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Q9D6F4

- GBRA4_MOUSE

UniProt

Q9D6F4 - GBRA4_MOUSE

Protein

Gamma-aminobutyric acid receptor subunit alpha-4

Gene

Gabra4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (04 May 2001)
      Previous versions | rss
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    Functioni

    GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

    GO - Molecular functioni

    1. chloride channel activity Source: UniProtKB-KW
    2. extracellular ligand-gated ion channel activity Source: InterPro
    3. GABA-A receptor activity Source: InterPro

    GO - Biological processi

    1. central nervous system development Source: MGI
    2. gamma-aminobutyric acid signaling pathway Source: InterPro
    3. regulation of response to drug Source: MGI

    Keywords - Molecular functioni

    Chloride channel, Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Chloride

    Enzyme and pathway databases

    ReactomeiREACT_198558. Ligand-gated ion channel transport.
    REACT_198560. GABA A receptor activation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-aminobutyric acid receptor subunit alpha-4
    Alternative name(s):
    GABA(A) receptor subunit alpha-4
    Gene namesi
    Name:Gabra4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:95616. Gabra4.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. chloride channel complex Source: UniProtKB-KW
    3. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3535Sequence AnalysisAdd
    BLAST
    Chaini36 – 552517Gamma-aminobutyric acid receptor subunit alpha-4PRO_0000000442Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi172 ↔ 186By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ9D6F4.
    PaxDbiQ9D6F4.
    PRIDEiQ9D6F4.

    PTM databases

    PhosphoSiteiQ9D6F4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9D6F4.
    BgeeiQ9D6F4.
    GenevestigatoriQ9D6F4.

    Interactioni

    Subunit structurei

    Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D6F4.
    SMRiQ9D6F4. Positions 49-357.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini36 – 258223ExtracellularCuratedAdd
    BLAST
    Topological domaini341 – 521181CytoplasmicCuratedAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei259 – 28022HelicalCuratedAdd
    BLAST
    Transmembranei285 – 30622HelicalCuratedAdd
    BLAST
    Transmembranei318 – 34023HelicalCuratedAdd
    BLAST
    Transmembranei522 – 54120HelicalCuratedAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG238757.
    GeneTreeiENSGT00550000074441.
    HOGENOMiHOG000231337.
    HOVERGENiHBG051707.
    InParanoidiQ9D6F4.
    KOiK05175.
    OMAiPNPFSHA.
    OrthoDBiEOG7JX342.
    PhylomeDBiQ9D6F4.
    TreeFamiTF315453.

    Family and domain databases

    Gene3Di2.70.170.10. 1 hit.
    InterProiIPR006028. GABAA/Glycine_rcpt.
    IPR001390. GABAAa_rcpt.
    IPR005434. GABBAa4_rcpt.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view]
    PRINTSiPR01079. GABAARALPHA.
    PR01617. GABAARALPHA4.
    PR00253. GABAARECEPTR.
    PR00252. NRIONCHANNEL.
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 2 hits.
    TIGRFAMsiTIGR00860. LIC. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9D6F4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSVQKVPAI ALCSGVSLAL LHFLCLAACL NESPGQNSKD EKLCPENFTR    50
    ILDSLLDGYD NRLRPGFGGP VTEVKTDIYV TSFGPVSDVE MEYTMDVFFR 100
    QTWIDKRLKY DGPIEILRLN NMMVTKVWTP DTFFRNGKKS VSHNMTAPNK 150
    LFRIMRNGTI LYTMRLTISA ECPMRLVDFP MDGHACPLKF GSYAYPKSEM 200
    IYTWTKGPEK SVEVPKESSS LVQYDLIGQT VSSETIKSIT GEYIVMTVYF 250
    HLRRKMGYFM IQTYIPCIMT VILSQVSFWI NKESVPARTV FGITTVLTMT 300
    TLSISARHSL PKVSYATAMD WFIAVCFAFV FSALIEFAAV NYFTNIQMQK 350
    AKKKISKPPP EVPAAPVLKE KHTETSLQNT HANLNMRKRT NALVHSESDV 400
    KSRTEVGNHS SKTSAVQESS EATPKAHLAS SPNPFSRANA AETMSAAARG 450
    LSSAASPSPH GTLRPASLGS ASTRPAFGSR LGRIKTTVNT TGAAGNVSAT 500
    PPPPAPPPSG SGTSKIDKYA RILFPVTFGA FNMVYWVVYL SKDTMEKSES 550
    LM 552
    Length:552
    Mass (Da):60,878
    Last modified:May 4, 2001 - v1
    Checksum:i213C16C423D7F97B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK013727 mRNA. Translation: BAB28975.1.
    CCDSiCCDS39107.1.
    RefSeqiNP_034381.1. NM_010251.2.
    UniGeneiMm.248731.

    Genome annotation databases

    EnsembliENSMUST00000031121; ENSMUSP00000031121; ENSMUSG00000029211.
    GeneIDi14397.
    KEGGimmu:14397.
    UCSCiuc008xqy.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK013727 mRNA. Translation: BAB28975.1 .
    CCDSi CCDS39107.1.
    RefSeqi NP_034381.1. NM_010251.2.
    UniGenei Mm.248731.

    3D structure databases

    ProteinModelPortali Q9D6F4.
    SMRi Q9D6F4. Positions 49-357.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q9D6F4.
    ChEMBLi CHEMBL2094133.
    GuidetoPHARMACOLOGYi 407.

    PTM databases

    PhosphoSitei Q9D6F4.

    Proteomic databases

    MaxQBi Q9D6F4.
    PaxDbi Q9D6F4.
    PRIDEi Q9D6F4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000031121 ; ENSMUSP00000031121 ; ENSMUSG00000029211 .
    GeneIDi 14397.
    KEGGi mmu:14397.
    UCSCi uc008xqy.1. mouse.

    Organism-specific databases

    CTDi 2557.
    MGIi MGI:95616. Gabra4.

    Phylogenomic databases

    eggNOGi NOG238757.
    GeneTreei ENSGT00550000074441.
    HOGENOMi HOG000231337.
    HOVERGENi HBG051707.
    InParanoidi Q9D6F4.
    KOi K05175.
    OMAi PNPFSHA.
    OrthoDBi EOG7JX342.
    PhylomeDBi Q9D6F4.
    TreeFami TF315453.

    Enzyme and pathway databases

    Reactomei REACT_198558. Ligand-gated ion channel transport.
    REACT_198560. GABA A receptor activation.

    Miscellaneous databases

    NextBioi 285935.
    PROi Q9D6F4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9D6F4.
    Bgeei Q9D6F4.
    Genevestigatori Q9D6F4.

    Family and domain databases

    Gene3Di 2.70.170.10. 1 hit.
    InterProi IPR006028. GABAA/Glycine_rcpt.
    IPR001390. GABAAa_rcpt.
    IPR005434. GABBAa4_rcpt.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view ]
    PRINTSi PR01079. GABAARALPHA.
    PR01617. GABAARALPHA4.
    PR00253. GABAARECEPTR.
    PR00252. NRIONCHANNEL.
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 2 hits.
    TIGRFAMsi TIGR00860. LIC. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Hippocampus.

    Entry informationi

    Entry nameiGBRA4_MOUSE
    AccessioniPrimary (citable) accession number: Q9D6F4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 4, 2001
    Last sequence update: May 4, 2001
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3