Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Intraflagellar transport protein 25 homolog

Gene

Hspb11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi29 – 291Calcium; via carbonyl oxygenBy similarity
Metal bindingi32 – 321CalciumBy similarity
Metal bindingi37 – 371CalciumBy similarity

GO - Molecular functioni

GO - Biological processi

  • heart development Source: MGI
  • intraciliary transport Source: MGI
  • left/right axis specification Source: MGI
  • lung development Source: MGI
  • skeletal system development Source: MGI
  • smoothened signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Stress response, Transport

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-5620924. Intraflagellar transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Intraflagellar transport protein 25 homolog
Alternative name(s):
Heat shock protein beta-11
Short name:
Hspb11
Placental protein 25
Short name:
PP25
Gene namesi
Name:Hspb11
Synonyms:Ift25
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1920188. Hspb11.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: MGI
  • cilium Source: MGI
  • extracellular exosome Source: MGI
  • intraciliary transport particle B Source: UniProtKB
  • primary cilium Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium

Pathology & Biotechi

Disruption phenotypei

Null mutants retain the ability to ciliate and survive through gestation. They die shortly after birth due to different phenotypes reminiscent of Shh signaling defects: polydactyly, cleft palate, lung isomerisms, and structural heart defects.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 143143Intraflagellar transport protein 25 homologPRO_0000058532Add
BLAST

Proteomic databases

EPDiQ9D6H2.
MaxQBiQ9D6H2.
PaxDbiQ9D6H2.
PeptideAtlasiQ9D6H2.
PRIDEiQ9D6H2.

PTM databases

PhosphoSiteiQ9D6H2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000063172.
GenevisibleiQ9D6H2. MM.

Interactioni

Subunit structurei

Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT27; the interaction is direct. Interacts with IFT88.2 Publications

Protein-protein interaction databases

BioGridi215658. 2 interactions.
STRINGi10090.ENSMUSP00000048810.

Structurei

3D structure databases

ProteinModelPortaliQ9D6H2.
SMRiQ9D6H2. Positions 1-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IFT25 family.Curated

Phylogenomic databases

eggNOGiENOG410INPG. Eukaryota.
ENOG4111WDR. LUCA.
GeneTreeiENSGT00390000012620.
HOGENOMiHOG000232198.
HOVERGENiHBG060331.
InParanoidiQ9D6H2.
KOiK19369.
OMAiFIIKSAF.
OrthoDBiEOG091G0RG0.
PhylomeDBiQ9D6H2.
TreeFamiTF336031.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR033558. IFT25.
[Graphical view]
PANTHERiPTHR33906. PTHR33906. 1 hit.
SUPFAMiSSF49785. SSF49785. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D6H2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKVDLCSVT EGTEVILATS SDEKHPPENI IDGNPETFWT TTGMFPQEFI
60 70 80 90 100
ICFHKHVKIE KLVIQSYLVR TLRIEKTTSK EPLDFEQWVE KDLVHTEGQL
110 120 130 140
QNEEIVARDG YATFLRFIIV SAFDHFASVH SISAEGLTVS SLP
Length:143
Mass (Da):16,281
Last modified:October 3, 2012 - v2
Checksum:iC05B1E8A496DB5EC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti74 – 741I → T in BAB28934 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013636 mRNA. Translation: BAB28934.1.
AK157651 mRNA. Translation: BAE34145.1.
AL645723 Genomic DNA. No translation available.
CH466527 Genomic DNA. Translation: EDL30781.1.
CH466527 Genomic DNA. Translation: EDL30782.1.
CH466527 Genomic DNA. Translation: EDL30783.1.
CCDSiCCDS18435.1.
RefSeqiNP_082670.1. NM_028394.2.
XP_006503487.1. XM_006503424.2.
XP_006503488.1. XM_006503425.1.
XP_006503489.1. XM_006503426.2.
UniGeneiMm.21787.

Genome annotation databases

EnsembliENSMUST00000046558; ENSMUSP00000048810; ENSMUSG00000063172.
ENSMUST00000106749; ENSMUSP00000102360; ENSMUSG00000063172.
ENSMUST00000152717; ENSMUSP00000118617; ENSMUSG00000063172.
GeneIDi72938.
KEGGimmu:72938.
UCSCiuc008tzn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013636 mRNA. Translation: BAB28934.1.
AK157651 mRNA. Translation: BAE34145.1.
AL645723 Genomic DNA. No translation available.
CH466527 Genomic DNA. Translation: EDL30781.1.
CH466527 Genomic DNA. Translation: EDL30782.1.
CH466527 Genomic DNA. Translation: EDL30783.1.
CCDSiCCDS18435.1.
RefSeqiNP_082670.1. NM_028394.2.
XP_006503487.1. XM_006503424.2.
XP_006503488.1. XM_006503425.1.
XP_006503489.1. XM_006503426.2.
UniGeneiMm.21787.

3D structure databases

ProteinModelPortaliQ9D6H2.
SMRiQ9D6H2. Positions 1-142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215658. 2 interactions.
STRINGi10090.ENSMUSP00000048810.

PTM databases

PhosphoSiteiQ9D6H2.

Proteomic databases

EPDiQ9D6H2.
MaxQBiQ9D6H2.
PaxDbiQ9D6H2.
PeptideAtlasiQ9D6H2.
PRIDEiQ9D6H2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046558; ENSMUSP00000048810; ENSMUSG00000063172.
ENSMUST00000106749; ENSMUSP00000102360; ENSMUSG00000063172.
ENSMUST00000152717; ENSMUSP00000118617; ENSMUSG00000063172.
GeneIDi72938.
KEGGimmu:72938.
UCSCiuc008tzn.1. mouse.

Organism-specific databases

CTDi51668.
MGIiMGI:1920188. Hspb11.

Phylogenomic databases

eggNOGiENOG410INPG. Eukaryota.
ENOG4111WDR. LUCA.
GeneTreeiENSGT00390000012620.
HOGENOMiHOG000232198.
HOVERGENiHBG060331.
InParanoidiQ9D6H2.
KOiK19369.
OMAiFIIKSAF.
OrthoDBiEOG091G0RG0.
PhylomeDBiQ9D6H2.
TreeFamiTF336031.

Enzyme and pathway databases

ReactomeiR-MMU-5620924. Intraflagellar transport.

Miscellaneous databases

ChiTaRSiHspb11. mouse.
PROiQ9D6H2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063172.
GenevisibleiQ9D6H2. MM.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR033558. IFT25.
[Graphical view]
PANTHERiPTHR33906. PTHR33906. 1 hit.
SUPFAMiSSF49785. SSF49785. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIFT25_MOUSE
AccessioniPrimary (citable) accession number: Q9D6H2
Secondary accession number(s): Q3TZR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 3, 2012
Last modified: September 7, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was initially classified as a member of the small heat shock family protein. However, it was later shown that it is not the case (PubMed:22595669).1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.