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Q9D662

- SC23B_MOUSE

UniProt

Q9D662 - SC23B_MOUSE

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Protein

Protein transport protein Sec23B

Gene
Sec23b
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex By similarity.

GO - Molecular functioni

  1. protein binding Source: MGI
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. ER to Golgi vesicle-mediated transport Source: InterPro
  2. intracellular protein transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec23B
Alternative name(s):
SEC23-related protein B
Gene namesi
Name:Sec23b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1350925. Sec23b.

Subcellular locationi

GO - Cellular componenti

  1. COPII vesicle coat Source: InterPro
  2. endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB-SubCell
  3. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  4. Golgi membrane Source: UniProtKB-SubCell
  5. perinuclear region of cytoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 767766Protein transport protein Sec23BPRO_0000205149Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei564 – 5641N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9D662.
PaxDbiQ9D662.
PRIDEiQ9D662.

PTM databases

PhosphoSiteiQ9D662.

Expressioni

Gene expression databases

ArrayExpressiQ9D662.
BgeeiQ9D662.
CleanExiMM_SEC23B.
GenevestigatoriQ9D662.

Interactioni

Subunit structurei

COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1 By similarity.

Protein-protein interaction databases

IntActiQ9D662. 2 interactions.
MINTiMINT-1856872.

Structurei

3D structure databases

ProteinModelPortaliQ9D662.
SMRiQ9D662. Positions 3-764.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5047.
GeneTreeiENSGT00390000006916.
HOGENOMiHOG000231690.
HOVERGENiHBG055039.
InParanoidiA2ANA1.
KOiK14006.
OMAiETIAQWQ.
OrthoDBiEOG72C4ZP.
PhylomeDBiQ9D662.
TreeFamiTF300693.

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR029006. ADF-H/Gelsolin-like_dom.
IPR007123. Gelsolin-like_dom.
IPR006900. Sec23/24_helical_dom.
IPR006896. Sec23/24_trunk_dom.
IPR012990. Sec23_24_beta_S.
IPR002035. VWF_A.
IPR006895. Znf_Sec23_Sec24.
[Graphical view]
PfamiPF00626. Gelsolin. 1 hit.
PF08033. Sec23_BS. 1 hit.
PF04815. Sec23_helical. 1 hit.
PF04811. Sec23_trunk. 1 hit.
PF04810. zf-Sec23_Sec24. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF81811. SSF81811. 1 hit.
SSF82919. SSF82919. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D662-1 [UniParc]FASTAAdd to Basket

« Hide

MATYLEFIQQ NEERDGVRFS WNVWPSSRLE ATRMVVPLAC LLTPLKERPD    50
LPPVQYEPVL CSRPTCKAIL NPLCQVDYRA KLWACNFCFQ RNQFPPAYAG 100
ISEVNQPAEL MPQFSTIEYM IQRGARSPLI FLYVVDTCLE EDDLQALKES 150
LQMSLSLLPP DALVGLITFG RMVQVHELSC EGISKSYVFR GTKDLTAKQI 200
QEMLGLTKSA MPVQQARPAQ PQEQPFVSSR FLQPIHKIDM NLTDLLGELQ 250
RDPWPVTQGK RPLRSTGVAL SIAVGLLEGT FPNTGARIML FTGGPPTQGP 300
GMVVGDELKT PIRSWHDIEK DNARFMKKAT KHYEMLANRT ATNGHCIDIY 350
ACALDQTGLL EMKCCPNLTG GHMVMGDSFN TSLFKQTFQR IFSKDFNGDF 400
RMAFGATLDV KTSRELKIAG AIGPCVSLNV KGPCVSENEL GVGGTSQWKI 450
CGLDPSSTLG IYFEVVNQHN APVPQGGRGA IQFVTQYQHS STQKRIRVTT 500
IARNWADAQS QLRHIEAAFD QEAAAVLMAR LGVFRAESEE GPDVLRWLDR 550
QLIRLCQKFG QYNKEDPTSF RLSDSFSLYP QFMFHLRRSP FLQVFNNSPD 600
ESSYYRHHFA RQDLTQSLIM IQPILYSYSF HGPPEPVLLD SSSILADRIL 650
LMDTFFQIVI YLGETIAQWR KAGYQDMPEY ENFKHLLQAP LDDAQEILQA 700
RFPMPRYINT EHGGSQARFL LSKVNPSQTH NNLYAWGQET GAPILTDDVS 750
LQVFMDHLKK LAVSSAS 767
Length:767
Mass (Da):86,437
Last modified:June 1, 2001 - v1
Checksum:i1CB8EAA252A93A97
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti314 – 3141S → W in AAF08301. 1 Publication
Sequence conflicti382 – 3832SL → CV in AAF08301. 1 Publication
Sequence conflicti536 – 5361A → T in AAH05464. 1 Publication
Sequence conflicti702 – 7021F → L in AAF08301. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK014597 mRNA. Translation: BAB29452.1.
AK149693 mRNA. Translation: BAE29030.1.
AK153214 mRNA. Translation: BAE31812.1.
AK166330 mRNA. Translation: BAE38710.1.
AF200326 mRNA. Translation: AAF08301.1.
AL808119 Genomic DNA. Translation: CAM26712.1.
BC005464 mRNA. Translation: AAH05464.1.
BC011160 mRNA. Translation: AAH11160.1.
CCDSiCCDS16822.1.
RefSeqiNP_001239472.1. NM_001252543.1.
NP_001239473.1. NM_001252544.1.
NP_001239474.1. NM_001252545.1.
NP_062761.2. NM_019787.4.
UniGeneiMm.248492.
Mm.487953.

Genome annotation databases

EnsembliENSMUST00000028916; ENSMUSP00000028916; ENSMUSG00000027429.
GeneIDi27054.
KEGGimmu:27054.
UCSCiuc008mrj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK014597 mRNA. Translation: BAB29452.1 .
AK149693 mRNA. Translation: BAE29030.1 .
AK153214 mRNA. Translation: BAE31812.1 .
AK166330 mRNA. Translation: BAE38710.1 .
AF200326 mRNA. Translation: AAF08301.1 .
AL808119 Genomic DNA. Translation: CAM26712.1 .
BC005464 mRNA. Translation: AAH05464.1 .
BC011160 mRNA. Translation: AAH11160.1 .
CCDSi CCDS16822.1.
RefSeqi NP_001239472.1. NM_001252543.1.
NP_001239473.1. NM_001252544.1.
NP_001239474.1. NM_001252545.1.
NP_062761.2. NM_019787.4.
UniGenei Mm.248492.
Mm.487953.

3D structure databases

ProteinModelPortali Q9D662.
SMRi Q9D662. Positions 3-764.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9D662. 2 interactions.
MINTi MINT-1856872.

PTM databases

PhosphoSitei Q9D662.

Proteomic databases

MaxQBi Q9D662.
PaxDbi Q9D662.
PRIDEi Q9D662.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028916 ; ENSMUSP00000028916 ; ENSMUSG00000027429 .
GeneIDi 27054.
KEGGi mmu:27054.
UCSCi uc008mrj.2. mouse.

Organism-specific databases

CTDi 10483.
MGIi MGI:1350925. Sec23b.

Phylogenomic databases

eggNOGi COG5047.
GeneTreei ENSGT00390000006916.
HOGENOMi HOG000231690.
HOVERGENi HBG055039.
InParanoidi A2ANA1.
KOi K14006.
OMAi ETIAQWQ.
OrthoDBi EOG72C4ZP.
PhylomeDBi Q9D662.
TreeFami TF300693.

Miscellaneous databases

ChiTaRSi SEC23B. mouse.
NextBioi 304995.
PROi Q9D662.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9D662.
Bgeei Q9D662.
CleanExi MM_SEC23B.
Genevestigatori Q9D662.

Family and domain databases

Gene3Di 3.40.20.10. 1 hit.
3.40.50.410. 1 hit.
InterProi IPR029006. ADF-H/Gelsolin-like_dom.
IPR007123. Gelsolin-like_dom.
IPR006900. Sec23/24_helical_dom.
IPR006896. Sec23/24_trunk_dom.
IPR012990. Sec23_24_beta_S.
IPR002035. VWF_A.
IPR006895. Znf_Sec23_Sec24.
[Graphical view ]
Pfami PF00626. Gelsolin. 1 hit.
PF08033. Sec23_BS. 1 hit.
PF04815. Sec23_helical. 1 hit.
PF04811. Sec23_trunk. 1 hit.
PF04810. zf-Sec23_Sec24. 1 hit.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 1 hit.
SSF81811. SSF81811. 1 hit.
SSF82919. SSF82919. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Low D.Y.H., Tang B.L., Hong W.J.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow, Mammary gland and Skin.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-564, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiSC23B_MOUSE
AccessioniPrimary (citable) accession number: Q9D662
Secondary accession number(s): A2ANA1
, Q3U6B3, Q99K49, Q9QZ68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi