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Q9D662

- SC23B_MOUSE

UniProt

Q9D662 - SC23B_MOUSE

Protein

Protein transport protein Sec23B

Gene

Sec23b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. ER to Golgi vesicle-mediated transport Source: InterPro
    2. intracellular protein transport Source: InterPro

    Keywords - Biological processi

    ER-Golgi transport, Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein transport protein Sec23B
    Alternative name(s):
    SEC23-related protein B
    Gene namesi
    Name:Sec23b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1350925. Sec23b.

    Subcellular locationi

    GO - Cellular componenti

    1. COPII vesicle coat Source: InterPro
    2. endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB-SubCell
    3. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    4. Golgi membrane Source: UniProtKB-SubCell
    5. perinuclear region of cytoplasm Source: MGI

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 767766Protein transport protein Sec23BPRO_0000205149Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei564 – 5641N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9D662.
    PaxDbiQ9D662.
    PRIDEiQ9D662.

    PTM databases

    PhosphoSiteiQ9D662.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9D662.
    BgeeiQ9D662.
    CleanExiMM_SEC23B.
    GenevestigatoriQ9D662.

    Interactioni

    Subunit structurei

    COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1.By similarity

    Protein-protein interaction databases

    IntActiQ9D662. 2 interactions.
    MINTiMINT-1856872.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D662.
    SMRiQ9D662. Positions 3-764.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SEC23/SEC24 family. SEC23 subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG5047.
    GeneTreeiENSGT00390000006916.
    HOGENOMiHOG000231690.
    HOVERGENiHBG055039.
    InParanoidiA2ANA1.
    KOiK14006.
    OMAiETIAQWQ.
    OrthoDBiEOG72C4ZP.
    PhylomeDBiQ9D662.
    TreeFamiTF300693.

    Family and domain databases

    Gene3Di3.40.20.10. 1 hit.
    3.40.50.410. 1 hit.
    InterProiIPR029006. ADF-H/Gelsolin-like_dom.
    IPR007123. Gelsolin-like_dom.
    IPR006900. Sec23/24_helical_dom.
    IPR006896. Sec23/24_trunk_dom.
    IPR012990. Sec23_24_beta_S.
    IPR002035. VWF_A.
    IPR006895. Znf_Sec23_Sec24.
    [Graphical view]
    PfamiPF00626. Gelsolin. 1 hit.
    PF08033. Sec23_BS. 1 hit.
    PF04815. Sec23_helical. 1 hit.
    PF04811. Sec23_trunk. 1 hit.
    PF04810. zf-Sec23_Sec24. 1 hit.
    [Graphical view]
    SUPFAMiSSF53300. SSF53300. 1 hit.
    SSF81811. SSF81811. 1 hit.
    SSF82919. SSF82919. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9D662-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATYLEFIQQ NEERDGVRFS WNVWPSSRLE ATRMVVPLAC LLTPLKERPD    50
    LPPVQYEPVL CSRPTCKAIL NPLCQVDYRA KLWACNFCFQ RNQFPPAYAG 100
    ISEVNQPAEL MPQFSTIEYM IQRGARSPLI FLYVVDTCLE EDDLQALKES 150
    LQMSLSLLPP DALVGLITFG RMVQVHELSC EGISKSYVFR GTKDLTAKQI 200
    QEMLGLTKSA MPVQQARPAQ PQEQPFVSSR FLQPIHKIDM NLTDLLGELQ 250
    RDPWPVTQGK RPLRSTGVAL SIAVGLLEGT FPNTGARIML FTGGPPTQGP 300
    GMVVGDELKT PIRSWHDIEK DNARFMKKAT KHYEMLANRT ATNGHCIDIY 350
    ACALDQTGLL EMKCCPNLTG GHMVMGDSFN TSLFKQTFQR IFSKDFNGDF 400
    RMAFGATLDV KTSRELKIAG AIGPCVSLNV KGPCVSENEL GVGGTSQWKI 450
    CGLDPSSTLG IYFEVVNQHN APVPQGGRGA IQFVTQYQHS STQKRIRVTT 500
    IARNWADAQS QLRHIEAAFD QEAAAVLMAR LGVFRAESEE GPDVLRWLDR 550
    QLIRLCQKFG QYNKEDPTSF RLSDSFSLYP QFMFHLRRSP FLQVFNNSPD 600
    ESSYYRHHFA RQDLTQSLIM IQPILYSYSF HGPPEPVLLD SSSILADRIL 650
    LMDTFFQIVI YLGETIAQWR KAGYQDMPEY ENFKHLLQAP LDDAQEILQA 700
    RFPMPRYINT EHGGSQARFL LSKVNPSQTH NNLYAWGQET GAPILTDDVS 750
    LQVFMDHLKK LAVSSAS 767
    Length:767
    Mass (Da):86,437
    Last modified:June 1, 2001 - v1
    Checksum:i1CB8EAA252A93A97
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti314 – 3141S → W in AAF08301. 1 PublicationCurated
    Sequence conflicti382 – 3832SL → CV in AAF08301. 1 PublicationCurated
    Sequence conflicti536 – 5361A → T in AAH05464. (PubMed:15489334)Curated
    Sequence conflicti702 – 7021F → L in AAF08301. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK014597 mRNA. Translation: BAB29452.1.
    AK149693 mRNA. Translation: BAE29030.1.
    AK153214 mRNA. Translation: BAE31812.1.
    AK166330 mRNA. Translation: BAE38710.1.
    AF200326 mRNA. Translation: AAF08301.1.
    AL808119 Genomic DNA. Translation: CAM26712.1.
    BC005464 mRNA. Translation: AAH05464.1.
    BC011160 mRNA. Translation: AAH11160.1.
    CCDSiCCDS16822.1.
    RefSeqiNP_001239472.1. NM_001252543.1.
    NP_001239473.1. NM_001252544.1.
    NP_001239474.1. NM_001252545.1.
    NP_062761.2. NM_019787.4.
    UniGeneiMm.248492.
    Mm.487953.

    Genome annotation databases

    EnsembliENSMUST00000028916; ENSMUSP00000028916; ENSMUSG00000027429.
    GeneIDi27054.
    KEGGimmu:27054.
    UCSCiuc008mrj.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK014597 mRNA. Translation: BAB29452.1 .
    AK149693 mRNA. Translation: BAE29030.1 .
    AK153214 mRNA. Translation: BAE31812.1 .
    AK166330 mRNA. Translation: BAE38710.1 .
    AF200326 mRNA. Translation: AAF08301.1 .
    AL808119 Genomic DNA. Translation: CAM26712.1 .
    BC005464 mRNA. Translation: AAH05464.1 .
    BC011160 mRNA. Translation: AAH11160.1 .
    CCDSi CCDS16822.1.
    RefSeqi NP_001239472.1. NM_001252543.1.
    NP_001239473.1. NM_001252544.1.
    NP_001239474.1. NM_001252545.1.
    NP_062761.2. NM_019787.4.
    UniGenei Mm.248492.
    Mm.487953.

    3D structure databases

    ProteinModelPortali Q9D662.
    SMRi Q9D662. Positions 3-764.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9D662. 2 interactions.
    MINTi MINT-1856872.

    PTM databases

    PhosphoSitei Q9D662.

    Proteomic databases

    MaxQBi Q9D662.
    PaxDbi Q9D662.
    PRIDEi Q9D662.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028916 ; ENSMUSP00000028916 ; ENSMUSG00000027429 .
    GeneIDi 27054.
    KEGGi mmu:27054.
    UCSCi uc008mrj.2. mouse.

    Organism-specific databases

    CTDi 10483.
    MGIi MGI:1350925. Sec23b.

    Phylogenomic databases

    eggNOGi COG5047.
    GeneTreei ENSGT00390000006916.
    HOGENOMi HOG000231690.
    HOVERGENi HBG055039.
    InParanoidi A2ANA1.
    KOi K14006.
    OMAi ETIAQWQ.
    OrthoDBi EOG72C4ZP.
    PhylomeDBi Q9D662.
    TreeFami TF300693.

    Miscellaneous databases

    ChiTaRSi SEC23B. mouse.
    NextBioi 304995.
    PROi Q9D662.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9D662.
    Bgeei Q9D662.
    CleanExi MM_SEC23B.
    Genevestigatori Q9D662.

    Family and domain databases

    Gene3Di 3.40.20.10. 1 hit.
    3.40.50.410. 1 hit.
    InterProi IPR029006. ADF-H/Gelsolin-like_dom.
    IPR007123. Gelsolin-like_dom.
    IPR006900. Sec23/24_helical_dom.
    IPR006896. Sec23/24_trunk_dom.
    IPR012990. Sec23_24_beta_S.
    IPR002035. VWF_A.
    IPR006895. Znf_Sec23_Sec24.
    [Graphical view ]
    Pfami PF00626. Gelsolin. 1 hit.
    PF08033. Sec23_BS. 1 hit.
    PF04815. Sec23_helical. 1 hit.
    PF04811. Sec23_trunk. 1 hit.
    PF04810. zf-Sec23_Sec24. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53300. SSF53300. 1 hit.
    SSF81811. SSF81811. 1 hit.
    SSF82919. SSF82919. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Low D.Y.H., Tang B.L., Hong W.J.
      Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone marrow, Mammary gland and Skin.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.
    5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-564, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiSC23B_MOUSE
    AccessioniPrimary (citable) accession number: Q9D662
    Secondary accession number(s): A2ANA1
    , Q3U6B3, Q99K49, Q9QZ68
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 31, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3