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Q9D662

- SC23B_MOUSE

UniProt

Q9D662 - SC23B_MOUSE

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Protein

Protein transport protein Sec23B

Gene

Sec23b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex (By similarity).By similarity

GO - Molecular functioni

  1. zinc ion binding Source: InterPro

GO - Biological processi

  1. ER to Golgi vesicle-mediated transport Source: InterPro
  2. intracellular protein transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec23B
Alternative name(s):
SEC23-related protein B
Gene namesi
Name:Sec23b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1350925. Sec23b.

Subcellular locationi

GO - Cellular componenti

  1. COPII vesicle coat Source: InterPro
  2. endoplasmic reticulum Source: UniProtKB-KW
  3. Golgi apparatus Source: UniProtKB-KW
  4. perinuclear region of cytoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 767766Protein transport protein Sec23BPRO_0000205149Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei564 – 5641N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9D662.
PaxDbiQ9D662.
PRIDEiQ9D662.

PTM databases

PhosphoSiteiQ9D662.

Expressioni

Gene expression databases

BgeeiQ9D662.
CleanExiMM_SEC23B.
ExpressionAtlasiQ9D662. baseline and differential.
GenevestigatoriQ9D662.

Interactioni

Subunit structurei

COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1.By similarity

Protein-protein interaction databases

IntActiQ9D662. 2 interactions.
MINTiMINT-1856872.

Structurei

3D structure databases

ProteinModelPortaliQ9D662.
SMRiQ9D662. Positions 3-764.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SEC23/SEC24 family. SEC23 subfamily.Curated

Phylogenomic databases

eggNOGiCOG5047.
GeneTreeiENSGT00390000006916.
HOGENOMiHOG000231690.
HOVERGENiHBG055039.
InParanoidiQ9D662.
KOiK14006.
OMAiETIAQWQ.
OrthoDBiEOG72C4ZP.
PhylomeDBiQ9D662.
TreeFamiTF300693.

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR029006. ADF-H/Gelsolin-like_dom.
IPR007123. Gelsolin-like_dom.
IPR006900. Sec23/24_helical_dom.
IPR006896. Sec23/24_trunk_dom.
IPR012990. Sec23_24_beta_S.
IPR002035. VWF_A.
IPR006895. Znf_Sec23_Sec24.
[Graphical view]
PfamiPF00626. Gelsolin. 1 hit.
PF08033. Sec23_BS. 1 hit.
PF04815. Sec23_helical. 1 hit.
PF04811. Sec23_trunk. 1 hit.
PF04810. zf-Sec23_Sec24. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF81811. SSF81811. 1 hit.
SSF82919. SSF82919. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D662-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATYLEFIQQ NEERDGVRFS WNVWPSSRLE ATRMVVPLAC LLTPLKERPD
60 70 80 90 100
LPPVQYEPVL CSRPTCKAIL NPLCQVDYRA KLWACNFCFQ RNQFPPAYAG
110 120 130 140 150
ISEVNQPAEL MPQFSTIEYM IQRGARSPLI FLYVVDTCLE EDDLQALKES
160 170 180 190 200
LQMSLSLLPP DALVGLITFG RMVQVHELSC EGISKSYVFR GTKDLTAKQI
210 220 230 240 250
QEMLGLTKSA MPVQQARPAQ PQEQPFVSSR FLQPIHKIDM NLTDLLGELQ
260 270 280 290 300
RDPWPVTQGK RPLRSTGVAL SIAVGLLEGT FPNTGARIML FTGGPPTQGP
310 320 330 340 350
GMVVGDELKT PIRSWHDIEK DNARFMKKAT KHYEMLANRT ATNGHCIDIY
360 370 380 390 400
ACALDQTGLL EMKCCPNLTG GHMVMGDSFN TSLFKQTFQR IFSKDFNGDF
410 420 430 440 450
RMAFGATLDV KTSRELKIAG AIGPCVSLNV KGPCVSENEL GVGGTSQWKI
460 470 480 490 500
CGLDPSSTLG IYFEVVNQHN APVPQGGRGA IQFVTQYQHS STQKRIRVTT
510 520 530 540 550
IARNWADAQS QLRHIEAAFD QEAAAVLMAR LGVFRAESEE GPDVLRWLDR
560 570 580 590 600
QLIRLCQKFG QYNKEDPTSF RLSDSFSLYP QFMFHLRRSP FLQVFNNSPD
610 620 630 640 650
ESSYYRHHFA RQDLTQSLIM IQPILYSYSF HGPPEPVLLD SSSILADRIL
660 670 680 690 700
LMDTFFQIVI YLGETIAQWR KAGYQDMPEY ENFKHLLQAP LDDAQEILQA
710 720 730 740 750
RFPMPRYINT EHGGSQARFL LSKVNPSQTH NNLYAWGQET GAPILTDDVS
760
LQVFMDHLKK LAVSSAS
Length:767
Mass (Da):86,437
Last modified:June 1, 2001 - v1
Checksum:i1CB8EAA252A93A97
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti314 – 3141S → W in AAF08301. 1 PublicationCurated
Sequence conflicti382 – 3832SL → CV in AAF08301. 1 PublicationCurated
Sequence conflicti536 – 5361A → T in AAH05464. (PubMed:15489334)Curated
Sequence conflicti702 – 7021F → L in AAF08301. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014597 mRNA. Translation: BAB29452.1.
AK149693 mRNA. Translation: BAE29030.1.
AK153214 mRNA. Translation: BAE31812.1.
AK166330 mRNA. Translation: BAE38710.1.
AF200326 mRNA. Translation: AAF08301.1.
AL808119 Genomic DNA. Translation: CAM26712.1.
BC005464 mRNA. Translation: AAH05464.1.
BC011160 mRNA. Translation: AAH11160.1.
CCDSiCCDS16822.1.
RefSeqiNP_001239472.1. NM_001252543.1.
NP_001239473.1. NM_001252544.1.
NP_001239474.1. NM_001252545.1.
NP_062761.2. NM_019787.4.
UniGeneiMm.248492.
Mm.487953.

Genome annotation databases

EnsembliENSMUST00000028916; ENSMUSP00000028916; ENSMUSG00000027429.
GeneIDi27054.
KEGGimmu:27054.
UCSCiuc008mrj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014597 mRNA. Translation: BAB29452.1 .
AK149693 mRNA. Translation: BAE29030.1 .
AK153214 mRNA. Translation: BAE31812.1 .
AK166330 mRNA. Translation: BAE38710.1 .
AF200326 mRNA. Translation: AAF08301.1 .
AL808119 Genomic DNA. Translation: CAM26712.1 .
BC005464 mRNA. Translation: AAH05464.1 .
BC011160 mRNA. Translation: AAH11160.1 .
CCDSi CCDS16822.1.
RefSeqi NP_001239472.1. NM_001252543.1.
NP_001239473.1. NM_001252544.1.
NP_001239474.1. NM_001252545.1.
NP_062761.2. NM_019787.4.
UniGenei Mm.248492.
Mm.487953.

3D structure databases

ProteinModelPortali Q9D662.
SMRi Q9D662. Positions 3-764.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9D662. 2 interactions.
MINTi MINT-1856872.

PTM databases

PhosphoSitei Q9D662.

Proteomic databases

MaxQBi Q9D662.
PaxDbi Q9D662.
PRIDEi Q9D662.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028916 ; ENSMUSP00000028916 ; ENSMUSG00000027429 .
GeneIDi 27054.
KEGGi mmu:27054.
UCSCi uc008mrj.2. mouse.

Organism-specific databases

CTDi 10483.
MGIi MGI:1350925. Sec23b.

Phylogenomic databases

eggNOGi COG5047.
GeneTreei ENSGT00390000006916.
HOGENOMi HOG000231690.
HOVERGENi HBG055039.
InParanoidi Q9D662.
KOi K14006.
OMAi ETIAQWQ.
OrthoDBi EOG72C4ZP.
PhylomeDBi Q9D662.
TreeFami TF300693.

Miscellaneous databases

ChiTaRSi Sec23b. mouse.
NextBioi 304995.
PROi Q9D662.
SOURCEi Search...

Gene expression databases

Bgeei Q9D662.
CleanExi MM_SEC23B.
ExpressionAtlasi Q9D662. baseline and differential.
Genevestigatori Q9D662.

Family and domain databases

Gene3Di 3.40.20.10. 1 hit.
3.40.50.410. 1 hit.
InterProi IPR029006. ADF-H/Gelsolin-like_dom.
IPR007123. Gelsolin-like_dom.
IPR006900. Sec23/24_helical_dom.
IPR006896. Sec23/24_trunk_dom.
IPR012990. Sec23_24_beta_S.
IPR002035. VWF_A.
IPR006895. Znf_Sec23_Sec24.
[Graphical view ]
Pfami PF00626. Gelsolin. 1 hit.
PF08033. Sec23_BS. 1 hit.
PF04815. Sec23_helical. 1 hit.
PF04811. Sec23_trunk. 1 hit.
PF04810. zf-Sec23_Sec24. 1 hit.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 1 hit.
SSF81811. SSF81811. 1 hit.
SSF82919. SSF82919. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Low D.Y.H., Tang B.L., Hong W.J.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow, Mammary gland and Skin.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-564, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiSC23B_MOUSE
AccessioniPrimary (citable) accession number: Q9D662
Secondary accession number(s): A2ANA1
, Q3U6B3, Q99K49, Q9QZ68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3