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Q9D662 (SC23B_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein transport protein Sec23B
Alternative name(s):
SEC23-related protein B
Gene names
Name:Sec23b
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length767 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex By similarity.

Subunit structure

COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1 By similarity.

Subcellular location

Golgi apparatus membrane By similarity. Endoplasmic reticulum membrane By similarity. Endoplasmic reticulum-Golgi intermediate compartment membrane By similarity.

Sequence similarities

Belongs to the SEC23/SEC24 family. SEC23 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 767766Protein transport protein Sec23B
PRO_0000205149

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue5641N6-acetyllysine Ref.5

Experimental info

Sequence conflict3141S → W in AAF08301. Ref.1
Sequence conflict382 – 3832SL → CV in AAF08301. Ref.1
Sequence conflict5361A → T in AAH05464. Ref.4
Sequence conflict7021F → L in AAF08301. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9D662 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 1CB8EAA252A93A97

FASTA76786,437
        10         20         30         40         50         60 
MATYLEFIQQ NEERDGVRFS WNVWPSSRLE ATRMVVPLAC LLTPLKERPD LPPVQYEPVL 

        70         80         90        100        110        120 
CSRPTCKAIL NPLCQVDYRA KLWACNFCFQ RNQFPPAYAG ISEVNQPAEL MPQFSTIEYM 

       130        140        150        160        170        180 
IQRGARSPLI FLYVVDTCLE EDDLQALKES LQMSLSLLPP DALVGLITFG RMVQVHELSC 

       190        200        210        220        230        240 
EGISKSYVFR GTKDLTAKQI QEMLGLTKSA MPVQQARPAQ PQEQPFVSSR FLQPIHKIDM 

       250        260        270        280        290        300 
NLTDLLGELQ RDPWPVTQGK RPLRSTGVAL SIAVGLLEGT FPNTGARIML FTGGPPTQGP 

       310        320        330        340        350        360 
GMVVGDELKT PIRSWHDIEK DNARFMKKAT KHYEMLANRT ATNGHCIDIY ACALDQTGLL 

       370        380        390        400        410        420 
EMKCCPNLTG GHMVMGDSFN TSLFKQTFQR IFSKDFNGDF RMAFGATLDV KTSRELKIAG 

       430        440        450        460        470        480 
AIGPCVSLNV KGPCVSENEL GVGGTSQWKI CGLDPSSTLG IYFEVVNQHN APVPQGGRGA 

       490        500        510        520        530        540 
IQFVTQYQHS STQKRIRVTT IARNWADAQS QLRHIEAAFD QEAAAVLMAR LGVFRAESEE 

       550        560        570        580        590        600 
GPDVLRWLDR QLIRLCQKFG QYNKEDPTSF RLSDSFSLYP QFMFHLRRSP FLQVFNNSPD 

       610        620        630        640        650        660 
ESSYYRHHFA RQDLTQSLIM IQPILYSYSF HGPPEPVLLD SSSILADRIL LMDTFFQIVI 

       670        680        690        700        710        720 
YLGETIAQWR KAGYQDMPEY ENFKHLLQAP LDDAQEILQA RFPMPRYINT EHGGSQARFL 

       730        740        750        760 
LSKVNPSQTH NNLYAWGQET GAPILTDDVS LQVFMDHLKK LAVSSAS 

« Hide

References

« Hide 'large scale' references
[1]Low D.Y.H., Tang B.L., Hong W.J.
Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Bone marrow, Mammary gland and Skin.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary tumor.
[5]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-564, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK014597 mRNA. Translation: BAB29452.1.
AK149693 mRNA. Translation: BAE29030.1.
AK153214 mRNA. Translation: BAE31812.1.
AK166330 mRNA. Translation: BAE38710.1.
AF200326 mRNA. Translation: AAF08301.1.
AL808119 Genomic DNA. Translation: CAM26712.1.
BC005464 mRNA. Translation: AAH05464.1.
BC011160 mRNA. Translation: AAH11160.1.
CCDSCCDS16822.1.
RefSeqNP_001239472.1. NM_001252543.1.
NP_001239473.1. NM_001252544.1.
NP_001239474.1. NM_001252545.1.
NP_062761.2. NM_019787.4.
UniGeneMm.248492.
Mm.487953.

3D structure databases

ProteinModelPortalQ9D662.
SMRQ9D662. Positions 3-764.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9D662. 2 interactions.
MINTMINT-1856872.

PTM databases

PhosphoSiteQ9D662.

Proteomic databases

MaxQBQ9D662.
PaxDbQ9D662.
PRIDEQ9D662.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000028916; ENSMUSP00000028916; ENSMUSG00000027429.
GeneID27054.
KEGGmmu:27054.
UCSCuc008mrj.2. mouse.

Organism-specific databases

CTD10483.
MGIMGI:1350925. Sec23b.

Phylogenomic databases

eggNOGCOG5047.
GeneTreeENSGT00390000006916.
HOGENOMHOG000231690.
HOVERGENHBG055039.
InParanoidA2ANA1.
KOK14006.
OMAETIAQWQ.
OrthoDBEOG72C4ZP.
PhylomeDBQ9D662.
TreeFamTF300693.

Gene expression databases

ArrayExpressQ9D662.
BgeeQ9D662.
CleanExMM_SEC23B.
GenevestigatorQ9D662.

Family and domain databases

Gene3D3.40.20.10. 1 hit.
3.40.50.410. 1 hit.
InterProIPR029006. ADF-H/Gelsolin-like_dom.
IPR007123. Gelsolin-like_dom.
IPR006900. Sec23/24_helical_dom.
IPR006896. Sec23/24_trunk_dom.
IPR012990. Sec23_24_beta_S.
IPR002035. VWF_A.
IPR006895. Znf_Sec23_Sec24.
[Graphical view]
PfamPF00626. Gelsolin. 1 hit.
PF08033. Sec23_BS. 1 hit.
PF04815. Sec23_helical. 1 hit.
PF04811. Sec23_trunk. 1 hit.
PF04810. zf-Sec23_Sec24. 1 hit.
[Graphical view]
SUPFAMSSF53300. SSF53300. 1 hit.
SSF81811. SSF81811. 1 hit.
SSF82919. SSF82919. 1 hit.
ProtoNetSearch...

Other

ChiTaRSSEC23B. mouse.
NextBio304995.
PROQ9D662.
SOURCESearch...

Entry information

Entry nameSC23B_MOUSE
AccessionPrimary (citable) accession number: Q9D662
Secondary accession number(s): A2ANA1 expand/collapse secondary AC list , Q3U6B3, Q99K49, Q9QZ68
Entry history
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot