphoSiteQ9D6H5.

Proteomic databases

PRIDEQ9D6H5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000001900; ENSMUSP00000001900; ENSMUSG00000001844.
ENSMUST00000161915; ENSMUSP00000124813; ENSMUSG00000001844.
GeneID72881.
KEGGmmu:72881.
UCSCuc009ajz.1. mouse.

Organism-specific databases

CTD55146.
MGIMGI:1920131. Zdhhc4.

Phylogenomic databases

eggNOGCOG5273.
GeneTreeENSGT00640000091441.
HOGENOMHOG000253024.
HOVERGENHBG054775.
InParanoidQ9D6H5.
OMALTCVTNP.
OrthoDBEOG428224.

Gene expression databases

ArrayExpressQ9D6H5.
BgeeQ9D6H5.
CleanExMM_ZDHHC4.
GenevestigatorQ9D6H5.

Family and domain databases

InterProIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEPS50216. ZF_DHHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio337077.
SOURCESearch...

Entry information

Entry nameZDHC4_MOUSE
AccessionPrimary (citable) accession number: Q9D6H5
Secondary accession number(s): Q8R5E0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: June 1, 2001
Last modified: April 3, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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